PARP12

Protein-coding gene in the species Homo sapiens

PARP12

| Available structures

PDB| Ortholog search: PDBe RCSB
| List of PDB id codes

2PQF

Identifiers
Aliases| PARP12, ARTD12, MST109, MSTP109, ZC3H1, ZC3HDC1, poly(ADP-ribose) polymerase family member 12
External IDs| OMIM: 612481; MGI: 2143990; HomoloGene: 11236; GeneCards: PARP12; OMA:PARP12 - orthologs
| Gene location (Human)

Chr.| Chromosome 7 (human)[1]

Band| 7q34| Start| 140,023,749 bp[1]
End| 140,062,951 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 6 (mouse)[2]

Band| 6|6 B1| Start| 39,063,344 bp[2]
End| 39,095,283 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* secondary oocyte

* granulocyte

* right lung

* upper lobe of left lung

* monocyte

* spleen

* mucosa of ileum

* mucosa of transverse colon

* rectum

* tibial nerve

| Top expressed in

* zygote

* secondary oocyte

* primary oocyte

* intestinal villus

* stroma of bone marrow

* pineal gland

* mucous cell of stomach

* left colon

* jejunum

* ileum

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* NAD+ ADP-ribosyltransferase activity
* metal ion binding
* transferase activity
* RNA binding
* protein ADP-ribosylase activity

Cellular component|

* nucleus

Biological process|

* protein auto-ADP-ribosylation
* protein mono-ADP-ribosylation

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

64761

243771

Ensembl| |

ENSG00000059378

ENSMUSG00000038507

UniProt| |

Q9H0J9

Q8BZ20

RefSeq (mRNA)| |

NM_022750

NM_172893

RefSeq (protein)| |

NP_073587

NP_766481

Location (UCSC)| Chr 7: 140.02 – 140.06 Mb| Chr 6: 39.06 – 39.1 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Poly [ADP-ribose] polymerase 12 is an enzyme that in humans is encoded by the PARP12 gene.[5][6][7]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000059378 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038507 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35\. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
6. ^ Katoh M, Katoh M (Jul 2003). "Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31". Int J Oncol. 23 (2): 541–7\. doi:10.3892/ijo.23.2.541. PMID 12851707.
7. ^ "Entrez Gene: PARP12 poly (ADP-ribose) polymerase family, member 12".

## Further reading

[edit]

* Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7\. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
* Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5\. doi:10.1038/ng1285. PMID 14702039.
* Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64\. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
* Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72\. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
* Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903\. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
* <Please add first missing authors to populate metadata.> (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108\. doi:10.1101/gr.8.11.1097. PMID 9847074.

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PDB gallery

* 2pqf: Human Poly(ADP-Ribose) Polymerase 12, Catalytic fragment in complex with an inhibitor 3-Aminobenzoic acid

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