Neuropeptide B

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|

Protein-coding gene in the species Homo sapiens

NPB

Identifiers
Aliases| NPB, L7, PPL7, PPneuropeptide B
External IDs| OMIM: 607996; MGI: 2387153; HomoloGene: 102151; GeneCards: NPB; OMA:NPB - orthologs
| Gene location (Human)

Chr.| Chromosome 17 (human)[1]

Band| 17q25.3| Start| 81,900,745 bp[1]
End| 81,902,905 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 11 (mouse)[2]

Band| 11|11 E2| Start| 120,499,303 bp[2]
End| 120,499,919 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* C1 segment

* testicle

* Hypothalamus

* substantia nigra

* nucleus accumbens

* Amygdala

* stromal cell of endometrium

* Brodmann area 9

* putamen

* anterior cingulate cortex

| Top expressed in

* stomach

* embryo

* testicle

* morula

* embryo

* right kidney

* spermatid

* placenta

* urinary bladder

* cerebellar cortex

More reference expression data
BioGPS| | n/a

| Gene ontology

Molecular function|

* protein binding
* G protein-coupled receptor binding

Cellular component|

* extracellular region

Biological process|

* neuropeptide signaling pathway
* G protein-coupled receptor signaling pathway

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

256933

208990

Ensembl| |

ENSG00000183979

ENSMUSG00000044034

UniProt| |

Q8NG41

Q8K4P1

RefSeq (mRNA)| |

NM_148896

NM_153288
NM_001347616
NM_001347617

RefSeq (protein)| |

NP_683694

NP_001334545
NP_001334546
NP_695020

Location (UCSC)| Chr 17: 81.9 – 81.9 Mb| Chr 11: 120.5 – 120.5 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Neuropeptide B is a short biologically active peptide whose precursor in humans is encoded by the NBP gene. Neuropeptide B acts via two G protein-coupled receptors, neuropeptide B/W receptors, called NPBW1 and NPBW2 encoded by the genes NPBWR1 and NPBWR2, respectively. Neuropeptide B is thought to be associated with the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.[5][6] It is expressed throughout the central nervous system with high levels in the substantia nigra, hypothalamus, hippocampus, and spinal cord.

## See also

[edit]

* Neuropeptide W

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183979 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044034 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Singh G, Davenport AP (Aug 2006). "Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system". British Journal of Pharmacology. 148 (8): 1033–41\. doi:10.1038/sj.bjp.0706825. PMC 1752024. PMID 16847439.
6. ^ Hondo M, Ishii M, Sakurai T (2008). "The NPB/NPW Neuropeptide System and Its Role in Regulating Energy Homeostasis, Pain, and Emotion". Orphan G Protein-Coupled Receptors and Novel Neuropeptides. Results and Problems in Cell Differentiation. Vol. 46\. pp. 239–56\. doi:10.1007/400_2007_056. ISBN 978-3-540-78350-3. PMID 18204824.

## External links

[edit]

* Uniprot: Neuropeptide B precursor

* v
* t
* e

Hydrolases: acid anhydride hydrolases (EC 3.6)

3.6.1|

* Pyrophosphatase
* Inorganic
* Thiamine
* Apyrase
* Thiamine-triphosphatase

3.6.2|

* Adenylylsulfatase
* Phosphoadenylylsulfatase

3.6.3-4: ATPase|

| 3.6.3|

| Cu++ (3.6.3.4)|

* Menkes/ATP7A
* Wilson/ATP7B

|

Ca+ (3.6.3.8)|

* SERCA
* ATP2A1
* ATP2A2
* ATP2A3
* Plasma membrane
* ATP2B1
* ATP2B2
* ATP2B3
* ATP2B4
* SPCA
* ATP2C1
* ATP2C2

Na+/K+ (3.6.3.9)|

* ATP1A1
* ATP1A2
* ATP1A3
* ATP1A4
* ATP1B1
* ATP1B2
* ATP1B3
* ATP1B4

H+/K+ (3.6.3.10)|

* ATP4A

Other P-type ATPase|

* ATP8B1
* ATP10A
* ATP11B
* ATP12A
* ATP13A2
* ATP13A3

3.6.4|

* Dynein
* Kinesin
* Myosin
* Katanin

3.6.5: GTPase|

| 3.6.5.1: Heterotrimeric G protein|

* Gαs
* Golf
* Gαi
* GNAI1
* GNAI2
* GNAI3
* Transducin
* GNAT1
* GNAT2
* Gustducin
* GNAT3
* Gαq/11
* GNAQ
* GNA11
* Gα12/13
* GNA12
* GNA13

|

3.6.5.2: Small GTPase > Ras superfamily|

* Rho family of GTPases: Cdc42
* CDC42
* TC10
* TCL
* RhoUV
* RhoU
* RhoV
* Rac
* Rac1
* 2
* 3
* RhoG
* RhoBTB
* 1
* 2
* RhoH
* Rho
* A
* B
* C
* Rnd
* 1
* 2
* 3
* RhoDF
* RhoF
* RhoD

* other: Ras
* HRAS
* KRAS
* NRAS
* Rab
* RAB23
* RAB27
* Arf
* ARF6
* SAR1B
* ARL13B
* ARL6
* Ran
* Rheb
* Rap
* RGK

3.6.5.3: Protein-synthesizing GTPase|

* Prokaryotic
* IF-2
* EF-Tu
* EF-G
* Eukaryotic

3.6.5.5-6: Polymerization motors|

* dynamin superfamily
* Dynamin
* Guanylate-binding protein
* Mitofusin-1
* MX1 and MX2
* OPA1
* Tubulin

* v
* t
* e

Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Diffusion-limited enzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)
* EC7 Translocases (list)

Portal:

* Biology

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