PREPL

Protein-coding gene in the species Homo sapiens

PREPL

Identifiers
Aliases| PREPL, prolyl endopeptidase-like, CMS22, prolyl endopeptidase like
External IDs| OMIM: 609557; MGI: 2441932; HomoloGene: 15481; GeneCards: PREPL; OMA:PREPL - orthologs
| Gene location (Human)

Chr.| Chromosome 2 (human)[1]

Band| 2p21| Start| 44,316,281 bp[1]
End| 44,361,862 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 17 (mouse)[2]

Band| 17|17 E4| Start| 85,370,898 bp[2]
End| 85,397,669 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* Brodmann area 23

* endothelial cell

* middle temporal gyrus

* postcentral gyrus

* pars compacta

* lateral nuclear group of thalamus

* external globus pallidus

* Pons

* pars reticulata

* entorhinal cortex

| Top expressed in

* ventromedial nucleus

* paraventricular nucleus of hypothalamus

* lateral hypothalamus

* ventral tegmental area

* pontine nuclei

* medial geniculate nucleus

* dorsomedial hypothalamic nucleus

* medial vestibular nucleus

* inferior colliculi

* central gray substance of midbrain

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* serine-type exopeptidase activity
* peptidase activity
* serine-type peptidase activity
* hydrolase activity
* serine-type endopeptidase activity
* protein binding

Cellular component|

* cytoplasm
* cytosol
* Golgi apparatus
* cytoskeleton

Biological process|

* proteolysis
* regulation of synaptic vesicle exocytosis

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

9581

213760

Ensembl| |

ENSG00000138078

ENSMUSG00000024127

UniProt| |

Q4J6C6

Q8C167

RefSeq (mRNA)| | NM_001042385
NM_001042386
NM_001171603
NM_001171606
NM_001171613

NM_001171617
NM_006036
NM_001374275
NM_001374276
NM_001374277

NM_001163622
NM_001163623
NM_001163624
NM_145984

RefSeq (protein)| | NP_001035844
NP_001035845
NP_001165074
NP_001165077
NP_001165084

NP_001165088
NP_006027
NP_001361204
NP_001361205
NP_001361206

NP_001157094
NP_001157095
NP_001157096
NP_666096

Location (UCSC)| Chr 2: 44.32 – 44.36 Mb| Chr 17: 85.37 – 85.4 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Prolyl endopeptidase-like is an enzyme that in humans is encoded by the PREPL gene.[5][6]

PREPL belongs to the prolyloligopeptidase subfamily of serine peptidases (Parvari et al., 2005).[supplied by OMIM][6]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138078 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024127 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Parvari R, Brodyansky I, Elpeleg O, Moses S, Landau D, Hershkovitz E (Sep 2001). "A recessive contiguous gene deletion of chromosome 2p16 associated with cystinuria and a mitochondrial disease". Am J Hum Genet. 69 (4): 869–875\. doi:10.1086/323624. PMC 1226072. PMID 11524703.869-875&rft.date=2001-09&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1226072#id-name=PMC&rft_id=info:pmid/11524703&rft_id=info:doi/10.1086/323624&rft.aulast=Parvari&rft.aufirst=R&rft.au=Brodyansky,+I&rft.au=Elpeleg,+O&rft.au=Moses,+S&rft.au=Landau,+D&rft.au=Hershkovitz,+E&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1226072&rfr_id=info:sid/en.wikipedia.org:PREPL" class="Z3988">
6. ^ a b "Entrez Gene: PREPL prolyl endopeptidase-like".

## Further reading

[edit]

* Martens K, Derua R, Meulemans S, et al. (2006). "PREPL: a putative novel oligopeptidase propelled into the limelight". Biol. Chem. 387 (7): 879–883\. doi:10.1515/BC.2006.111. PMID 16913837. S2CID 7983864.879-883&rft.date=2006&rft_id=https://api.semanticscholar.org/CorpusID:7983864#id-name=S2CID&rft_id=info:pmid/16913837&rft_id=info:doi/10.1515/BC.2006.111&rft.au=Martens+K&rft.au=Derua+R&rft.au=Meulemans+S&rft.au=Waelkens,+Etienne&rft.au=Jaeken,+Jaak&rft.au=Matthijs,+Gert&rft.au=Creemers,+John+W.M.&rfr_id=info:sid/en.wikipedia.org:PREPL" class="Z3988">
* Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50\. doi:10.1006/geno.1994.1457. PMID 7829101.42-50&rft.date=1995&rft_id=info:doi/10.1006/geno.1994.1457&rft_id=info:pmid/7829101&rft.au=Robertson+NG&rft.au=Khetarpal+U&rft.au=Gutiérrez-Espeleta+GA&rft.au=Bieber,+FR&rft.au=Morton,+CC&rfr_id=info:sid/en.wikipedia.org:PREPL" class="Z3988">
* Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–313\. doi:10.1093/dnares/4.5.307. PMID 9455477.307-313&rft.date=1998&rft_id=info:doi/10.1093/dnares/4.5.307&rft_id=info:pmid/9455477&rft.au=Ishikawa+K&rft.au=Nagase+T&rft.au=Nakajima+D&rft.au=Seki,+N&rft.au=Ohira,+M&rft.au=Miyajima,+N&rft.au=Tanaka,+A&rft.au=Kotani,+H&rft.au=Nomura,+N&rft_id=https://doi.org/10.1093%2Fdnares%2F4.5.307&rfr_id=info:sid/en.wikipedia.org:PREPL" class="Z3988">
* Kim DK, Kanai Y, Choi HW, et al. (2002). "Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells". Biochim. Biophys. Acta. 1565 (1): 112–122\. doi:10.1016/S0005-2736(02)00516-3. PMID 12225859.112-122&rft.date=2002&rft_id=info:doi/10.1016/S0005-2736(02)00516-3&rft_id=info:pmid/12225859&rft.au=Kim+DK&rft.au=Kanai+Y&rft.au=Choi+HW&rft.au=Tangtrongsup,+S&rft.au=Chairoungdua,+A&rft.au=Babu,+E&rft.au=Tachampa,+K&rft.au=Anzai,+N&rft.au=Iribe,+Y&rfr_id=info:sid/en.wikipedia.org:PREPL" class="Z3988">
* Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903\. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.16899-16903&rft.date=2003&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241#id-name=PMC&rft_id=info:pmid/12477932&rft_id=info:doi/10.1073/pnas.242603899&rft_id=info:bibcode/2002PNAS...9916899M&rft.au=Strausberg+RL&rft.au=Feingold+EA&rft.au=Grouse+LH&rft.au=Derge,+JG&rft.au=Klausner,+RD&rft.au=Collins,+FS&rft.au=Wagner,+L&rft.au=Shenmen,+CM&rft.au=Schuler,+GD&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241&rfr_id=info:sid/en.wikipedia.org:PREPL" class="Z3988">
* Parvari R, Gonen Y, Alshafee I, et al. (2005). "The 2p21 deletion syndrome: characterization of the transcription content". Genomics. 86 (2): 195–211\. doi:10.1016/j.ygeno.2005.04.001. PMID 15913950.195-211&rft.date=2005&rft_id=info:doi/10.1016/j.ygeno.2005.04.001&rft_id=info:pmid/15913950&rft.au=Parvari+R&rft.au=Gonen+Y&rft.au=Alshafee+I&rft.au=Buriakovsky,+S&rft.au=Regev,+K&rft.au=Hershkovitz,+E&rfr_id=info:sid/en.wikipedia.org:PREPL" class="Z3988">
* Szeltner Z, Alshafee I, Juhász T, et al. (2005). "The PREPL A protein, a new member of the prolyl oligopeptidase family, lacking catalytic activity". Cell. Mol. Life Sci. 62 (19–20): 2376–2381\. doi:10.1007/s00018-005-5262-5. PMC 11139102. PMID 16143824. S2CID 11081394.19–20&rft.pages=2376-2381&rft.date=2005&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11139102#id-name=PMC&rft_id=https://api.semanticscholar.org/CorpusID:11081394#id-name=S2CID&rft_id=info:pmid/16143824&rft_id=info:doi/10.1007/s00018-005-5262-5&rft.au=Szeltner+Z&rft.au=Alshafee+I&rft.au=Juhász+T&rft.au=Parvari,+R.&rft.au=Polgár,+L.&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11139102&rfr_id=info:sid/en.wikipedia.org:PREPL" class="Z3988">
* Jaeken J, Martens K, Francois I, et al. (2006). "Deletion of PREPL, a gene encoding a putative serine oligopeptidase, in patients with hypotonia-cystinuria syndrome". Am. J. Hum. Genet. 78 (1): 38–51\. doi:10.1086/498852. PMC 1380222. PMID 16385448.38-51&rft.date=2006&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1380222#id-name=PMC&rft_id=info:pmid/16385448&rft_id=info:doi/10.1086/498852&rft.au=Jaeken+J&rft.au=Martens+K&rft.au=Francois+I&rft.au=Eyskens,+François&rft.au=Lecointre,+Claudine&rft.au=Derua,+Rita&rft.au=Meulemans,+Sandra&rft.au=Slootstra,+Jerry+W.&rft.au=Waelkens,+Etienne&rft_id=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1380222&rfr_id=info:sid/en.wikipedia.org:PREPL" class="Z3988">

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

|

* v
* t
* e

*[v]: View this template
*[t]: Discuss this template
*[e]: Edit this template