Lutz Gissmann

German virologist

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Lutz Gissmann (born September 18, 1949, in Kaufbeuren, Germany) is a German virologist and was head of the division Genome Modifications and Carcinogenesis at the German Cancer Research Center (DKFZ) in Heidelberg until his retirement in 2015. Lutz Gissmann is known for his seminal research in the field of human papillomaviruses (HPV) and their causal association with human cancer, especially cervical cancer. In his early work, he demonstrated genetic heterogeneity among HPV isolates leading the way to the now well-established concept of distinct HPV types (up to now more than 200) of which some are associated with specific benign or malignant disease.[1][2] In the early 1980s in the laboratory of later Nobel Prize laureate Harald zur Hausen he was the first (together with the postgraduates Matthias Dürst and Michael Boshart supervised by him) to isolate and characterize HPV16 and HPV18, the two most oncogenic HPV types causing the vast majority of HPV-induced anogenital and head-and-neck cancers.[3][4] This groundbreaking work of Lutz Gissmann provided experimental evidence for the causal association of specific HPV types with human cancer, and laid the foundation for the development of prophylactic HPV vaccines for the prevention of cervical cancer and other HPV-induced cancers. His current research interest is on development of second generation prophylactic and therapeutic HPV vaccines.

## Professional biography

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Gissmann obtained a diploma in biology and a PhD in Microbiology and Genetics of the University of Erlangen (Germany). Together with Harald zur Hausen he moved to the University of Freiburg as a post doc and later became assistant professor in virology. In 1983 he was appointed as head of the division Genome Modifications and Carcinogenesis at the German Cancer Research Center (DKFZ) in Heidelberg and professor of virology at the University of Heidelberg. He was on leave of absence from 1993 to 1997 as director of research in the department of Obstetrics and Gynecology and chairman of the program Viral Oncology at the Loyola University Medical Center, Chicago, USA, and from 1998 to 1999 as vice president of research and development, MediGene AG, Martinsried, Germany. Gissmann was a member of the DKFZ board of trustees (2002–2012), speaker of the research programs Applied Tumor Virology (1991–1993) and Infection and Cancer (2012–2014) and ombudsman for the PhD students at DKFZ (2004–2010). Under his guidance numerous diploma and Ph.D. students were introduced to the fascination of science and the fun side of life in a research laboratory.

Gissmann has published more than 200 peer reviewed scientific contributions, holds several patents and has written numerous book contributions. He received several honorary memberships and awards (including the Warren Alpert Foundation Prize in 2007 together with Harald zur Hausen "for work leading to the development of a vaccine against human papillomavirus").

## References

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1. ^ Gissmann, L; Zur Hausen, H (1976). "Human papilloma virus DNA: Physical mapping and genetic heterogeneity". Proceedings of the National Academy of Sciences of the United States of America. 73 (4): 1310–3. Bibcode:1976PNAS...73.1310G. doi:10.1073/pnas.73.4.1310. PMC 430256. PMID 177985.
2. ^ Gissmann, L; Pfister, H; Zur Hausen, H (1977). "Human papilloma viruses (HPV): Characterization of four different isolates". Virology. 76 (2): 569–80. doi:10.1016/0042-6822(77)90239-2. PMID 65825.
3. ^ Dürst, M; Gissmann, L; Ikenberg, H; Zur Hausen, H (1983). "A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions". Proceedings of the National Academy of Sciences of the United States of America. 80 (12): 3812–5. Bibcode:1983PNAS...80.3812D. doi:10.1073/pnas.80.12.3812. PMC 394142. PMID 6304740.
4. ^ Boshart, M; Gissmann, L; Ikenberg, H; Kleinheinz, A; Scheurlen, W; Zur Hausen, H (1984). "A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer". The EMBO Journal. 3 (5): 1151–7. doi:10.1002/j.1460-2075.1984.tb01944.x. PMC 557488. PMID 6329740.

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