Joseph Paul Robinson

Australian-American scientist and inventor

J. Paul Robinson

Born|

Joseph Paul Robinson

1953 (age 70-71)

Inverell, NSW, Australia

Nationality| Australian, American
Known for| spectral cytometry
Title| Distinguished Professor of Cytometry
Spouse|

Susan C. Robinson

(m. 1976)​

Children| Tim, Alissa, David
Academic background
Alma mater| University of New South Wales
Thesis| The application of chemiluminescence to human blood cells: Microbial and biochemical ligand activation (1983)
Academic work
Discipline| microbiology, immunology, cytometry
Institutions| Purdue University College of Veterinary Medicine, Weldon School of Biomedical Engineering

J. Paul Robinson (ORCID 0000-0001-8383-3240) is an Australian/American educator, biologist, biomedical engineer, and expert in the applications of flow cytometry.[1][2] He is a Distinguished Professor of Cytometry[3] in the Purdue University College of Veterinary Medicine, Department of Basic Medical Sciences, a professor of Biomedical Engineering in the Weldon School of Biomedical Engineering, a professor of Computer and Information Management at Purdue University, an adjunct professor of Microbiology & Immunology at West Lafayette Center for Medical Education, Indiana University School of Medicine, and the Director of Purdue University Cytometry Laboratories.

## Early life and education

[edit]

Robinson was born in 1953 in Inverell in New South Wales, Australia. J. P. Robinson's early education was in a small three-teacher school at Tambar Springs, New South Wales followed by Inverell High School. He took his BSc and MSc at the University of New South Wales, Kensington, New South Wales, where he was a member of the New College from 1975 before earning a doctorate from the Faculty of Medicine, St Vincent's Hospital, Sydney, University of New South Wales. He completed a postdoctoral fellowship at the University of Michigan Medical School working under the supervision of Dr. Peter A. Ward.

## Scientific expertise

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Robinson's initial research centered primarily on reactive oxygen species in neutrophils and cell lines, such as HL-60 cells.[4] His laboratory's research emphasis was on mitochondrial function[5][6] and the role of the reactive oxygen species.[7] In addition, he was engaged in the development of translational tools for improved cervical cancer diagnostics.[8] In recent years, his research interests focused on bioengineering, including development of single-cell analysis technologies such as high-speed hyperspectral cytometry,[9][10] optical tools for quantitative fluorescence measurement, and label-free organisms classification methods for general microbiology[11][12] and biodefense applications,[13] as well as high-content, high-throughput screening technologies[14][15]

Robinson is the co-inventor of multiple patents in the areas of single cell analysis[16][17][18][19][20][21][22][23] and technologies associated with fluorescence detection,[24][25] elastic light scatter,[26][16][27] bacteria detection,[28] and laser microanalysis.[29] Robinson was a member of the Purdue University engineering research team that developed spectral flow cytometry.[16][30] This technology has been licensed by Sony Biotechnology and became a basis for the first commercial multispectral flow cytometry system introduced in 2012.[31] In 2020 the spectral cytometry technology was licensed by Propel Labs (now ThermoFisher Scientific).[32] Robinson is also a co-inventor of automated microbial classification systems using elastic laser light scatter.[26][33] Another area of his work includes development of a new range of single photon detectors.[34]

## Selected peer-reviewed publications

[edit]

* Robinson, J. Paul, Leon H. Bruner, Carl-F. Bassoe, Jerry L. Hudson, Peter A. Ward, and Sem H. Phan. 1988. "Measurement of Intracellular Fluorescence of Human Monocytes Relative to Oxidative Metabolism." Journal of Leukocyte Biology 43 (4): 304–10. https://doi.org/10.1002/jlb.43.4.304.
* Carter, W O, P K Narayanan, and J P Robinson. 1994. "Intracellular Hydrogen Peroxide and Superoxide Anion Detection in Endothelial Cells." Journal of Leukocyte Biology 55 (2): 253–58. https://doi.org/10.1002/jlb.55.2.253.
* Brightman, A. O., B. P. Rajwa, J. E. Sturgis, M. E. McCallister, J. P. Robinson, and S. L. Voytik-Harbin. 2000. "Time-Lapse Confocal Reflection Microscopy of Collagen Fibrillogenesis and Extracellular Matrix Assembly in Vitro." Biopolymers 54 (3): 222–34. <222::AID-BIP80>3.0.CO;2-K https://doi.org/10.1002/1097-0282(200009)54:3<222::AID-BIP80>3.0.CO;2-K.
* Roeder, Blayne A., Klod Kokini, Jennifer E. Sturgis, J. Paul Robinson, and Sherry L. Voytik-Harbin. 2002. "Tensile Mechanical Properties of Three-Dimensional Type I Collagen Extracellular Matrices with Varied Microstructure." Journal of Biomechanical Engineering 124 (2): 214–22. https://doi.org/10.1115/1.1449904.
* Li, Nianyu, Kathy Ragheb, Gretchen Lawler, Jennie Sturgis, Bartek Rajwa, J. Andres Melendez, and J. Paul Robinson. 2003. "Mitochondrial Complex I Inhibitor Rotenone Induces Apoptosis through Enhancing Mitochondrial Reactive Oxygen Species Production." Journal of Biological Chemistry 278 (10): 8516–25. https://doi.org/10.1074/jbc.M210432200.
* Li, Nianyu, Kathy Ragheb, Gretchen Lawler, Jennie Sturgis, Bartek Rajwa, J. Andres Melendez, and J. Paul Robinson. 2003. "DPI Induces Mitochondrial Superoxide-Mediated Apoptosis." Free Radical Biology and Medicine 34 (4): 465–77. https://doi.org/10.1016/S0891-5849(02)01325-4.
* Lu, Yiqing, Jiangbo Zhao, Run Zhang, Yujia Liu, Deming Liu, Ewa M. Goldys, Xusan Yang, et al. 2014. "Tunable Lifetime Multiplexing Using Luminescent Nanocrystals." Nature Photonics 8 (1): 32–36. https://doi.org/10.1038/nphoton.2013.322.

## Honors and awards

[edit]

In 2002 Robinson received the Gamma Sigma Delta Award of Merit in Research. In 2003 he was elected to the College of Fellows, American Institute for Medical and Biological Engineering (AIMBE).[35] In 2004 he received the Pfizer Foundation Scientific Innovation Award. In 2017 he received honoris causa doctorate from the Aix-Marseille Université, Marseille, France.[36] In 2017 Robinson received College of Veterinary Medicine Excellence in Research Award.[37] In 2019 he received the Distinguished Service Award from the International Society for the Advancement of Cytometry.[38] In 2020 he was elected American Association for the Advancement of Science (AAAS) fellow.[39] In December 2022 Robinson was named a fellow of the National Academy of Inventors (NAI).[40][41] In January 2023 Robinson was announced as new Honorary Fellow of the Royal Microscopical Society.[42]

## Service

[edit]

In 2013 Robinson was elected as chair of the Purdue University Senate and worked closely with the newly elected president of Purdue University Mitch Daniels, who assumed the presidency of Purdue University in January 2014.[43]

## Educational activities and outreach

[edit]

Robinson is a past President of the International Society for Advancement of Cytometry. He is the Editor-in-Chief of Current Protocols in Cytometry[44] He has previously served as an Associate Editor of Folia Histochemica et Cytobiologica and Cytometry Part A.

Robinson has established a not-for-profit charity, "Cytometry for Life" with the goal of providing low-cost CD4 screening technology to resource-poor areas, initially focusing on countries in Africa.[45][46] The foundation activities include development of appropriate low-cost CD4 screening technology and the efforts in education and training in the field of cytometry, partnering with Africa International Biotechnology and Biomedical Conference (AIBBC).

## Hobbies

[edit]

Robinson is an accomplished mountaineer summiting Mount Rainier, Denali, Manaslu and in Mount Everest as part of a team led by Russell Brice and organized by Himex.[47][48]

## External links

[edit]

* J. Paul Robinson publications indexed by Google Scholar
* J. Paul Robinson publications indexed by the Scopus bibliographic database. (subscription required)
* International Society for Advancement of Cytometry
* Current Protocols in Cytometry
* Weldon School of Biomedical Engineering
* Inverell High School

## References

[edit]

1. ^ Robinson, J. Paul; Roederer, Mario (2015-11-13). "Flow cytometry strikes gold". Science. 350 (6262): 739–740. Bibcode:2015Sci...350..739R. doi:10.1126/science.aad6770. ISSN 0036-8075. PMID 26564833. S2CID 206644389.
2. ^ Robinson, J. Paul (2022) [4 Apr 2022]. "Flow cytometry: past and future". BioTechniques. 72 (4): 159–169. doi:10.2144/btn-2022-0005. ISSN 0736-6205. PMID 35369735. S2CID 247938224.
3. ^ Doerr, Kevin (December 10, 2021). "Purdue Trustees Ratify Appointment of Dr. J. Paul Robinson as Distinguished Professor of Cytometry". Purdue University Marketing and Communications (Press release).
4. ^ Narayanan, P. K.; Ragheb, K.; Lawler, G.; Robinson, J. P. (1997). "Defects in intracellular oxidative metabolism of neutrophils undergoing apoptosis". Journal of Leukocyte Biology. 61 (4): 481–488. doi:10.1002/jlb.61.4.481. ISSN 1938-3673. PMID 9103235. S2CID 15340763.
5. ^ Li, Nianyu; Ragheb, Kathy; Lawler, Gretchen; Sturgis, Jennie; Rajwa, Bartek; Melendez, J. Andres; Robinson, J. Paul (2003-03-07). "Mitochondrial Complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production". Journal of Biological Chemistry. 278 (10): 8516–8525. doi:10.1074/jbc.M210432200. PMID 12496265.
6. ^ Li, Nianyu; Ragheb, Kathy; Lawler, Gretchen; Sturgis, Jennie; Rajwa, Bartek; Melendez, J. Andres; Robinson, J. Paul (2003-02-15). "DPI induces mitochondrial superoxide-mediated apoptosis". Free Radical Biology and Medicine. 34 (4): 465–477. doi:10.1016/S0891-5849(02)01325-4. ISSN 0891-5849. PMID 12566072. Retrieved 2022-09-29.
7. ^ Carter, W. O.; Narayanan, P. K.; Robinson, J. P. (1994). "Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells". Journal of Leukocyte Biology. 55 (2) (published Feb 1, 1994): 253–258. doi:10.1002/jlb.55.2.253. PMID 8301222. S2CID 16870500.
8. ^ "Purdue receives $1.35 million grant to develop cervical cancer diagnostic tool" (Press release). West Lafayette, IN: Purdue University. December 10, 2010. Retrieved 2022-09-30.
9. ^ Grégori, Gérald; Patsekin, Valery; Rajwa, Bartek; Jones, James; Ragheb, Kathy; Holdman, Cheryl; Robinson, J. Paul (2012). "Hyperspectral cytometry at the single-cell level using a 32-channel photodetector". Cytometry Part A. 81A (1): 35–44. doi:10.1002/cyto.a.21120. ISSN 1552-4930. PMID 22173900. S2CID 400265.
10. ^ Robinson, J. Paul; Rajwa, Bartek; Gregori, Gerald; Jones, James; Patsekin, Valeri (2005-04-01). Multispectral cytometry of single bio-particles using a 32-channel detector. Advanced Biomedical and Clinical Diagnostic Systems III. Vol. 5692\. SPIE. pp. 359–365. doi:10.1117/12.591365. Retrieved 2022-09-30.
11. ^ Whitworth, Joseph James (December 1, 2015). "Ready, Aim, Fire! Pathogen detection by laser". Food Navigator. Crawley, UK: William Reed.
12. ^ "Purdue Creates New Low-cost System To Detect Bacteria". Science Daily. July 27, 2006. Retrieved Sep 30, 2022. "Researchers at Purdue University have developed a new low-cost system that analyzes scattered laser light to quickly identify bacteria for applications in medicine, food processing and homeland security at one-tenth the cost of conventional technologies."
13. ^ "Purdue biodefense technology project awarded $1.3 million NIH seed grant" (Press release). West Lafayette, IN: Purdue University. August 26, 2010. Retrieved 2022-09-30.
14. ^ Tsiper, Maria V.; Sturgis, Jennifer; Avramova, Larisa V.; Parakh, Shilpa; Fatig, Raymond; Juan-García, Ana; Li, Nianyu; Rajwa, Bartek; Narayanan, Padma; Jr, C. W. Qualls; Robinson, J. Paul; Davisson, V. Jo (2012-10-15). "Differential mitochondrial toxicity screening and multi-parametric data analysis". PLOS ONE. 7 (10): –45226. Bibcode:2012PLoSO...745226T. doi:10.1371/journal.pone.0045226. ISSN 1932-6203. PMC 3471932. PMID 23077490.
15. ^ Robinson, J. Paul; Patsekin, Valery; Holdman, Cheryl; Ragheb, Kathy; Sturgis, Jennifer; Fatig, Ray; Avramova, Larisa V.; Rajwa, Bartek; Davisson, V. Jo; Lewis, Nicole; Narayanan, Padma; Li, Nianyu; Qualls, C. W. (2013-02-01). "High-throughput secondary screening at the single-cell level". Journal of Laboratory Automation. 18 (1): 85–98. doi:10.1177/2211068212456978. ISSN 2211-0682. PMC 4380503. PMID 22968419. Retrieved 2022-09-30.
16. ^ a b c US 7280204, Robinson, Joseph Paul; Rajwa, Bartlomiej & Grégori, Gérald et al., "Multi-spectral detector and analysis system", published 2007-10-09, assigned to Purdue Research Foundation
17. ^ US 9372143, Yamamoto, Masanobu & Robinson, J. Paul, "Scanning image flow cytometer", published 2016-06-21, assigned to CAPTL LLC
18. ^ US 10036698, Yamamoto, Masanobu & Robinson, J. Paul, "Time-sequential cytometry", published 2018-07-31, assigned to CAPTL LLC
19. ^ US 10060850, Yamamoto, Masanobu & Robinson, J. Paul, "Particle detection using reflective surface", published 2018-08-28, assigned to CAPTL LLC
20. ^ US 10613096, Yamamoto, Masanobu & Robinson, J. Paul, "Multi-spectral microparticle-fluorescence photon cytometry", published 2020-04-07, assigned to CAPTL LLC
21. ^ US 10900885, Yamamoto, Masanobu; Robinson, J. Paul & Masuda, Yuji et al., "Flow cytometry using hydrodynamically planar flow", published 2021-01-26, assigned to CAPTL LLC and Hamamatsu Photonics KK
22. ^ US 11187584, Yamamoto, Masanobu; Hernandez, Keegan & Robinson, J. Paul, "Photon counting and spectroscopy", published 2021-11-30, assigned to CAPTL LLC
23. ^ US 11255771, Yamamoto, Masanobu; Robinson, J. Paul & Hernandez, Keegan, "Photon signal processing for particle detection", published 2022-02-22, assigned to CAPTL LLC
24. ^ US 7842512, Blatchley, III, Ernest R.; Shen, Chengyue & Naunovic, Zorana et al., "Dyed microspheres for characterization of photochemical reactor behavior", published 2010-11-30, assigned to Purdue Research Foundation
25. ^ US 8831889, Rajwa, Bartlomiej P.; Bernas, Tytus S & Robinson, Joseph P., "Quantification of differences between measured values and statistical validation based on the differences", published 2014-09-09, assigned to Purdue Research Foundation
26. ^ a b US 8787633, Robinson, J. Paul; Rajwa, Bartlomiej & Bayraktar, Bulent et al., "System and method of organism identification", published 2014-07-22, assigned to Purdue Research Foundation
27. ^ US 10719691, Robinson, Joseph Paul; Rajwa, Bartlomiej P. & Ragheb, Kathryn E. et al., "Culture imaging system", published 2020-07-21, assigned to Purdue Research Foundation
28. ^ US 7306924, Gomez, Rafael; Bashir, Rashid & Bhunia, Arun K. et al., "Biosensor and related method", published 2007-12-11, assigned to Purdue Research Foundation
29. ^ US 10514338, Robinson, Joseph Paul; Rajwa, Bartlomiej P. & Patsekin, Valery P. et al., "Metal-antibody tagging and plasma-based detection", published 2019-12-24, assigned to Purdue Research Foundation
30. ^ Clift, Ian C. (Oct 2022). "Flow Cytometry Rides Successive Waves of Innovation". Genetic Engineering & Biotechnology News. New Rochelle, NY: Mary Ann Liebert, Inc. pp. 34–38.
31. ^ "Sony announces the development of the "Spectral" cell analyzer, the industry's first cell analysis instrument capable of detecting full spectrum fluorescence to facilitate highly accurate analysis". Sony News Releases. June 19, 2012. Retrieved September 29, 2022.
32. ^ "Licensing partnership advances cytometry technology for cancer identification, patient monitoring". Research Foundation News. August 31, 2020. Retrieved September 29, 2022.
33. ^ US 10769409, Robinson, Joseph Paul; Rajwa, Bartlomiej & Patsekin, Valery, "Culture detection and measurement over time", published 2020-09-08
34. ^ Yamamoto, M; Robinson, JP (2021). "Quantum approach for nanoparticle fluorescence by sub-ns photon detection". Cytometry Part A. 99 (2): 145–151. doi:10.1002/cyto.a.24310. PMID 33476076. S2CID 232021453.
35. ^ "AIMBE College of Fellows Class of 2004". Fellowbook. American Institute for Medical and Biological Engineering. Retrieved Sep 30, 2022. "For contributions to cell and tissue engineering, complex imaging of physiological processes and innovations in medical diagnostic techniques."
36. ^ Soirée Scientifique d'Aix-Marseille Université 2017 (PDF) (Report). Aix-Marseille Université. 2017. p. 2. Retrieved Sep 30, 2022.
37. ^ Doerr, Kevin (May 5, 2017). "PVM Faculty Honored at Purdue Awards Convocation". College of Veterinary Medicine, Purdue University.
38. ^ "2019 Award Winners". ISAC Awards. Retrieved Sep 30, 2022.
39. ^ Doerr, Kevin (December 4, 2020). "PVM Professor Elected as Fellow of the American Association for the Advancement of Science" (Press release). West Lafayette, IN: Purdue University. Retrieved 2022-09-30.
40. ^ "National Academy of Inventors names J. Paul Robinson as 2022 fellow". Dec 8, 2022.
41. ^ "2 Purdue inventors named national academy fellows". The Exponent. Dec 13, 2022.
42. ^ "Professor J Paul Robinson announced as new RMS Honorary Fellow". RMS News. 4 Jan 2023.
43. ^ "Past-Chairs of the Purdue University Senate". University Senate, Office of the Provost. Purdue University. Retrieved September 30, 2022.
44. ^ "Current Protocols in Cytometry".
45. ^ Venere, Emil; Fiorini, Phillip (March 1, 2007). "Purdue to show low-cost AIDS-testing technology to African officials" (Press release). West Lafayette, IN: Purdue University. Retrieved 2022-09-30.
46. ^ Olson, Scott (April 9, 2007). "Purdue professor developing weapon for AIDS battle: Lower-cost testing device could save money for more treatment in disease-ravaged Africa, other countries". Indianapolis Business Journal. Indianapolis, IN.
47. ^ Vincent, Taylor (Jun 17, 2013). "Professor reflects on tackling Mt. Everest". The Exponent. Retrieved Sep 29, 2022.
48. ^ Boiler Bytes: Purdue researcher scales Mount Everest to help those affected by HIV/AIDS. West Lafayette, IN: Purdue University. Oct 8, 2009 - via YouTube.

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*[m.]: married