Mitochondrial ribosomal protein L1

Protein-coding gene in the species Homo sapiens

MRPL1

Identifiers
Aliases| MRPL1, BM022, L1MT, MRP-L1, mitochondrial ribosomal protein L1
External IDs| OMIM: 611821 MGI: 2137202 HomoloGene: 41355 GeneCards: MRPL1
| Gene location (Human)

Chr.| Chromosome 4 (human)[1]

Band| 4q21.1| Start| 77,862,830 bp[1]
End| 77,952,785 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 5 (mouse)[2]

Band| 5|5 E3| Start| 96,357,352 bp[2]
End| 96,414,586 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* deltoid muscle

* quadriceps femoris muscle

* vastus lateralis muscle

* tibialis anterior muscle

* rectum

* gastrocnemius muscle

* ganglionic eminence

* islet of Langerhans

* right ventricle

* smooth muscle tissue

| Top expressed in

* interventricular septum

* intercostal muscle

* myocardium of ventricle

* seminiferous tubule

* soleus muscle

* left lobe of liver

* cumulus cell

* quadriceps femoris muscle

* spermatid

* tibialis anterior muscle

More reference expression data
BioGPS| | n/a

| Gene ontology

Molecular function|

* structural constituent of ribosome
* protein binding
* RNA binding
* box H/ACA snoRNA binding

Cellular component|

* mitochondrial inner membrane
* large ribosomal subunit
* ribosome
* cytosolic large ribosomal subunit
* mitochondrion
* box H/ACA snoRNP complex

Biological process|

* mitochondrial translational elongation
* mitochondrial translational termination
* maturation of LSU-rRNA
* protein biosynthesis
* cleavage involved in rRNA processing
* rRNA pseudouridine synthesis
* snRNA pseudouridine synthesis

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

65008

94061

Ensembl| |

ENSG00000169288

ENSMUSG00000029486

UniProt| |

Q9BYD6

Q99N96

RefSeq (mRNA)| |

NM_020236

NM_001039084
NM_053158

RefSeq (protein)| |

NP_064621

NP_001034173
NP_444388

Location (UCSC)| Chr 4: 77.86 – 77.95 Mb| Chr 5: 96.36 – 96.41 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

39S ribosomal protein L1, mitochondrial is a protein that in humans is encoded by the MRPL1 gene.[5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family.[5]

## References[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169288 \- Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029486 \- Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ a b "Entrez Gene: MRPL1 mitochondrial ribosomal protein L1".

## Further reading[edit]

* Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
* Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
* Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria". J. Biol. Chem. 276 (24): 21724–36. doi:10.1074/jbc.M100432200. PMID 11279069.
* Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
* Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
* Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
* Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
* Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
* Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
* Choy KW, Wang CC, Ogura A, et al. (2007). "Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes". Physiol. Genomics. 25 (1): 9–15. doi:10.1152/physiolgenomics.00121.2005. PMID 16368877.

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PDB gallery

* 2ftc: Structural Model for the Large Subunit of the Mammalian Mitochondrial Ribosome

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Protein biosynthesis: translation (bacterial, archaeal, eukaryotic)

Proteins|

| Initiation factor|

| Bacterial|

* IF1
* IF2
* IF3

|

Mitochondrial|

* MTIF1
* MTIF2
* MTIF3

Archaeal|

* aIF1
* aIF2
* aIF5
* aIF6

Eukaryotic|

| eIF1|

* eIF1
* B
* SUI1 family
* eIF1A
* Y

|

eIF2|

* α
* β
* γ
* eIF2B
* 1
* 2
* 3
* 4
* 5
* kinase
* eIF2A
* eIF2D

eIF3|

* A
* B
* C
* D
* E
* F
* G
* H
* I
* J
* K
* L
* M

eIF4|

* A
* 1
* 2
* 3
* E1
* 2
* 3
* G
* 1
* 2
* 3
* B
* H

eIF5|

* EIF5
* EIF5A
* 2
* 5B

eIF6|

* EIF6

Elongation factor|

| Bacterial/​Mitochondrial|

* EF-Tu
* EF-Ts
* EF-G
* EF-4
* EF-P
* TSFM
* GFM1
* GFM2

|

Archaeal/​Eukaryotic|

* a/eEF-1
* A1
* 2
* 3
* B
* P1
* P2
* P3
* D
* E
* G
* a/eEF-2

Release factor|

* Class 1
* eRF1
* Class 2/RF3
* GSPT1
* GSPT2

Ribosomal Proteins|

| Cytoplasmic|

| 60S subunit|

* RPL3
* RPL4
* RPL5
* RPL6
* RPL7
* RPL7A
* RPL8
* RPL9
* RPL10
* RPL10A
* RPL10-like
* RPL11
* RPL12
* RPL13
* RPL13A
* RPL14
* RPL15
* RPL17
* RPL18
* RPL18A
* RPL19
* RPL21
* RPL22
* RPL23
* RPL23A
* RPL24
* RPL26
* RPL27
* RPL27A
* RPL28
* RPL29
* RPL30
* RPL31
* RPL32
* RPL34
* RPL35
* RPL35A
* RPL36
* RPL36A
* RPL37
* RPL37A
* RPL38
* RPL39
* RPL40
* RPL41
* RPLP0
* RPLP1
* RPLP2
* RRP15-like
* RSL24D1

|

40S subunit|

* RPSA
* RPS2
* RPS3
* RPS3A
* RPS4 (RPS4X, RPS4Y1, RPS4Y2)
* RPS5
* RPS6
* RPS7
* RPS8
* RPS9
* RPS10
* RPS11
* RPS12
* RPS13
* RPS14
* RPS15
* RPS15A
* RPS16
* RPS17
* RPS18
* RPS19
* RPS20
* RPS21
* RPS23
* RPS24
* RPS25
* RPS26
* RPS27
* RPS27A
* RPS28
* RPS29
* RPS30
* RACK1

Mitochondrial|

| 39S subunit|

* MRPL1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* 9
* 10
* 11
* 12
* 13
* 14
* 15
* 16
* 17
* 18
* 19
* 20
* 21
* 22
* 23
* 24
* 25
* 26
* 27
* 28
* 29
* 30
* 31
* 32
* 33
* 34
* 35
* 36
* 37
* 38
* 39
* 40
* 41
* 42

|

28S subunit|

* MRPS1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* 9
* 10
* 11
* 12
* 13
* 14
* 15
* 16
* 17
* 18
* 19
* 20
* 21
* 22
* 23
* 24
* 25
* 26
* 27
* 28
* 29
* 30
* 31
* 32
* 33
* 34
* 35

Other concepts|

* Aminoacyl tRNA synthetase
* Reading frame
* Start codon
* Stop codon
* Shine-Dalgarno sequence/Kozak consensus sequence

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Ribosomal RNA / ribosome subunits

Archaea
(70S)|

Large (50S):

* 5S
* 23S

Small (30S):

* 16S

Bacteria
(70S)|

Large (50S):

* 5S
* 23S

Small (30S):

* 16S

Eukaryotes|

| Cytoplasmic (80S)|

Large (60S):

* 5S
* 5.8S
* 28S

Small (40S):

* 18S

|

Mitochondrial (55S)|

Large (28S):

* MT-RNR2, 16S
* MT-tRNAVal

Small (39S):

* MT-RNR1, 12S

Chloroplast (70S)|

Large (50S):

* 5S
* 4.5S
* 23S

Small (30S):

* 16S

Ribosomal proteins|

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