methylglutamate dehydrogenase

Identifiers
EC no.| 1.5.99.5
CAS no.| 37217-26-8
Databases
IntEnz| IntEnz view
BRENDA| BRENDA entry
ExPASy| NiceZyme view
KEGG| KEGG entry
MetaCyc| metabolic pathway
PRIAM| profile
PDB structures| RCSB PDB PDBe PDBsum
Gene Ontology| AmiGO  / QuickGO
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In enzymology, a methylglutamate dehydrogenase (EC 1.5.99.5) is an enzyme that catalyzes the chemical reaction

N-methyl-L-glutamate + acceptor + H2O  ⇌ {\displaystyle \rightleftharpoons } L-glutamate + formaldehyde + reduced acceptor

The 3 substrates of this enzyme are N-methyl-L-glutamate, acceptor, and H2O, whereas its 3 products are L-glutamate, formaldehyde, and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with other acceptors. The systematic name of this enzyme class is N-methyl-L-glutamate:acceptor oxidoreductase (demethylating). Other names in common use include N-methylglutamate dehydrogenase, and N-methyl-L-glutamate:(acceptor) oxidoreductase (demethylating). This enzyme participates in methane metabolism.

## References

[edit]

* Hersh LB, Stark MJ, Worthen S, Fiero MK (1972). "N-methylglutamate dehydrogenase: kinetic studies on the solubilized enzyme". Arch. Biochem. Biophys. 150 (1): 219–26. doi:10.1016/0003-9861(72)90029-X. PMID 5028076.

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Oxidoreductases: CH-NH (EC 1.5)

1.5.1: NAD or NADP acceptor|

* Dihydrofolate reductase
* Saccharopine dehydrogenase
* Methylenetetrahydrofolate reductase

1.5.3: oxygen acceptor|

* Dihydrobenzophenanthridine oxidase
* Sarcosine oxidase
* Proline oxidase

1.5.5: quinone acceptor|

* Electron-transferring-flavoprotein dehydrogenase

1.5.99|

* Sarcosine dehydrogenase
* Cytokinin dehydrogenase

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Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Diffusion-limited enzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)
* EC7 Translocases (list)

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