Poly(adp-ribose) polymerase family member 14

Protein-coding gene in the species Homo sapiens

PARP14

| Available structures

PDB| Ortholog search: PDBe RCSB
| List of PDB id codes

3GOY, 3Q6Z, 3Q71, 3SE2, 3SMI, 3SMJ, 3VFQ, 4ABK, 4ABL, 4D86, 4F1L, 4F1Q, 4PY4

Identifiers
Aliases| PARP14, ARTD8, BAL2, PARP-14, pART8, poly(ADP-ribose) polymerase family member 14
External IDs| OMIM: 610028 MGI: 1919489 HomoloGene: 19697 GeneCards: PARP14
| Gene location (Human)

Chr.| Chromosome 3 (human)[1]

Band| 3q21.1| Start| 122,680,839 bp[1]
End| 122,730,840 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 16 (mouse)[2]

Band| 16|16 B3| Start| 35,653,244 bp[2]
End| 35,691,914 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* sural nerve

* Achilles tendon

* monocyte

* spleen

* appendix

* lymph node

* upper lobe of left lung

* bone marrow cells

* right lung

* trigeminal ganglion

| Top expressed in

* intestinal villus

* Paneth cell

* lymph node

* jejunum

* mucous cell of stomach

* conjunctival fornix

* ileum

* subcutaneous adipose tissue

* carotid body

* blood

More reference expression data
BioGPS| | n/a

| Gene ontology

Molecular function|

* transferase activity
* glycosyltransferase activity
* RNA binding
* protein binding
* NAD+ binding
* NAD+ ADP-ribosyltransferase activity
* enzyme binding
* protein ADP-ribosylase activity

Cellular component|

* membrane
* nucleus
* cytosol
* cytoplasm

Biological process|

* regulation of transcription, DNA-templated
* transcription, DNA-templated
* protein poly-ADP-ribosylation
* protein ADP-ribosylation
* negative regulation of gene expression
* positive regulation of tyrosine phosphorylation of STAT protein
* negative regulation of tyrosine phosphorylation of STAT protein
* negative regulation of interferon-gamma-mediated signaling pathway
* positive regulation of interleukin-4-mediated signaling pathway
* immune system process
* innate immune response
* protein mono-ADP-ribosylation

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

54625

547253

Ensembl| |

ENSG00000173193

ENSMUSG00000034422

UniProt| |

Q460N5
Q8N546

Q2EMV9

RefSeq (mRNA)| |

NM_017554

NM_001039530

RefSeq (protein)| |

NP_060024
NP_060024.2

NP_001034619

Location (UCSC)| Chr 3: 122.68 – 122.73 Mb| Chr 16: 35.65 – 35.69 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Poly(ADP-ribose) polymerase family member 14 is a protein that, in humans, is encoded by the PARP14 gene. [5]

## Function[edit]

Poly(ADP-ribosyl)ation is an immediate DNA damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP14 belongs to the superfamily of enzymes that perform this modification (Ame et al., 2004 [PubMed 15273990]).

## References[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173193 \- Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034422 \- Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: Poly(ADP-ribose) polymerase family member 14". Retrieved 2016-03-02.

## Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

|

* v
* t
* e

* v
* t
* e

DNA repair

Excision repair|

* Base excision repair/AP site
* DNA glycosylase
* Uracil-DNA glycosylase
* Poly ADP ribose polymerase
* Nucleotide excision repair/ERCC
* XPA
* XPB
* XPC
* XPD/ERCC2
* XPE/DDB1
* XPF/DDB1
* XPG/ERCC5
* ERCC1
* RPA
* RAD23A
* RAD23B
* Excinuclease
* DNA mismatch repair
* MLH1
* MSH2

Other forms of repair|

* Transcription-coupled repair
* ERCC6
* ERCC8
* Homology directed repair
* Non-homologous end joining
* Ku
* Microhomology-mediated end joining
* Postreplication repair
* Photolyase
* CRY1
* CRY2

Other/ungrouped proteins|

* Ogt
* PcrA
* Proliferating Cell Nuclear Antigen
* Homologous recombination
* RecA/RAD51
* Sgs1
* Slx4

Regulation|

* SOS box
* SOS response

Other/ungrouped|

* 8-Oxoguanine
* Adaptive response
* Meiotic recombination checkpoint
* RecF pathway

* DNA helicase: BLM
* WRN

* FANC proteins: core protein complex
* FANCA
* FANCB
* FANCC
* FANCE
* FANCF
* FANCG
* FANCL
* FANCM
* FANCD1
* FANCD2
* FANCI
* FANCJ
* FANCN

* Category
* Commons

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