Poppers

Class of recreational drug

For other uses, see Popper (disambiguation).

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|

Pharmaceutical compound

Poppers

A selection of over-the-counter poppers on display

Clinical data
Other names| popper, poppe, pops
Routes of
administration| Inhalation
Drug class| Vasodilator
Legal status
Legal status|

* AU: S4 (Prescription only) in general; some exceptions[1]
* Elsewhere, usually available OTC

Pharmacokinetic data
Bioavailability| When inhaled,

* Amyl nitrite: unknown
* Isopropyl nitrite: 43%
* Isobutyl nitrite: unknown

Metabolism| Liver
Metabolites|

* Amyl nitrite: pentanol (amyl alcohol)
* Isopropyl nitrite: isopropanol
* Isobutyl nitrite: isobutanol

Onset of action| 15 seconds
Elimination half-life| Suspected to be minutes to less than an hour
Duration of action| 30 seconds to 5 minutes
Excretion| Primarily urine
Chemical and physical data
Formula|  Depends on primary active ingredient
Molar mass|  Depends on primary active ingredient
Boiling point| Depends on primary active ingredient

Poppers are recreational drugs belonging to the alkyl nitrite family of chemical compounds. When fumes from these substances are inhaled, they act as potent vasodilators, producing mild euphoria, warmth, and dizziness. Most effects have a rapid onset and are short-acting.[2] Its recreational use is believed to be potentially dangerous for people with heart problems, anaemia, or glaucoma. Reported adverse effects include fainting, retinal toxicity, and vision loss.[3][4]

As poppers include a broad range of chemical types, their legality differs across different jurisdictions. They are often packaged under the guise of room deodorizer, leather polish, nail polish remover, or videotape head cleaner to evade anti-drug laws.[2]

The term poppers comes from the popping sound made when glass vials of the substance were crushed to release the vapors for inhalation. Amyl nitrite was originally prescribed in the late 1800s for the medical management of angina.[2] Many analogues exist, such as isoamyl nitrite, isopentyl nitrite, isopropyl nitrite, and isobutyl nitrite. These substances are subject to different regulations; for example, isobutyl nitrite is banned in the European Union.

Poppers act as muscle relaxants, causing the relaxation of involuntary smooth muscles such as the throat and anus.[5][6] Such physiological effects, along with others (such as mild euphoria), have resulted in poppers being used as recreational drugs, sometimes during sexual intercourse, as the effects can heighten arousal and help facilitate acts such as anal intercourse.[7] Poppers were a part of the club culture which began during the mid-1970s disco scene, and surged in popularity during the rave scene of the 1980s and 1990s.[8][9]

## Administration and effects

[edit]

A selection of poppers

### Administration

[edit]

Poppers come in liquid form, but this liquid is not directly consumed. When the bottle is opened, the vapors are inhaled, rather than the liquid. This is typically done through the nasal cavities, commonly directly from the bottle (avoiding touching the bottle to the skin) or with the help of small inhalers.

### Effects

[edit]

#### Physiological effects

[edit]

Inhaling nitrites produces a fast-acting, short-lived and non-specific relaxation of smooth muscles (along with the sphincter muscles of the anus and the vagina).[10] Blood vessels are surrounded by smooth musculature, which directly influences blood pressure by increasing or decreasing its inward pressure on the blood vessels.

With relaxation of the smooth muscles, the 'inward' pressure on the blood vessels decreases and they dilate, resulting in a drop in blood pressure and an immediate (compensatory) increase in heart rate (reflex tachycardia). Vasodilation may cause giddiness, dizziness, headache, nausea, vomiting and flushing, and may produce a sensation of heat and excitement. Maximum vasodilatory effect is usually reached within 30 seconds, with (secondary) physiological effects lasting for 5 to 10 minutes.[11][12][13][14]

#### Psychological effects

[edit]

Inhaling nitrites produces several psychological effects such as euphoria, increased sensual awareness, lowered inhibitions or increased confidence, and potential for impaired judgement and disorientation.[12]

## Interactions

[edit]

### Vasodilators

[edit]

Addiction experts in psychiatry, chemistry, pharmacology, forensic science, epidemiology, and the police and legal services engaged in delphic analysis regarding 20 popular recreational drugs. Alkyl nitrites were ranked 20th in social and physical harm, and 18th in dependence.[15]

Alkyl nitrites interact with other vasodilators, such as sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis), to cause a serious decrease in blood pressure, which can cause strokes, and low blood pressure leading to people fainting.[16] Side effects of popper abuse include tachycardia, headaches, migraines, dizziness and fainting.[17]

### Toxicity

[edit]

The Merck Manual of Diagnosis and Therapy reports insignificant hazard associated with inhalation of alkyl nitrites,[18] and British governmental guidance on the relative harmfulness of alkyl nitrites places them among the less harmful of recreational drugs.[19]

If in contact with the skin, butyl nitrite poppers can cause chemical burns and contact dermatitis of the skin around the mouth and nose.[20]

Swallowing poppers (rather than inhaling the vapour) may cause cyanosis, methemoglobinemia, unconsciousness, coma, and complications leading to death.[10][21][22][23][24] Accidental aspiration of amyl or butyl nitrites may cause lipoid pneumonia.[25]

#### Isopropyl nitrite

[edit]

Isopropyl nitrite poppers may be a cause of maculopathy (eye damage), as reported in France and the United Kingdom.[26] Some studies have concluded that there may be increased risk for at least temporary retinal damage with habitual popper use in certain users; in a letter to the New England Journal of Medicine,[27] an ophthalmologist described four cases in which recreational users of isopropyl nitrite poppers suffered temporary changes in vision.[28] In November 2014, it was observed maculopathy is a rare complication of isopropyl nitrite abuse. A full recovery of visual acuity in longterm abuse could be demonstrated after drug abstinence.[29] Studies have shown that poppers users who have HIV and/or use Sildenafil in combination with poppers are at an increased risk of developing poppers‐associated maculopathy.[30]

Foveal (center-of-gaze) damage has also been described, in six habitual users of isopropyl nitrite poppers.[31] Furthermore, in June 2014, optometrists and ophthalmologists reported having noticed an increase in vision loss in chronic popper users in the United Kingdom associated with isopropyl nitrite (substitute for isobutyl nitrite which was banned in 2007).[32][33]

#### Isobutyl nitrite

[edit]

A working group in 2019 from the International Agency for Research on Cancer determined there to be "sufficient evidence" to suggest carcinogenic properties of isobutyl nitrite on experimental animals, and because they could not find any sufficient studies regarding its carcinogenic effects on humans, they determined that isobutyl nitrite is "possibly carcinogenic to humans". The group primarily looked at 2 studies on animals, one on rats and one on mice. Both of these involved the administration of doses of isobutyl nitrite at seemingly low doses (0, 37.5, 75, or 150 ppm) 6 hours a day, 5 days a week, for a total of 103 weeks.[34] This is different from the relatively brief exposure to isobutyl nitrite that inhaling poppers recreationally usually provides. Nonetheless, in the studies there was shown to be no increase in death rates for the animals exposed to isobutyl nitrite, but there was shown to be an increase in tumors in the lungs of the males and females of both species in the groups exposed, as well as in the thyroids of the male mice exposed.[34] Isobutyl Nitrite is no longer sold as 'Poppers' having been banned in the EU since 2007 and banned in the US since 1990.[35]

### Refuted link with HIV/AIDS

[edit]

Early in the AIDS crisis, widespread use of poppers among AIDS patients led to the later disproved hypothesis that poppers contributed to the development of Kaposi's sarcoma, a rare form of cancer that occurs in AIDS patients.[36][37] Modest, short-term reductions in immune function were observed in animal studies, but not replicated in human studies.[38][39]

### Cyanide treatment

[edit]

Amyl nitrites were part of some kits used to treat cyanide poisoning, containing amyl nitrite, sodium nitrite, and sodium thiosulfate. The nitrites were administered to produce methemoglobin and induce vasodilation.[40][41] Amyl nitrites were discontinued in 2012 in standard cyanide kits.[42] Cyanide kits now use hydroxocobalamin.[43]

## Chemistry

[edit]

Main article: Alkyl nitrites

Poppers contain a class of chemicals called alkyl nitrites. To the extent that poppers products contain alkyl nitrites, the following applies.

The following table summarizes alkyl nitrite chemical and physical properties, including chemical structure:[44]

Alkyl nitrite | CAS | Formula | Molecular weight (g·mol−1) | Physical state  | Color | Boiling point

|
|
|
|
|
|

Amyl nitrite (isoamyl nitrite, isopentyl nitrite)  | 110-46-3  | (CH3)2CH(CH2)2ONO | 117.15  | liquid  | yellow[45] | 97–99 °C (207–210 °F)
Pentyl nitrite (n-pentyl nitrite)  | 463-04-7  | CH3(CH2)4ONO  | 117.15  | liquid  | yellow  | 104 °C (219 °F)
Butyl nitrite (n-butyl nitrite)  | 544-16-1  | CH3(CH2)3ONO  | 103.12  | liquid  | yellow  | 78 °C (172 °F)
Isobutyl nitrite (2-methylpropyl nitrite)  | 542-56-3  | (CH3)2CHCH2ONO  | 103.12  | liquid  | colorless (transparent)  | 67 °C (153 °F)
Isopropyl nitrite (2-propyl nitrite)  | 541-42-4  | (CH3)2CHONO  | 89.09  | liquid  | yellow  | 39 °C (102 °F)
Hexyl nitrite | 638-51-7  | CH3(CH2)5ONO  | 131.17  | liquid  | colorless (transparent)  | 130 °C (266 °F)

## History

[edit]

This section needs expansion with: a sourced paragraph on the transition from its use in medicine to its use as a recreational drug. You can help by adding to it. (June 2016)

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### 19th-century discovery

[edit]

The French chemist Antoine Jérôme Balard synthesized amyl nitrite in 1844.[46] Sir Thomas Lauder Brunton, a Scottish physician born in the year of amyl nitrite's first synthesis, documented its clinical use to treat angina pectoris in 1867 when patients experiencing chest pains would experience complete relief after inhalation.[47] Brunton was inspired by earlier work with the same agent, performed by Arthur Gamgee and Benjamin Ward Richardson.[47] Brunton reasoned that the angina sufferer's pain and discomfort could be reduced by administering amyl nitrite—to dilate the coronary arteries of patients, thus improving blood flow to the heart muscle.[47]

Amyl nitrites were originally enclosed in a glass mesh called "pearls". The usual administration of these pearls was done by crushing them between the fingers, followed by a popping sound. This administration process seems to be the origin of the slang term "poppers". It was then administered via direct inhalation of the vapors or inhalation through silk that covered the capsule.

Brunton found that amyl nitrites had effects of dilating blood vessels and flushing of the face. Isobutyl nitrites were also documented around the late 1890s by Brunton and despite being found to have generally the same effects as amyl nitrites, they were never used as a clinical alternative to amyl nitrates. Brunton also found that propyl nitrites had the same effects as well.[48][49]

### 20th century

[edit]

Although amyl nitrite is known for its practical therapeutic applications, the first documented case of recreational use was in 1964.[50][51] The poppers "craze" began in the early 1970s in the gay male community in bars, discothèques and bathhouses.[52][53] It was packaged and sold pharmaceutically in fragile glass ampoules wrapped in cloth sleeves which, when crushed or "popped" in the fingers, released the amyl nitrite for inhalation, hence the colloquialism poppers.[52] The term extended to the drug in any form as well as to other drugs with similar effects, e.g. butyl nitrite which is packaged under a variety of trade names in small bottles.[52]

In the late 1970s, Time magazine[54] and The Wall Street Journal[55] reported that popper use among gay men began as a way to enhance sexual pleasure, but "quickly spread to avant-garde heterosexuals". A series of interviews conducted in the late 1970s revealed a wide spectrum of users.[54][failed verification]

### 21st century

[edit]

Poppers were well established in the gay community, with more than a third of gay men in the United States having used poppers at least once.[56] Poppers were partial inspiration for songs such as Troye Sivan's 2023 song "Rush".[57]

## Legal status

[edit]

### Australia

[edit]

Poppers are legal in Australia, and from 2020, poppers can also be purchased as a schedule 3 substance from pharmacies, or a schedule 4 substance with a prescription.[58]

#### History of poppers legislation in Australia

[edit]

In June 2018, the Therapeutic Goods Administration (TGA) motioned to reschedule alkyl nitrites to be in the same category as heroin and cocaine (Schedule 9).[59] This was met by criticism from the LGBTQI community for being discriminatory and further evidence was demanded and further consultation sought.[60]

In October 2018, the Australian Federation of AIDS Organisations (AFAO) pointed out the lack of quality evidence provided by the TGA to justify the rescheduling[61] and that use of amyl nitrites has been stable over the past decade with very little evidence of harm and has been in use by a high proportion of gay men over a long period.

A final decision was pushed back from 29 November 2018 to late January or early February 2019 for further consultation with the public.[62]

As of March 2019, two public meetings have taken place in Sydney and Melbourne with The Kirby Institute and the Australian Research Centre in Sex, Health and Society (ARCSHS). Along with 70 written public proposals, there was significant opposition to alkyl nitrites rescheduling.[63] Banning alkyl nitrites was not considered acceptable as their use was said to help reduce harms such as anal injury and blood-borne disease transmission during anal sex.[64]

In June 2019, Australia decided not to ban poppers.[65]

### Canada

[edit]

Since 2013, Health Canada has banned all distribution and sales of poppers.[66]

### Continental Europe

[edit]

Since 2007, reformulated poppers containing isopropyl nitrite are sold in the EU; isobutyl nitrite is prohibited.[67]

In France, the sale of products containing butyl nitrite has been prohibited since 1990 on grounds of danger to consumers.[68] In 2007, the government extended this prohibition to all alkyl nitrites that were not authorized for sale as drugs.[69] After litigation by sex shop owners, this extension was quashed by the Council of State on the grounds that the government had failed to justify such a blanket prohibition: according to the court, the risks cited, concerning rare accidents often following abnormal usage, rather justified compulsory warnings on the packaging.[70]

The possession in Germany, Austria and Switzerland is not subject to any regulations regarding anesthetic drugs and is therefore legal; however, the purchase, sale or trade of amyl nitrite without permission violates the drug laws of the corresponding countries. Occasionally, poppers were seized from sex shops, when sold there illegally.[71][72]

### United Kingdom

[edit]

Poppers are sold in nightclubs, bars, sex shops, drug paraphernalia head shops, over the Internet and in markets. It is illegal under Medicines Act 1968 to sell them advertised for human consumption. The Advisory Council on the Misuse of Drugs noted in 2011 that poppers, rather than being a psychoactive substance or a legal high, "appear to fall within the scope of The Intoxicating Substances (Supply) Act 1985".[73]

The Psychoactive Substances Act 2016, scheduled to be enacted 1 April 2016, was initially claimed to impose a blanket ban on the production, import and distribution of all poppers.[74] On 20 January 2016 a motion to exempt poppers (alkyl nitrites) from this legislation was defeated.[75] This was opposed by Conservative MP Ben Howlett. Howlett's fellow Conservative MP Crispin Blunt declared that he has used and currently uses poppers. Manufacturers expressed concern over loss of business and potential unemployment.[76][77]

In March 2016, the Advisory Council on the Misuse of Drugs stated that, because alkyl nitrites do not directly stimulate or depress the central nervous system, poppers do not fall within the scope of the Psychoactive Substances Act 2016.[78]

### United States

[edit]

Amyl nitrite was originally marketed as a prescription drug in 1937. It remained so until 1960, when the Food and Drug Administration removed the prescription requirement due to its safety record. This requirement was reinstated in 1969, after observing an increase in recreational use. There was a huge increase in the number of brands for butyl nitrites after the FDA put in the prescription requirement again in 1969.[47]

Butyl nitrites were outlawed in 1988 by the Anti-Drug Abuse Act of 1988.[79] This prompted distributors to sell other alkyl nitrites not yet banned, like isopropyl nitrite. In 1990, isopropyl nitrites and other nitrites not yet banned were outlawed by the Crime Control Act of 1990.[80] Both of these laws include an exception for commercial purpose, defined as any use other than for the production of consumer products containing volatile alkyl nitrites meant for inhaling or otherwise introducing volatile alkyl nitrites into the human body for euphoric or physical effects.[81]

## See also

[edit]

* Alcohol and sex
* Sex and drugs

## References

[edit]

1. ^ Therapeutic Goods (Poisons Standard—October 2024) Instrument 2024 (Cth). Amyl nitrite also classified in Schedule 3 (Pharmacist only) in certain preparations. Isopropyl nitrite classified in Schedule 10 (Dangerous substance).
2. ^ a b c Romanelli F, Smith KM, Thornton AC, Pomeroy C (January 2004). "Poppers: epidemiology and clinical management of inhaled nitrite abuse". Pharmacotherapy. 24 (1): 69–78\. doi:10.1592/phco.24.1.69.34801. PMID 14740789. S2CID 44991387.
3. ^ Davies AJ, Kelly SP, Naylor SG, Bhatt PR, Mathews JP, Sahni J, et al. (November 2012). "Adverse ophthalmic reaction in poppers users: case series of 'poppers maculopathy'". Eye. 26 (11): 1479–1486\. doi:10.1038/eye.2012.191. PMC 3496104. PMID 23079752.
4. ^ Vignal-Clermont C, Audo I, Sahel JA, Paques M (October 2010). "Poppers-associated retinal toxicity". The New England Journal of Medicine. 363 (16): 1583–1585\. doi:10.1056/NEJMc1005118. PMID 20942681.
5. ^ Zhao P, Tang S, Wang C, Zhang Y, Best J, Tangthanasup TM, et al. (20 January 2017). "Recreational Drug Use among Chinese MSM and Transgender Individuals: Results from a National Online Cross-Sectional Study". PLOS ONE. 12 (1): e0170024. Bibcode:2017PLoSO..1270024Z. doi:10.1371/journal.pone.0170024. PMC 5249205. PMID 28107391.
6. ^ Schmidt AJ, Bourne A, Weatherburn P, Reid D, Marcus U, Hickson F (December 2016). "Illicit drug use among gay and bisexual men in 44 cities: Findings from the European MSM Internet Survey (EMIS)". The International Journal on Drug Policy. 38: 4–12\. doi:10.1016/j.drugpo.2016.09.007. PMID 27788450.
7. ^ "Sex and Poppers". SexInfo Online. 28 November 2017. Archived from the original on 2019-12-26. Retrieved 2020-05-01.
8. ^ "Nitrites". Drugscope. Archived from the original on 2007-04-05. Retrieved 2007-04-24.
9. ^ Nickerson M (1979). Isobutyl nitrite and related compounds. Pharmex. OCLC 4790673.[page needed]
10. ^ a b "Amyl Nitrite". Medsafe. New Zealand Medicines and Medical Devices Safety Authority. 18 May 2000. Archived from the original on 2006-11-11. Retrieved 2007-03-15.
11. ^ "Amyl Nitrite (Professional Patient Advice)". Drugs.com. Retrieved 2016-06-29.
12. ^ a b "Drug Facts - Amyl Nitrite". Alcohol & Drug Foundation (ADF). Retrieved 2018-10-25.
13. ^ Iversen L (16 March 2016). "ACMD review of alkyl nitrites ("poppers")" (PDF). gov.uk. www.gov.uk. Retrieved 2016-10-10.
14. ^ "Poppers". Dutch Poisons Information Center. 25 November 2022. Retrieved 2022-11-25 - via www.vergiftigingen.info.
15. ^ Nutt D, King LA, Saulsbury W, Blakemore C (March 2007). "Development of a rational scale to assess the harm of drugs of potential misuse". The Lancet. 369 (9566): 1047–1053\. doi:10.1016/s0140-6736(07)60464-4. PMID 17382831. S2CID 5903121.
16. ^ Harte CB, Meston CM (June 2011). "Recreational use of erectile dysfunction medications in undergraduate men in the United States: characteristics and associated risk factors". Archives of Sexual Behavior. 40 (3): 597–606\. doi:10.1007/s10508-010-9619-y. PMC 2909482. PMID 20358273.
17. ^ Wood RW (1989). "The acute toxicity of nitrite inhalants". NIDA Research Monograph. 83. National Institute on Drug Abuse: 28–38\. hdl:1802/1150. PMID 3140020.
18. ^ O'Malley GF, O'Malley R (January 2016). "Volatile Nitrites". In Porter RS, et al. (eds.). The Merck Manual Online. Merck & Co. Retrieved 2017-09-16.
19. ^ Nutt D, King LA, Saulsbury W, Blakemore C (March 2007). "Development of a rational scale to assess the harm of drugs of potential misuse". Lancet. 369 (9566): 1047–1053\. doi:10.1016/S0140-6736(07)60464-4. PMID 17382831. S2CID 5903121.
20. ^ Wood RW (19 April 1988). "The acute toxicity of nitrite inhalants". NIDA Research Monograph. 83: 28–38\. PMID 3140020.
21. ^ Dixon DS, Reisch RF, Santinga PH (July 1981). "Fatal methemoglobinemia resulting from ingestion of isobutyl nitrite, a "room odorizer" widely used for recreational purposes". Journal of Forensic Sciences. 26 (3): 587–593\. doi:10.1520/JFS11404J. PMID 7252472.
22. ^ Pruijm MT, de Meijer PH (December 2002). "[Methemoglobinemia due to ingestion of isobutyl nitrite ('poppers')]". Nederlands Tijdschrift voor Geneeskunde. 146 (49): 2370–2373\. PMID 12510403.
23. ^ Stalnikowicz R, Amitai Y, Bentur Y (2004). "Aphrodisiac drug-induced hemolysis". Journal of Toxicology. Clinical Toxicology. 42 (3): 313–316\. doi:10.1081/clt-120037435. PMID 15362601. S2CID 9389458.
24. ^ Emergency Medicine: Principles and Practice (2nd ed.). Harper & Collins. 2008. pp. 42–51\. ISBN 978-0-86433-073-4.
25. ^ Hagan IG, Burney K (July–August 2007). "Radiology of recreational drug abuse". Radiographics. 27 (4): 919–940\. doi:10.1148/rg.274065103. PMID 17620459.
26. ^ Davies AJ, Kelly SP, Bhatt PR (June 2012). "'Poppers maculopathy'--an emerging ophthalmic reaction to recreational substance abuse". Eye (correspondence). 26 (6): 888. doi:10.1038/eye.2012.37. PMC 3376285. PMID 22402700.
27. ^ Vignal-Clermont C, Audo I, Sahel JA, Paques M (October 2010). "Poppers-associated retinal toxicity". The New England Journal of Medicine. 363 (16): 1583–1585\. doi:10.1056/NEJMc1005118. PMID 20942681.
28. ^ Rabin RC (18 October 2010). "Vision: A Quick High for Sex May Damage Vision". The New York Times. ISSN 0362-4331. Retrieved 2022-10-15.
29. ^ Pahlitzsch M, Mai C, Joussen AM, Bergholz R (2016). "Poppers Maculopathy: Complete Restitution of Macular Changes in OCT after Drug Abstinence". Seminars in Ophthalmology. 31 (5): 479–484\. doi:10.3109/08820538.2014.962175. PMID 25398125. S2CID 7780239.
30. ^ Bral NO, Marinkovic M, Leroy BP, Hoornaert K, van Lint M, ten Tusscher MP (February 2016). "Do not turn a blind eye to alkyl nitrite (poppers)!". Acta Ophthalmologica. 94 (1): e82 – e83. doi:10.1111/aos.12753. PMID 25975842. S2CID 39061955.
31. ^ Audo I, El Sanharawi M, Vignal-Clermont C, Villa A, Morin A, Conrath J, et al. (June 2011). "Foveal damage in habitual poppers users". Archives of Ophthalmology. 129 (6): 703–708\. doi:10.1001/archophthalmol.2011.6. PMID 21320953.
32. ^ Storr K (8 July 2014). "More evidence 'poppers' may damage eyesight". Reuters Health. Archived from the original on 2020-08-08. Retrieved 2021-07-06.
33. ^ Gruener AM, Jeffries MA, El Housseini Z, Whitefield L (November 2014). "Poppers maculopathy". Lancet. 384 (9954): 1606. doi:10.1016/S0140-6736(14)60887-4. PMID 24954683. S2CID 8083375.
34. ^ a b IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2019). Isobutyl Nitrite, β-Picoline, and Some Acrylates. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Lyon (FR): International Agency for Research on Cancer. pp. 33–60\. ISBN 978-92-832-0160-1. PMID 32520473.
35. ^ Brazil R (16 September 2021). "The Science of Alkyl Nitrites". chemistryworld.com.
36. ^ Duesberg P, Koehnlein C, Rasnick D (June 2003). "The chemical bases of the various AIDS epidemics: recreational drugs, anti-viral chemotherapy and malnutrition". Journal of Biosciences. 28 (4): 383–412\. doi:10.1007/BF02705115. PMID 12799487. S2CID 56553.
37. ^ Schechter MT, Craib KJ, Gelmon KA, Montaner JS, Le TN, O'Shaughnessy MV (March 1993). "HIV-1 and the aetiology of AIDS". Lancet. 341 (8846): 658–659\. doi:10.1016/0140-6736(93)90421-c. PMID 8095571. S2CID 23141531.
38. ^ Romanelli F, Smith KM, Thornton AC, Pomeroy C (January 2004). "Poppers: epidemiology and clinical management of inhaled nitrite abuse". Pharmacotherapy. 24 (1): 69–78\. doi:10.1592/phco.24.1.69.34801. PMID 14740789. S2CID 44991387.
39. ^ James JS (April 1999). "Poppers: large cancer increase and immune suppression in animal tests". AIDS Treatment News (317): 1–2\. PMID 11366993.
40. ^ Johnson WS, Hall AH, Rumack BH (July 1989). "Cyanide poisoning successfully treated without 'therapeutic methemoglobin levels'". The American Journal of Emergency Medicine. 7 (4): 437–440\. doi:10.1016/0735-6757(89)90057-0. PMID 2567600.
41. ^ Marraffa JM, Cohen V, Howland MA (February 2012). "Antidotes for toxicological emergencies: a practical review". American Journal of Health-System Pharmacy. 69 (3): 199–212\. doi:10.2146/ajhp110014. PMID 22261941.
42. ^ "cyanide antidote kit (sodium thiosulfate, sodium nitrite, & amyl nitrite) dosing, indications, interactions, adverse effects, and more". reference.medscape.com. Archived from the original on 2019-12-26. Retrieved 2019-12-02.
43. ^ "Products Approved for Chemical Emergencies". Center for Drug Evaluation and Research. U.S. Food and Drug Administration. 14 August 2019.[dead link]
44. ^ Sutton WL (1963). "Aliphatic nitro compounds, nitrates, nitrites, alkyl nitrites". Industrial Hygiene and Toxicology. 2: 414–438.
45. ^ "Isoamyl nitrite, 97%, stabilized, Thermo Scientific Chemicals". Retrieved 2024-08-15.
46. ^ Fischer J, Ganellin CR (2006). "Chapter 10: Development of Organic Nitrates for Coronary Heart Disease". Analogue-based Drug Discovery. United States: John Wiley & Sons. pp. 247, 248. ISBN 978-3-527-60749-5.
47. ^ a b c d Fye WB (August 1986). "T. Lauder Brunton and amyl nitrite: a Victorian vasodilator". Circulation. 74 (2): 222–229\. doi:10.1161/01.cir.74.2.222. PMID 3524895.
48. ^ Newell GR, Spitz MR, Wilson MB (1988). "Nitrite inhalants: historical perspective". NIDA Research Monograph. 83: 1–14\. PMID 3140018. Also published as: Newell GR, Spitz MR, Wilson MB (1988). "Nitrite Inhalants: Historical Perspective". In Haverkos HW, Dougherty JA (eds.). Health Hazards of Nitrite Inhalants. U.S. Department of Health and Human Services, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, National Institute on Drug Abuse. pp. 1–14\. CiteSeerX 10.1.1.152.4015. OCLC 18456297.
49. ^ Brunton TL (1898). Lectures on the Action of Medicines: Being the Course of Lectures on Pharmacology and Therapeutics Delivered at St. Bartholomew's Hospital During the Summer Session of 1896. Macmillan. pp. 332–339. "Brunton, T.L Lectures on the actions of medicines."
50. ^ Lubell, I. Correspondence with Burroughs Wellcome Co., 1964, U.S. Food and Drug Administration, 1967.
51. ^ "How gay culture bottled a formula that has broken down boundaries". The Independent. 22 January 2016. Retrieved 2019-05-21.
52. ^ a b c Israelstam S, Lambert S, Oki G (November 1978). "Poppers, a new recreational drug craze". Canadian Psychiatric Association Journal. 23 (7): 493–495\. doi:10.1177/070674377802300711. PMID 709498. S2CID 9696049.
53. ^ French R, Power R (1 January 1998). "A Qualitative Study of the Social Contextual Use of Alkyl Nitrites (Poppers) among Targeted Groups". Journal of Drug Issues. 28 (1): 57–76\. doi:10.1177/002204269802800104. ISSN 0022-0426. S2CID 58853221.
54. ^ a b "Rushing to a new high". Time. 17 July 1978. Retrieved 2020-09-08.
55. ^ Sansweet SJ (10 October 1977). "wall street journal - A new way to glow and giggle, and get a headache. "Poppers, legally sniffable, becoming a big business; The FDA isn't interested". Wall Street Journal October 10, 1977 Stephen J. Sansweet. Retrieved 2016-10-10 - via virusmythpoppersmyth.org.[permanent dead link]
56. ^ Le A, Yockey A, Palamar JJ (2020). "Use of "Poppers" among Adults in the United States, 2015-2017". Journal of Psychoactive Drugs. 52 (5): 433–439\. doi:10.1080/02791072.2020.1791373. PMC 7704544. PMID 32669067.
57. ^ Wratten M (13 July 2023). "Troye Sivan's Rush music video is a sweaty, queer party and fans are in love". PinkNews. Retrieved 2024-02-02.
58. ^ Butler G (7 June 2019). "You'll Soon Be Allowed to Buy Amyl in Australian Pharmacies—But There's A Catch". Vice.
59. ^ "Consultation: Proposed amendments to the Poisons Standard being referred to the June 2018 meetings of the ACCS, ACMS and Joint ACCS/ACMS". Therapeutic Goods Administration (TGA). Australian Government. 7 June 2018. Retrieved 2019-01-31.
60. ^ "LGBTIQ Health Experts Slam Proposed Government Ban On Poppers". QNews. 18 October 2018. Retrieved 2019-01-31.
61. ^ "Submission to the Publication of interim decision proposing to amend, or not amend, the current Poisons Standard, September 2018" (PDF). Australian Federation of AIDS Organisations. 11 October 2018.
62. ^ "Further public consultation on appropriate access and safety controls (Poisons Standard schedule) for alkyl nitrites". Therapeutic Goods Administration (TGA). Australian Government. 22 November 2018. Retrieved 2019-01-31.
63. ^ Butler G (25 April 2019). "It Looks Like the Australian Government Probably Won't Ban Amyl". Vice.
64. ^ "Public meeting communique: Regulatory options for appropriate access and safety controls for alkyl nitrites". Therapeutic Goods Administration (TGA). Australian Government. 7 March 2019. Retrieved 2019-05-23.
65. ^ Badge J (10 June 2019). "Australia's decision not to ban poppers is a win for sensible drug policy, but the stigma remains". The Guardian.
66. ^ "Poppers sold across Canada pose serious risks". www.healthycanadians.gc.ca. Retrieved 2019-05-23.
67. ^ "Directive 2005/90/EC of the European Parliament and of the Council". Official Journal of the European Union. 18 January 2006.
68. ^ "Decree 90–274 of 26 March 1990" (in French). Legifrance.gouv.fr. 15 May 2009. Retrieved 2012-07-26.
69. ^ "Decree 2007-1636 of 20 November 2007" (in French). Legifrance.gouv.fr. Retrieved 2012-07-26.
70. ^ "Conseil d'État, 10ème et 9ème sous-sections réunies, 15/05/2009, 312449, Publié au recueil Lebon". Legifrance.gouv.fr (in French). 15 May 2009. Retrieved 2016-01-11.
71. ^ "Sexdroge Poppers: Zur Ekstase geschnüffelt". news.de (in German).
72. ^ ""Poppers" sichergestellt. Polizei entdeckt 400 Flaschen des Schnüffelstoffs in Sex-Shop". Die Welt (in German). 8 December 2005.
73. ^ "Consideration of the Novel Psychoactive Substances ('Legal Highs')" (PDF). Advisory Council on the Misuse of Drugs. pp. 52–54.
74. ^ "publications.parliament.uk" (PDF). Retrieved 2019-01-31.
75. ^ "House of Commons Hansard Debates for 20 January 2016 (pt 0003)". parliament.uk. Retrieved 2016-06-29.
76. ^ Sutcliffe R. "UK's biggest poppers manufacturer vows to fight legal high ban on product he's made for 35 years". Mirror.
77. ^ Tayag Y (11 February 2016). "The UK is at war with synthetic drugs and brain boosters are in the crossfire".
78. ^ "The Government thought it had banned Poppers but actually accidentally didn't". The Independent. 16 March 2016. Retrieved 2016-03-16.
79. ^ "15 U.S. Code § 2057a - Banning of butyl nitrite". LII / Legal Information Institute. Retrieved 2019-12-02.
80. ^ "15 U.S. Code § 2057b - Banning of isopropal nitrite and other nitrites". LII / Legal Information Institute. Retrieved 2019-12-02.
81. ^ Anti-Drug Abuse Act of 1988 (Public Law 100-690, section 2404) (15 U.S.C. 2d57a(e)(2)).

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Euphoriants

* μ-Opioid receptor agonists (opioids) (e.g., morphine, heroin, hydrocodone, oxycodone, opium, kratom)
* α2δ subunit-containing voltage-dependent calcium channels blockers (gabapentinoids) (e.g., gabapentin, pregabalin, phenibut)
* AMPA receptor antagonists (e.g., perampanel)
* CB1 receptor agonists (cannabinoids) (e.g., THC, cannabis)
* Dopamine receptor agonists (e.g., levodopa)
* Dopamine releasing agents (e.g., amphetamine, methamphetamine, MDMA, mephedrone)
* Dopamine reuptake inhibitors (e.g., cocaine, methylphenidate)
* GABAA receptor positive allosteric modulators (e.g., barbiturates, benzodiazepines, carbamates, ethanol (alcohol) (alcoholic drink), inhalants, nonbenzodiazepines, quinazolinones)
* GHB (sodium oxybate) and analogues
* Glucocorticoids (corticosteroids) (e.g., dexamethasone, prednisone)
* nACh receptor agonists (e.g., nicotine, tobacco, arecoline, areca nut)
* Nitric oxide prodrugs (e.g., alkyl nitrites (poppers))
* NMDA receptor antagonists (e.g., DXM, ketamine, methoxetamine, nitrous oxide, phencyclidine, inhalants)
* Orexin receptor antagonists (e.g., suvorexant)

See also: Recreational drug use
*[AU]: Australia
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