POLR1D

Protein-coding gene in the species Homo sapiens

POLR1D

Identifiers
Aliases| POLR1D, AC19, POLR1C, RPA16, RPA9, RPAC2, RPC16, RPO1-3, TCS2, polymerase (RNA) I subunit D, RNA polymerase I subunit D, RNA polymerase I and III subunit D
External IDs| OMIM: 613715; MGI: 108403; HomoloGene: 22239; GeneCards: POLR1D; OMA:POLR1D - orthologs
| Gene location (Human)

Chr.| Chromosome 13 (human)[1]

Band| 13q12.2| Start| 27,620,742 bp[1]
End| 27,744,237 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 5 (mouse)[2]

Band| 5|5 G3| Start| 147,077,050 bp[2]
End| 147,111,597 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* body of pancreas

* secondary oocyte

* skin of abdomen

* body of stomach

* cerebellar hemisphere

* right adrenal cortex

* right hemisphere of cerebellum

* left ovary

* left adrenal cortex

* right testis

| Top expressed in

* facial motor nucleus

* temporal muscle

* sternocleidomastoid muscle

* yolk sac

* triceps brachii muscle

* digastric muscle

* salivary gland

* embryo

* submandibular gland

* lacrimal gland

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* DNA binding
* protein dimerization activity
* RNA polymerase III activity
* DNA-directed 5'-3' RNA polymerase activity
* protein binding
* RNA polymerase I activity

Cellular component|

* cytosol
* nucleoplasm
* RNA polymerase I complex
* RNA polymerase III complex
* nucleus

Biological process|

* termination of RNA polymerase I transcription
* epigenetic maintenance of chromatin in transcription-competent conformation
* transcription initiation from RNA polymerase I promoter
* transcription, DNA-templated
* transcription elongation from RNA polymerase I promoter
* positive regulation of type I interferon production
* transcription by RNA polymerase III

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

51082

20018

Ensembl| |

ENSG00000186184

ENSMUSG00000029642

UniProt| |

P0DPB5

P97304

RefSeq (mRNA)| |

NM_001206559
NM_015972
NM_152705
NM_001374407

NM_009087
NM_181730

RefSeq (protein)| |

NP_001193488
NP_057056
NP_689918
NP_001361336

NP_033113
NP_859419

Location (UCSC)| Chr 13: 27.62 – 27.74 Mb| Chr 5: 147.08 – 147.11 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

DNA-directed RNA polymerases I and III subunit RPAC2 is a protein that in humans is encoded by the POLR1D gene.[5][6][7]

## Interactions

[edit]

POLR1D has been shown to interact with POLR1C.[8][9]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186184 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029642 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Oct 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
6. ^ Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N (Nov 2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits" (PDF). Molecular and Cellular Biology. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170.
7. ^ "Entrez Gene: POLR1D polymerase (RNA) I polypeptide D, 16kDa".
8. ^ Yao Y, Yamamoto K, Nishi Y, Nogi Y, Muramatsu M (Dec 1996). "Mouse RNA polymerase I 16-kDa subunit able to associate with 40-kDa subunit is a homolog of yeast AC19 subunit of RNA polymerases I and III". The Journal of Biological Chemistry. 271 (51): 32881–5. doi:10.1074/jbc.271.51.32881. PMID 8955128.
9. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

## Further reading

[edit]

* Yao Y, Yamamoto K, Nishi Y, Nogi Y, Muramatsu M (Dec 1996). "Mouse RNA polymerase I 16-kDa subunit able to associate with 40-kDa subunit is a homolog of yeast AC19 subunit of RNA polymerases I and III". The Journal of Biological Chemistry. 271 (51): 32881–5. doi:10.1074/jbc.271.51.32881. PMID 8955128.
* Dundr M, Hoffmann-Rohrer U, Hu Q, Grummt I, Rothblum LI, Phair RD, Misteli T (Nov 2002). "A kinetic framework for a mammalian RNA polymerase in vivo". Science. 298 (5598): 1623–6. Bibcode:2002Sci...298.1623D. doi:10.1126/science.1076164. PMID 12446911. S2CID 36392120.
* Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
* Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M (Jul 2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Molecular and Cellular Biology. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC 434256. PMID 15226435.
* Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (Jan 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
* Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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