Mrp superfamily

Large group of transport proteins

The Na+ Transporting Mrp Superfamily is a superfamily of integral membrane transport proteins.

It includes the TC families:

2.A.63 \- The Monovalent Cation (K+ or Na+):Proton Antiporter-3 (CPA3) Family

3.D.1 \- The H+ or Na+-translocating NADH Dehyrogenase (NDH) Family

3.D.9 \- The H+-translocating F420H2 Dehydrogenase (F420H2DH) Family

Mrp of Bacillus subtilis is a 7 subunit Na+/H+ antiporter complex (TC# 2.A.63.1.4). All subunits are homologous to the subunits in other members of this monovalent cation (K+ or Na+):proton antiporter-3 (CPA3) family as well as subunits in the archaeal hydrogenases (TC#s 3.D.1.4.1 and 3.D.1.4.2), which share several subunits with NADH dehydrogenase subunits (3.D.1). The largest subunits of the Mrp complex (MrpA and MrpD) are homologous to subunits in NADH dehydrogenases (NDHs): ND2, ND4 and ND5 in the fungal NADH dehydrogenase complex and most other NDHs, as well as subunits in the F420H2 dehydrogenase of Methanosarcina mazei (TC#3.D.9.1.1).[1] These homologous subunits may catalyze Na+/K+ and/or H+ transport.

## See also

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* Transporter Classification Database

## References

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1. ^ Zickermann, Volker; Wirth, Christophe; Nasiri, Hamid; Siegmund, Karin; Schwalbe, Harald; Hunte, Carola; Brandt, Ulrich (2015-01-02). "Structural biology. Mechanistic insight from the crystal structure of mitochondrial complex I" (PDF). Science. 347 (6217): 44–49\. doi:10.1126/science.1259859. ISSN 1095-9203. PMID 25554780.

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