N2-(2-carboxyethyl)arginine synthase

Enzyme

N2-(2-carboxyethyl)arginine synthase

Identifiers
EC no.| 2.5.1.66
Databases
IntEnz| IntEnz view
BRENDA| BRENDA entry
ExPASy| NiceZyme view
KEGG| KEGG entry
MetaCyc| metabolic pathway
PRIAM| profile
PDB structures| RCSB PDB PDBe PDBsum
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PMC| articles
PubMed| articles
NCBI| proteins

In enzymology, a N2-(2-carboxyethyl)arginine synthase (EC 2.5.1.66) is an enzyme that catalyzes the chemical reaction

D-glyceraldehyde 3-phosphate + L-arginine  ⇌ {\displaystyle \rightleftharpoons } N2-(2-carboxyethyl)-L-arginine + phosphate

Thus, the two substrates of this enzyme are D-glyceraldehyde 3-phosphate and L-arginine, whereas its two products are N2-(2-carboxyethyl)-L-arginine and phosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is glyceraldehyde-3-phosphate:L-arginine N2-(2-hydroxy-3-oxopropyl) transferase (2-carboxyethyl-forming). Other names in common use include CEAS, N2-(2-carboxyethyl)arginine synthetase, CEA synthetase, glyceraldehyde-3-phosphate:L-arginine 2-N-(2-hydroxy-3-oxopropyl), and transferase (2-carboxyethyl-forming). This enzyme participates in clavulanic acid biosynthesis.

## Structural studies

[edit]

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2IHT and 2IHV.

## References

[edit]

* Caines ME, Elkins JM, Hewitson KS, Schofield CJ (2004). "Crystal structure and mechanistic implications of N2-(2-carboxyethyl)arginine synthase, the first enzyme in the clavulanic acid biosynthesis pathway". J. Biol. Chem. 279 (7): 5685–92\. doi:10.1074/jbc.M310803200. PMID 14623876.
* Khaleeli N; Li R; Townsend CA (1999). "Origin of the beta-lactam carbons in clavulanic acid from an unusual thiamine pyrophosphate-mediated reaction". J. Am. Chem. Soc. 121 (39): 9223–9224\. Bibcode:1999JAChS.121.9223K. doi:10.1021/ja9923134.

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Transferases: alkyl and aryl (EC 2.5)

2.5.1|

* Dimethylallyltranstransferase
* Thiaminase I
* Methionine adenosyltransferase
* Riboflavin synthase
* Dihydropteroate synthase
* Spermidine synthase
* Glutathione S-transferase
* Farnesyl-diphosphate farnesyltransferase
* Spermine synthase
* Alkylglycerone phosphate synthase
* Farnesyltransferase
* Geranylgeranyltransferase type 1
* Porphobilinogen deaminase

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Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Diffusion-limited enzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)
* EC7 Translocases (list)

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