Matthew Hurles

Matt Hurles

FRS FMedSci

Born|

Matthew Edward Hurles

(1974-05-08) 8 May 1974 (age 51)[5][3]

Hammersmith, London, England[5]

Education| Hampton School
Alma mater| University of Oxford (BA)[4]
University of Leicester (PhD)
Awards| Crick Lecture (2013)[1]
Scientific career
Fields| Genetics[2]
Institutions| Wellcome Sanger Institute
University of Cambridge
Congenica Ltd[3]
Thesis| Mutation and variability of the human Y chromosome (1999)
Doctoral advisor| Mark Jobling[4]
Website| www.sanger.ac.uk/people/directory/hurles-matthew

Matthew Edward Hurles (born 1974)[5] is a British scientist who is director of the Wellcome Sanger Institute[6][2] and an honorary professor of Human Genetics and Genomics at the University of Cambridge.[7]

## Education

[edit]

Hurles was privately educated at Hampton School[5] and the University of Oxford where he was awarded a Bachelor of Arts degree in Biochemistry. He completed his PhD in 1999 on the genetics of the Y chromosome at the University of Leicester supervised by Mark Jobling[4][8][9]

## Research and career

[edit]

Hurles research investigates the causes and consequences of new mutations as DNA is passed from one generation to the next.[1] He is best known for his work on characterizing the extent and impact of structural variation in the human genome and on deciphering the genetic architecture of severe neurodevelopmental disorders.[1]

Hurles group has used large-scale genomic studies to highlight the predominant role that new mutations of many different types play in causing diverse developmental disorders and has led to the discovery of tens of previously unrecognised genetic diseases.[1][10][11][12]

### Awards and honours

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Hurles was elected a Fellow of the Royal Society (FRS) in 2019.[5][1] He is also a Fellow of the Academy of Medical Sciences (FMedSci) and was awarded the Crick Medal and Lecture in 2013.[1]

## References

[edit]

1. ^ a b c d e f Anon (2019). "Professor Matthew Hurles FMedSci FRS". royalsociety.org. London: Royal Society. Archived from the original on 24 April 2019. One or more of the preceding sentences incorporates text from the royalsociety.org website where:

> “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)

2. ^ a b Matthew Hurles publications indexed by Google Scholar
3. ^ a b Anon (2018). "Matthew Hurles: Congenica Ltd". companieshouse.gov.uk. London: Companies House. Archived from the original on 25 October 2019.
4. ^ a b c Hurles, Matthew (1999). Mutation and variability of the human Y chromosome. le.ac.uk (PhD thesis). University of Leicester. hdl:2381/30320. OCLC 505103676. EThOS uk.bl.ethos.696631.
5. ^ a b c d e Anon (2023). "HURLES, Dr. Matthew". Who's Who (online Oxford University Press ed.). Oxford: A & C Black. doi:10.1093/ww/9780199540884.013.U290131. (Subscription or UK public library membership required.)
6. ^ Matthew Hurles publications indexed by the Scopus bibliographic database. (subscription required)
7. ^ Matthew Hurles publications from Europe PubMed Central
8. ^ Hurles, Matthew E.; Veitia, Reiner; Arroyo, Eduardo; Armenteros, Manuel; Bertranpetit, Jaume; Pérez-Lezaun, Anna; Bosch, Elena; Shlumukova, Maria; Cambon-Thomsen, Anne; McElreavey, Ken; López de Munain, Adolfo; Röhl, Arne; Wilson, Ian J.; Singh, Lalji; Pandya, Arpita; Santos, Fabrício R.; Tyler-Smith, Chris; Jobling, Mark A. (1999). "Recent Male-Mediated Gene Flow over a Linguistic Barrier in Iberia, Suggested by Analysis of a Y-Chromosomal DNA Polymorphism". The American Journal of Human Genetics. 65 (5): 1437–1448\. doi:10.1086/302617. ISSN 0002-9297. PMC 1288297. PMID 10521311.
9. ^ Hurles, Matthew E.; Irven, Catherine; Nicholson, Jayne; Taylor, Paul G.; Santos, Fabricio R.; Loughlin, John; Jobling, Mark A.; Sykes, Bryan C. (1998). "European Y-Chromosomal Lineages in Polynesians: A Contrast to the Population Structure Revealed by mtDNA". The American Journal of Human Genetics. 63 (6): 1793–1806\. doi:10.1086/302147. ISSN 0002-9297. PMC 1377652. PMID 9837833.
10. ^ The 1000 Genomes Project Consortium (2010). "A map of human genome variation from population-scale sequencing". Nature. 467 (7319): 1061–1073\. Bibcode:2010Natur.467.1061T. doi:10.1038/nature09534. ISSN 0028-0836. PMC 3042601. PMID 20981092.`{{cite journal}}`: CS1 maint: numeric names: authors list (link)
11. ^ The 1000 Genomes Project Consortium (2012). "An integrated map of genetic variation from 1,092 human genomes". Nature. 491 (7422): 56–65\. Bibcode:2012Natur.491...56T. doi:10.1038/nature11632. ISSN 0028-0836. PMC 3498066. PMID 23128226.`{{cite journal}}`: CS1 maint: numeric names: authors list (link)
12. ^ Redon, Richard; Ishikawa, Shumpei; Fitch, Karen R.; Feuk, Lars; Perry, George H.; Andrews, T. Daniel; Fiegler, Heike; Shapero, Michael H.; Carson, Andrew R.; Chen, Wenwei; Cho, Eun Kyung; Dallaire, Stephanie; Freeman, Jennifer L.; González, Juan R.; Gratacòs, Mònica; Huang, Jing; Kalaitzopoulos, Dimitrios; Komura, Daisuke; MacDonald, Jeffrey R.; Marshall, Christian R.; Mei, Rui; Montgomery, Lyndal; Nishimura, Kunihiro; Okamura, Kohji; Shen, Fan; Somerville, Martin J.; Tchinda, Joelle; Valsesia, Armand; Woodwark, Cara; Yang, Fengtang; Zhang, Junjun; Zerjal, Tatiana; Zhang, Jane; Armengol, Lluis; Conrad, Donald F.; Estivill, Xavier; Tyler-Smith, Chris; Carter, Nigel P.; Aburatani, Hiroyuki; Lee, Charles; Jones, Keith W.; Scherer, Stephen W.; Hurles, Matthew E. (2006). "Global variation in copy number in the human genome". Nature. 444 (7118): 444–454\. Bibcode:2006Natur.444..444R. doi:10.1038/nature05329. ISSN 0028-0836. PMC 2669898. PMID 17122850.

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Fellows of the Royal Society elected in 2019

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* Salim Abdool Karim
* Charles Bangham
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* Véronique Gouverneur
* Christopher Hacon
* Mark Handley
* Richard Harland
* Peter H. Haynes
* Martin Head-Gordon
* Matthew Hurles
* Richard Jozsa
* Gagandeep Kang
* Steve A. Kay
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* Roy Kerr
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* Marta Kwiatkowska
* Mark Mayer
* Gareth H. McKinley
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Yusuf Hamied

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