OR1E1

Protein-coding gene in the species Homo sapiens

OR1E1

Identifiers
Aliases| OR1E1, HGM071, OR13-66, OR17-2, OR17-32, OR1E5, OR1E6, OR1E8P, OR1E9P, OST547, olfactory receptor family 1 subfamily E member 1
External IDs| HomoloGene: 74111 GeneCards: OR1E1
| Gene location (Human)

Chr.| Chromosome 17 (human)[1]

Band| 17p13.3| Start| 3,397,104 bp[1]
End| 3,398,410 bp[1]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* gastrocnemius muscle

* placenta

* mammary gland

* breast

* prefrontal cortex

* temporal lobe

* tibial nerve

* sigmoid colon

* heart

* ventricle

n/a

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* G protein-coupled receptor activity
* transmembrane signaling receptor activity
* signal transducer activity
* olfactory receptor activity

Cellular component|

* membrane
* plasma membrane
* integral component of membrane

Biological process|

* detection of chemical stimulus involved in sensory perception
* signal transduction
* response to stimulus
* sensory perception of smell
* detection of chemical stimulus involved in sensory perception of smell
* G protein-coupled receptor signaling pathway

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

8387

n/a

Ensembl| |

ENSG00000180016

n/a

UniProt| |

P30953

n/a

RefSeq (mRNA)| |

NM_003553

n/a

RefSeq (protein)| |

NP_003544

n/a

Location (UCSC)| Chr 17: 3.4 – 3.4 Mb| n/a
PubMed search| [2]| n/a
Wikidata
| View/Edit Human|

|

Olfactory receptor 1E1 is a protein that in humans is encoded by the OR1E1 gene.[3][4][5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

## See also[edit]

* Olfactory receptor

## References[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000180016 \- Ensembl, May 2017
2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. ^ Ben-Arie N, Lancet D, Taylor C, Khen M, Walker N, Ledbetter DH, Carrozzo R, Patel K, Sheer D, Lehrach H, et al. (Jul 1994). "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire". Hum Mol Genet. 3 (2): 229–35. doi:10.1093/hmg/3.2.229. PMID 8004088.
4. ^ Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J, et al. (Mar 1992). "Expression of members of the putative olfactory receptor gene family in mammalian germ cells". Nature. 355 (6359): 453–5. Bibcode:1992Natur.355..453P. doi:10.1038/355453a0. PMID 1370859. S2CID 43926.
5. ^ a b "Entrez Gene: OR1E1 olfactory receptor, family 1, subfamily E, member 1".

## Further reading[edit]

* Rouquier S, Taviaux S, Trask BJ, et al. (1998). "Distribution of olfactory receptor genes in the human genome". Nat. Genet. 18 (3): 243–50. doi:10.1038/ng0398-243. PMID 9500546. S2CID 31129045.
* Glusman G, Sosinsky A, Ben-Asher E, et al. (2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID 10673334. S2CID 23416814.
* Rouquier S, Blancher A, Giorgi D (2000). "The olfactory receptor gene repertoire in primates and mouse: evidence for reduction of the functional fraction in primates". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2870–4. Bibcode:2000PNAS...97.2870R. doi:10.1073/pnas.040580197. PMC 16022. PMID 10706615.
* Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
* Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

## External links[edit]

* OR1E1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

* v
* t
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G protein-coupled receptors: olfactory receptors

Class I
(fish-like receptors)|

| Family 51|

* A2
* A4
* A7
* B2
* B4
* B5
* B6
* D1
* E1
* E2
* F1
* F2
* G1
* G2
* H1
* I1
* I2
* L1
* M1
* Q1
* S1
* T1
* V1

|

Family 52|

* A1
* A4
* A5
* B2
* B4
* B6
* D1
* E1
* E2
* E4
* E5
* E6
* E8
* H1
* I1
* I2
* J3
* K1
* K2
* L1
* L2
* M1
* N1
* N2
* N4
* N5
* P1
* R1
* W1

Family 56|

* A1
* A3
* A4
* B1
* B4

Class II
(tetrapod specific receptors)|

| Family 1|

* A1
* A2
* B1
* C1
* D2
* D4
* D5
* E1
* E2
* E3
* F1
* F2
* G1
* I1
* J1
* J2
* J4
* K1
* L1
* L3
* L4
* L6
* L8
* M1
* N1
* N2
* Q1
* S1
* S2

|

Family 2|

* A1
* A2
* A4
* A5
* A7
* A12
* A14
* A25
* A42
* AE1
* AG1
* AG2
* AJ1
* AK2
* AP1
* AT4
* B2
* B3
* B6
* B8
* B11
* C1
* C3
* D2
* D3
* F1
* F2
* G2
* G3
* G6
* H1
* H2
* J1
* J2
* J3
* K2
* L2
* L3
* L5
* L8
* L13
* M2
* M3
* M4
* M5
* M7
* S2
* T1
* T2
* T3
* T4
* T5
* T6
* T8
* T10
* T11
* T12
* T27
* T29
* T33
* T34
* T35
* V1
* V2
* W1
* W3
* W5
* Y1
* Z1

Family 3|

* A1
* A2
* A3
* A4

Family 4|

* A5
* A15
* A16
* A47
* B1
* C3
* C5
* C6
* C11
* C12
* C13
* C15
* C16
* C45
* C46
* D1
* D2
* D5
* D6
* D9
* D10
* D11
* E2
* F3
* F4
* F5
* F6
* F15
* F16
* F17
* F21
* F29
* K1
* K2
* K3
* K5
* K13
* K14
* K15
* K17
* L1
* M1
* M2
* N2
* N4
* N5
* P4
* Q3
* S1
* S2
* X1
* X2

Family 5|

* A1
* A2
* AC2
* AK2
* AK3
* AN1
* AP2
* AR1
* AS1
* AT1
* AU1
* AY1
* B2
* B3
* B12
* B17
* B21
* BF1
* BU1
* C1
* D13
* D14
* D16
* D18
* F1
* H1
* H2
* H6
* H14
* H15
* I1
* J2
* K1
* K2
* K3
* K4
* L1
* L2
* M1
* M3
* M8
* M9
* M10
* M11
* P2
* P3
* R1
* T1
* T2
* T3
* U1
* V1
* W2

Family 6|

* A2
* B1
* B2
* B3
* C1
* C2
* C3
* C4
* C6
* C65
* C68
* C70
* C74
* C75
* C76
* F1
* J1
* K2
* K3
* K6
* M1
* N1
* N2
* P1
* Q1
* S1
* T1
* V1
* X1
* Y1

Family 7|

* A2
* A5
* A10
* A17
* C1
* C2
* D2
* D4
* E24
* G1
* G2
* G3

Family 8|

* A1
* B2
* B3
* B4
* B8
* B12
* D1
* D2
* D4
* G1
* G2
* G5
* H1
* H2
* H3
* I2
* J1
* J3
* K1
* K3
* K5
* S1
* U1

Family 9|

* A2
* A4
* G1
* G4
* I1
* K2
* Q1
* Q2

Family 10|

* A2
* A3
* A4
* A5
* A6
* A7
* AD1
* AG1
* C1
* D4
* G2
* G3
* G4
* G6
* G7
* G8
* G9
* H1
* H2
* H3
* H4
* H5
* J1
* J3
* J5
* J6
* K1
* K2
* P1
* Q1
* R2
* S1
* T2
* V1
* W1
* X1
* Z1

Family 11|

* A1
* G2
* H1
* H4
* H6
* L1

Family 12|

* D2
* D3

Family 13|

* A1
* C2
* C3
* C4
* C5
* C8
* C9
* D1
* F1
* G1
* H1
* J1

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