JWH-200

Chemical compound

JWH-200

Clinical data
Other names| WIN 55,225
Legal status
Legal status|

* AU: S9 (Prohibited substance)
* CA: Schedule II
* DE: Anlage II (Authorized trade only, not prescriptible)
* UK: Class B
* US: Schedule I

Identifiers

IUPAC name

* (1-(2-Morpholin-4-ylethyl)indol-3-yl)-naphthalen-1-ylmethanone

CAS Number|

* 103610-04-4 Y

PubChem CID|

* 10045570

ChemSpider|

* 8221134

UNII|

* 9HN5J913P3

CompTox Dashboard (EPA)|

* DTXSID60145946

Chemical and physical data
Formula| C25H24N2O2
Molar mass| 384.479 g·mol−1
3D model (JSmol)|

* Interactive image

SMILES

* O=C(C1=CC=CC2=C1C=CC=C2)C3=CN(C4=C3C=CC=C4)CCN5CCOCC5

InChI

* InChI=1S/C25H24N2O2/c28-25(22-10-5-7-19-6-1-2-8-20(19)22)23-18-27(24-11-4-3-9-21(23)24)13-12-26-14-16-29-17-15-26/h1-11,18H,12-17H2

* Key:SZWYXJHTNGJPKU-UHFFFAOYSA-N

(verify)

JWH-200 (WIN 55,225[1]) is an analgesic chemical from the aminoalkylindole family that acts as a cannabinoid receptor agonist. Its binding affinity, Ki at the CB1 receptor is 42 nM, around the same as that of THC,[2] but its analgesic potency in vivo was higher than that of other analogues with stronger CB1 binding affinity in vitro,[3] around 3 times that of THC but with less sedative effect,[4] most likely reflecting favourable pharmacokinetic characteristics. It was discovered in 1991 by Sterling Drug as a potential analgesic following the earlier identification of related compounds such as pravadoline and WIN 55,212-2.[5]

## Legal status[edit]

### Australia[edit]

JWH-200 is considered a Schedule 9 prohibited substance in Australia under the Poisons Standard (October 2015).[6] A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities.[6]

### Canada[edit]

In July 2015, JWH-200 became a controlled substance in Canada.[7]

### United States[edit]

The US DEA temporarily declared JWH-200 a schedule I controlled substance on 1 March 2011 through 76 FR 11075, and permanently instated the same schedule on 9 July 2012 in the Section 1152 of the Food and Drug Administration Safety and Innovation Act.[8]

## See also[edit]

* A-796,260
* BMS-F
* JWH-018
* JWH-073
* CP-47,497
* HU-210
* MEPIRAPIM

## References[edit]

1. ^ Dutta AK, Ryan W, Thomas BF, Singer M, Compton DR, Martin BR, Razdan RK (August 1997). "Synthesis, pharmacology, and molecular modeling of novel 4-alkyloxy indole derivatives related to cannabimimetic aminoalkyl indoles (AAIs)". Bioorganic & Medicinal Chemistry. 5 (8): 1591–600. doi:10.1016/S0968-0896(97)00111-9. PMID 9313864.
2. ^ Huffman JW, Padgett LW (2005). "Recent developments in the medicinal chemistry of cannabimimetic indoles, pyrroles and indenes". Current Medicinal Chemistry. 12 (12): 1395–411. doi:10.2174/0929867054020864. PMID 15974991.
3. ^ Bell MR, D'Ambra TE, Kumar V, Eissenstat MA, Herrmann JL, Wetzel JR, et al. (March 1991). "Antinociceptive (aminoalkyl)indoles". Journal of Medicinal Chemistry. 34 (3): 1099–110. doi:10.1021/jm00107a034. PMID 1900533.
4. ^ Compton DR, Gold LH, Ward SJ, Balster RL, Martin BR (December 1992). "Aminoalkylindole analogs: cannabimimetic activity of a class of compounds structurally distinct from delta 9-tetrahydrocannabinol". The Journal of Pharmacology and Experimental Therapeutics. 263 (3): 1118–26. PMID 1335057.
5. ^ Compton DR, Gold LH, Ward SJ, Balster RL, Martin BR (December 1992). "Aminoalkylindole analogs: cannabimimetic activity of a class of compounds structurally distinct from delta 9-tetrahydrocannabinol". The Journal of Pharmacology and Experimental Therapeutics. 263 (3): 1118–26. PMID 1335057.
6. ^ a b "Poisons Standard". October 2015.
7. ^ "Order Amending Schedule II to the Controlled Drugs and Substances Act (Synthetic Cannabinoids)". Government of Canada. 29 July 2015.
8. ^ "Schedules of Controlled Substances: Temporary Placement of Four Synthetic Cannabinoids Into Schedule I". DEA Office of Diversion Control. Retrieved 11 March 2014.

* v
* t
* e

Cannabinoids

Phytocannabinoids
(comparison)|

| Cannabibutols|

* CBB

|

Cannabichromenes|

* CBC
* CBCA
* CBCA-A
* CBCB
* CBCBA
* CBCP
* CBCPA
* CBCV
* CBCVA
* CBCQ

Cannabicyclols|

* CBL
* CBLA
* CBLB
* CBLP
* CBLPA
* CBLV
* CBLVA

Cannabidiols|

* CBD
* CBDA
* CBD-C1
* CBD-C5
* CBDB
* CBDBA
* CBDD
* CBDH
* CBDP
* CBDPA
* CBDM
* CBDMA
* CBDV
* CBDVA
* CBDQ

Cannabielsoins|

* CBE
* CBEA
* CBEA-A
* CBEA-B
* CBEB
* CBEP
* CBEPA
* CBEV

Cannabigerols|

* CBG
* CBGA
* CBGB
* CBGBA
* CBGM
* CBGAM
* CBGP
* CBGPA
* CBNR
* CBNRA
* CBNRA-A
* CBGV
* CBGVA
* CBGVA-A
* CBGQ

Cannabiphorols|

* CBP

Cannabinols|

* CBN
* CBNA
* CBN-C1
* CBN-C2
* CBN-C4
* CBNM
* CBND
* CBNDA
* CBNP
* CBNPA
* CBVD
* CBVDA

Cannabitriols|

* CBT
* CBTA
* CBTB
* CBTV
* CBTVA
* CBTP
* CBTPA

Cannabivarins|

* CBV
* CBVA

Delta-8-tetrahydrocannabinols|

* Delta-8-THC
* Delta-8-THCA
* Delta-8-THCA-A
* Delta-8-THCB
* Delta-8-THCP
* Delta-8-THCV

Delta-9-tetrahydrocannabinols|

* Delta-9-THC (THC)
* THCA
* THCMA
* THCA-A
* THCA-B
* THCBA
* THCA-C4
* THCC
* THCA-C1
* THCA-A-C1
* THCA-B-C1
* THCB
* THCH
* THCP
* THCPA
* THCV
* THCVA
* THCQ

Delta-10-Tetrahydrocannabinols|

* Delta-10-THC

Miscellaneous cannabinoids|

* Δ8-iso-THC
* Δ4(8)-iso-THC
* 7,8-Dihydrocannabinol
* 8,9-Dihydrocannabidiol
* CBCF
* Cannabicitran
* CBF
* Cannabiglendol
* CBM
* CBR
* CBRPA
* Caryophyllene
* DCBF
* Alkylamides
* Epigallocatechin gallate
* Gallocatechol
* Hexahydrocannabinol (HHC)
* Perrottetinene
* Serinolamide A
* Yangonin

Active metabolites|

* 3'-OH-THC
* 7-OH-CBD
* 8,11-DiOH-THC
* 11-COOH-THC
* 11-OH-CBN
* 11-OH-HHC
* 11-OH-Δ8-THC
* 11-OH-Δ9-THC

Endocannabinoids|

* Arachidonoyl ethanolamide (AEA; anandamide)
* 2-Arachidonoylglycerol (2-AG)
* 2-Arachidonyl glyceryl ether (2-AGE; noladin ether)
* 2-Oleoylglycerol (2-OG)
* N-Arachidonoyl dopamine (NADA)
* N-Arachidonylglycine (NAGly)
* 2-Arachidonoyl lysophosphatidylinositol (2-ALPI)
* N-Arachidonoyl serotonin (AA-5-HT)
* Docosatetraenoylethanolamide (DEA)
* Lysophosphatidylinositol (LPI)
* Oleamide
* Oleoylethanolamide (OEA)
* Palmitoylethanolamide (PEA)
* RVD-Hpα
* Stearoylethanolamide (SEA)
* O-Arachidonoyl ethanolamine (O-AEA; virodhamine)

Synthetic
cannabinoid
receptor
agonists /
neocannabinoids|

| Classical cannabinoids
(dibenzopyrans)|

* 9-OH-HHC
* 9-Nor-9β-HHC
* A-40174
* A-41988
* A-42574
* Ajulemic acid
* AM-087
* AM-411
* AM-855
* AM-905
* AM-906
* AM-919
* AM-926
* AM-938
* AM-2389
* AM-4030
* AM-7438
* AM-11245
* AMG-1
* AMG-3
* AMG-36
* AMG-41
* CP 42,096
* Delta-3-THC
* Delta-4-THC
* Delta-7-THC
* Delta-10-THC
* Dexanabinol (HU-211)
* DMHP
* Dronabinol
* HU-210
* HU-243
* JWH-051
* JWH-056
* JWH-057
* JWH-065
* JWH-091
* JWH-102
* JWH-103
* JWH-124
* JWH-130
* JWH-133
* JWH-138
* JWH-139
* JWH-142
* JWH-143
* JWH-161
* JWH-186
* JWH-187
* JWH-188
* JWH-189
* JWH-190
* JWH-191
* JWH-215
* JWH-216
* JWH-217
* JWH-224
* JWH-225
* JWH-226
* JWH-227
* JWH-229
* JWH-230
* JWH-233
* JWH-247
* JWH-254
* JWH-256
* JWH-277
* JWH-278
* JWH-298
* JWH-299
* JWH-300
* JWH-301
* JWH-310
* JWH-336
* JWH-338
* JWH-339
* JWH-340
* JWH-341
* JWH-349
* JWH-350
* JWH-352
* JWH-353
* JWH-354
* JWH-355
* JWH-356
* JWH-357
* JWH-358
* JWH-359
* JWH-360
* JWH-361
* JWH-362
* KM-233
* L-759,633
* L-759,656
* Levonantradol (CP 50,5561)
* Menabitan
* Nabazenil
* Nabidrox (Canbisol)
* Nabilone
* Nabitan
* Naboctate
* O-224
* O-581
* O-774
* O-806
* O-823
* O-1057
* O-1125
* O-1191
* O-1238
* O-2048
* O-2113
* O-2365
* O-2372
* O-2373
* O-2383
* O-2426
* O-2484
* O-2545
* O-2694
* O-2715
* O-2716
* O-3223
* O-3226
* Parahexyl
* Pirnabine
* SP-111
* THC hemisuccinate
* THC-O-acetate
* THC-O-phosphate

|

Non-classical
cannabinoids|

* Cannabicyclohexanol
* Cannabinor
* CBD-DMH
* CP 47,497
* (C6)-CP 47,497
* (C9)-CP 47,497
* CP 55,244
* CP 55,940
* Delta-6-Cannabidiol
* Etrinabdione
* HU-308
* HU-320
* HU-331
* HU-336
* HU-345
* HU-446
* HU-465
* HU-910
* HUF-101
* Nonabine
* O-1376
* O-1422
* O-1601
* O-1656
* O-1657
* O-1660
* O-1663
* O-1871
* SPA-229
* Tinabinol

Adamantoylindoles|

* 5F-AKB-48
* APICA
* STS-135

Benzimidazoles|

* AZ-11713908
* AZD-1940
* BIM-018
* FUBIMINA
* MCHB-1
* PF-03550096
* RQ-00202730

Benzoylindoles|

* 1-Butyl-3-(2-methoxybenzoyl)indole
* 1-Butyl-3-(4-methoxybenzoyl)indole
* 1-Pentyl-3-(2-methoxybenzoyl)indole
* AM-630
* AM-679
* AM-694
* AM-1241
* AM-2233
* GW-405,833 (L-768,242)
* Pravadoline
* RCS-4
* WIN 54,461

Cyclohexylphenols|

* CP-47,947
* CP-55,940

Eicosanoids|

* AM-883
* AM-1346
* ACEA
* ACPA
* Methanandamide (AM-356)
* O-585
* O-689
* O-1812
* O-1860
* O-1861

Hydrocarbons|

* JWH-171
* JWH-176
* JWH-220

Indazole carboxamides|

* AB-PINACA
* AB-FUBINACA

Indazole-3-
carboxamides|

* 4F-MDMB-BINACA
* 4'Cl-CUMYL-PINACA
* 4'F-CUMYL-5F-PINACA
* 5Cl-APINACA
* 5F-ADB
* 5F-ADB-PINACA
* 5F-AMB
* 5F-APINACA
* 5F-CUMYL-PINACA
* 5F-EDMB-PINACA
* 5F-EMB-PINACA
* AB-CHMINACA
* AB-FUBINACA
* AB-FUBINACA 2-fluorobenzyl isomer
* AB-PINACA
* ADB-BINACA
* ADB-CHMINACA
* ADB-HEXINACA
* ADB-FUBINACA
* ADB-PINACA
* ADB-4en-PINACA
* ADB-5'Br-PINACA
* Adamantyl-THPINACA
* ADSB-FUB-187
* AMB-CHMINACA
* AMB-FUBINACA
* APINACA (AKB48)
* APP-FUBINACA
* CUMYL-4CN-BINACA
* CUMYL-CBMINACA
* CUMYL-FUBINACA
* CUMYL-NBMINACA
* CUMYL-PINACA
* CUMYL-THPINACA
* CUMYL-TSINACA
* EMB-FUBINACA
* FUB-APINACA
* MDMB-4en-PINACA
* MDMB-5Br-INACA
* MDMB-FUBINACA
* MDMB-CHMINACA
* MN-18
* PX-2
* PX-3

Indole-3-carboxamides|

* 4'F-CUMYL-5F-PICA
* 5F-ADBICA
* 5F-EDMB-PICA
* 5F-MDMB-PICA
* 5F-NNE1
* 5F-PCN
* 5F-SDB-006
* AB-FUBICA
* AB-PICA
* ADBICA
* ADB-FUBICA
* APICA
* BMS-F
* CUMYL-BICA
* CUMYL-CBMICA
* CUMYL-CHMICA
* CUMYL-NBMICA
* CUMYL-PICA
* CUMYL-5F-PICA
* FDU-NNE1
* MDMB-CHMICA
* MMB-CHMICA
* MMB-2201
* MN-25 (UR-12)
* NNE1
* PX-1
* Org 28312
* Org 28611
* SDB-006
* STS-135

Indole-3-carboxylates|

* 5F-PB-22
* FDU-PB-22
* FUB-PB-22
* QUCHIC (BB-22)
* QUPIC (PB-22)
* NM-2201

Naphthoylindazoles|

* THJ-018
* THJ-2201

Naphthoylindoles|

* 5F-JWH-398
* AM-1220
* AM-1221
* AM-1235
* AM-2201
* AM-2232
* CHM-081
* EAM-2201
* FUB-JWH-018
* JWH-004
* JWH-007
* JWH-009
* JWH-011
* JWH-015
* JWH-016
* JWH-018
* JWH-019
* JWH-020
* JWH-042
* JWH-043
* JWH-046
* JWH-047
* JWH-048
* JWH-049
* JWH-050
* JWH-070
* JWH-072
* JWH-073
* JWH-076
* JWH-077
* JWH-079
* JWH-080
* JWH-081
* JWH-082
* JWH-083
* JWH-093
* JWH-094
* JWH-095
* JWH-096
* JWH-097
* JWH-098
* JWH-099
* JWH-100
* JWH-116
* JWH-120
* JWH-122
* JWH-148
* JWH-149
* JWH-151
* JWH-153
* JWH-159
* JWH-160
* JWH-163
* JWH-164
* JWH-165
* JWH-166
* JWH-180
* JWH-181
* JWH-182
* JWH-189
* JWH-193
* JWH-198
* JWH-200
* JWH-210
* JWH-211
* JWH-212
* JWH-213
* JWH-234
* JWH-235
* JWH-236
* JWH-239
* JWH-240
* JWH-241
* JWH-242
* JWH-258
* JWH-259
* JWH-260
* JWH-261
* JWH-262
* JWH-265
* JWH-266
* JWH-267
* JWH-268
* JWH-387
* JWH-398
* JWH-416
* JWH-417
* JWH-422
* JWH-423
* JWH-424
* JWH-425
* MAM-1220
* MAM-2201
* NE-CHMIMO

Naphthoylpyrroles|

* JWH-030
* JWH-031
* JWH-032
* JWH-033
* JWH-036
* JWH-044
* JWH-045
* JWH-145
* JWH-146
* JWH-147
* JWH-150
* JWH-156
* JWH-243
* JWH-244
* JWH-245
* JWH-246
* JWH-292
* JWH-293
* JWH-307
* JWH-308
* JWH-309
* JWH-346
* JWH-347
* JWH-348
* JWH-363
* JWH-364
* JWH-365
* JWH-366
* JWH-367
* JWH-368
* JWH-369
* JWH-370
* JWH-371
* JWH-372
* JWH-373

Naphthylmethylindenes|

* JWH-171
* JWH-176
* JWH-220

Naphthylmethylindoles|

* JWH-175
* JWH-184
* JWH-185
* JWH-192
* JWH-194
* JWH-195
* JWH-196
* JWH-197
* JWH-199

Phenylacetylindoles|

* Cannabipiperidiethanone
* JWH-167
* JWH-201
* JWH-202
* JWH-203
* JWH-204
* JWH-205
* JWH-206
* JWH-207
* JWH-208
* JWH-209
* JWH-237
* JWH-248
* JWH-249
* JWH-250
* JWH-251
* JWH-252
* JWH-253
* JWH-302
* JWH-303
* JWH-304
* JWH-305
* JWH-306
* JWH-311
* JWH-312
* JWH-313
* JWH-314
* JWH-315
* JWH-316
* RCS-8

Pyrazolecarboxamides|

* 5F-AB-FUPPYCA
* 5F-AMPPPCA
* AB-CHFUPYCA

Pyrrolobenzoxazines|

* WIN 55,212-2

Quinolinyl esters|

* PB-22
* 5F-PB-22

Tetramethylcyclo-
propanoylindazoles|

* FAB-144

Tetramethylcyclo-
propanoylindoles|

* 5Br-UR-144
* 5Cl-UR-144
* A-796,260
* A-834,735
* FUB-144
* UR-144
* XLR-11
* XLR-12

Tetramethylcyclo-
propylindoles|

* UR-144
* XLR-11

Others|

* 2F-QMPSB
* 4-HTMPIPO
* 4CN-CUMYL-BUT7AICA
* 5F-PY-PICA
* 5F-PY-PINACA
* 5F-3-pyridinoylindole
* 5F-ADB-P7AICA
* 5F-CUMYL-P7AICA
* 5F-CUMYL-PEGACLONE
* A-836,339
* A-955,840
* Abnormal cannabidiol
* AB-001
* ADB-FUBIATA
* ADB-P7AICA
* AM-1248
* AM-1714
* BAY 38-7271
* BAY 59-3074
* BzODZ-EPyr
* CB-13
* CB-86
* CBS-0550
* CUMYL-4CN-B7AICA
* CUMYL-CB-MEGACLONE
* CUMYL-CH-MEGACLONE
* CUMYL-PEGACLONE
* EG-018
* GSK-554,418A
* GW-842,166X
* JTE 7-31
* LASSBio-881
* LBP-1
* Leelamine
* MDA-7
* MDA-19
* MEPIRAPIM
* NESS-040C5
* NMP-7
* O-889
* O-1269
* O-1270
* O-1399
* O-1602
* O-2220
* Olorinab
* PF-03550096
* PSB-SB-1202
* PTI-1
* PTI-2
* PTI-3
* QMPSB
* S-444,823
* S-777,469
* SER-601
* Tedalinab
* URB-447
* VSN-16
* WIN 56,098

Allosteric CBRTooltip Cannabinoid receptor ligands|

* AEF0117
* GAT100
* Org 27569
* Org 27759
* Org 29647
* PSNCBAM-1
* Pregnenolone
* RTI-371
* ZCZ-011

Endocannabinoid
enhancers
(inactivation inhibitors)|

* 4-Nonylphenylboronic acid
* AM-404
* Arachidonoyl serotonin
* Arvanil
* BIA 10-2474
* Biochanin A
* CAY-10401
* CAY-10429
* Genistein
* Guineesine
* IDFP
* JNJ 1661010
* JNJ-42165279
* JZL184
* JZL195
* Kaempferol
* LY-2183240
* MK-4409
* O-1624
* O-2093
* Oleoylethanolamide (OEA)
* Olvanil
* Palmitoylethanolamide (PEA)
* PF-04457845
* PF-622
* PF-750
* PF-3845
* PHOP
* URB-447
* URB-597
* URB-602
* URB-754
* VDM-11

Anticannabinoids
(antagonists/inverse
agonists/antibodies)|

* AM-251
* AM-281
* AM-630
* AM-1387
* AM-4113
* AM-6527
* AM-6545
* BML-190
* Brizantin (Бризантин)
* CAY-10508
* CB-25
* CB-52
* CB-86
* Dietressa (Диетресса)
* Drinabant (AVE1625)
* Hemopressin
* Ibipinabant (SLV319)
* JTE-907
* LH-21
* LY-320,135
* MDA-77
* MJ-15
* MK-9470
* NESS-0327
* NIDA-41020
* O-606
* O-1184
* O-1248
* O-1918
* O-2050
* O-2654
* Otenabant (CP-945,598)
* PF-514273
* PipISB
* PSB-SB-487
* Rimonabant (SR141716)
* Rosonabant (E-6776)
* SR-144,528
* Surinabant (SR147778)
* Taranabant (MK-0364)
* TM-38837
* VCHSR

* See also: Cannabinoid receptor modulators (cannabinoids by pharmacology)
* List of: AM cannabinoids
* JWH cannabinoids
* Designer drugs § Synthetic cannabimimetics

* v
* t
* e

Hallucinogens

Psychedelics
(5-HT2A
agonists)|

| Benzofurans|

* 2C-B-FLY
* 2CBFly-NBOMe
* 5-MeO-BFE
* 5-MeO-DiBF
* Bromo-DragonFLY
* F-2
* F-22
* TFMFly

|

Lyserg‐
amides|

* 1B-LSD
* 1cP-LSD
* 1P-ETH-LAD
* 1P-LSD
* 1cP-AL-LAD
* 1cP-MiPLA
* 1V-LSD
* 2-Butyllysergamide
* 3-Pentyllysergamide
* AL-LAD
* ALD-52
* BU-LAD
* Diallyllysergamide
* Dimethyllysergamide
* ECPLA
* Ergometrine
* ETH-LAD
* IP-LAD
* LAE-32
* LAMPA
* LPD-824
* LSA
* LSD
* LSD-Pip
* LSH
* LSM-775
* LSZ
* Methylergometrine
* MIPLA
* Methysergide
* MLD-41
* PARGY-LAD
* PRO-LAD

Phenethyl‐
amines|

| 2C-x|

* 2C-B
* 2C-B-AN
* 2C-Bn
* 2C-Bu
* 2C-C
* 2C-CN
* 2C-CP
* 2C-D
* 2C-E
* 2C-EF
* 2C-F
* 2C-G
* 2C-G-1
* 2C-G-2
* 2C-G-3
* 2C-G-4
* 2C-G-5
* 2C-G-6
* 2C-G-N
* 2C-H
* 2C-I
* 2C-iP
* 2C-N
* 2C-NH2
* 2C-O
* 2C-O-4
* 2C-P
* 2C-Ph
* 2C-SE
* 2C-T
* 2C-T-2
* 2C-T-3
* 2C-T-4
* 2C-T-5
* 2C-T-6
* 2C-T-7
* 2C-T-8
* 2C-T-9
* 2C-T-10
* 2C-T-11
* 2C-T-12
* 2C-T-13
* 2C-T-14
* 2C-T-15
* 2C-T-16
* 2C-T-17
* 2C-T-18
* 2C-T-19
* 2C-T-20
* 2C-T-21
* 2C-T-22
* 2C-T-22.5
* 2C-T-23
* 2C-T-24
* 2C-T-25
* 2C-T-27
* 2C-T-28
* 2C-T-30
* 2C-T-31
* 2C-T-32
* 2C-T-33
* 2C-TFE
* 2C-TFM
* 2C-YN
* 2C-V

| 25x-NBx|

| 25x-NB|

* 25B-NB
* 25C-NB

|

25x-NB3OMe|

* 25B-NB3OMe
* 25C-NB3OMe
* 25D-NB3OMe
* 25E-NB3OMe
* 25H-NB3OMe
* 25I-NB3OMe
* 25N-NB3OMe
* 25P-NB3OMe
* 25T2-NB3OMe
* 25T4-NB3OMe
* 25T7-NB3OMe
* 25TFM-NB3OMe

25x-NB4OMe|

* 25B-NB4OMe
* 25C-NB4OMe
* 25D-NB4OMe
* 25E-NB4OMe
* 25H-NB4OMe
* 25I-NB4OMe
* 25N-NB4OMe
* 25P-NB4OMe
* 25T2-NB4OMe
* 25T4-NB4OMe
* 25T7-NB4OMe
* 25TFM-NB4OMe

25x-NBF|

* 25B-NBF
* 25C-NBF
* 25D-NBF
* 25E-NBF
* 25H-NBF
* 25I-NBF
* 25P-NBF
* 25T2-NBF
* 25T7-NBF
* 25TFM-NBF

25x-NBMD|

* 25B-NBMD
* 25C-NBMD
* 25D-NBMD
* 25E-NBMD
* 25F-NBMD
* 25H-NBMD
* 25I-NBMD
* 25P-NBMD
* 25T2-NBMD
* 25T7-NBMD
* 25TFM-NBMD

25x-NBOH|

* 25B-NBOH
* 25C-NBOH
* 25CN-NBOH
* 25D-NBOH
* 25E-NBOH
* 25F-NBOH
* 25H-NBOH
* 25I-NBOH
* 25P-NBOH
* 25T2-NBOH
* 25T7-NBOH
* 25TFM-NBOH

25x-NBOMe|

* 25B-NBOMe
* 25C-NBOMe
* 25CN-NBOMe
* 25D-NBOMe
* 25E-NBOMe
* 25F-NBOMe
* 25G-NBOMe
* 25H-NBOMe
* 25I-NBOMe
* 25iP-NBOMe
* 25N-NBOMe
* 25P-NBOMe
* 25T-NBOMe
* 25T2-NBOMe
* 25T4-NBOMe
* 25T7-NBOMe
* 25TFM-NBOMe

Atypical structures|

* 25B-N1POMe
* 25B-NAcPip
* 25B-NB23DM
* 25B-NB25DM
* 25C-NBCl
* 25C-NBOEt
* 25C-NBOiPr
* 25I-N2Nap1OH
* 25I-N3MT2M
* 25I-N4MT3M
* 25I-NB34MD
* 25I-NBAm
* 25I-NBBr
* 25I-NBMeOH
* 25I-NBTFM
* 2CBCB-NBOMe
* 2CBFly-NBOMe
* 4-EA-NBOMe
* 5-APB-NBOMe
* 5MT-NBOMe
* C30-NBOMe
* DOB-NBOMe
* DOI-NBOMe
* FECIMBI-36
* MDPEA-NBOMe
* N-Ethyl-2C-B
* NBOMe-escaline
* NBOMe-mescaline
* ZDCM-04

25x-NMx|

* 25B-NMe7BF
* 25B-NMe7BT
* 25B-NMe7Bim
* 25B-NMe7Box
* 25B-NMe7DHBF
* 25B-NMe7Ind
* 25B-NMe7Indz
* 25B-NMePyr
* 25I-NMe7DHBF
* 25I-NMeFur
* 25I-NMeTHF
* 25I-NMeTh

N-(2C)-fentanyl|

* N-(2C-B) fentanyl
* N-(2C-C) fentanyl
* N-(2C-D) fentanyl
* N-(2C-E) fentanyl
* N-(2C-G) fentanyl
* N-(2C-H) fentanyl
* N-(2C-I) fentanyl
* N-(2C-IP) fentanyl
* N-(2C-N) fentanyl
* N-(2C-P) fentanyl
* N-(2C-T) fentanyl
* N-(2C-T-2) fentanyl
* N-(2C-T-4) fentanyl
* N-(2C-T-7) fentanyl
* N-(2C-TFM) fentanyl

3C-x|

* 3C-AL
* 3C-BZ
* 3C-DFE
* 3C-E
* 3C-MAL
* 3C-P

4C-x|

* 4C-B
* 4C-C
* 4C-D
* 4C-E
* 4C-I
* 4C-N
* 4C-P
* 4C-T-2

DOx|

* DOT
* DOB
* DOC
* DOEF
* DOET
* DOF
* DOI
* DOiPR
* DOM
* DON
* DOPR
* DOTFM
* MEM

HOT-x|

* HOT-2
* HOT-7
* HOT-17

MDxx|

* DMMDA
* DMMDA-2
* Lophophine
* MDA
* MDAI
* MDBZ
* MDMA
* MMDA
* MMDA-2
* MMDA-3a
* MMDMA

Mescaline (subst.)|

* 2-Bromomescaline
* 3-TE
* 4-TE
* 3-TM
* 4-TM
* Allylescaline
* Asymbescaline
* Buscaline
* Cyclopropylmescaline
* Difluoromescaline
* Difluoroescaline
* Escaline
* Fluoroproscaline
* Isobuscaline
* Isoproscaline
* Jimscaline
* Mescaline
* Metaescaline
* Methallylescaline
* Proscaline
* Thioproscaline
* Trifluoroescaline
* Trifluoromescaline

TMAs|

* TMA
* TMA-2
* TMA-3
* TMA-4
* TMA-5
* TMA-6

Others|

* 2C-B-BUTTERFLY
* 2C-B-DragonFLY
* 2C-B-DragonFLY-NBOH
* 2C-B-FLY-NB2EtO5Cl
* 2CB-5-hemifly
* 2CB-Ind
* 2CD-5EtO
* 2-TOET
* 5-TOET
* 2-TOM
* 5-TOM
* BOB
* BOD
* βk-2C-B
* βk-2C-I
* DESOXY
* DMCPA
* DMBMPP
* DOB-FLY
* Fenfluramine
* Ganesha
* Macromerine
* MMA
* TCB-2
* TOMSO

Piperazines|

* 2C-B-PP
* BZP
* pFPP

Tryptamines|

| alpha-alkyltryptamines|

* 4,5-DHP-α-MT
* 5-MeO-α-ET
* 5-MeO-α-MT
* α-ET
* α-MT

|

x-DALT|

* (Daltocin) 4-HO-DALT
* (Daltacetin) 4-AcO-DALT
* 5-MeO-DALT
* DALT

x-DET|

* (Ethacetin) 4-AcO-DET
* (Ethocin) 4-HO-DET
* 5-MeO-DET
* (T-9) DET
* (Ethocybin) 4-PO-DET

x-DiPT|

* (Ipracetin) 4-AcO-DiPT
* (Iprocin) 4-HO-DiPT
* 5-MeO-DiPT
* DiPT

x-DMT|

* 4,5-DHP-DMT
* 2,N,N-TMT
* 4-AcO-DMT
* 4-HO-5-MeO-DMT
* 4,N,N-TMT
* 4-Propionyloxy-DMT
* 5,6-diBr-DMT
* 5-AcO-DMT
* 5-Bromo-DMT
* 5-MeO-2,N,N-TMT
* 5-MeO-4,N,N-TMT
* 5-MeO-α,N,N-TMT
* 5-MeO-DMT
* 5-N,N-TMT
* 7,N,N-TMT
* α,N,N-TMT
* (Bufotenin) 5-HO-DMT
* DMT
* Norbaeocystin
* (Psilocin) 4-HO-DMT
* (Psilocybin) 4-PO-DMT

x-DPT|

* (Depracetin) 4-AcO-DPT
* (Deprocin) 4-HO-DPT
* 5-MeO-DPT
* (The Light) DPT

Ibogaine-related|

* 18-MAC
* 18-MC
* Coronaridine
* Ibogaine
* Ibogamine
* ME-18-MC
* Noribogaine
* Tabernanthine
* Voacangine

x-MET|

* (Metocin) 4-HO-MET
* (Metocetin) 4-AcO-MET
* 5-MeO-MET
* MET

x-MiPT|

* (Mipracetin) 4-AcO-MiPT
* (Miprocin) 4-HO-MiPT
* 5-Me-MiPT
* (Moxy) 5-MeO-MiPT
* MiPT

Others|

* 4-HO-DBT
* 4-HO-EPT
* 4-HO-McPT
* (Lucigenol) 4-HO-MPMI
* (Meprocin) 4-HO-MPT
* 5-MeO-EiPT
* 5-MeO-MALT
* 5-MeO-MPMI
* Aeruginascin
* Baeocystin
* DBT
* DCPT
* EiPT
* EPT
* MPT
* PiPT

Others|

* AL-38022A
* ALPHA
* Dimemebfe
* Efavirenz
* Glaucine
* Lorcaserin
* M-ALPHA
* RH-34
Also empathogens in general (e. g.: 5-APB, 5-MAPB, 6-APB and other substituted benzofurans).

Dissociatives
(NMDAR
antagonists)|

| Arylcyclo‐
hexylamines|

| Ketamine-related|

* 2-Fluorodeschloroketamine
* Arketamine ((R)-ketamine)
* Deschloroketamine
* Ethketamine (N-Ethylnorketamine)
* Esketamine ((S)-ketamine)
* Ketamine
* Methoxetamine
* Methoxmetamine
* Methoxyketamine
* MXiPr
* Norketamine
* Tiletamine

|

PCP-related|

* 2'-Oxo-PCE
* 3-HO-PCP
* 3-MeO-PCE
* 3-MeO-PCMo
* 3-MeO-PCP
* 4-MeO-PCP
* BDPC
* Dieticyclidine (PCDE)
* Eticyclidine (PCE)
* PCPr
* Phencyclidine (PCP)
* Rolicyclidine (PCPy)
* Tenocyclidine (TCP)

Others|

* BTCP
* Gacyclidine
* PRE-084

Diarylethylamines|

* Diphenidine
* Ephenidine
* Fluorolintane
* Methoxphenidine

Morphinans|

* Dextrallorphan
* Dextromethorphan
* Dextrorphan
* Racemethorphan
* Racemorphan

Others|

* 2-EMSB
* 2-MDP
* 8A-PDHQ
* Aptiganel
* Budipine
* Delucemine
* Dexoxadrol
* Dizocilpine
* Etoxadrol
* Herkinorin
* Ibogaine
* Midafotel
* NEFA
* Neramexane
* Nitrous oxide
* Noribogaine
* Perzinfotel
* RB-64
* Remacemide
* Selfotel
* Xenon

Deliriants
(mAChR
antagonists)|

* Atropine
* Benactyzine
* Benzatropine
* Benzydamine
* Biperiden
* BRN-1484501
* Brompheniramine
* BZ
* CAR-226,086
* CAR-301,060
* CAR-302,196
* CAR-302,282
* CAR-302,368
* CAR-302,537
* CAR-302,668
* Chloropyramine
* Chlorphenamine
* Clemastine
* CS-27349
* Cyclizine
* Cyproheptadine
* Dicycloverine
* Dimenhydrinate
* Diphenhydramine
* Ditran
* Doxylamine
* EA-3167
* EA-3443
* EA-3580
* EA-3834
* Elemicin
* Flavoxate
* Hyoscyamine
* JB-318
* JB-336
* Meclozine
* Mepyramine
* Myristicin
* Orphenadrine
* Oxybutynin
* Pheniramine
* Phenyltoloxamine
* Procyclidine
* Promethazine
* Scopolamine
* Tolterodine
* Trihexyphenidyl
* Tripelennamine
* Triprolidine
* WIN-2299

Others|

| Cannabinoids
(CB1 agonists)|

| Natural|

* Salvinorin A
* THC (Dronabinol)
* THCV

|

Synthetic|

| AM-x|

* AM-087
* AM-251
* AM-279
* AM-281
* AM-356
* AM-374
* AM-381
* AM-404
* AM-411
* AM-630
* AM-661
* AM-678
* AM-679
* AM-694
* AM-735
* AM-855
* AM-881
* AM-883
* AM-905
* AM-906
* AM-919
* AM-926
* AM-938
* AM-1116
* AM-1172
* AM-1220
* AM-1221
* AM-1235
* AM-1241
* AM-1248
* AM-1710
* AM-1714
* AM-1902
* AM-2201
* AM-2212
* AM-2213
* AM-2232
* AM-2233
* AM-2389
* AM-3102
* AM-4030
* AM-4054
* AM-4056
* AM-4113
* AM-6545

|

CP x|

* CP 47,497
* CP 55,244
* CP 55,940
* (±)-CP 55,940
* (+)-CP 55,940
* (-)-CP 55,940

HU-x|

* HU-210
* HU-211
* HU-239
* HU-243
* HU-308
* HU-320
* HU-331
* HU-336
* HU-345

JWH-x|

* JWH-007
* JWH-015
* JWH-018
* JWH-019
* JWH-030
* JWH-047
* JWH-048
* JWH-051
* JWH-057
* JWH-073
* JWH-081
* JWH-098
* JWH-116
* JWH-120
* JWH-122
* JWH-133
* JWH-139
* JWH-147
* JWH-148
* JWH-149
* JWH-149
* JWH-161
* JWH-164
* JWH-166
* JWH-167
* JWH-171
* JWH-175
* JWH-176
* JWH-181
* JWH-182
* JWH-184
* JWH-185
* JWH-192
* JWH-193
* JWH-194
* JWH-195
* JWH-196
* JWH-197
* JWH-198
* JWH-199
* JWH-200
* JWH-203
* JWH-205
* JWH-210
* JWH-210
* JWH-213
* JWH-220
* JWH-229
* JWH-234
* JWH-249
* JWH-250
* JWH-251
* JWH-253
* JWH-258
* JWH-300
* JWH-302
* JWH-307
* JWH-336
* JWH-350
* JWH-359
* JWH-387
* JWH-398
* JWH-424

Misc. designer cannabinoids|

* 4-HTMPIPO
* 5F-AB-FUPPYCA
* 5F-AB-PINACA
* 5F-ADB
* 5F-ADB-PINACA
* 5F-ADBICA
* 5F-AMB
* 5F-APINACA
* 5F-CUMYL-PINACA
* 5F-NNE1
* 5F-PB-22
* 5F-SDB-006
* A-796,260
* A-836,339
* AB-001
* AB-005
* AB-CHFUPYCA
* AB-CHMINACA
* AB-FUBINACA
* AB-PINACA
* ADAMANTYL-THPINACA
* ADB-CHMINACA
* ADB-FUBINACA
* ADB-PINACA
* ADBICA
* ADSB-FUB-187
* AMB-FUBINACA
* APICA
* APINACA
* APP-FUBINACA
* CB-13
* CUMYL-PICA
* CUMYL-PINACA
* CUMYL-THPINACA
* DMHP
* EAM-2201
* FAB-144
* FDU-PB-22
* FUB-144
* FUB-APINACA
* FUB-JWH-018
* FUB-PB-22
* FUBIMINA
* JTE 7-31
* JTE-907
* Levonantradol
* MDMB-CHMICA
* MDMB-CHMINACA
* MDMB-FUBINACA
* MEPIRAPIM
* MAM-2201
* MDA-19
* MN-18
* MN-25
* NESS-0327
* NESS-040C5
* Nabilone
* Nabitan
* NM-2201
* NNE1
* Org 28611
* Parahexyl
* PTI-1
* PTI-2
* PX-1
* PX-2
* PX-3
* QUCHIC
* QUPIC
* RCS-4
* RCS-8
* SDB-005
* SDB-006
* STS-135
* THC-O-acetate
* THC-O-phosphate
* THJ-018
* THJ-2201
* UR-144
* WIN 55,212-2
* XLR-11

D2 agonists|

* Apomorphine
* Aporphine
* Bromocriptine
* Cabergoline
* Lisuride
* LSD
* Memantine
* Nuciferine
* Pergolide
* Phenethylamine
* Piribedil
* Pramipexole
* Ropinirole
* Rotigotine
* Salvinorin A
Also indirect D2 agonists, such as dopamine reuptake inhibitors (cocaine, methylphenidate), releasing agents (amphetamine, methamphetamine), and precursors (levodopa).

GABAA
enhancers|

* CI-966
* Eszopiclone
* Ibotenic acid
* Muscimol (Amanita muscaria)
* Zaleplon
* Zolpidem
* Zopiclone

Inhalants
(Mixed MOA)|

* Aliphatic hydrocarbons
* Butane
* Gasoline
* Kerosene
* Propane
* Aromatic hydrocarbons
* Toluene
* Ethers
* Diethyl ether
* Enflurane
* Haloalkanes
* Chlorofluorocarbons
* Chloroform

κOR agonists|

* 2-EMSB
* Alazocine
* Bremazocine
* Butorphan
* Butorphanol
* Cyclazocine
* Cyclorphan
* Cyprenorphine
* Diprenorphine
* Enadoline
* Herkinorin
* Heroin
* HZ-2
* Ibogaine
* Ketazocine
* Levallorphan
* Levomethorphan
* Levorphanol
* LPK-26
* Metazocine
* Morphine
* Nalbuphine
* Nalmefene
* Nalorphine
* Noribogaine
* Oxilorphan
* Pentazocine
* Phenazocine
* Proxorphan
* Racemethorphan
* Racemorphan
* Salvinorin A
* Spiradoline
* Tifluadom
* U-50488
* U-69,593
* Xorphanol

Oneirogens|

* Calea zacatechichi
* Silene capensis
* Galantamine

Others|

* Glaucine
* Isoaminile
* Noscapine
* Pukateine

*[AU]: Australia
*[CA]: Canada
*[DE]: Germany
*[UK]: United Kingdom
*[US]: United States
*[CID]: Compound ID
*[EPA]: U.S. Environmental Protection Agency
*[v]: View this template
*[t]: Discuss this template
*[e]: Edit this template
*[CBR]: Cannabinoid receptor
*[NB]: NB: N-benzyl
*[NB3OMe]: NB: N-benzyl; 3OMe: 3-methoxy
*[NB4OMe]: NB: N-benzyl; 4OMe: 4-methoxy
*[NBF]: NB: N-benzyl; F: fluoro
*[NBMD]: NB: N-benzyl; MD: methylenedioxy
*[NBOH]: NB: N-benzyl; OH: hydroxy
*[NBOMe]: NB: N-benzyl; OMe: methoxy
*[DALT]: N,N-Diallyltryptamine
*[DET]: N,N-Diethyltryptamine
*[DiPT]: N,N-Diisopropyltryptamine
*[DMT]: N,N-Dimethyltryptamine
*[DPT]: N,N-Dipropyltryptamine
*[MET]: N-Methyl-N-ethyltryptamine
*[MiPT]: N-Methyl-N-isopropyltryptamine