List of keratins

The first sequences of keratins revealed that keratins could be grouped into two categories based on their sequence homologies.[1][2] These two groups of keratins were named as type I and type II keratins.[2] These two categories also represent the first two categories of the superfamily of intermediate filament proteins.

Keratins in this table are classified in the first two columns according to the nomenclature established in 2006.[3] Other names previously used are listed in columns 3 and 4.

## Type I keratins[edit]

### Human epithelial keratins[edit]

Protein name[3] | Gene name[3] | Other protein name | Other gene name

|
|
|

K9 | KRT9 | Ka9 |
K10 | KRT10 | Ka10 |
K12 | KRT12 | Ka12 |
K13 | KRT13 | Ka13 |
K14 | KRT14 | Ka14 |
K15 | KRT15 | Ka15 |
K16 | KRT16 | Ka16 |
K17 | KRT17 | Ka17 |
K18 | KRT18 | Ka18 |
K19 | KRT19 | Ka19 |
K20 | KRT20 | Ka20 |
K23 | KRT23 | Ka23 |
K24 | KRT24 | Ka24 |
K25 | KRT25 | Ka38, K25irs1, K10C, hIRSa1 | KRT25A
K26 | KRT26 | Ka39, K25irs2, K10D |
K27 | KRT27 | Ka40, K25irs3, K10B, hIRSa3.1 |
K28 | KRT28 | Ka41, K25irs4, hIRSa2 |

### Human hair keratins[edit]

Protein name[3] | Gene name[3] | Other protein name | Other gene name

|
|
|

K31 | KRT31 | Ka25, Ha1 | KRTHA1
K32 | KRT32 | Ka26, Ha2 | KRTHA2
K33a | KRT33A | Ka27, Ha3-I | KRTHA3A
K33b | KRT33B | Ka28, Ha3-II | KRTHA3B
K34 | KRT34 | Ka29, Ha4 | KRTHA4
K35 | KRT35 | Ka30, Ha5 | KRTHA5
K36 | KRT36 | Ka31, Ha6 | KRTHA6
K37 | KRT37 | Ka32, Ha7 | KRTHA7
K38 | KRT38 | Ka33, Ha8 | KRTHA8
K39 | KRT39 | Ka35 |
K40 | KRT40 | Ka36 |

### Nonhuman hair/epithelial keratins[edit]

Protein name[3] | Gene name[3] | Other protein name | Other gene name

|
|
|

K41 chimp, gorilla, dog[4] | KRT41 chimp, gorilla, dog; KRT41P man, horse |  | φhHaA, Ka34P man
K42 mouse, rat | KRT42 mouse, rat; KRT42P man | Ka22 mouse, rat, K17n mouse, rat |

### Human keratin pseudogenes[edit]

Protein name[3] | Gene name[3] | Other protein name | Other gene name

|
|
|

| KRT221P |  | φhHaB
| KRT222P |  | φKRTI, Ka21P
| KRT223P |  | φKRTJ, Ka37P

## Type II keratins[edit]

### Human epithelial keratin[edit]

Protein name[3] | Gene name[3] | Other protein name | Other gene name

|
|
|

K1 | KRT1 | Kb1 |
K2 | KRT2 | Kb2, K2e | KRT2A
K3 | KRT3 | Kb3 |
K4 | KRT4 | Kb4 |
K5 | KRT5 | Kb5 |
K6a | KRT6A | Kb6 |
K6b | KRT6B | Kb10 |
K7 | KRT7 | Kb7 |
K8 | KRT8 | Kb8 |
K71 | KRT71 | Kb34, K6irs1 |
K72 | KRT72 | Kb35, K6irs2 |
K73 | KRT73 | Kb36, K6irs3 |
K74 | KRT74 | Kb37, K6irs4 |
K75 | KRT75 | Kb18, K6hf |
K76 | KRT76 | Kb9, K2p | KRT2B
K77 | KRT77 | Kb39, K1b |
K78 | KRT78 | Kb40, K5b |
K79 | KRT79 | Kb38, K6I |
K80 | KRT80 | Kb20 |

### Human hair keratins[edit]

Protein name[3] | Gene name[3] | Other protein name | Other gene name

|
|
|

K81 | KRT81 | Kb21, Hb1, K2.9 | KRTHB1
K82 | KRT82 | Kb22, Hb2 | KRTHB2
K83 | KRT83 | Kb23, Hb3, K2.10 | KRTHB3
K84 | KRT84 | Kb24, Hb4 | KRTHB4
K85 | KRT85 | Kb25, Hb5, K2.12 | KRTHB5
K86 | KRT86 | Kb26, Hb6, K2.11 | KRTHB6

### Human keratin pseudogenes[edit]

Protein name[3] | Gene name[3] | Other protein name | Other gene name

|
|
|

| KRT121P |  | φhHbD, Kb31P
| KRT122P |  | φhHbC, Kb30P
| KRT123P |  | φhHbB, Kb29P
| KRT124P |  | φhHbA, Kb28P
| KRT125P |  | φKRTH
| KRT126P |  | φKRTG, Kb19P
| KRT127P |  | φKRTF
| KRT128P |  | φKRTE

## See also[edit]

* Keratins
* Skin
* Epidermis

## References[edit]

1. ^ Hanukoglu, I.; Fuchs, E. (Nov 1982). "The cDNA sequence of a human epidermal keratin: divergence of sequence but conservation of structure among intermediate filament proteins". Cell. 31 (1): 243–52. doi:10.1016/0092-8674(82)90424-X. PMID 6186381. S2CID 35796315.
2. ^ a b Hanukoglu, I.; Fuchs, E. (Jul 1983). "The cDNA sequence of a Type II cytoskeletal keratin reveals constant and variable structural domains among keratins". Cell. 33 (3): 915–24. doi:10.1016/0092-8674(83)90034-X. PMID 6191871. S2CID 21490380.
3. ^ a b c d e f g h i j k l m n o Schweizer J, Bowden PE, Coulombe PA, et al. (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
4. ^ Balmer, P; Bauer, A; Pujar, S; McGarvey, KM; Welle, M; Galichet, A; Müller, EJ; Pruitt, KD; Leeb, T; Jagannathan, V (2017). "A curated catalog of canine and equine keratin genes". PLOS ONE. 12 (8): e0180359. Bibcode:2017PLoSO..1280359B. doi:10.1371/journal.pone.0180359. PMC 5573215. PMID 28846680.