MT1E

Protein-coding gene in the species Homo sapiens

MT1E

Identifiers
Aliases| MT1E, MT1, MTD, MT-1E, MT-IE, metallothionein 1E
External IDs| OMIM: 156351; HomoloGene: 138433; GeneCards: MT1E; OMA:MT1E - orthologs
| Gene location (Human)

Chr.| Chromosome 16 (human)[1]

Band| 16q13| Start| 56,625,475 bp[1]
End| 56,627,112 bp[1]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* mucosa of transverse colon

* mucosa of ileum

* external globus pallidus

* pericardium

* right lobe of liver

* synovial joint

* internal globus pallidus

* kidney tubule

* left uterine tube

* pars reticulata

n/a

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* zinc ion binding
* metal ion binding

Cellular component|

* cytoplasm
* perinuclear region of cytoplasm
* nucleus

Biological process|

* negative regulation of growth
* cellular response to cadmium ion
* cellular response to zinc ion
* cellular zinc ion homeostasis
* detoxification of copper ion
* cellular response to copper ion

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

4493

n/a

Ensembl| |

ENSG00000169715

n/a

UniProt| |

P04732

n/a

RefSeq (mRNA)| |

NM_175617
NM_001363555

n/a

RefSeq (protein)| |

NP_783316
NP_001350484

n/a

Location (UCSC)| Chr 16: 56.63 – 56.63 Mb| n/a
PubMed search| [2]| n/a
Wikidata
| View/Edit Human|

|

Metallothionein-1E is a protein that in humans is encoded by the MT1E gene.[3][4][5]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169715 - Ensembl, May 2017
2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. ^ Karin M, Eddy RL, Henry WM, Haley LL, Byers MG, Shows TB (Oct 1984). "Human metallothionein genes are clustered on chromosome 16". Proc Natl Acad Sci U S A. 81 (17): 5494–8. Bibcode:1984PNAS...81.5494K. doi:10.1073/pnas.81.17.5494. PMC 391732. PMID 6089206.
4. ^ Schmidt CJ, Jubier MF, Hamer DH (Jul 1985). "Structure and expression of two human metallothionein-I isoform genes and a related pseudogene". J Biol Chem. 260 (12): 7731–7. doi:10.1016/S0021-9258(17)39668-0. PMID 2581970.
5. ^ "Entrez Gene: MT1E metallothionein 1E".

## Further reading

[edit]

* West AK, Stallings R, Hildebrand CE, et al. (1991). "Human metallothionein genes: structure of the functional locus at 16q13". Genomics. 8 (3): 513–8. doi:10.1016/0888-7543(90)90038-V. PMID 2286373.
* Le Beau MM, Diaz MO, Karin M, Rowley JD (1985). "Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia". Nature. 313 (6004): 709–11. Bibcode:1985Natur.313..709L. doi:10.1038/313709a0. PMID 3856101. S2CID 4321473.
* Carter AD, Felber BK, Walling MJ, et al. (1985). "Duplicated heavy metal control sequences of the mouse metallothionein-I gene". Proc. Natl. Acad. Sci. U.S.A. 81 (23): 7392–6. doi:10.1073/pnas.81.23.7392. PMC 392152. PMID 6095291.
* Kondo Y, Kuo SM, Lazo JS (1994). "Interleukin-1 beta-mediated metallothionein induction and cytoprotection against cadmium and cis-diamminedichloroplatinum". J. Pharmacol. Exp. Ther. 270 (3): 1313–8. PMID 7932184.
* Pauwels M, van Weyenbergh J, Soumillion A, et al. (1994). "Induction by zinc of specific metallothionein isoforms in human monocytes". Eur. J. Biochem. 220 (1): 105–10. doi:10.1111/j.1432-1033.1994.tb18603.x. PMID 8119276.
* Vandeghinste N, Proost P, De Ley M (2000). "Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes". Cell. Mol. Biol. (Noisy-le-grand). 46 (2): 419–33. PMID 10774930.
* Nguyen A, Jing Z, Mahoney PS, et al. (2000). "In vivo gene expression profile analysis of metallothionein in renal cell carcinoma". Cancer Lett. 160 (2): 133–40. doi:10.1016/S0304-3835(00)00534-6. PMID 11053642.
* Oppermann B, Zhang W, Magabo K, Kantorow M (2001). "Identification and spatial analysis of metallothioneins expressed by the adult human lens". Invest. Ophthalmol. Vis. Sci. 42 (1): 188–93. PMC 2957813. PMID 11133866.
* Garrett SH, Belcastro M, Sens MA, et al. (2001). "Acute exposure to arsenite induces metallothionein isoform-specific gene expression in human proximal tubule cells". J. Toxicol. Environ. Health A. 64 (4): 343–55. Bibcode:2001JTEHA..64..343G. doi:10.1080/152873901316981321. PMID 11693492. S2CID 43143430.
* Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
* Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
* Hawse JR, Cumming JR, Oppermann B, et al. (2003). "Activation of metallothioneins and alpha-crystallin/sHSPs in human lens epithelial cells by specific metals and the metal content of aging clear human lenses". Invest. Ophthalmol. Vis. Sci. 44 (2): 672–9. doi:10.1167/iovs.02-0018. PMC 2825746. PMID 12556398.
* Sens D, Rossi M, Park S, et al. (2003). "Metallothionein isoform 1 and 2 gene expression in a human urothelial cell line (UROtsa) exposed to CdCl2 and NaAsO2". J. Toxicol. Environ. Health A. 66 (21): 2031–46. Bibcode:2003JTEHA..66.2031S. doi:10.1080/713853980. PMID 14555400.
* Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
* Sun NN, Fastje CD, Wong SS, et al. (2005). "Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line". Toxicology and Industrial Health. 19 (7–10): 157–63. doi:10.1191/0748233703th185oa. PMID 15747776. S2CID 14394243.
* Lederer CW, Torrisi A, Pantelidou M, et al. (2007). "Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis". BMC Genomics. 8: 26. doi:10.1186/1471-2164-8-26. PMC 1796866. PMID 17244347.

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PDB gallery

* 1mhu: THE THREE-DIMENSIONAL STRUCTURE OF HUMAN [113CD7] METALLOTHIONEIN-2 IN SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

* 1mrb: THREE-DIMENSIONAL STRUCTURE OF RABBIT LIVER CD7 METALLOTHIONEIN-2A IN AQUEOUS SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE

* 2mhu: THE THREE-DIMENSIONAL STRUCTURE OF HUMAN [113CD7] METALLOTHIONEIN-2 IN SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

* 2mrt: CONFORMATION OF CD-7 METALLOTHIONEIN-2 FROM RAT LIVER IN AQUEOUS SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

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