Melatonin receptor 1C

Protein

Melatonin receptor 1C

Identifiers
Symbol| Mtnr1c
NCBI gene| 30661
RefSeq| AY166825
UniProt| Q804I9
| Search for

Structures| Swiss-model
Domains| InterPro

Melatonin receptor 1C, also known as MTNR1C, is a protein that is encoded by the Mtnr1c gene. This receptor has been identified in fish, amphibia, and birds, but not in humans.[1]

## References

[edit]

1. ^ Sugden D, Davidson K, Hough KA, Teh MT (2004). "Melatonin, melatonin receptors and melanophores: a moving story". Pigment Cell Res. 17 (5): 454–60\. doi:10.1111/j.1600-0749.2004.00185.x. PMID 15357831.

## Further reading

[edit]

* Brzezinski A; Brzezinski, Amnon (1997). "Melatonin in humans". N. Engl. J. Med. 336 (3): 186–95\. doi:10.1056/NEJM199701163360306. PMID 8988899.
* Reppert SM, Weaver DR, Ebisawa T, et al. (1996). "Cloning of a melatonin-related receptor from human pituitary". FEBS Lett. 386 (2–3): 219–24\. doi:10.1016/0014-5793(96)00437-1. PMID 8647286. S2CID 38587331.2–3&rft.pages=219-24&rft.date=1996&rft_id=https://api.semanticscholar.org/CorpusID:38587331#id-name=S2CID&rft_id=info:pmid/8647286&rft_id=info:doi/10.1016/0014-5793(96)00437-1&rft.aulast=Reppert&rft.aufirst=SM&rft.au=Weaver,+DR&rft.au=Ebisawa,+T&rft_id=https://doi.org/10.1016%2F0014-5793%2896%2900437-1&rfr_id=info:sid/en.wikipedia.org:Melatonin+receptor+1C" class="Z3988">
* Niles LP, Wang J, Shen L, et al. (2000). "Melatonin receptor mRNA expression in human granulosa cells". Mol. Cell. Endocrinol. 156 (1–2): 107–10\. doi:10.1016/S0303-7207(99)00135-5. PMID 10612428. S2CID 42730113.1–2&rft.pages=107-10&rft.date=2000&rft_id=https://api.semanticscholar.org/CorpusID:42730113#id-name=S2CID&rft_id=info:pmid/10612428&rft_id=info:doi/10.1016/S0303-7207(99)00135-5&rft.aulast=Niles&rft.aufirst=LP&rft.au=Wang,+J&rft.au=Shen,+L&rfr_id=info:sid/en.wikipedia.org:Melatonin+receptor+1C" class="Z3988">
* Roy D, Angelini NL, Fujieda H, et al. (2001). "Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin". Endocrinology. 142 (11): 4711–20\. doi:10.1210/en.142.11.4711. PMID 11606436.
* Ayoub MA, Couturier C, Lucas-Meunier E, et al. (2002). "Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer". J. Biol. Chem. 277 (24): 21522–8\. doi:10.1074/jbc.M200729200. PMID 11940583.
* Yuan L, Collins AR, Dai J, et al. (2003). "MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells". Mol. Cell. Endocrinol. 192 (1–2): 147–56\. doi:10.1016/S0303-7207(02)00029-1. PMID 12088876. S2CID 54393974.1–2&rft.pages=147-56&rft.date=2003&rft_id=https://api.semanticscholar.org/CorpusID:54393974#id-name=S2CID&rft_id=info:pmid/12088876&rft_id=info:doi/10.1016/S0303-7207(02)00029-1&rft.aulast=Yuan&rft.aufirst=L&rft.au=Collins,+AR&rft.au=Dai,+J&rfr_id=info:sid/en.wikipedia.org:Melatonin+receptor+1C" class="Z3988">
* Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903\. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
* Slominski A, Pisarchik A, Zbytek B, et al. (2003). "Functional activity of serotoninergic and melatoninergic systems expressed in the skin". J. Cell. Physiol. 196 (1): 144–53\. doi:10.1002/jcp.10287. PMID 12767050. S2CID 24534729.
* Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7\. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
* Suzuki S, Masui Y, Ohnuki M, et al. (2007). "Induction of metallothionein synthesis by cilostazol in mice and in human cultured neuronal cell lines". Biol. Pharm. Bull. 30 (4): 791–4\. doi:10.1248/bpb.30.791. PMID 17409522.

## See also

[edit]

* Melatonin receptor

* v
* t
* e

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

| Neurotransmitter|

| Adrenergic|

* α1 (A
* B
* D)
* α2 (A
* B
* C)
* β1
* β2
* β3

|

Purinergic|

* Adenosine (A1
* A2A
* A2B
* A3)
* P2Y (1
* 2
* 4
* 5
* 6
* 8
* 9
* 10
* 11
* 12
* 13
* 14)

Serotonin|

* (all but 5-HT3) 5-HT1 (A
* B
* D
* E
* F)
* 5-HT2 (A
* B
* C)
* 5-HT (4
* 5A
* 6
* 7)

Other|

* Acetylcholine (M1
* M2
* M3
* M4
* M5)
* Dopamine
* D1
* D2
* D3
* D4
* D5
* GHB receptor
* Histamine
* H1
* H2
* H3
* H4
* Melatonin (1A
* 1B
* 1C)
* TAAR (1
* 2
* 5
* 6
* 8
* 9)

Metabolites and
signaling molecules|

| Eicosanoid|

* CysLT (1
* 2)
* LTB4
* 1
* 2
* FPRL1
* OXE
* Prostaglandin
* DP (1
* 2), EP (1
* 2
* 3
* 4), FP
* Prostacyclin
* Thromboxane

|

Other|

* Bile acid
* Cannabinoid (CB1
* CB2, GPR (18
* 55
* 119))
* EBI2
* Estrogen
* Free fatty acid (1
* 2
* 3
* 4)
* Hydroxycarboxylic acids
* 1
* 2
* 3
* Lysophosphatidic acid (1
* 2
* 3
* 4
* 5
* 6)
* Lysophospholipid (1
* 2
* 3
* 4
* 5
* 6
* 7
* 8)
* Oxoglutarate
* PAF
* Sphingosine-1-phosphate (1
* 2
* 3
* 4
* 5)
* Succinate

Peptide|

| Neuropeptide|

* B/W (1
* 2)
* FF (1
* 2)
* S
* Y (1
* 2
* 4
* 5)
* Neuromedin (B
* U (1
* 2))
* Neurotensin (1
* 2)

|

Other|

* Anaphylatoxin (C3a
* C5a (1
* 2))
* Angiotensin (1
* 2)
* Apelin
* Bombesin
* BRS3
* GRPR
* NMBR)
* Bradykinin (B1
* B2)
* Chemokine
* Cholecystokinin (A
* B)
* Endothelin
* A
* B
* Formyl peptide (1
* 2
* 3)
* FSH
* Galanin (1
* 2
* 3)
* Gonadotropin-releasing hormone (1
* 2)
* Ghrelin
* Kisspeptin
* Luteinizing hormone/choriogonadotropin
* MAS (1
* 1L
* D
* E
* F
* G
* X1
* X2
* X3
* X4)
* Melanocortin (1
* 2
* 3
* 4
* 5)
* MCHR (1
* 2)
* Motilin
* Opioid (Delta
* Kappa
* Mu
* Nociceptin & Zeta, but not Sigma)
* Orexin (1
* 2)
* Oxytocin
* Prokineticin (1
* 2)
* Prolactin-releasing peptide
* Relaxin (1
* 2
* 3
* 4)
* Somatostatin (1
* 2
* 3
* 4
* 5)
* Tachykinin (1
* 2
* 3)
* Thyrotropin
* Thyrotropin-releasing hormone
* Urotensin-II
* Vasopressin (1A
* 1B
* 2)

Miscellaneous|

| Taste, bitter|

* TAS2R
* 1
* 3
* 4
* 5
* 7
* 8
* 9
* 10
* 13
* 14
* 16
* 19
* 20
* 30
* 31
* 38
* 39
* 40
* 41
* 42
* 43
* 45
* 46
* 50
* 60
* Vomeronasal receptor type 1

|

Orphan|

* GPR (1
* 3
* 4
* 6
* 12
* 15
* 17
* 18
* 19
* 20
* 21
* 22
* 23
* 25
* 26
* 27
* 31
* 32
* 33
* 34
* 35
* 37
* 39
* 42
* 44
* 45
* 50
* 52
* 55
* 61
* 62
* 63
* 65
* 68
* 75
* 78
* 81
* 82
* 83
* 84
* 85
* 87
* 88
* 92
* 101
* 103
* 109A
* 109B
* 119
* 120
* 132
* 135
* 137B
* 139
* 141
* 142
* 146
* 148
* 149
* 150
* 151
* 152
* 153
* 160
* 161
* 162
* 171
* 173
* 174
* 176
* 177
* 182
* 183)

Other|

* Adrenomedullin
* Olfactory
* Opsin (3
* 4
* 5
* 1LW
* 1MW
* 1SW
* RGR
* RRH)
* Protease-activated (1
* 2
* 3
* 4)
* SREB (1
* 2
* 3)

Class B: Secretin-like

| Adhesion|

* ADGRB
* Brain-specific angiogenesis inhibitor
* 1
* 2
* 3
* ADGRC
* Cadherin
* 1
* 2
* 3
* ADGRE
* EMR
* 1
* 2
* 3
* CD97
* ADGRG
* 1
* 2
* 3
* 4
* 5
* 6
* 7
* ADGRL
* Latrophilin
* 1
* 2
* 3
* ELTD1

|

Orphan|

* GPR (56
* 64
* 97
* 98
* 110
* 111
* 112
* 113
* 114
* 115
* 116
* 123
* 124
* 125
* 126
* 128
* 133
* 143
* 144
* 155
* 157)

Other|

* Calcitonin
* CALCRL
* Corticotropin-releasing hormone (1
* 2)
* Glucagon (GR
* GIPR
* GLP1R
* GLP2R)
* Growth-hormone-releasing hormone
* PACAPR1
* GPR
* Methuselah-like proteins
* Parathyroid hormone (1
* 2)
* Secretin
* Vasoactive intestinal peptide (1
* 2)

Class C: Metabotropic glutamate / pheromone

| Taste, sweet|

* TAS1R
* 1
* 2
* 3
* Vomeronasal receptor, type 2

|

Other|

* Calcium-sensing receptor
* GABAB (1
* 2)
* Glutamate receptor (Metabotropic glutamate (1
* 2
* 3
* 4
* 5
* 6
* 7
* 8))
* GPRC6A
* GPR (156
* 158
* 179)
* RAIG (1
* 2
* 3
* 4)

Class F: Frizzled & Smoothened

| Frizzled|

* Frizzled (1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* 9
* 10)

|

Smoothened|

* Smoothened

* v
* t
* e

Melatonin receptor modulators

MT1Tooltip Melatonin receptor 1|

* Agonists: 2-Iodomelatonin
* 6-Hydroxymelatonin
* Agomelatine
* Fabomotizole (afobazole)
* GR-196,429
* Melatonin
* N-Acetylserotonin (normelatonin)
* Piromelatine
* Ramelteon
* Tasimelteon
* TIK-301 (LY-156,735)

* Antagonists: Luzindole

MT2Tooltip Melatonin receptor 2|

* Agonists: 2-Iodomelatonin
* 6-Hydroxymelatonin
* Agomelatine
* GR-196,429
* Melatonin
* N-Acetylserotonin (normelatonin)
* Piromelatine
* Ramelteon
* Tasimelteon
* TIK-301 (LY-156,735)

* Antagonists: Luzindole

Unsorted|

* Agonists: 2-Phenylmelatonin
* 5-Methoxyluzindole
* 6-Chloromelatonin
* 6-Fluoromelatonin
* 6-Methoxymelatonin
* 6,7-Dichloro-2-methylmelatonin
* 8-M-PDOT
* AMMTC
* GR-135,531 (of MT3Tooltip melatonin receptor 1C)
* N-Acetyltryptamine
* N-Butanoylmelatonin
* N-Propionylmelatonin
* S-24268
* S-25150

* Antagonists: 4-P-ADOT
* 4-P-PDOT
* DH-97
* N-Acetyltryptamine (of MT3)
* Prazosin (of MT3)
* S-20928
* S-22153
* S-24601
* S-25567
* S-26131

* See also: Receptor/signaling modulators
* Adrenergics
* Dopaminergics
* Serotonergics
* Monoamine metabolism modulators

## Further reading

[edit]

* Classification of protein families - Melatonin receptor type 1C
* Sleep drops with melatonin and lavender in German
* Melatonin receptor genes (mel-1a, mel-1b, mel-1c) are differentially expressed in the avian germ line

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*[v]: View this template
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*[MT1]: Melatonin receptor 1
*[MT2]: Melatonin receptor 2
*[MT3]: melatonin receptor 1C