MCC (gene)

Protein-coding gene in the species Homo sapiens

MCC

Identifiers
Aliases| MCC, MCC1, mutated in colorectal cancers, WNT signaling pathway regulator, MCC regulator of WNT signaling pathway
External IDs| OMIM: 159350; MGI: 96930; HomoloGene: 20539; GeneCards: MCC; OMA:MCC - orthologs
| Gene location (Human)

Chr.| Chromosome 5 (human)[1]

Band| 5q22.2| Start| 113,022,099 bp[1]
End| 113,488,823 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 18 (mouse)[2]

Band| 18 B3|18 23.74 cM| Start| 44,558,127 bp[2]
End| 44,945,249 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* gingival epithelium

* sural nerve

* skin of hip

* left ovary

* germinal epithelium

* skin of thigh

* retinal pigment epithelium

* endothelial cell

* seminal vesicula

* pars reticulata

| Top expressed in

* zygote

* otolith organ

* utricle

* lobe of cerebellum

* cerebellar vermis

* secondary oocyte

* gastrula

* ventral tegmental area

* iris

* parotid gland

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* protein binding
* signaling receptor activity

Cellular component|

* cytoplasm
* plasma membrane
* cell projection
* membrane
* nucleus
* lamellipodium
* nucleoplasm
* cytosol

Biological process|

* establishment of protein localization
* negative regulation of epithelial cell proliferation
* negative regulation of epithelial cell migration
* Wnt signaling pathway
* negative regulation of canonical Wnt signaling pathway
* signal transduction

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

4163

328949

Ensembl| |

ENSG00000171444

ENSMUSG00000071856

UniProt| |

P23508

n/a

RefSeq (mRNA)| |

NM_001085377
NM_002387

NM_001033406
NM_001085373
NM_001085374

RefSeq (protein)| |

NP_001078846
NP_002378

n/a

Location (UCSC)| Chr 5: 113.02 – 113.49 Mb| Chr 18: 44.56 – 44.95 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Colorectal mutant cancer protein is a protein that in humans is encoded by the MCC gene.[5][6]

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different  isoforms have been found for this gene.[6]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171444 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000071856 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Kinzler KW, Nilbert MC, Vogelstein B, Bryan TM, Levy DB, Smith KJ, Preisinger AC, Hamilton SR, Hedge P, Markham A, et al. (Apr 1991). "Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers". Science. 251 (4999): 1366–70\. Bibcode:1991Sci...251.1366K. doi:10.1126/science.1848370. PMID 1848370. S2CID 40048385.
6. ^ a b "Entrez Gene: MCC mutated in colorectal cancers".

## Further reading

[edit]

* Lindgren V, Bryke CR, Ozcelik T, et al. (1992). "Phenotypic, cytogenetic, and molecular studies of three patients with constitutional deletions of chromosome 5 in the region of the gene for familial adenomatous polyposis". Am. J. Hum. Genet. 50 (5): 988–97\. PMC 1682619. PMID 1315124.
* Nishisho I, Nakamura Y, Miyoshi Y, et al. (1991). "Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients". Science. 253 (5020): 665–9\. Bibcode:1991Sci...253..665N. doi:10.1126/science.1651563. PMID 1651563.
* Hoshino Y, Horikawa I, Oshimura M, Yuasa Y (1991). "Normal human chromosome 5, on which a familial adenomatous polyposis gene is located, has tumor suppressive activity". Biochem. Biophys. Res. Commun. 174 (1): 298–304\. doi:10.1016/0006-291X(91)90520-H. PMID 1846539.
* Curtis LJ, Bubb VJ, Gledhill S, et al. (1994). "Loss of heterozygosity of MCC is not associated with mutation of the retained allele in sporadic colorectal cancer". Hum. Mol. Genet. 3 (3): 443–6\. doi:10.1093/hmg/3.3.443. PMID 8012355.
* Matsumine A, Senda T, Baeg GH, et al. (1996). "MCC, a cytoplasmic protein that blocks cell cycle progression from the G0/G1 to S phase". J. Biol. Chem. 271 (17): 10341–6\. doi:10.1074/jbc.271.17.10341. PMID 8626604.
* Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806\. doi:10.1101/gr.6.9.791. PMID 8889548.
* Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95\. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
* Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35\. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
* Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903\. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
* Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5\. doi:10.1038/ng1285. PMID 14702039.
* Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105\. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
* Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7\. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
* Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44\. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
* Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
* Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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