Magnesium gluconate

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Magnesium gluconate

Names
IUPAC name

Magnesium bis[(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate]

Identifiers

CAS Number

* 3632-91-5 Y

3D model (JSmol)

* Interactive image

ChEMBL |

* ChEMBL2107145

ChemSpider |

* 9593457

ECHA InfoCard | 100.020.772
E number | E580 (acidity regulators, ...)

PubChem CID

* 11418570

UNII |

* TH52F4317B Y

CompTox Dashboard (EPA)

* DTXSID50890579

InChI

* InChI=1S/2C6H12O7.Mg/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;/h2*2-5,7-11H,1H2,(H,12,13);/q;;+2/p-2/t2*2-,3-,4+,5-;/m11./s1

SMILES

* [Mg+2].[O-]C(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.[O-]C(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

Properties

Chemical formula

| C12H22MgO14
Molar mass | 414.599 g·mol−1
Pharmacology

ATC code

| A12CC03 (WHO)

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Infobox references

Chemical compound

Magnesium gluconate is a compound with formula MgC12H22O14. It is the magnesium salt of gluconic acid.

According to one study, magnesium gluconate showed the highest level[dubious – discuss] of bioavailability of any magnesium salt which implies its viability as a supplement, although of the 10 salts studied, all increased magnesium levels significantly.[non-primary source needed][1][non-primary source needed] This study did not include magnesium glycinate, which is one of the most bioavailable forms of magnesium.[medical citation needed]

It has E number "E580".

## Use in medicine

[edit]

There are data on the pharmacological properties of magnesium gluconate. Gluconic acid is the initial substrate for the reactions of pentose phosphate path of oxidation of glucose, so it was suggested that it may affect the energy metabolism of mitochondria.[citation needed] In Ukraine, magnesium gluconate, together with potassium gluconate in the drug Rhythmocor is used to treat heart disease. Pilot studies have shown efficacy in various cardiac arrhythmia.[2] Whether these effects are from the influence of gluconic acid on the metabolism of the heart or from the influence of magnesium and potassium on osmotic pressure is unknown.[medical citation needed]

## References

[edit]

1. ^ Coudray, C; Rambeau, M; Feillet-Coudray, C; Gueux, E; Tressol, JC; Mazur, A; Rayssiguier, Y (2005). "Study of magnesium bioavailability from ten organic and inorganic Mg salts in Mg-depleted rats using a stable isotope approach". Magnesium Research. 18 (4): 215–23\. PMID 16548135.
2. ^ Gromova, O. A.; Torshin, I. Y.; Kalacheva, A. G.; Grishina, T. R. (2016). "On Synergism of Potassium and Magnesium in Maintenance of Myocardial Function". Kardiologiia. 56 (3): 73–80\. doi:10.18565/cardio.2016.3.73-80. PMID 28294893.

*[CID]: Compound ID
*[EPA]: U.S. Environmental Protection Agency