KCNA7

Protein-coding gene in the species Homo sapiens

KCNA7

Identifiers
Aliases| KCNA7, HAK6, KV1.7, potassium voltage-gated channel subfamily A member 7
External IDs| OMIM: 176268; MGI: 96664; HomoloGene: 7791; GeneCards: KCNA7; OMA:KCNA7 - orthologs
| Gene location (Human)

Chr.| Chromosome 19 (human)[1]

Band| 19q13.33| Start| 49,067,397 bp[1]
End| 49,072,699 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 7 (mouse)[2]

Band| 7 B3|7 29.3 cM| Start| 45,055,077 bp[2]
End| 45,059,187 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* Skeletal muscle tissue of rectus abdominis

* vastus lateralis muscle

* muscle of thigh

* Skeletal muscle tissue of biceps brachii

* gastrocnemius muscle

* deltoid muscle

* tibialis anterior muscle

* body of tongue

* apex of heart

* right auricle of heart

| Top expressed in

* muscle of thigh

* skeletal muscle tissue

* quadriceps femoris muscle

* zone of skin

* lip

* esophagus

* embryo

* heart

* spermatocyte

* placenta

More reference expression data
BioGPS| | n/a

| Gene ontology

Molecular function|

* ion channel activity
* potassium channel activity
* voltage-gated ion channel activity
* voltage-gated potassium channel activity
* delayed rectifier potassium channel activity

Cellular component|

* integral component of membrane
* voltage-gated potassium channel complex
* plasma membrane
* membrane

Biological process|

* potassium ion transport
* regulation of ion transmembrane transport
* protein homooligomerization
* ion transport
* transmembrane transport
* potassium ion transmembrane transport

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

3743

16495

Ensembl| |

ENSG00000104848

ENSMUSG00000038201

UniProt| |

Q96RP8

Q17ST2

RefSeq (mRNA)| |

NM_031886

NM_010596

RefSeq (protein)| |

NP_114092

NP_034726

Location (UCSC)| Chr 19: 49.07 – 49.07 Mb| Chr 7: 45.06 – 45.06 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Potassium voltage-gated channel subfamily A member 7 also known as Kv1.7 is a protein that in humans is encoded by the KCNA7 gene.[5] The protein encoded by this gene is a voltage-gated potassium channel subunit. It may contribute to the cardiac transient outward potassium current (Ito1), the main contributing current to the repolarizing phase 1 of the cardiac action potential.[6]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104848 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038201 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508\. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.
6. ^ Oudit GY, Kassiri Z, Sah R, Ramirez RJ, Zobel C, Backx PH (May 2001). "The molecular physiology of the cardiac transient outward potassium current (I(to)) in normal and diseased myocardium". J. Mol. Cell. Cardiol. 33 (5): 851–72\. doi:10.1006/jmcc.2001.1376. PMID 11343410.

## Further reading

[edit]

* Kashuba VI, Kvasha SM, Protopopov AI, et al. (2001). "Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family". Gene. 268 (1–2): 115–22\. doi:10.1016/S0378-1119(01)00423-1. PMID 11368907.1–2&rft.pages=115-22&rft.date=2001&rft_id=info:doi/10.1016/S0378-1119(01)00423-1&rft_id=info:pmid/11368907&rft.aulast=Kashuba&rft.aufirst=VI&rft.au=Kvasha,+SM&rft.au=Protopopov,+AI&rfr_id=info:sid/en.wikipedia.org:KCNA7" class="Z3988">
* Kalman K, Nguyen A, Tseng-Crank J, et al. (1998). "Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7". J. Biol. Chem. 273 (10): 5851–7\. doi:10.1074/jbc.273.10.5851. PMID 9488722.
* Ding Q, Zhao YY, Dong LY, et al. (2003). "[Distribution and significance of cSNP in KCNA7 gene as a novel NIDDM candidate gene in the population of northeast China]". Yi Chuan. 25 (2): 129–32\. PMID 15639836.
* Bardien-Kruger S, Wulff H, Arieff Z, et al. (2002). "Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI)". Eur. J. Hum. Genet. 10 (1): 36–43\. doi:10.1038/sj.ejhg.5200739. PMID 11896454. S2CID 8333189.

## External links

[edit]

* Kv1.7+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
* KCNA7+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

* v
* t
* e

Membrane transport protein: ion channels (TC 1A)

Ca2+: Calcium channel

| Ligand-gated|

* Inositol trisphosphate receptor
* 1
* 2
* 3
* Ryanodine receptor
* 1
* 2
* 3

|

Voltage-gated|

* L-type/Cavα
* 1.1
* 1.2
* 1.3
* 1.4
* N-type/Cavα2.2
* P-type/Cavα
* 2.1
* Q-type/Cavα2.1
* R-type/Cavα2.3
* T-type/Cavα
* 3.1
* 3.2
* 3.3

* α2δ-subunits
* 1
* 2
* β-subunits
* β1
* β2
* β3
* β4
* γ-subunits
* γ1
* γ2
* γ3
* γ4

* Cation channels of sperm
* 1
* 2
* 3
* 4
* Two-pore channel
* 1
* 2

Na+: Sodium channel

| Constitutively active|

* Epithelial sodium channel
* α
* β
* γ
* δ

|

Proton-gated|

* Amiloride-sensitive cation channel
* 1
* 2
* 3
* 4

Voltage-gated|

* Navα
* 1.1
* 1.2
* 1.3
* 1.4
* 1.5
* 1.6
* 1.7
* 1.8
* 1.9
* 7A
* Navβ
* 1
* 2
* 3
* 4

K+: Potassium channel

| Calcium-activated|

* BK channel
* α1
* β1
* β2
* β3
* β4
* SK channel
* SK1
* SK2
* SK3
* IK channel
* IK1
* KCa
* 1.1
* 2.1
* 2.2
* 2.3
* 3.1
* 4.1
* 4.2
* 5.1

|

Inward-rectifier|

* KATP
* Kir
* 1.1
* 2.1
* 2.2
* 2.3
* 2.4
* 2.6
* GIRK/Kir
* 3.1
* 3.2
* 3.3
* 3.4
* Kir
* 4.1
* 4.2
* 5.1
* 6.1
* 6.2
* 7.1

Tandem pore domain|

* K2P
* 1
* 2
* 3
* 4
* 5
* 6
* 7
* 9
* 10
* 12
* 13
* 15
* 16
* 17
* 18

Voltage-gated|

* Kvα1-6
* 1.1
* 1.2
* 1.3
* 1.4
* 1.5
* 1.6
* 1.7
* 1.8
*     * 2.1
* 2.2
*     * 3.1
* 3.2
* 3.3
* 3.4
*     * 4.1
* 4.2
* 4.3
*     * 5.1
*     * 6.1
* 6.2
* 6.3
* 6.4

* Kvα7-12
* 7.1
* 7.2
* 7.3
* 7.4
* 7.5
*     * 8.1
* 8.2
*     * 9.1
* 9.2
* 9.3
*     * 10.1
* 10.2
*     * 11.1/hERG
* 11.2
* 11.3
*     * 12.1
* 12.2
* 12.3

* Kvβ
* 1
* 2
* 3
* KCNIP
* 1
* 2
* 3
* 4
* minK/ISK
* minK/ISK-like
* MiRP
* 1
* 2
* 3
* Shaker (gene)

Miscellaneous

| Cl−: Chloride channel|

* Calcium-activated chloride channels
* Anoctamin
* ANO1
* Bestrophin
* 1
* 2
* Chloride Channel Accessory
* 1
* 2
* 3
* 4
* CFTR
* CLCN
* 1
* 2
* 3
* 4
* 5
* 6
* 7
* KA
* KB
* CLIC
* 1
* 2
* 3
* 4
* 5
* 6
* L1
* CLNS
* 1A
* 1B

|

H+: Proton channel|

* HVCN1

M+: CNG cation channel|

* α
* 1
* 2
* 3
* 4
* β
* 1
* 2
* 3
* HCN
* FC
* 1
* 2
* 3
* 4

M+: TRP cation channel|

* TRPA (1)
* TRPC
* 1
* 2
* 3
* 4
* 4AP
* 5
* 6
* 7
* TRPM
* 1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* TRPML
* 1
* 2
* 3
* TRPN
* TRPP
* 1
* 2
* TRPV
* 1
* 2
* 3
* 4
* 5
* 6

H2O (+ solutes): Porin|

* Aquaporin
* 0
* 1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* 9
* Voltage-dependent anion channel
* 1
* 2
* 3
* General bacterial porin family

Cytoplasm: Gap junction|

* Connexin
* A
* GJA1
* GJA3
* GJA4
* GJA5
* GJA8
* GJA9
* GJA10
* B
* GJB1
* GJB2
* GJB3
* GJB4
* GJB5
* GJB6
* GJB7
* C
* GJC1
* GJC2
* GJC3
* D
* GJD2
* GJD3
* GJD4
* Innexin

By gating mechanism

| Ion channel class|

* Ligand-gated
* Light-gated
* Voltage-gated
* Stretch-activated

|

see also disorders

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