NFRKB

| Available structures

PDB| Ortholog search: PDBe RCSB
| List of PDB id codes

3U21, 4UF6, 4WLP

Identifiers
Aliases| NFRKB, INO80G, nuclear factor related to kappaB binding protein
External IDs| OMIM: 164013 MGI: 2442410 HomoloGene: 4492 GeneCards: NFRKB
| Gene location (Human)

Chr.| Chromosome 11 (human)[1]

Band| 11q24.3| Start| 129,863,636 bp[1]
End| 129,895,590 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 9 (mouse)[2]

Band| 9|9 A4| Start| 31,297,488 bp[2]
End| 31,332,629 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* secondary oocyte

* endothelial cell

* left lobe of thyroid gland

* right uterine tube

* right lobe of thyroid gland

* testicle

* skin of abdomen

* vagina

* gastrocnemius muscle

* body of pancreas

| Top expressed in

* secondary oocyte

* superior cervical ganglion

* hand

* otolith organ

* utricle

* medullary collecting duct

* spermatocyte

* thymus

* fossa

* cumulus cell

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* protease binding
* DNA binding
* protein binding

Cellular component|

* nucleus
* Ino80 complex
* nucleoplasm

Biological process|

* DNA recombination
* inflammatory response
* regulation of transcription, DNA-templated
* transcription by RNA polymerase II
* DNA repair
* transcription, DNA-templated
* cellular response to DNA damage stimulus
* protein deubiquitination

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

4798

235134

Ensembl| |

ENSG00000170322

ENSMUSG00000042185

UniProt| |

Q6P4R8

Q6PIJ4

RefSeq (mRNA)| |

NM_001143835
NM_006165

NM_172766
NM_001359654

RefSeq (protein)| |

NP_001137307
NP_006156
NP_001137307.1

| NP_766354
NP_001346583
NP_001392026
NP_001392027
NP_001392028

NP_001392030
NP_001392031

Location (UCSC)| Chr 11: 129.86 – 129.9 Mb| Chr 9: 31.3 – 31.33 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Nuclear factor related to kappa-B-binding protein is a protein that in humans is encoded by the NFRKB gene.[5][6]

## References[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170322 \- Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042185 \- Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Adams BS, Leung K, Meltzer PS, Lewis KA, Wagner-McPherson C, Evans GA, Nabel GJ (Dec 1992). "Localization of the gene encoding R kappa B (NFRKB), a tissue-specific DNA binding protein, to chromosome 11q24-q25" (PDF). Genomics. 14 (2): 270–4. doi:10.1016/S0888-7543(05)80216-2. hdl:2027.42/29810. PMID 1427843.
6. ^ "Entrez Gene: NFRKB nuclear factor related to kappaB binding protein".

## Further reading[edit]

* Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
* Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
* Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
* Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
* Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
* Urban MB, Schreck R, Baeuerle PA (1991). "NF-kappa B contacts DNA by a heterodimer of the p50 and p65 subunit". EMBO J. 10 (7): 1817–25. doi:10.1002/j.1460-2075.1991.tb07707.x. PMC 452856. PMID 2050119.
* Adams BS, Leung KY, Hanley EW, Nabel GJ (1992). "Cloning of R kappa B, a novel DNA-binding protein that recognizes the interleukin-2 receptor alpha chain kappa B site". New Biol. 3 (11): 1063–73. PMID 1777480.

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