Keratin 6C

KRT6C

Identifiers
Aliases| KRT6C, keratin 6C, K6E, KRT6E, PPKNEFD
External IDs| OMIM: 612315; MGI: 1333768; HomoloGene: 138409; GeneCards: KRT6C; OMA:KRT6C - orthologs
| Gene location (Human)

Chr.| Chromosome 12 (human)[1]

Band| 12q13.13| Start| 52,468,516 bp[1]
End| 52,473,805 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 15 (mouse)[2]

Band| 15 F2|15 56.97 cM| Start| 101,584,458 bp[2]
End| 101,588,722 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* mucosa of esophagus

* thymus

* vagina

* skin of abdomen

* ectocervix

* tonsil

* skin of leg

* minor salivary glands

* sural nerve

* right coronary artery

| Top expressed in

* conjunctival fornix

* ciliary body

* corneal stroma

* cervix

* retinal pigment epithelium

* epithelium of lens

* lip

* umbilical cord

* iris

* sexually immature organism

More reference expression data
BioGPS| | n/a

| Gene ontology

Molecular function|

* protein binding
* structural molecule activity

Cellular component|

* keratin filament
* extracellular exosome
* intermediate filament
* cytosol

Biological process|

* intermediate filament cytoskeleton organization
* keratinization
* cornification

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

286887

16688

Ensembl| |

ENSG00000170465

ENSMUSG00000023041

UniProt| |

P48668

Q9Z331
Q3UV11

RefSeq (mRNA)| |

NM_173086

NM_010669

RefSeq (protein)| |

NP_775109

NP_034799

Location (UCSC)| Chr 12: 52.47 – 52.47 Mb| Chr 15: 101.58 – 101.59 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Keratin 6C (protein name K6C; gene name KRT6C), is a type II cytokeratin, one of a number of isoforms of keratin 6 encoded by separate genes located within the type II keratin gene cluster on human chromosome 12q. This gene was uncovered recently by the Human Genome Project and its expression patterns in humans remains unknown.

## Keratins

[edit]

Keratins are the intermediate filament proteins that form a dense meshwork of filaments throughout the cytoplasm of epithelial cells.[5] Keratins form heteropolymers consisting of a type I and a type II keratin. Keratins are generally expressed in particular pairs of type I and type II keratin proteins in a tissue-specific and cellular differentiation-specific manner.

The keratin proteins of epithelial tissues are commonly known as "keratins" or are sometimes referred to as "epithelial keratins" or "cytokeratins". The specialized keratins of hair and nail are known as "hard keratins" or "trichocyte keratins". Trichocytes are the specialized epithelial cells from which hair and nail are composed. Trichocyte keratins are similar in their gene and protein structure to keratins except that they are especially rich in the sulfur-containing amino acid cysteine, which facilitates chemical cross-linking of the assembled hard keratins to form a more structurally resilient material.

Both epithelial keratins and hard keratins can be further subdivided into type I (acidic) keratins and type II (neutral-basic) keratins. The genes for the type I keratins are located in a gene cluster on human chromosome 17q, whereas the genes for type II keratins are located in a cluster on human chromosome 12q (the exception being K18, a type I keratin located in the type II gene cluster).

Like the closely related KRT6A and KRT6B genes, the KRT6C gene consists of 9 exons separated by 8 introns and is located in the type II keratin gene cluster on human chromosome 12q. Keratin 6A and keratin 6B are encoded by the neighbouring genes, which are identical in intron-exon organization to KRT6C and are more than 99% identical in their DNA coding sequences.

## Genetic disorders

[edit]

Mutations in K6C have been identified as being able to cause diffuse and focal palmoplantar keratodermas.[6][7][8] This has been identified as a form of Pachyonychia congenita.[9][10]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170465 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023041 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Quinlan R, Hutchison C, Lane B (1995). "Intermediate filament proteins". Protein Profile. 2 (8): 795–952\. PMID 8771189.
6. ^ Wilson NJ, Messenger AG, Leachman SA, O'Toole EA, Lane EB, McLean WH, Smith FJ (2010). "Keratin K6c mutations cause focal palmoplantar keratoderma". J. Invest. Dermatol. 130 (2): 425–9\. doi:10.1038/jid.2009.215. PMID 19609311.
7. ^ Bowden PE (2010). "Mutations in a keratin 6 isomer (K6c) cause a type of focal palmoplantar keratoderma". J. Invest. Dermatol. 130 (2): 336–8\. doi:10.1038/jid.2009.395. PMID 20081885.
8. ^ Akasaka E, Nakano H, Nakano A, Toyomaki Y, Takiyoshi N, Rokunohe D, Nishikawa Y, Korekawa A, Matsuzaki Y, Mitsuhashi Y, Sawamura D (2011). "Diffuse and focal palmoplantar keratoderma can be caused by a keratin 6c mutation". Br. J. Dermatol. 165 (6): 1290–2\. doi:10.1111/j.1365-2133.2011.10552.x. PMID 21801157. S2CID 36039184.
9. ^ van Steensel MA, Coulombe PA, Kaspar RL, Milstone LM, McLean IW, Roop DR, Smith FJ, Sprecher E, Schwartz ME (2014). "Report of the 10th Annual International Pachyonychia Congenita Consortium Meeting". J. Invest. Dermatol. 134 (3): 588–91\. doi:10.1038/jid.2013.392. PMC 3930927. PMID 24518109.
10. ^ O'Toole EA, Kaspar RL, Sprecher E, Schwartz ME, Rittié L (2014). "Pachyonychia congenita cornered: report on the 11th Annual International Pachyonychia Congenita Consortium Meeting". Br. J. Dermatol. 171 (5): 974–7\. doi:10.1111/bjd.13341. hdl:2027.42/109650. PMID 25124823. S2CID 1481875.

## Further reading

[edit]

* "What Is Pachyonychia Congenita?". pachyonychia.org. Archived from the original on 2013-11-27. Retrieved 2014-10-05.

* v
* t
* e

Protein: scleroproteins

Extracellular
matrix|

| Collagen|

| Fibril forming|

* type I
* COL1A1
* COL1A2
* type II (COL2A1)
* type III
* type V
* COL5A1
* COL5A2
* COL5A3
* COL24A1
* COL26A1

|

Other|

* FACIT: type IX
* COL9A1
* COL9A2
* COL9A3
* type XII (COL12A1)
* COL14A1
* COL16A1
* COL19A1
* COL20A1
* COL21A1
* COL22A1

* basement membrane: type IV
* COL4A1
* COL4A2
* COL4A3
* COL4A4
* COL4A5
* COL4A6

* multiplexin: COL15A1
* type XVIII
* COL18A1
* Endostatin

* transmembrane: COL13A1
* COL17A1
* COL23A1
* COL25A1

* other: type VI
* COL6A1
* COL6A2
* COL6A3
* COL6A5
* type VII (COL7A1)
* type VIII
* COL8A1
* COL8A2
* type X (COL10A1)
* type XI
* COL11A1
* COL11A2
* COL27A1
* COL28A1

Enzymes|

* Prolyl hydroxylase/Lysyl hydroxylase
* Cartilage associated protein/Leprecan
* ADAMTS2
* Procollagen peptidase
* Lysyl oxidase

Laminin|

* alpha
* LAMA1
* LAMA2
* LAMA3
* LAMA4
* LAMA5
* beta
* LAMB1
* LAMB2
* LAMB3
* LAMB4
* gamma
* LAMC1
* LAMC2
* LAMC3

Other|

* ALCAM
* Elastin
* Tropoelastin
* Vitronectin
* FRAS1
* FREM2
* Decorin
* FAM20C
* ECM1
* Matrix gla protein
* Tectorin
* TECTA
* TECTB

Other|

* Keratin/Cytokeratin
* Gelatin
* Reticulin
* Cartilage oligomeric matrix protein

See also
diseases
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