KLC2

Protein-coding gene in the species Homo sapiens

KLC2

| Available structures

PDB| Ortholog search: PDBe RCSB
| List of PDB id codes

3CEQ, 3EDT

Identifiers
Aliases| KLC2, kinesin light chain 2
External IDs| OMIM: 611729; MGI: 107953; HomoloGene: 22468; GeneCards: KLC2; OMA:KLC2 - orthologs
| Gene location (Human)

Chr.| Chromosome 11 (human)[1]

Band| 11q13.2| Start| 66,257,294 bp[1]
End| 66,267,860 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 19 (mouse)[2]

Band| 19 A|19 4.25 cM| Start| 5,157,774 bp[2]
End| 5,168,588 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* right hemisphere of cerebellum

* right frontal lobe

* prefrontal cortex

* Brodmann area 9

* anterior cingulate cortex

* right testis

* endothelial cell

* left testis

* anterior pituitary

* primary visual cortex

| Top expressed in

* superior frontal gyrus

* primary visual cortex

* cerebellar cortex

* dentate gyrus of hippocampal formation granule cell

* neural layer of retina

* pontine nuclei

* superior colliculus

* inferior colliculi

* muscle of thigh

* Medulla Oblongata

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* microtubule motor activity
* protein binding
* kinesin binding
* cadherin binding

Cellular component|

* cytoplasm
* cytosol
* microtubule
* cytoskeleton
* membrane
* kinesin I complex
* kinesin complex
* nucleoplasm
* mitochondrion
* plasma membrane
* protein-containing complex

Biological process|

* microtubule-based movement
* antigen processing and presentation of exogenous peptide antigen via MHC class II
* retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

64837

16594

Ensembl| |

ENSG00000174996

ENSMUSG00000024862

UniProt| |

Q9H0B6

O88448

RefSeq (mRNA)| |

NM_001134774
NM_001134775
NM_001134776
NM_022822
NM_001318734

NM_008451
NM_001369360
NM_001369361
NM_001369362

RefSeq (protein)| |

NP_001128246
NP_001128247
NP_001128248
NP_001305663
NP_073733

n/a

Location (UCSC)| Chr 11: 66.26 – 66.27 Mb| Chr 19: 5.16 – 5.17 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Kinesin light chain 2 is a protein that in humans is encoded by the KLC2 gene.[5][6]

## Interactions

[edit]

KLC2 has been shown to interact with MAPK8IP3[7] and KIF5B.[5][8]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000174996 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024862 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ a b Rahman A, Friedman DS, Goldstein LS (Jun 1998). "Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins". The Journal of Biological Chemistry. 273 (25): 15395–403\. doi:10.1074/jbc.273.25.15395. PMID 9624122.15395-403&rft.date=1998-06&rft_id=info:doi/10.1074/jbc.273.25.15395&rft_id=info:pmid/9624122&rft.aulast=Rahman&rft.aufirst=A&rft.au=Friedman,+DS&rft.au=Goldstein,+LS&rft_id=https://doi.org/10.1074%2Fjbc.273.25.15395&rfr_id=info:sid/en.wikipedia.org:KLC2" class="Z3988">
6. ^ "Entrez Gene: KLC2 kinesin light chain 2".
7. ^ Bowman AB, Kamal A, Ritchings BW, Philp AV, McGrail M, Gindhart JG, Goldstein LS (Nov 2000). "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. 103 (4): 583–94\. doi:10.1016/S0092-8674(00)00162-8. PMID 11106729. S2CID 247102.583-94&rft.date=2000-11&rft_id=https://api.semanticscholar.org/CorpusID:247102#id-name=S2CID&rft_id=info:pmid/11106729&rft_id=info:doi/10.1016/S0092-8674(00)00162-8&rft.aulast=Bowman&rft.aufirst=AB&rft.au=Kamal,+A&rft.au=Ritchings,+BW&rft.au=Philp,+AV&rft.au=McGrail,+M&rft.au=Gindhart,+JG&rft.au=Goldstein,+LS&rft_id=https://doi.org/10.1016%2FS0092-8674%2800%2900162-8&rfr_id=info:sid/en.wikipedia.org:KLC2" class="Z3988">
8. ^ Rahman A, Kamal A, Roberts EA, Goldstein LS (Sep 1999). "Defective kinesin heavy chain behavior in mouse kinesin light chain mutants". The Journal of Cell Biology. 146 (6): 1277–88\. doi:10.1083/jcb.146.6.1277. PMC 2156125. PMID 10491391.1277-88&rft.date=1999-09&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2156125#id-name=PMC&rft_id=info:pmid/10491391&rft_id=info:doi/10.1083/jcb.146.6.1277&rft.aulast=Rahman&rft.aufirst=A&rft.au=Kamal,+A&rft.au=Roberts,+EA&rft.au=Goldstein,+LS&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2156125&rfr_id=info:sid/en.wikipedia.org:KLC2" class="Z3988">

## Further reading

[edit]

* Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95\. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.1788-95&rft.date=2000-11&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310948#id-name=PMC&rft_id=info:pmid/11076863&rft_id=info:doi/10.1101/gr.143000&rft.aulast=Hartley&rft.aufirst=JL&rft.au=Temple,+GF&rft.au=Brasch,+MA&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310948&rfr_id=info:sid/en.wikipedia.org:KLC2" class="Z3988">
* Bowman AB, Kamal A, Ritchings BW, Philp AV, McGrail M, Gindhart JG, Goldstein LS (Nov 2000). "Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein". Cell. 103 (4): 583–94\. doi:10.1016/S0092-8674(00)00162-8. PMID 11106729. S2CID 247102.583-94&rft.date=2000-11&rft_id=https://api.semanticscholar.org/CorpusID:247102#id-name=S2CID&rft_id=info:pmid/11106729&rft_id=info:doi/10.1016/S0092-8674(00)00162-8&rft.aulast=Bowman&rft.aufirst=AB&rft.au=Kamal,+A&rft.au=Ritchings,+BW&rft.au=Philp,+AV&rft.au=McGrail,+M&rft.au=Gindhart,+JG&rft.au=Goldstein,+LS&rft_id=https://doi.org/10.1016%2FS0092-8674%2800%2900162-8&rfr_id=info:sid/en.wikipedia.org:KLC2" class="Z3988">
* Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35\. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.422-35&rft.date=2001-03&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311072#id-name=PMC&rft_id=info:pmid/11230166&rft_id=info:doi/10.1101/gr.GR1547R&rft.aulast=Wiemann&rft.aufirst=S&rft.au=Weil,+B&rft.au=Wellenreuther,+R&rft.au=Gassenhuber,+J&rft.au=Glassl,+S&rft.au=Ansorge,+W&rft.au=Böcher,+M&rft.au=Blöcker,+H&rft.au=Bauersachs,+S&rft.au=Blum,+H&rft.au=Lauber,+J&rft.au=Düsterhöft,+A&rft.au=Beyer,+A&rft.au=Köhrer,+K&rft.au=Strack,+N&rft.au=Mewes,+HW&rft.au=Ottenwälder,+B&rft.au=Obermaier,+B&rft.au=Tampe,+J&rft.au=Heubner,+D&rft.au=Wambutt,+R&rft.au=Korn,+B&rft.au=Klein,+M&rft.au=Poustka,+A&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC311072&rfr_id=info:sid/en.wikipedia.org:KLC2" class="Z3988">
* Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92\. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.287-92&rft.date=2000-09&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1083732#id-name=PMC&rft_id=info:pmid/11256614&rft_id=info:doi/10.1093/embo-reports/kvd058&rft.aulast=Simpson&rft.aufirst=JC&rft.au=Wellenreuther,+R&rft.au=Poustka,+A&rft.au=Pepperkok,+R&rft.au=Wiemann,+S&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1083732&rfr_id=info:sid/en.wikipedia.org:KLC2" class="Z3988">
* Newsome TP, Scaplehorn N, Way M (Oct 2004). "SRC mediates a switch from microtubule- to actin-based motility of vaccinia virus". Science. 306 (5693): 124–9\. Bibcode:2004Sci...306..124N. doi:10.1126/science.1101509. PMID 15297625. S2CID 45392007.124-9&rft.date=2004-10&rft_id=info:doi/10.1126/science.1101509&rft_id=https://api.semanticscholar.org/CorpusID:45392007#id-name=S2CID&rft_id=info:pmid/15297625&rft_id=info:bibcode/2004Sci...306..124N&rft.aulast=Newsome&rft.aufirst=TP&rft.au=Scaplehorn,+N&rft.au=Way,+M&rfr_id=info:sid/en.wikipedia.org:KLC2" class="Z3988">
* Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5\. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.12130-5&rft.date=2004-08&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514446#id-name=PMC&rft_id=info:pmid/15302935&rft_id=info:doi/10.1073/pnas.0404720101&rft_id=info:bibcode/2004PNAS..10112130B&rft.aulast=Beausoleil&rft.aufirst=SA&rft.au=Jedrychowski,+M&rft.au=Schwartz,+D&rft.au=Elias,+JE&rft.au=Villén,+J&rft.au=Li,+J&rft.au=Cohn,+MA&rft.au=Cantley,+LC&rft.au=Gygi,+SP&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514446&rfr_id=info:sid/en.wikipedia.org:KLC2" class="Z3988">
* Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50\. Bibcode:2004CBio...14.1436J. CiteSeerX 10.1.1.323.5263. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.1436-50&rft.date=2004-08&rft_id=https://api.semanticscholar.org/CorpusID:2371325#id-name=S2CID&rft_id=info:bibcode/2004CBio...14.1436J&rft_id=https://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.323.5263#id-name=CiteSeerX&rft_id=info:pmid/15324660&rft_id=info:doi/10.1016/j.cub.2004.07.051&rft.aulast=Jin&rft.aufirst=J&rft.au=Smith,+FD&rft.au=Stark,+C&rft.au=Wells,+CD&rft.au=Fawcett,+JP&rft.au=Kulkarni,+S&rft.au=Metalnikov,+P&rft.au=O'Donnell,+P&rft.au=Taylor,+P&rft.au=Taylor,+L&rft.au=Zougman,+A&rft.au=Woodgett,+JR&rft.au=Langeberg,+LK&rft.au=Scott,+JD&rft.au=Pawson,+T&rft_id=https://doi.org/10.1016%2Fj.cub.2004.07.051&rfr_id=info:sid/en.wikipedia.org:KLC2" class="Z3988">
* Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44\. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.2136-44&rft.date=2004-10&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528930#id-name=PMC&rft_id=info:pmid/15489336&rft_id=info:doi/10.1101/gr.2576704&rft.aulast=Wiemann&rft.aufirst=S&rft.au=Arlt,+D&rft.au=Huber,+W&rft.au=Wellenreuther,+R&rft.au=Schleeger,+S&rft.au=Mehrle,+A&rft.au=Bechtel,+S&rft.au=Sauermann,+M&rft.au=Korf,+U&rft.au=Pepperkok,+R&rft.au=Sültmann,+H&rft.au=Poustka,+A&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528930&rfr_id=info:sid/en.wikipedia.org:KLC2" class="Z3988">
* Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (Jun 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–95\. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.785-95&rft.date=2005-06&rft_id=info:doi/10.1074/mcp.M500021-MCP200&rft_id=info:pmid/15778465&rft.aulast=Benzinger&rft.aufirst=A&rft.au=Muster,+N&rft.au=Koch,+HB&rft.au=Yates,+JR&rft.au=Hermeking,+H&rft_id=https://doi.org/10.1074%2Fmcp.M500021-MCP200&rfr_id=info:sid/en.wikipedia.org:KLC2" class="Z3988">
* Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
* Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14\. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.801-14&rft.date=2006-05&rft_id=https://api.semanticscholar.org/CorpusID:13709685#id-name=S2CID&rft_id=info:pmid/16713569&rft_id=info:doi/10.1016/j.cell.2006.03.032&rft.aulast=Lim&rft.aufirst=J&rft.au=Hao,+T&rft.au=Shaw,+C&rft.au=Patel,+AJ&rft.au=Szabó,+G&rft.au=Rual,+JF&rft.au=Fisk,+CJ&rft.au=Li,+N&rft.au=Smolyar,+A&rft.au=Hill,+DE&rft.au=Barabási,+AL&rft.au=Vidal,+M&rft.au=Zoghbi,+HY&rft_id=https://doi.org/10.1016%2Fj.cell.2006.03.032&rfr_id=info:sid/en.wikipedia.org:KLC2" class="Z3988">
* Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92\. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.1285-92&rft.date=2006-10&rft_id=https://api.semanticscholar.org/CorpusID:14294292#id-name=S2CID&rft_id=info:pmid/16964243&rft_id=info:doi/10.1038/nbt1240&rft.aulast=Beausoleil&rft.aufirst=SA&rft.au=Villén,+J&rft.au=Gerber,+SA&rft.au=Rush,+J&rft.au=Gygi,+SP&rfr_id=info:sid/en.wikipedia.org:KLC2" class="Z3988">
* Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48\. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.635-48&rft.date=2006-11&rft_id=https://api.semanticscholar.org/CorpusID:7827573#id-name=S2CID&rft_id=info:pmid/17081983&rft_id=info:doi/10.1016/j.cell.2006.09.026&rft.aulast=Olsen&rft.aufirst=JV&rft.au=Blagoev,+B&rft.au=Gnad,+F&rft.au=Macek,+B&rft.au=Kumar,+C&rft.au=Mortensen,+P&rft.au=Mann,+M&rft_id=https://doi.org/10.1016%2Fj.cell.2006.09.026&rfr_id=info:sid/en.wikipedia.org:KLC2" class="Z3988">
* Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.