LGTN

Protein-coding gene in the species Homo sapiens

EIF2D

Identifiers
Aliases| EIF2D, HCA56, LGTN, eukaryotic translation initiation factor 2D
External IDs| OMIM: 613709; MGI: 109342; HomoloGene: 38244; GeneCards: EIF2D; OMA:EIF2D - orthologs
| Gene location (Human)

Chr.| Chromosome 1 (human)[1]

Band| 1q32.1| Start| 206,571,292 bp[1]
End| 206,612,465 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 1 (mouse)[2]

Band| 1 E4|1 56.9 cM| Start| 131,080,918 bp[2]
End| 131,115,395 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* left ovary

* body of uterus

* right ovary

* right uterine tube

* glutes

* muscle of thigh

* parotid gland

* body of pancreas

* muscle layer of sigmoid colon

* canal of the cervix

| Top expressed in

* Paneth cell

* fossa

* condyle

* hair follicle

* internal carotid artery

* lacrimal gland

* primitive streak

* external carotid artery

* endothelial cell of lymphatic vessel

* epiblast

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* translation initiation factor activity
* RNA binding
* signaling receptor activity

Cellular component|

* cytoplasm
* cytosolic small ribosomal subunit
* cytosol
* nuclear body

Biological process|

* translational initiation
* intracellular protein transport
* ribosome disassembly
* protein biosynthesis
* formation of translation preinitiation complex
* IRES-dependent viral translational initiation
* signal transduction

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

1939

16865

Ensembl| |

ENSG00000143486

ENSMUSG00000026427

UniProt| |

P41214
Q5SY38

Q61211

RefSeq (mRNA)| |

NM_001201478
NM_006893

NM_001136070
NM_010709

RefSeq (protein)| |

NP_001188407
NP_008824

NP_001129542
NP_034839

Location (UCSC)| Chr 1: 206.57 – 206.61 Mb| Chr 1: 131.08 – 131.12 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Ligatin, otherwise known as eIF2D, is a protein that in humans is encoded by the LGTN gene.[5][6] This protein is not a component of the heterotrimeric eIF2 complex, but instead functions in different pathways of eukaryotic translation.

## Function

[edit]

This gene encodes a protein receptor that localizes phosphoglycoproteins within endosomes and at the cell periphery. This trafficking receptor for phosphoglycoproteins may play a role in neuroplasticity by modulating cell-cell interactions, intracellular adhesion, and protein binding at membrane surfaces. In hippocampal neurons, long-lasting down-regulation of ligation mRNA levels occurs via post-transcriptional RNA processing following glutamate receptor activation. This protein contains single PUA and SUI1 domains and these domains may function in RNA binding and translation initiation, respectively.[6]

## See also

[edit]

* Eukaryotic translation
* Eukaryotic initiation factor

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143486 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026427 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Jakoi ER, Brown AL, Ho YS, Snyderman R (June 1989). "Molecular cloning of the cDNA for ligatin". Journal of Cell Science. 93 ( Pt 2) (2): 227–32\. doi:10.1242/jcs.93.2.227. PMID 2482295.
6. ^ a b "Entrez Gene: LGTN ligatin".

## Further reading

[edit]

* Jakoi ER, Ross PE, Ping Ting-Beall H, Kaufman B, Vanaman TC (January 1987). "Ligatin: a peripheral membrane protein with covalently bound palmitic acid". The Journal of Biological Chemistry. 262 (3): 1300–4\. doi:10.1016/S0021-9258(19)75786-X. PMID 3805022.
* Gaston SM, Marchase RB, Jakoi ER (1982). "Brain ligatin: a membrane lectin that binds acetylcholinesterase". Journal of Cellular Biochemistry. 18 (4): 447–59\. doi:10.1002/jcb.1982.240180406. PMID 7085778. S2CID 22975039.
* Marchase RB, Koro LA, Kelly CM, McClay DR (1982). "A possible role for ligatin and the phosphoglycoproteins it binds in calcium-dependent retinal cell adhesion". Journal of Cellular Biochemistry. 18 (4): 461–8\. doi:10.1002/jcb.1982.240180407. PMID 7085779. S2CID 44992995.
* Jakoi ER, Kempe K, Gaston SM (1982). "Ligatin binds phosphohexose residues on acidic hydrolases". Journal of Supramolecular Structure and Cellular Biochemistry. 16 (2): 139–53\. doi:10.1002/jsscb.1981.380160205. PMID 7299841.
* Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4\. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.1–2&rft.pages=171-4&rft.date=1994-01&rft_id=info:doi/10.1016/0378-1119(94)90802-8&rft_id=info:pmid/8125298&rft.aulast=Maruyama&rft.aufirst=K&rft.au=Sugano,+S&rfr_id=info:sid/en.wikipedia.org:LGTN" class="Z3988">
* Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56\. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.1–2&rft.pages=149-56&rft.date=1997-10&rft_id=info:doi/10.1016/S0378-1119(97)00411-3&rft_id=info:pmid/9373149&rft.aulast=Suzuki&rft.aufirst=Y&rft.au=Yoshitomo-Nakagawa,+K&rft.au=Maruyama,+K&rft.au=Suyama,+A&rft.au=Sugano,+S&rfr_id=info:sid/en.wikipedia.org:LGTN" class="Z3988">
* Wang Y, Han KJ, Pang XW, Vaughan HA, Qu W, Dong XY, Peng JR, Zhao HT, Rui JA, Leng XS, Cebon J, Burgess AW, Chen WF (July 2002). "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies". Journal of Immunology. 169 (2): 1102–9\. doi:10.4049/jimmunol.169.2.1102. PMID 12097419.
* Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5\. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
* Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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