Mitochondrial uncoupling protein 4

SLC25A27

Identifiers
Aliases| SLC25A27, solute carrier family 25, member 27, UCP4, solute carrier family 25 member 27
External IDs| OMIM: 613725 MGI: 1921261 HomoloGene: 12523 GeneCards: SLC25A27
| Gene location (Human)

Chr.| Chromosome 6 (human)[1]

Band| 6p12.3| Start| 46,652,915 bp[1]
End| 46,678,190 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 17 (mouse)[2]

Band| 17|17 B3| Start| 43,641,891 bp[2]
End| 43,667,214 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* gastric mucosa

* anterior pituitary

* right uterine tube

* cerebellar hemisphere

* left lobe of thyroid gland

* right lobe of thyroid gland

* canal of the cervix

* Brodmann area 9

* tibial nerve

* Achilles tendon

| Top expressed in

* hand

* otolith organ

* utricle

* superior cervical ganglion

* superior frontal gyrus

* visual cortex

* ganglionic eminence

* cerebellar cortex

* neural tube

* olfactory bulb

More reference expression data
BioGPS| | n/a

| Gene ontology

Molecular function|

* transmembrane transporter activity

Cellular component|

* membrane
* apical part of cell
* neuronal cell body
* mitochondrion
* mitochondrial inner membrane
* integral component of membrane
* mitochondrial membrane

Biological process|

* negative regulation of mitochondrial calcium ion concentration
* cellular triglyceride homeostasis
* positive regulation of cell population proliferation
* regulation of glucose import
* neuron death
* negative regulation of mitochondrial membrane potential
* inner ear development
* negative regulation of apoptotic process
* mitochondrial transport
* response to cold
* regulation of mitochondrial membrane potential
* transmembrane transport
* proton transmembrane transport
* transport

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

9481

74011

Ensembl| |

ENSG00000153291

ENSMUSG00000023912

UniProt| |

O95847

Q9D6D0

RefSeq (mRNA)| |

NM_001204051
NM_001204052
NM_004277

NM_028711
NM_001357122
NM_001357123

RefSeq (protein)| |

NP_001190980
NP_001190981
NP_004268

NP_082987
NP_001344051
NP_001344052

Location (UCSC)| Chr 6: 46.65 – 46.68 Mb| Chr 17: 43.64 – 43.67 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Mitochondrial uncoupling protein 4 is a protein that in humans is encoded by the SLC25A27 gene.[5][6][7]

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are detected only in brain tissue and are specifically modulated by various environmental conditions.[7] Recently, the proton transport activity of UCP4 has also been shown to be activated by fatty acids and inhibited by purine nucleotides.[8] In addition, reconstituted UCP4 exhibited a distinct conformation, compared to other UCPs in the family.[9]

## See also[edit]

* Solute carrier family
* Uncoupling protein

## References[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153291 \- Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023912 \- Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Mao W, Yu XX, Zhong A, Li W, Brush J, Sherwood SW, Adams SH, Pan G (Mar 1999). "UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells". FEBS Lett. 443 (3): 326–30. doi:10.1016/S0014-5793(98)01713-X. PMID 10025957. S2CID 314036.
6. ^ Jezek P, Urbankova E (Jun 2000). "Specific sequence of motifs of mitochondrial uncoupling proteins". IUBMB Life. 49 (1): 63–70. doi:10.1080/713803586. PMID 10772343. S2CID 8541209.
7. ^ a b "Entrez Gene: SLC25A27 solute carrier family 25, member 27".
8. ^ Hoang T, Smith MD, Jelokhani-Niaraki M (2012). "Toward Understanding the Mechanism of Ion Transport Activity of Neuronal Uncoupling Proteins UCP2, UCP4, and UCP5". Biochemistry. 51 (19): 4004–14. doi:10.1021/bi3003378. PMID 22524567.
9. ^ Ivanova M, Hoang T, McSorly FR, Krnac G, Smith MD, Jelokhani-Niaraki M (2010). "A comparative study on conformation and ligand binding of the neuronal uncoupling proteins". Biochemistry. 49 (3): 512–21. doi:10.1021/bi901742g. PMID 20000716.

## Further reading[edit]

* Ricquier D, Bouillaud F (2000). "The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP". Biochem. J. 345 (2): 161–79. doi:10.1042/0264-6021:3450161. PMC 1220743. PMID 10620491.
* Muzzin P (2002). "The uncoupling proteins". Ann. Endocrinol. 63 (2 Pt 1): 106–10. PMID 11994670.
* Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
* Yu XX, Mao W, Zhong A, et al. (2000). "Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation". FASEB J. 14 (11): 1611–8. doi:10.1096/fj.14.11.1611. PMID 10928996.
* Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
* Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
* Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
* Liu D, Chan SL, de Souza-Pinto NC, et al. (2007). "Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress". Neuromolecular Med. 8 (3): 389–414. doi:10.1385/NMM:8:3:389. PMID 16775390. S2CID 7377782.
* Chan SL, Liu D, Kyriazis GA, et al. (2007). "Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neural cells". J. Biol. Chem. 281 (49): 37391–403. doi:10.1074/jbc.M605552200. PMID 17035241.
* Yasuno K, Ando S, Misumi S, et al. (2007). "Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (2): 250–3. doi:10.1002/ajmg.b.30443. PMID 17066476. S2CID 30129988.
* Ho PW, Ho JW, Tse HM, et al. (2012). "Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells". PLOS ONE. 7 (2): e32810. Bibcode:2012PLoSO...732810H. doi:10.1371/journal.pone.0032810. PMC 3303587. PMID 22427795.
* Ho JW, Ho PW, Liu HF, et al. (2012). "UCP4 is a target effector of the NF-κB c-Rel prosurvival pathway against oxidative stress". Free Radic Biol Med. 53 (2): 383–394. doi:10.1016/j.freeradbiomed.2012.05.002. PMID 22580300.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

* v
* t
* e

Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)

By group

SLC1–10

| (1):|

* high affinity glutamate and neutral amino-acid transporter
* SLC1A1
* 2
* 3
* 4
* 5
* 6
* 7

|

(2):|

* facilitative GLUT transporter
* SLC2A1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* 9
* 10
* 11
* 12
* 13
* 14

(3):|

* heavy subunits of heterodimeric amino-acid transporters
* SLC3A1
* 2

(4):|

* bicarbonate transporter
* SLC4A1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* 9
* 10
* 11

(5):|

* sodium glucose cotransporter
* SLC5A1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* 9
* 10
* 11
* 12

(6):|

* sodium\- and chloride\- dependent sodium:neurotransmitter symporters
* SLC6A1
* SLC6A2
* SLC6A3
* SLC6A4
* SLC6A5
* SLC6A6
* SLC6A7
* SLC6A8
* SLC6A9
* SLC6A10
* SLC6A11
* SLC6A12
* SLC6A13
* SLC6A14
* SLC6A15
* SLC6A16
* SLC6A17
* SLC6A18
* SLC6A19
* SLC6A20

(7):|

* cationic amino-acid transporter/glycoprotein-associated
* SLC7A1
* SLC7A2
* SLC7A3
* SLC7A4
* glycoprotein-associated/light or catalytic subunits of heterodimeric amino-acid transporters
* SLC7A5
* SLC7A6
* SLC7A7
* SLC7A8
* SLC7A9
* SLC7A10
* SLC7A11
* SLC7A13
* SLC7A14

(8):|

* Na+/Ca2+ exchanger
* SLC8A1
* SLC8A2
* SLC8A3

(9):|

* Na+/H+ exchanger
* SLC9A1
* SLC9A2
* SLC9A3
* SLC9A4
* SLC9A5
* SLC9A6
* SLC9A7
* SLC9A8
* SLC9A9
* SLC9A10
* SLC9A11

(10):|

* sodium bile salt cotransport
* SLC10A1
* SLC10A2
* SLC10A3
* SLC10A4
* SLC10A5
* SLC10A6
* SLC10A7
* 10A1
* 10A2
* 10A3
* 10A7

SLC11–20

| (11):|

* proton coupled metal ion transporter
* SLC11A1
* SLC11A211A3

|

(12):|

* electroneutral cation-Cl cotransporter
* SLC12A1
* SLC12A2
* SLC12A3
* SLC12A4
* SLC12A5
* SLC12A6
* SLC12A7
* SLC12A8
* SLC12A9

(13):|

* human Na+-sulfate/carboxylate cotransporter
* SLC13A1
* SLC13A2
* SLC13A3
* SLC13A4
* SLC13A5

(14):|

* urea transporter
* SLC14A1
* SLC14A2

(15):|

* proton oligopeptide cotransporter
* SLC15A1
* SLC15A2
* SLC15A3
* SLC15A4

(16):|

* monocarboxylate transporter
* SLC16A1
* SLC16A2
* SLC16A3
* SLC16A4
* SLC16A5
* SLC16A6
* SLC16A7
* SLC16A8
* SLC16A9
* SLC16A10
* SLC16A11
* SLC16A12
* SLC16A13
* SLC16A14

(17):|

* Vesicular glutamate transporter 1
* SLC17A1
* SLC17A2
* SLC17A3
* SLC17A4
* SLC17A5
* SLC17A6
* SLC17A7
* SLC17A8
* SLC17A9

(18):|

* vesicular monoamine transporter
* SLC18A1
* SLC18A2
* SLC18A3

(19):|

* folate/thiamine transporter
* SLC19A1
* SLC19A2
* SLC19A3

(20):|

* type III Na+-phosphate cotransporter
* SLC20A1
* SLC20A2

SLC21–30

| (21):|

* Organic anion-transporting polypeptide
* SLCO1A2
* SLCO1B1
* SLCO1B3
* SLCO1B4
* SLCO1C1
*     * SLCO2A1
* SLCO2B1
*     * SLCO3A1
*     * SLCO4A1
* SLCO4C1
*     * SLCO5A1(SLCO6A1)

|

(22):|

* organic cation/anion/zwitterion transporter
* SLC22A1
* SLC22A2
* SLC22A3
* SLC22A4
* SLC22A5
* SLC22A6
* SLC22A7
* SLC22A8
* SLC22A9
* SLC22A10
* SLC22A11
* SLC22A12
* SLC22A13
* SLC22A14
* SLC22A15
* SLC22A16
* SLC22A17
* SLC22A18
* SLC22A19
* SLC22A20

(23):|

* Na+-dependent ascorbic acid transporter
* SLC23A1
* SLC23A2
* SLC23A3
* SLC23A4

(24):|

* Na+/(Ca2+-K+) exchanger
* SLC24A1
* SLC24A2
* SLC24A3
* SLC24A4
* SLC24A5
* SLC24A6

(25):|

* mitochondrial carrier
* SLC25A1
* SLC25A2
* SLC25A3
* SLC25A4
* SLC25A5
* SLC25A6
* SLC25A7
* SLC25A8
* SLC25A9
* SLC25A10
* SLC25A11
* SLC25A12
* SLC25A13
* SLC25A14
* SLC25A15
* SLC25A16
* SLC25A17
* SLC25A18
* SLC25A19
* SLC25A20
* SLC25A21
* SLC25A22
* SLC25A23
* SLC25A24
* SLC25A25
* SLC25A26
* SLC25A27
* SLC25A28
* SLC25A29
* SLC25A30
* SLC25A31
* SLC25A32
* SLC25A33
* SLC25A34
* SLC25A35
* SLC25A36
* SLC25A37
* SLC25A38
* SLC25A39
* SLC25A40
* SLC25A41
* SLC25A42
* SLC25A43
* SLC25A44
* SLC25A45
* SLC25A46

(26):|

* multifunctional anion exchanger
* SLC26A1
* SLC26A2
* SLC26A3
* SLC26A4
* SLC26A5
* SLC26A6
* SLC26A7
* SLC26A8
* SLC26A9
* SLC26A10
* SLC26A11

(27):|

* fatty acid transport proteins
* SLC27A1
* SLC27A2
* SLC27A3
* SLC27A4
* SLC27A5
* SLC27A6

(28):|

* Na+-coupled nucleoside transport (SLC28A1
* SLC28A2
* SLC28A3

(29):|

* facilitative nucleoside transporter
* SLC29A1
* SLC29A2
* SLC29A3
* SLC29A4

(30):|

* zinc efflux
* SLC30A1
* SLC30A2
* SLC30A3
* SLC30A4
* SLC30A5
* SLC30A6
* SLC30A7
* SLC30A8
* SLC30A9
* SLC30A10

SLC31–40

| (31):|

* copper transporter
* SLC31A1

|

(32):|

* Vesicular glutamate transporter 1
* SLC32A1

(33):|

* Acetyl-CoA transporter
* SLC33A1

(34):|

* type II Na+-phosphate cotransporter
* SLC34A1
* SLC34A2
* SLC34A3

(35):|

* nucleoside-sugar transporter
* SLC35A1
* SLC35A2
* SLC35A3
* SLC35A4
* SLC35A5
*     * SLC35B1
* SLC35B2
* SLC35B3
* SLC35B4
*     * SLC35C1
* SLC35C2
*     * SLC35D1
* SLC35D2
* SLC35D3
*     * SLC35E1
* SLC35E2
* SLC35E3
* SLC35E4

(36):|

* proton-coupled amino-acid transporter
* SLC36A1
* SLC36A2
* SLC36A3
* SLC36A436A2

(37):|

* sugar-phosphate/phosphate exchanger
* SLC37A1
* SLC37A2
* SLC37A3
* SLC37A4

(38):|

* System A & N, sodium-coupled neutral amino-acid transporter
* SLC38A1
* SLC38A2
* SLC38A3
* SLC38A4
* SLC38A5
* SLC38A6
* SLC38A10

(39):|

* metal ion transporter
* SLC39A1
* SLC39A2
* SLC39A3
* SLC39A4
* SLC39A5
* SLC39A6
* SLC39A7
* SLC39A8
* SLC39A9
* SLC39A10
* SLC39A11
* SLC39A12
* SLC39A13
* SLC39A14

(40):|

* basolateral iron transporter
* SLC40A1

SLC41–48

| (41):|

* Magnesium transporter E
* SLC41A1
* SLC41A2
* SLC41A3

|

(42):|

* Ammonia transporter
* RhAG
* RhBG
* RhCG

(43):|

* Na+-independent, system-L like amino-acid transporter
* SLC43A1
* SLC43A2
* SLC43A3

(44):|

* Choline-like transporter
* SLC44A1
* SLC44A2
* SLC44A3
* SLC44A4
* SLC44A5

(45):|

* Putative sugar transporter
* SLC45A1
* SLC45A2
* SLC54A3
* SLC45A4

(46):|

* Folate transporter
* SLC46A1
* SLC46A2

(47):|

* multidrug and toxin extrusion
* SLC47A1
* SLC47A2

(48):|

* Heme transporter

SLCO1–4

* O1A2
* O1B1
* O1B3
* O2B1
* O431
* O4A1

Ion pumps

| Symporter, Cotransporter|

* Na+/K+,Cl−
* Na+/Pi3
* Na+/Cl−
* Na+/glucose
* Na+/I−
* Cl−/K+
* 4
* 5

|

Antiporter (exchanger)|

* Na+/H+
* Na+/Ca2+
* Na+/(Ca2+-K+) - Cl−/HCO−
3 (Band 3)
* Cl−-formate
* Cl−-oxalate

see also solute carrier disorders

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