L1TD1

Protein-coding gene in the species Homo sapiens

L1TD1

| Available structures

PDB| Ortholog search: PDBe RCSB
| List of PDB id codes

2LR6, 3SOO

Identifiers
Aliases| L1TD1, ECAT11, LINE-1 type transposase domain containing 1, LINE1 type transposase domain containing 1
External IDs| MGI: 3578435; HomoloGene: 136289; GeneCards: L1TD1; OMA:L1TD1 - orthologs
| Gene location (Human)

Chr.| Chromosome 1 (human)[1]

Band| 1p31.3| Start| 62,194,849 bp[1]
End| 62,212,328 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 4 (mouse)[2]

Band| 4|4 C6| Start| 98,614,971 bp[2]
End| 98,626,717 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* gonad

* testicle

* placenta

* appendix

* mucosa of transverse colon

* white blood cell

* monocyte

* right testis

* left testis

* epithelium of colon

| Top expressed in

* yolk sac

* epiblast

* embryo

* blastocyst

* blastocyst

* primitive streak

* morula

* embryo

* tail of embryo

* hand

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* single-stranded RNA binding
* protein binding

Cellular component|

* ribonucleoprotein complex

Biological process|

* transposition, RNA-mediated

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

54596

381591

Ensembl| |

ENSG00000240563

ENSMUSG00000087166

UniProt| |

Q5T7N2

Q587J6

RefSeq (mRNA)| |

NM_019079
NM_001164835

NM_001081202

RefSeq (protein)| |

NP_001158307
NP_061952

NP_001074671

Location (UCSC)| Chr 1: 62.19 – 62.21 Mb| Chr 4: 98.61 – 98.63 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

LINE-1 type transposase domain containing 1, also known as L1TD1, is an RNA-binding protein that involved with self-renewal of undifferentiated human embryonic stem cells and cancer cell proliferation. L1TD1 has been reported to associate with the development of several cancers. [5] [6] [7] [8]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000240563 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000087166 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Iwabuchi KA, Yamakawa T, Sato Y, Ichisaka T, Takahashi K, Okita K, Yamanaka S (May 2011). "ECAT11/L1td1 is enriched in ESCs and rapidly activated during iPSC generation, but it is dispensable for the maintenance and induction of pluripotency". PLOS ONE. 6 (5): e20461. Bibcode:2011PLoSO...620461I. doi:10.1371/journal.pone.0020461. PMC 3102727. PMID 21637830.
6. ^ Närvä E, Rahkonen N, Emani MR, Lund R, Pursiheimo JP, Nästi J, Autio R, Rasool O, Denessiouk K, Lähdesmäki H, Rao A, Lahesmaa R (March 2012). "RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation". Stem Cells. 30 (3): 452–60. doi:10.1002/stem.1013. PMC 3507993. PMID 22162396.
7. ^ Wong RC, Ibrahim A, Fong H, Thompson N, Lock LF, Donovan PJ (April 2011). "L1TD1 is a marker for undifferentiated human embryonic stem cells". PLOS ONE. 6 (4): e19355. Bibcode:2011PLoSO...619355W. doi:10.1371/journal.pone.0019355. PMC 3084827. PMID 21559406.
8. ^ Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Maruyama R, Nojima M, Ashida M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y (October 2008). "LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis". Cancer Epidemiol Biomarkers Prev. 17 (10): 2555–64. doi:10.1158/1055-9965.EPI-08-0112. PMID 18842996. S2CID 24719399.

## Further reading

[edit]

* Mitsui K, Tokuzawa Y, Itoh H, et al. (2003). "The homeoprotein Nanog isrequired for maintenance of pluripotency in mouse epiblast and ES cells". Cell. 113 (5): 631–42. doi:10.1016/S0092-8674(03)00393-3. PMID 12787504. S2CID 18836242.
* Cash HL, Tao L, Yuan JM, et al. (2012). "LINE-1 hypomethylation is associated with bladder cancer risk among nonsmoking Chinese". Int J Cancer. 130 (5): 1151–9. doi:10.1002/ijc.26098. PMC 3208798. PMID 21445976.