Plague of Justinian

541–549 AD in the Byzantine Empire, later northern Europe

This article is about the first episode of the First Plague Pandemic, 541–549. For the series of plague pandemics, 541–767, see First plague pandemic.

Plague of Justinian

Saint Sebastian pleads with Jesus for the life of a gravedigger afflicted during the plague of Justinian. (Josse Lieferinxe, c. 1497–1499)

Disease| Bubonic plague
Location| Mediterranean basin, Europe, Near East
Date| 541–549

Deaths

| 15 million – 100 million (estimated)
A characteristic of Yersinia pestis infection is necrosis of the hand. (photo from 1975 plague victim) A map of the Byzantine Empire in 550 (a decade after the Plague of Justinian) with Justinian's conquests shown in green

The plague of Justinian or Justinianic plague (AD 541–549) was an epidemic that afflicted the entire Mediterranean Basin, Europe, and the Near East, severely affecting the Sasanian Empire and the Byzantine Empire, especially Constantinople.[1][2][3] The plague is named for the Byzantine Emperor Justinian I (r. 527–565), who according to his court historian Procopius contracted the disease and recovered in 542, at the height of the epidemic which killed about a fifth of the population in the imperial capital.[1][2] The contagion arrived in Roman Egypt in 541, spread around the Mediterranean Sea until 544, and persisted in Northern Europe and the Arabian Peninsula until 549. By 543, the plague had spread to every corner of the empire.[4][1] As the first episode of the first plague pandemic, it had profound economic, social, and political effects across Europe and the Near East and cultural and religious impact on Eastern Roman society.[5]

In 2013, researchers confirmed earlier speculation that the cause of the plague of Justinian was Yersinia pestis, the same bacterium responsible for the Black Death (1346–1353).[6] Ancient and modern Yersinia pestis strains are closely related to the ancestor of the Justinian plague strain that has been found in the Tian Shan, a system of mountain ranges on the borders of Kyrgyzstan, Kazakhstan, and China, suggesting that the Justinian plague originated in or near that region.[7][8] However, there would appear to be no mention of bubonic plague in China until the year 610.[9]

## History

[edit]

Incomplete basilica in Philippi; its construction is believed to have been halted by the plague of Justinian.

The Byzantine historian Procopius first reported the epidemic in 541 from the port of Pelusium, near Suez in Egypt.[10] Two other first hand reports of the plague's ravages were by the Syriac church historian John of Ephesus[11] and Evagrius Scholasticus, who was a child in Antioch at the time and later became a church historian. Evagrius was afflicted with the buboes associated with the disease but survived. During the disease's four returns in his lifetime, he lost his wife, a daughter and her child, other children, most of his servants and people from his country estate.[12]

According to contemporary sources, the outbreak in Constantinople was thought to have been carried to the city by infected rats on grain ships arriving from Egypt.[10][13] To feed its citizens, the city and outlying communities imported large amounts of grain, mostly from Egypt. The rat population in Egypt thrived on feeding from the large granaries maintained by the government, and the fleas thrived as well.[citation needed]

Procopius,[14] in a passage closely modelled on Thucydides, recorded that at its peak the plague was killing 10,000 people in Constantinople daily, but the accuracy of the figure is in question, and the true number will probably never be known. He noted that because there was no room to bury the dead, bodies were left stacked in the open. Funeral rites were often left unattended to, and the entire city smelled like the dead.[15] Given such circumstances, it is highly probable that a sudden increase in mortality rates may not have been as accurately recorded, hence why the overall death toll is based on an estimate.[16] In his Secret History, he records the devastation in the countryside and reports the ruthless response by the hard-pressed Justinian:

> When pestilence swept through the whole known world and notably the Roman Empire, wiping out most of the farming community and of necessity leaving a trail of desolation in its wake, Justinian showed no mercy towards the ruined freeholders. Even then, he did not refrain from demanding the annual tax, not only the amount at which he assessed each individual, but also the amount for which his deceased neighbors were liable.[17]

As a result of the plague in the countryside, farmers could not take care of crops and the price of grain rose in Constantinople. Justinian had expended huge amounts of money for wars against the Vandals in the region of Carthage and the Ostrogoths' kingdom in Italy. He had invested heavily in the construction of great churches, such as Hagia Sophia. As the empire tried to fund the projects, the plague caused tax revenues to decline through the massive number of deaths and the disruption of agriculture and trade. Justinian swiftly enacted new legislation to deal more efficiently with the glut of inheritance suits being brought as a result of victims dying intestate.[18]

The plague's long-term effects on European and Christian history were enormous. As the disease spread to port cities around the Mediterranean, the struggling Goths were reinvigorated and their conflict with Constantinople entered a new phase. The plague weakened the Byzantine Empire at a critical point, when Justinian's armies had nearly retaken all of Italy and the western Mediterranean coast; the evolving conquest would have reunited the core of the Western Roman Empire with the Eastern Roman Empire. Although the conquest occurred in 554, the reunification did not last long. In 568, the Lombards invaded Northern Italy, defeated the small Byzantine army that had been left behind and established the Kingdom of the Lombards.[10][19]

Gaul is known to have suffered severely from the plague,[20] and plague victims at an early Anglo-Saxon burial site at Edix Hill near Cambridge show that it also reached Britain.[21]

### Onset of the first plague pandemic

[edit]

Main article: First plague pandemic

The Plague of Justinian is the first and the best known outbreak of the first plague pandemic, which continued to recur until the middle of the 8th century.[1][22] Some historians believe the first plague pandemic was one of the deadliest pandemics in history, resulting in the deaths of an estimated 15–100 million people during two centuries of recurrence, a death toll equivalent to 25–60% of Europe's population at the time of the first outbreak.[23][24][25][26] Research published in 2019 argued that the 200-year-long pandemic's death toll and social effects have been exaggerated, comparing it to the modern third plague pandemic (1855–1960s).[23][27] Furthermore, historians seek to play down the effects of the late-antique bubonic plague, arguing that our eyewitness accounts of the disease are hysterical in tone and misleading in effect.[28]

## Epidemiology

[edit]

### Genetics of the Justinian plague strain

[edit]

The plague of Justinian is generally regarded as the first historically recorded epidemic of Yersinia pestis.[29][30] This conclusion is based on historical descriptions of the clinical manifestations of the disease[31] and the detection of Y. pestis DNA from human remains at ancient grave sites dated to that period.[32][33]

Genetic studies of modern and ancient Yersinia pestis DNA suggest that the origin of the Justinian plague was in Central Asia. The most basal or root level existing strains of the Yersinia pestis as a whole species are found in Qinghai, China.[34] Other scholars contest that, rather than Central Asia, the specific strain that composed the Justinian plague began in sub-Saharan Africa, and that the plague was spread to the Mediterranean by merchants from the Kingdom of Aksum in East Africa. This point of origin aligns more with the general south–north spread of the disease from Egypt into the rest of the Mediterranean world. It also explains why Sassanid Persia saw a later development of the outbreak despite stronger trade links with Central Asia.[35][36][37][38] After samples of DNA from Yersinia pestis were isolated from skeletons of Justinian plague victims in Germany,[39] it was found that modern strains currently found in the Tian Shan mountain range system are most basal known in comparison with the Justinian plague strain.[7] Additionally, a skeleton found in Tian Shan dating to around 180 AD and identified as an "early Hun" was found to contain DNA from Yersinia pestis closely related to the Tian Shan strain basal ancestor of the Justinian plague strain German samples.[8] This finding suggests that the expansion of nomadic peoples who moved across the Eurasian steppe, such as the Xiongnu and the later Huns, had a role in spreading plague to West Eurasia from an origin in Central Asia.[8]

Earlier samples of Yersinia pestis DNA have been found in skeletons dating from 3000 to 800 BC, across West and East Eurasia.[40] The strain of Yersinia pestis responsible for the Black Death, the devastating pandemic of bubonic plague, does not appear to be a direct descendant of the Justinian plague strain. However, the spread of Justinian plague may have caused the evolutionary radiation that gave rise to the currently extant 0ANT.1 clade of strains.[41][42]

### Virulence and mortality rate

[edit]

The number of deaths is uncertain. Some modern scholars believe that the plague killed up to 5,000 people per day in Constantinople at the peak of the pandemic.[27] According to one view, the initial plague ultimately killed perhaps 40% of the city's inhabitants and caused the deaths of up to a quarter of the human population of the Eastern Mediterranean.[43] Frequent subsequent waves of the plague continued to strike throughout the 6th, 7th and 8th centuries, with the disease becoming more localized and less virulent. [citation needed]

A revisionist view expressed by scholars such as Lee Mordechai and Merle Eisenberg argues that the mortality of the Justinian Plague was far lower than previously believed. They say that the plague might have caused high mortality in specific places, but it did not cause widespread demographic decline or decimate Mediterranean populations. According to them, any direct mid-to-long term effects of plague were minor.[27] However, their position has been the subject of a concerted critique by Peter Sarris. Sarris challenged both their core methodology and their handling of the sources. Sarris also provides up-to-date discussion of the genetic evidence, including the suggestion that the plague may have entered Western Eurasia via more than one route, and perhaps struck England before Constantinople.[21]

## See also

[edit]

* List of epidemics
* Medieval demography
* Plague of Amwas
* The volcanic winter of 536

## Notes

[edit]

1. ^ a b c d Stathakopoulos, Dionysios (2018), "Plague, Justinianic (Early Medieval Pandemic)", The Oxford Dictionary of Late Antiquity, Oxford University Press, doi:10.1093/acref/9780198662778.001.0001, ISBN 978-0-19-866277-8, retrieved 2020-05-16
2. ^ a b Arrizabalaga, Jon (2010), Bjork, Robert E. (ed.), "plague and epidemics", The Oxford Dictionary of the Middle Ages, Oxford University Press, doi:10.1093/acref/9780198662624.001.0001, ISBN 978-0-19-866262-4, retrieved 2020-05-16
3. ^ Floor, Willem (2018). Studies in the History of Medicine in Iran. Costa Mesa, California: Mazda Publishers. p. 3\. ISBN 978-1933823942. "The Justinian plague (bubonic plague) also attacked the Sasanian lands."
4. ^ Meier, Mischa (August 2016). "The Justianic Plague: The economic consequences of the pandemic in the Eastern Roman empire and its cultural and religious effects". Early Medieval Europe. 24 (3): 267–292. doi:10.1111/emed.12152. S2CID 163966072.
5. ^ Gârdan, Gabriel-Viorel (2020). ""The Justinianic Plague": The Effects of a Pandemic in Late Antiquity and the Early Middle Ages". Romanian Journal of Artistic Creativity. 8 (4): 3–18. Retrieved 26 January 2023.
6. ^ "Modern lab reaches across the ages to resolve plague DNA debate". phys.org. May 20, 2013.
* Maria Cheng (January 28, 2014). "Plague DNA found in ancient teeth shows medieval Black Death, 1,500-year pandemic caused by same disease". National Post.
7. ^ a b Eroshenko, Galina A.; et al. (October 26, 2017). "Yersinia pestis strains of ancient phylogenetic branch 0.ANT are widely spread in the high-mountain plague foci of Kyrgyzstan". PLOS ONE. 12 (10): e0187230. Bibcode:2017PLoSO..1287230E. doi:10.1371/journal.pone.0187230. PMC 5658180. PMID 29073248.
8. ^ a b c Damgaard, Peter de B.; et al. (May 9, 2018). "137 ancient human genomes from across the Eurasian steppes". Nature. 557 (7705): 369–374. Bibcode:2018Natur.557..369D. doi:10.1038/s41586-018-0094-2. hdl:1887/3202709. PMID 29743675. S2CID 13670282.
9. ^ Sarris, Peter (August 2002). "The Justinianic plague: origins and effects" (PDF). Continuity and Change. 17 (2): 171. doi:10.1017/S0268416002004137. S2CID 144954310. Retrieved 7 December 2023.
10. ^ a b c Wade, Nicholas (October 31, 2010). "Europe's Plagues Came From China, Study Finds". The New York Times. New York City. Retrieved November 1, 2010.
11. ^ John of Ephesus, Ecclesiastical History, part 2. Translation of relevant portions here.
12. ^ Evagrius, Historia Ecclesiae, IV.29.
13. ^ Eiland, Murray (2022). "Networks of Rome, Byzantium, and China". Antiqvvs. 4 (1). Interview with Johannes Preiser-Kapeller: 44.
14. ^ Procopius, Persian War II.22–23.
15. ^ Procopius: The Plague, 542
16. ^ Sarris, Peter (August 2002). "The Justinianic plague: origins and effects" (PDF). Continuity and Change. 17 (2): 174. doi:10.1017/S0268416002004137. S2CID 144954310. Retrieved 8 December 2023.
17. ^ Procopius, Anekdota, 23.20f.
18. ^ Justinian, Edict IX.3; J. Moorhead 1994; Averil Cameron, The Mediterranean World in Late Antiquity, AD 395–600, 1993:111.
19. ^ Rosen, William (2007). Justinian's Flea: Plague, Empire, and the Birth of Europe. New York City: Viking Adult. pp. 321–322. ISBN 978-0-670-03855-8.
20. ^ Charles-Edwards, T. M. (2013). Wales and the Britons 350–1064. Oxford, UK: Oxford University Press. p. 216\. ISBN 978-0-19-821731-2.
21. ^ a b Sarris, Peter (November 13, 2021). "Viewpoint New Approaches to the 'Plague of Justinian'". Past & Present. 254 (1). Oxford University Press: 315–346. doi:10.1093/pastj/gtab024.
22. ^ Eisenberg, Merle; Mordechai, Lee (December 2020). "The Justinianic Plague and Global Pandemics: The Making of the Plague Concept". The American Historical Review. 125 (5): 1632–1667. doi:10.1093/ahr/rhaa510.
23. ^ a b Mordechai, Lee; Eisenberg, Merle; Newfield, Timothy P.; Izdebski, Adam; Kay, Janet E.; Poinar, Hendrik (2019-12-17). "The Justinianic Plague: An inconsequential pandemic?". Proceedings of the National Academy of Sciences. 116 (51): 25546–25554. Bibcode:2019PNAS..11625546M. doi:10.1073/pnas.1903797116. ISSN 0027-8424. PMC 6926030. PMID 31792176.
24. ^ Maugh, Thomas. "An Empire's Epidemic". www.ph.ucla.edu. Retrieved 20 March 2020.
25. ^ Rosen, William (2007). Justinian's Flea: Plague, Empire, and the Birth of Europe. New York City: Viking Adult. p. 3\. ISBN 978-0-670-03855-8.
26. ^ "The Plague of Justinian". History Magazine. 11 (1): 9–12. 2009.
27. ^ a b c Mordechai, Lee; Eisenberg, Merle (August 1, 2019). "Rejecting Catastrophe: The Case of the Justinianic Plague". Past & Present. 244 (1). Oxfordshire, England: Oxford University Press: 46. doi:10.1093/pastj/gtz009. ISSN 0031-2746.
28. ^ Sarris, Peter (August 2002). "The Justinianic plague: origins and effects" (PDF). Continuity and Change. 17 (2): 173. doi:10.1017/S0268416002004137. S2CID 144954310. Retrieved 2023-12-08.
29. ^ Russell, Josiah C. (1968). "That earlier plague". Demography. 5. Ashburn, Virginia: Springer: 174–184. doi:10.1007/bf03208570. S2CID 46979303.
30. ^ "Justinian's Plague (541-542 CE)". World History Encyclopedia.
31. ^ Procopius, History of the Wars, 7 Vols., trans. H. B. Dewing, Loeb Library of the Greek and Roman Classics, (Cambridge, Mass.: Harvard University Press, 1914), Vol. I, pp. 451–473.
32. ^ Wiechmann I, Grupe G. Detection of Yersinia pestis DNA in two early medieval skeletal finds from Aschheim (Upper Bavaria, 6th century A.D.)" Am J Phys Anthropol 2005 Jan;126(1) 48–55
33. ^ Harbeck, Michaela; Seifert, Lisa; Hänsch, Stephanie; Wagner, David M.; Birdsell, Dawn; Parise, Katy L.; Wiechmann, Ingrid; Grupe, Gisela; Thomas, Astrid; Keim, P; Zöller, L; Bramanti, B; Riehm, JM; Scholz, HC (2013). Besansky, Nora J (ed.). "Yersinia pestis DNA from Skeletal Remains from the 6th Century AD Reveals Insights into Justinianic Plague". PLOS Pathogens. 9 (5): e1003349. doi:10.1371/journal.ppat.1003349. PMC 3642051. PMID 23658525.
34. ^ Morelli, Giovanna; et al. (October 31, 2010). "Yersinia pestis genome sequencing identifies patterns of global phylogenetic diversity". Nature Genetics. 42 (12): 1140–1143. doi:10.1038/ng.705. PMC 2999892. PMID 21037571.
35. ^ Yohannes Gebre Selassie (2011), Plague as a Possible Factor for the Decline and Collapse of the Aksumite Empire: a New Interpretation, Northeast African Journal of Social Sciences
36. ^ Peter Sarris (2007), "Bubonic Plague in Byzantium: The Evidence of Non-Literary Sources", in Lester K. Little (ed.), Plague and the End of Antiquity: The Pandemic of 541–750, Cambridge University Press, pp. 119–132, at 121–123
37. ^ Michael McCormick (2007), "Toward a Molecular History of the Justinianic Pandemic", in Lester K. Little (ed.), Plague and the End of Antiquity: The Pandemic of 541–750, Cambridge University Press, pp. 290–312, at 303–304.
38. ^ Sarris, Peter (August 2002). "The Justinianic plague: origins and effects" (PDF). Continuity and Change. 17 (2): 173. doi:10.1017/S0268416002004137. S2CID 144954310. Retrieved 2023-12-08.
39. ^ Wagner, David M.; et al. (April 2014). "Yersinia pestis and the Plague of Justinian 541–543 AD: a genomic analysis". The Lancet. 14 (4): 319–326. doi:10.1016/S1473-3099(13)70323-2. PMID 24480148.
40. ^ Rasmussen, Simon; et al. (October 22, 2015). "Early Divergent Strains of Yersinia pestis in Eurasia 5,000 Years Ago". Cell. 163 (3): 571–582. doi:10.1016/j.cell.2015.10.009. PMC 4644222. PMID 26496604.
41. ^ McGrath, Matt (12 October 2011). "Black Death Genetic Code 'Built'". BBC World Service. Retrieved 12 October 2011.
42. ^ Bos, Kirsten; Schuenemann, Verena J.; Golding, G. Brian; Burbano, Hernán A.; Waglechner, Nicholas; Coombes, Brian K.; McPhee, Joseph B.; Dewitte, Sharon N.; Meyer, Matthias; Schmedes, Sarah; Wood, James; Earn, David J. D.; Herring, D. Ann; Bauer, Peter; Poinar, Hendrik N.; Krause, Johannes (12 October 2011). "A draft genome of Yersinia pestis from victims of the Black Death". Nature. 478 (7370): 506–510. Bibcode:2011Natur.478..506B. doi:10.1038/nature10549. PMC 3690193. PMID 21993626.
43. ^ Cyril A. Mango (1980). Byzantium: The Empire of New Rome. emphasizes the demographic effects; Mark Whittow (1990). "Ruling the late Roman and Byzantine city". Past and Present (33). argues against too great reliance on literary sources.

## Sources

[edit]

* Charles-Edwards, T. M. (2013). Wales and the Britons 350–1064. Oxford, UK: Oxford University Press. ISBN 978-0-19-821731-2.
* Harbeck, M; Seifert, L; Hänsch, S; Wagner, DM; Birdsell, D; et al. (2013). "Yersinia pestis DNA from Skeletal Remains from the 6th Century AD Reveals Insights into Justinianic Plague". PLOS Pathog. 9 (5): e1003349. doi:10.1371/journal.ppat.1003349. PMC 3642051. PMID 23658525.
* Little, Lester K., ed. (2006). Plague and the End of Antiquity: The Pandemic of 541–750. Cambridge University Press. ISBN 978-0-521-84639-4.
* Moorhead, J. (1994). Justinian.
* Mordechai, Lee, and Merle Eisenberg. 2019. "Rejecting Catastrophe: the case of the Justinianic Plague." Past & Present
* Mordechai, L; Eisenberg M; Newfield T; Izdebski A; Kay Janet; Poinar H. (2019). "The Justinianic Plague: An inconsequential pandemic?", PNAS https://doi.org/10.1073/pnas.1903797116.
* Procopius. History of the Wars, Books I and II (The Persian War). Trans. H. B. Dewing. Vol. 1. Cambridge: Loeb-Harvard UP, 1954.—Chapters XXII and XXIII of Book II (pages 451–473) are Procopius's famous description of the Plague of Justinian. This includes the famous statistic of 10,000 people per day dying in Constantinople (page 465).

## Further reading

[edit]

* Drancourt, M; Roux, V; Dang, LV; Tran-Hung, L; Castex, D; Chenal-Francisque, V; et al. (2004). "Genotyping, Orientalis-like Yersinia pestis, and plague pandemics". Emerging Infectious Diseases. 10 (9): 1585–1592. doi:10.3201/eid1009.030933. PMC 3320270. PMID 15498160.
* Eisenberg, Merle, and Lee Mordechai. "The Justinianic Plague and Global Pandemics: The Making of the Plague Concept." American Historical Review 125.5 (2020): 1632–1667.
* McNeill, William H. (1976). Plagues and Peoples. New York: Bantam Doubleday Dell. ISBN 978-0-385-12122-4.
* Orent, Wendy (2004). Plague, The Mysterious Past and Terrifying Future of the World's Most Dangerous Disease. New York: Simon & Schuster. ISBN 978-0-7432-3685-0.
* Russell, J. C. (1958). "Late Ancient and Medieval Population". Transactions of the American Philosophical Society. New Series. 48 (3): 71–99. doi:10.2307/1005708. JSTOR 1005708.
* Sarris, Peter (13 November 2021). "New Approaches to the 'Plague of Justinian'". Past & Present. doi:10.1093/pastj/gtab024.
* Schindel, Nikolaus (2022). "The Justinianic Plague and Sasanian Iran: the Numismatic Evidence". Sasanian Studies: Late Antique Iranian World. 1 (1): 259–276. doi:10.13173/SSt.1.259. S2CID 244880937.

* v
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Pandemics, epidemics and notable disease outbreaks

* List of epidemics and pandemics

Local|

| Ancient|

* Hittite plague (c. 1330 BC)
* Plague of Athens (429–426 BC)
* Antonine Plague (165–180 AD)
* Plague of Cyprian (250–266)

|

Post-
classical|

* Plague of Justinian (541–542)
* Roman Plague (590)
* Plague of Sheroe (627–628)
* Plague of Amwas (638–639)
* Plague of 664 (664–689)
* Japanese smallpox (735–737)
* Black Death (1346–1353)
* Sweating sickness (1485–1551)

Early
modern|

| 16th century|

* Influenza pandemic (1510)
* Mexican smallpox (1520)
* "Cocoliztli" epidemics in colonial Mexico (1545, 1576)
* Influenza pandemic (1557–1559)
* London plague (1563–1564)
* Maltese plague (1592–1593)
* London plague (1592–1593)

|

17th century|

* London plague (1603)
* Maltese plague (1623)
* Italian plague (1629–1631)
* Massachusetts smallpox (1633)
* Great Plague in the late Ming dynasty (1633–1644)
* Great Plague of Seville (1647–1652)
* Maltese plague (1655)
* Naples Plague (1656)
* Great Plague of London (1665–1666)
* Maltese plague (1675–1676)
* Great Plague of Vienna (1679)

18th century|

* Iceland smallpox epidemic (1707–1708)
* Great Northern War plague (1710–1712)
* Great Plague of Marseille (1720–1722)
* Great Plague of 1738 (1738)
* Russian plague (1770–1772)
* Persian Plague (1772)
* North American smallpox (1780–1782)
* Philadelphia yellow fever (1793–1798)

Modern|

| 19th century|

* Ottoman plague (1812–1819)
* Maltese plague (1813–1814)
* Caragea's plague (1813)
* Groningen epidemic (1829)
* Great Plains smallpox (1837–1838)
* Typhus (1847–1848)
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* Guam smallpox (1856)
* Pacific Northwest smallpox (1862–1863)
* Barcelona yellow fever (1870)
* Buenos Aires yellow fever (1871)
* Hong Kong plague (1894)

|

20th century|

* San Francisco plague (1900–1904)
* Manchurian plague (1910–1911)
* LA pneumonic plague (1924)
* Croydon typhoid (1937)
* NYC smallpox (1947)
* Wrocław smallpox (1963)
* Yugoslav smallpox (1972)
* London flu (1972–1973)
* Indian smallpox (1974)
* Surat plague (1994)
* Malaysian Nipah virus (1998–1999)

21st century|

* SARS (2002–2004)
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* Pakistani dengue (2011)
* Darfur yellow fever (2012)
* MERS (2012)
* Singaporean dengue (2013)
* Swansea measles (2013)
* Chikungunya (2013–2014)
* Western African Ebola (2013–2016)
* DR Congo Ebola (2014)
* Madagascar plague (2014)
* Odisha hepatitis (2014)
* Polio declaration (2014)
* Indian swine flu (2015)
* South Korean MERS (2015)
* Zika (2015–2016)
* Angolan yellow fever (2016)
* Yemeni cholera (2016–2022)
* Gorakhpur Japanese encephalitis (2017)
* Saudi Arabian MERS (2018)
* Kerala Nipah virus (2018)
* Équateur province Ebola (2018)
* Kivu Ebola (2018–2020)
* Madagascar measles (2018)
* Samoa measles (2019)
* Philippine measles (2019)
* Pacific NW measles (2019)
* New York measles (2019)
* Kuala Koh measles (2019)
* Tonga measles (2019)
* DRC measles (2019–2020)
* New Zealand measles (2019–2020)
* Singaporean dengue (2020)
* Uganda Ebola (2022–2023)
* Jamaica dengue (2023)
* Bangsamoro measles (2023–present)
* 2024 Latin American dengue
* Argentina (2024)

Global|

* First plague pandemic (541–767)
* Second plague pandemic (1348–19th century)
* Influenza pandemic (1510)
* Influenza pandemic (1557–1559)
* First cholera pandemic (1816–1826)
* Second cholera pandemic (1829–1851)
* Third cholera pandemic (1852–1860)
* Third plague pandemic (1855–1860)
* Fourth cholera pandemic (1863–1879)
* Fifth cholera pandemic (1881–1896)
* Russian flu (1889–1890)
* Sixth cholera pandemic (1899–1923)
* Spanish flu (1918–1920)
* encephalitis lethargica epidemic (1919–1930)
* Asian flu (1957–1958)
* Seventh cholera pandemic (1961–1975)
* Hong Kong flu (1968–1970)
* Russian flu pandemic (1977–1979)
* HIV/AIDS (1981–present)
* Swine flu (2009–2010)
* COVID-19 (2019–present*)
* Mpox (clade II) outbreak (2022–2023)
* Mpox (clade Ib) epidemic (2023–2024)

Authority control databases: National |

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