PhSeZn-halides

PhSeZn-halides (Santi's reagent)

PhSeZn-halides (Santi's reagent) is a class of chemical compounds with general formula PhSeZnX (X = Cl, Br). This is the first example of bench stable zinc selenolates with a remarkable nucleophilic reactivity under on-water conditions. The synthesis and application of these reagents were first reported by Dr. Claudio Santi of the University of Perugia in 2008.[1] In 2016, the lead compound (PhSeZnCl) becomes commercially available.[2]

## Laboratory preparation

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PhSeX + Zn → PhSeZnX[3]

## References

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1. ^ Santi C., Santoro S., Battistelli B., Testaferri L., Tiecco, M. Preparation of the First Bench‐Stable Phenyl Selenolate: an Interesting “On Water” Nucleophilic Reagent. Eur. J. Org. Chem. 2008, 5387–5390 https://onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.200800869
2. ^ "Phenylselenozinc chloride 766089". Sigma-Aldrich.
3. ^ Santi, C. (15 September 2011). "Phenylselenenylzinc Halides". Encyclopedia of Reagents for Organic Synthesis. John Wiley & Sons, Ltd. doi:10.1002/047084289x.rn01352. ISBN 978-0471936237.