Mitochondrial ribosomal protein L22

MRPL22

| Available structures

PDB| Ortholog search: PDBe RCSB
| List of PDB id codes

3J7Y

Identifiers
Aliases| MRPL22, L22mt, MRP-L22, MRP-L25, RPML25, HSPC158, mitochondrial ribosomal protein L22
External IDs| OMIM: 611835 MGI: 1333794 HomoloGene: 56664 GeneCards: MRPL22
| Gene location (Human)

Chr.| Chromosome 5 (human)[1]

Band| 5q33.2| Start| 154,941,073 bp[1]
End| 154,969,411 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 11 (mouse)[2]

Band| 11|11 B1.3| Start| 58,062,487 bp[2]
End| 58,070,391 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* left ventricle

* islet of Langerhans

* right ventricle

* Right adrenal gland

* Left adrenal gland

* body of pancreas

* right lobe of liver

* anterior pituitary

* rectum

* Stromal cell of endometrium

| Top expressed in

* morula

* proximal tubule

* adrenal gland

* blastocyst

* neural tube

* quadriceps femoris muscle

* yolk sac

* heart

* stomach

* skeletal muscle tissue

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* structural constituent of ribosome
* RNA binding

Cellular component|

* mitochondrial inner membrane
* large ribosomal subunit
* ribosome
* mitochondrion
* mitochondrial large ribosomal subunit

Biological process|

* mitochondrial translational elongation
* mitochondrial translational termination
* protein biosynthesis
* ribosome assembly

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

29093

216767

Ensembl| |

ENSG00000082515

ENSMUSG00000020514

UniProt| |

Q9NWU5

Q8BU88

RefSeq (mRNA)| |

NM_014180
NM_001014990

NM_175001

RefSeq (protein)| |

NP_001014990
NP_054899

NP_778166
NP_001390902

Location (UCSC)| Chr 5: 154.94 – 154.97 Mb| Chr 11: 58.06 – 58.07 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

39S ribosomal protein L22, mitochondrial is a protein that in humans is encoded by the MRPL22 gene.[5]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene.[5]

## References[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000082515 \- Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020514 \- Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ a b "Entrez Gene: MRPL22 mitochondrial ribosomal protein L22".

## Further reading[edit]

* Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
* Goldschmidt-Reisin S, Kitakawa M, Herfurth E, et al. (1999). "Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences". J. Biol. Chem. 273 (52): 34828–36. doi:10.1074/jbc.273.52.34828. PMID 9857009.
* Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
* Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
* Koc EC, Burkhart W, Blackburn K, et al. (2001). "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present". J. Biol. Chem. 276 (47): 43958–69. doi:10.1074/jbc.M106510200. PMID 11551941.
* O'Brien TW (2002). "Evolution of a protein-rich mitochondrial ribosome: implications for human genetic disease". Gene. 286 (1): 73–9. doi:10.1016/S0378-1119(01)00808-3. PMID 11943462.
* Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
* Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
* Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
* Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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PDB gallery

* 2ftc: Structural Model for the Large Subunit of the Mammalian Mitochondrial Ribosome

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Protein biosynthesis: translation (bacterial, archaeal, eukaryotic)

Proteins|

| Initiation factor|

| Bacterial|

* IF1
* IF2
* IF3

|

Archaeal|

* aIF1
* aIF2
* aIF5
* aIF6

Eukaryotic|

| eIF1|

* eIF1
* B
* family
* eIF1A
* Y

|

eIF2|

* α
* β
* γ
* eIF2B
* 1
* 2
* 3
* 4
* 5
* kinase
* eIF2A
* eIF2D

eIF3|

* A
* B
* C
* D
* E
* F
* G
* H
* I
* J
* K
* L
* M

eIF4|

* A
* 1
* 2
* 3
* E1
* 2
* 3
* G
* 1
* 2
* 3
* B
* H

eIF5|

* EIF5
* EIF5A
* 2
* 5B

eIF6|

* EIF6

Elongation factor|

| Bacterial/​Mitochondrial|

* EF-Tu
* EF-Ts
* EF-G
* EF-4
* EF-P
* TSFM
* GFM1
* GFM2

|

Archaeal/​Eukaryotic|

* a/eEF-1
* A1
* 2
* 3
* B
* P1
* P2
* P3
* D
* E
* G
* a/eEF-2

Release factor|

* Class 1
* eRF1
* Class 2/RF3
* GSPT1
* GSPT2

Ribosomal Proteins|

| Cytoplasmic|

| 60S subunit|

* RPL3
* RPL4
* RPL5
* RPL6
* RPL7
* RPL7A
* RPL8
* RPL9
* RPL10
* RPL10A
* RPL10-like
* RPL11
* RPL12
* RPL13
* RPL13A
* RPL14
* RPL15
* RPL17
* RPL18
* RPL18A
* RPL19
* RPL21
* RPL22
* RPL23
* RPL23A
* RPL24
* RPL26
* RPL27
* RPL27A
* RPL28
* RPL29
* RPL30
* RPL31
* RPL32
* RPL34
* RPL35
* RPL35A
* RPL36
* RPL36A
* RPL37
* RPL37A
* RPL38
* RPL39
* RPL40
* RPL41
* RPLP0
* RPLP1
* RPLP2
* RRP15-like
* RSL24D1

|

40S subunit|

* RPSA
* RPS2
* RPS3
* RPS3A
* RPS4 (RPS4X, RPS4Y1, RPS4Y2)
* RPS5
* RPS6
* RPS7
* RPS8
* RPS9
* RPS10
* RPS11
* RPS12
* RPS13
* RPS14
* RPS15
* RPS15A
* RPS16
* RPS17
* RPS18
* RPS19
* RPS20
* RPS21
* RPS23
* RPS24
* RPS25
* RPS26
* RPS27
* RPS27A
* RPS28
* RPS29
* RPS30
* RACK1

Mitochondrial|

| 39S subunit|

* MRPL1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* 9
* 10
* 11
* 12
* 13
* 14
* 15
* 16
* 17
* 18
* 19
* 20
* 21
* 22
* 23
* 24
* 25
* 26
* 27
* 28
* 29
* 30
* 31
* 32
* 33
* 34
* 35
* 36
* 37
* 38
* 39
* 40
* 41
* 42

|

28S subunit|

* MRPS1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* 9
* 10
* 11
* 12
* 13
* 14
* 15
* 16
* 17
* 18
* 19
* 20
* 21
* 22
* 23
* 24
* 25
* 26
* 27
* 28
* 29
* 30
* 31
* 32
* 33
* 34
* 35

Other concepts|

* Aminoacyl tRNA synthetase
* Reading frame
* Start codon
* Stop codon
* Shine-Dalgarno sequence/Kozak consensus sequence

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Ribosomal RNA / ribosome subunits

Archaea
(70S)|

Large (50S):

* 5S
* 23S

Small (30S):

* 16S

Bacteria
(70S)|

Large (50S):

* 5S
* 23S

Small (30S):

* 16S

Eukaryotes|

| Cytoplasmic (80S)|

Large (60S):

* 5S
* 5.8S
* 28S

Small (40S):

* 18S

|

Mitochondrial (55S)|

Large (28S):

* MT-RNR2, 16S
* MT-tRNAVal

Small (39S):

* MT-RNR1, 12S

Chloroplast (70S)|

Large (50S):

* 5S
* 4.5S
* 23S

Small (30S):

* 16S

Ribosomal proteins|

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