OR2M3

Protein-coding gene in the species Homo sapiens

OR2M3

Identifiers
Aliases| OR2M3, OR1-54, OR2M3P, OR2M6, OST003, olfactory receptor family 2 subfamily M member 3
External IDs| MGI: 3029998; HomoloGene: 51725; GeneCards: OR2M3; OMA:OR2M3 - orthologs
| Gene location (Human)

Chr.| Chromosome 1 (human)[1]

Band| 1q44| Start| 248,197,265 bp[1]
End| 248,212,925 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 16 (mouse)[2]

Band| 16|16 A3| Start| 19,102,854 bp[2]
End| 19,132,814 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* mucosa of transverse colon

* sural nerve

* rectum

* endometrium

* renal cortex

* prefrontal cortex

* muscle layer of sigmoid colon

* fundus

| Top expressed in

* spleen

* uterus

* thymus

* duodenum

More reference expression data
BioGPS| | n/a

| Gene ontology

Molecular function|

* G protein-coupled receptor activity
* olfactory receptor activity
* signal transducer activity

Cellular component|

* integral component of membrane
* plasma membrane
* membrane

Biological process|

* sensory perception of smell
* signal transduction
* response to stimulus
* detection of chemical stimulus involved in sensory perception of smell
* G protein-coupled receptor signaling pathway

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

127062

258443

Ensembl| |

ENSG00000228198

ENSMUSG00000050742

UniProt| |

Q8NG83

Q8VF87

RefSeq (mRNA)| |

NM_001004689

NM_146451

RefSeq (protein)| |

NP_001004689

NP_666662

Location (UCSC)| Chr 1: 248.2 – 248.21 Mb| Chr 16: 19.1 – 19.13 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Olfactory receptor 2M3 is a protein that in humans is encoded by the OR2M3 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

OR2M3 has a copper binding pocket.[6]

## Ligands

[edit]

* 3-Mercapto-2-methylpentan-1-ol [7]

This chemical is associated with characteristic smell of raw onions.

## See also

[edit]

* Olfactory receptor

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000228198 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050742 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ a b "Entrez Gene: OR2M3 olfactory receptor, family 2, subfamily M, member 3".
6. ^ Haag F, Ahmed L, Reiss K, Block E, Batista VS, Krautwurst D (August 2019). "Copper-mediated thiol potentiation and mutagenesis-guided modeling suggest a highly conserved copper-binding motif in human OR2M3". Cellular and Molecular Life Sciences. 77 (11): 2157–2179. doi:10.1007/s00018-019-03279-y. PMC 7256108. PMID 31435697.
7. ^ Noe F, Polster J, Geithe C, Kotthoff M, Schieberle P, Krautwurst D (March 2017). "OR2M3: A Highly Specific and Narrowly Tuned Human Odorant Receptor for the Sensitive Detection of Onion Key Food Odorant 3-Mercapto-2-methylpentan-1-ol". Chemical Senses. 42 (3): 195–210. doi:10.1093/chemse/bjw118. PMID 27916748.

## Further reading

[edit]

* Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, et al. (September 2002). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
* Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

## External links

[edit]

* OR2M3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

* v
* t
* e

G protein-coupled receptors: olfactory receptors

Class I
(fish-like receptors)|

| Family 51|

* A2
* A4
* A7
* B2
* B4
* B5
* B6
* D1
* E1
* E2
* F1
* F2
* G1
* G2
* H1
* I1
* I2
* L1
* M1
* Q1
* S1
* T1
* V1

|

Family 52|

* A1
* A4
* A5
* B2
* B4
* B6
* D1
* E1
* E2
* E4
* E5
* E6
* E8
* H1
* I1
* I2
* J3
* K1
* K2
* L1
* L2
* M1
* N1
* N2
* N4
* N5
* P1
* R1
* W1

Family 56|

* A1
* A3
* A4
* B1
* B4

Class II
(tetrapod specific receptors)|

| Family 1|

* A1
* A2
* B1
* C1
* D2
* D4
* D5
* E1
* E2
* E3
* F1
* F2
* G1
* I1
* J1
* J2
* J4
* K1
* L1
* L3
* L4
* L6
* L8
* M1
* N1
* N2
* Q1
* S1
* S2

|

Family 2|

* A1
* A2
* A4
* A5
* A7
* A12
* A14
* A25
* A42
* AE1
* AG1
* AG2
* AJ1
* AK2
* AP1
* AT4
* B2
* B3
* B6
* B8
* B11
* C1
* C3
* D2
* D3
* F1
* F2
* G2
* G3
* G6
* H1
* H2
* J1
* J2
* J3
* K2
* L2
* L3
* L5
* L8
* L13
* M2
* M3
* M4
* M5
* M7
* S2
* T1
* T2
* T3
* T4
* T5
* T6
* T8
* T10
* T11
* T12
* T27
* T29
* T33
* T34
* T35
* V1
* V2
* W1
* W3
* W5
* Y1
* Z1

Family 3|

* A1
* A2
* A3
* A4

Family 4|

* A5
* A15
* A16
* A47
* B1
* C3
* C5
* C6
* C11
* C12
* C13
* C15
* C16
* C45
* C46
* D1
* D2
* D5
* D6
* D9
* D10
* D11
* E2
* F3
* F4
* F5
* F6
* F15
* F16
* F17
* F21
* F29
* K1
* K2
* K3
* K5
* K13
* K14
* K15
* K17
* L1
* M1
* M2
* N2
* N4
* N5
* P4
* Q3
* S1
* S2
* X1
* X2

Family 5|

* A1
* A2
* AC2
* AK2
* AK3
* AN1
* AP2
* AR1
* AS1
* AT1
* AU1
* AY1
* B2
* B3
* B12
* B17
* B21
* BF1
* BU1
* C1
* D13
* D14
* D16
* D18
* F1
* H1
* H2
* H6
* H14
* H15
* I1
* J2
* K1
* K2
* K3
* K4
* L1
* L2
* M1
* M3
* M8
* M9
* M10
* M11
* P2
* P3
* R1
* T1
* T2
* T3
* U1
* V1
* W2

Family 6|

* A2
* B1
* B2
* B3
* C1
* C2
* C3
* C4
* C6
* C65
* C68
* C70
* C74
* C75
* C76
* F1
* J1
* K2
* K3
* K6
* M1
* N1
* N2
* P1
* Q1
* S1
* T1
* V1
* X1
* Y1

Family 7|

* A2
* A5
* A10
* A17
* C1
* C2
* D2
* D4
* E24
* G1
* G2
* G3

Family 8|

* A1
* B2
* B3
* B4
* B8
* B12
* D1
* D2
* D4
* G1
* G2
* G5
* H1
* H2
* H3
* I2
* J1
* J3
* K1
* K3
* K5
* S1
* U1

Family 9|

* A2
* A4
* G1
* G4
* I1
* K2
* Q1
* Q2

Family 10|

* A2
* A3
* A4
* A5
* A6
* A7
* AD1
* AG1
* C1
* D4
* G2
* G3
* G4
* G6
* G7
* G8
* G9
* H1
* H2
* H3
* H4
* H5
* J1
* J3
* J5
* J6
* K1
* K2
* P1
* Q1
* R2
* S1
* T2
* V1
* W1
* X1
* Z1

Family 11|

* A1
* G2
* H1
* H4
* H6
* L1

Family 12|

* D2
* D3

Family 13|

* A1
* C2
* C3
* C4
* C5
* C8
* C9
* D1
* F1
* G1
* H1
* J1

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