PAPLN

Protein-coding gene in the species Homo sapiens

PAPLN

Identifiers
Aliases| PAPLN, papilin, proteoglycan like sulfated glycoprotein, PPN
External IDs| OMIM: 617785 MGI: 2386139 HomoloGene: 71541 GeneCards: PAPLN
| Gene location (Human)

Chr.| Chromosome 14 (human)[1]

Band| 14q24.2| Start| 73,237,497 bp[1]
End| 73,274,640 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 12 (mouse)[2]

Band| 12|12 D1| Start| 83,810,408 bp[2]
End| 83,839,156 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* tibial nerve

* trigeminal ganglion

* spinal ganglia

* gastric mucosa

* sural nerve

* left uterine tube

* lymph node

* spleen

* endometrium

* left lobe of thyroid gland

| Top expressed in

* molar

* lip

* spermatocyte

* esophagus

* superior frontal gyrus

* yolk sac

* spermatid

* uterus

* duodenum

* jejunum

More reference expression data
BioGPS| | n/a

| Gene ontology

Molecular function|

* peptidase inhibitor activity
* peptidase activity
* serine-type endopeptidase inhibitor activity

Cellular component|

* extracellular region

Biological process|

* negative regulation of peptidase activity
* negative regulation of endopeptidase activity
* proteolysis

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

89932

170721

Ensembl| |

ENSG00000100767

ENSMUSG00000021223

UniProt| |

O95428

Q9EPX2

RefSeq (mRNA)| |

NM_173462
NM_001365906
NM_001365907

NM_001205343
NM_130887

RefSeq (protein)| |

NP_775733
NP_001352835
NP_001352836

NP_001192272
NP_570957

Location (UCSC)| Chr 14: 73.24 – 73.27 Mb| Chr 12: 83.81 – 83.84 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Papilin is a protein that in humans is encoded by the PAPLN gene.[5][6][7] Papilin is an extracellular matrix glycoprotein.

## References[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100767 \- Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021223 \- Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: papilin".
6. ^ Kramerova IA, Kawaguchi N, Fessler LI, Nelson RE, Chen Y, Kramerov AA, Kusche-Gullberg M, Kramer JM, Ackley BD, Sieron AL, Prockop DJ, Fessler JH (December 2000). "Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases". Development. 127 (24): 5475–85. doi:10.1242/dev.127.24.5475. PMID 11076767.
7. ^ Apte SS (November 2009). "A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms". J. Biol. Chem. 284 (46): 31493–7. doi:10.1074/jbc.R109.052340. PMC 2797218. PMID 19734141.

## Further reading[edit]

* Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
* Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
* Laje G, Allen AS, Akula N, et al. (2009). "Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients". Pharmacogenet. Genomics. 19 (9): 666–74. doi:10.1097/FPC.0b013e32832e4bcd. PMC 2819190. PMID 19724244.
* Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.