Isochem

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PMC Isochem

Company type| S.A.S
Industry| Chemicals and Speciality Products
Founded| 1974
Headquarters| Vert-le-Petit, France

Key people

| Björn Schlosser (CEO)
Products| Chemicals

Number of employees

| 330 (2016)
Subsidiaries| Framochem (Hongrie), Wychem (Grande-Bretagne), Isochem Gmbh (Allemagne)
Website| www.isochem.eu

PMC Isochem is a French chemical company that was established in 1974 that specializes in custom chemical synthesis.

## Timeline and history[edit]

* 1974: Isochem was created in Gennevilliers.
* 1977: A site was opened in Pithiviers (formerly Agrifarm), in central France.
* 1979: The company was audited and approved by the U.S. Food and Drug Administration (FDA) for the first time.
* 1990: Isochem joined the Groupe SNPE, a French holding company that specializes in explosives.
* 1991: Isochem acquired the Vert-le-Petit site (formerly IRCHA Fine Chemicals and Propeptide).[1]
* 2003: Isochem acquired the Pont-de-Claix platform and the Hungarian subsidiary Framochem.
* 2010: Isochem was acquired by the German industrial holding company Aurelius AG [de].[2]
* 2012: Isochem acquired Wychem (UK).[3],[4]
* 2014: Isochem sold its Framochem subsidiary.
* 2016: Isochem sold its Wychem subsidiary.

* 2017: PMC Group France, a wholly owned subsidiary of PMC Group International Inc., announced the acquisition of Isochem. This resulted in the name change to PMC Isochem.[5]

In its early days, Isochem mainly specialized in the extraction and semi-synthesis of natural substances, such as quinine.

In the 1990s, Isochem collaborated with Groupe SNPE (Société Nationale des Poudres et Explosifs) to implement technologies such as phosgenation,[6] nitration, and the manufacture of amino-acid derivatives such as NCAs,[7],[8] UNCAs, and peptides.[9],[10]

Now, Isochem has expanded to the field of multi-step industrial production[11] encompassing operations including Grignard, Friedel-Crafts, Sandmeyer, Vilsmeier-Haack Reaction, deprotonation using butyllithium, and reduction using metal hydrides and hydrogenation.[12]

## Industrial sites and specific expertise[edit]

Isochem's industrial sites include:

* Vert-le-Petit: Head office and phosgene chemistry.
* Gennevilliers: Fractional distillation and cold reactions (-70 °C).
* Pithiviers: Hydrogenation under pressure and waste processing.[13][14]
* Pont de Claix: Active ingredients and intermediates for agrochemicals.

Most sites have a research and development team; in addition, the Vert-le-Petit site has the equipment required to study process safety.[15]

## References[edit]

1. ^ Infogreffe Isochem
2. ^ [1], Isochem cherche des chemins pour grandir, Industrie Pharma, octobre, 2010.
3. ^ [2], Isochem rachète la société britannique Wychem, Industrie Pharma, janvier, 2013.
4. ^ [3], Isochem renforce son offre en chimie fine et s'implante en Grande-Bretagne, Usine Nouvelle, juillet, 2013.
5. ^ "PMC Group International Announces Acquisition of Pharma Company in France". www.businesswire.com. 2017-12-05. Retrieved 2024-03-02.
6. ^ Phosgene Futures, Specialty Chemicals Magazine, November, 2011.
7. ^ [4], Controlled Ring Opening of N-Sulfinyl- and N-Silyl-N-Carboxyanhydrides (NCA), Synlett, 2009 (2), 279-283.
8. ^ Amino-Acid N-CarboxyAnhydrides: Industrial solutions for a growing demand, Specialty Chemicals Magazine, 28, n°5, June, 2008.
9. ^ Peptide synthesis and Fine Chemistry merging for progress, PharmaChem, novembre-december, 2004
10. ^ UNCAs - Focus on peptides & Amino-acids, Chimica Oggi / Chemistry Today, 23, n°3, June, 2005.
11. ^ Growing challenges of API process development in custom manufacturing, Chimica Oggi / Chemistry Today, 27, n°5, september-october, 2009.
12. ^ Hydrogenation the key?, Specialty Chemicals Magazine, juin, 2009.
13. ^ La Société Isochem à la pointe du traitement des déchets, Le Courrier du Loiret, n°3439, 29 novembre 2012
14. ^ Isochem vise l'autonomie totale - Traitement des rejets, La République - Pithiviers, 29 novembre 2012.
15. ^ [5] Archived 2014-02-26 at the Wayback Machine, Phosgene-triphosgene: different approach in risk management?, Chimica Oggi / Chemistry Today, 29, n°4, july-august, 2011.

## External links[edit]

* Official Website Isochem