Macrophage elastase

Identifiers
EC no.| 3.4.24.65
CAS no.| 2594837
Databases
IntEnz| IntEnz view
BRENDA| BRENDA entry
ExPASy| NiceZyme view
KEGG| KEGG entry
MetaCyc| metabolic pathway
PRIAM| profile
PDB structures| RCSB PDB PDBe PDBsum
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PMC| articles
PubMed| articles
NCBI| proteins

Macrophage elastase (EC 3.4.24.65, metalloelastase, human macrophage metalloelastase (HME), MMP-12) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction

Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at -Ala14-Leu- and -Tyr16-Leu- in the B chain of insulin

This enzyme belongs to the peptidase family M10.

## See also

[edit]

* Matrix metallopeptidase 12

## References

[edit]

1. ^ Banda MJ, Werb Z (February 1981). "Mouse macrophage elastase. Purification and characterization as a metalloproteinase". The Biochemical Journal. 193 (2): 589–605\. PMID 7030312.
2. ^ Kettner C, Shaw E, White R, Janoff A (May 1981). "The specificity of macrophage elastase on the insulin B-chain". The Biochemical Journal. 195 (2): 369–72\. PMID 7032505.
3. ^ Shapiro SD, Griffin GL, Gilbert DJ, Jenkins NA, Copeland NG, Welgus HG, Senior RM, Ley TJ (March 1992). "Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase". The Journal of Biological Chemistry. 267 (7): 4664–71\. PMID 1537850.
4. ^ Shapiro SD, Kobayashi DK, Ley TJ (November 1993). "Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages". The Journal of Biological Chemistry. 268 (32): 23824–9\. PMID 8226919.

## External links

[edit]

* Macrophage+elastase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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Proteases: metalloendopeptidases (EC 3.4.24)

ADAM proteins|

* Alpha secretases
* ADAM9
* ADAM10
* ADAM17
* ADAM19
* ADAM2
* ADAM7
* ADAM8
* ADAM11
* ADAM12
* ADAM15
* ADAM18
* ADAM22
* ADAM23
* ADAM28
* ADAM33
* ADAMTS1
* ADAMTS2
* ADAMTS3
* ADAMTS4
* ADAMTS5
* ADAMTS8
* ADAMTS9
* ADAMTS10
* ADAMTS12
* ADAMTS13

Matrix metalloproteinases|

* Collagenases
* MMP1
* MMP8
* Gelatinases
* MMP2
* MMP9
* MMP3
* MMP7
* MMP10
* MMP11
* MMP12
* MMP13
* MMP14
* MMP15
* MMP16
* MMP17
* MMP19
* MMP20
* MMP21
* MMP23A
* MMP23B
* MMP24
* MMP25
* MMP26
* MMP27
* MMP28

Other|

* Neprilysin
* Procollagen peptidase
* Thermolysin
* Pregnancy-associated plasma protein A
* Bone morphogenetic protein 1
* Lysostaphin
* Insulin-degrading enzyme
* ZMPSTE24

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Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Diffusion-limited enzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)
* EC7 Translocases (list)

Portal:

* Biology

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