Propionate CoA-transferase

Class of enzymes

propionate CoA-transferase

Identifiers
EC no.| 2.8.3.1
CAS no.| 9026-15-7
Databases
IntEnz| IntEnz view
BRENDA| BRENDA entry
ExPASy| NiceZyme view
KEGG| KEGG entry
MetaCyc| metabolic pathway
PRIAM| profile
PDB structures| RCSB PDB PDBe PDBsum
Gene Ontology| AmiGO  / QuickGO
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PMC| articles
PubMed| articles
NCBI| proteins

In enzymology, a propionate CoA-transferase (EC 2.8.3.1) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + propanoate  ⇌ {\displaystyle \rightleftharpoons } acetate + propanoyl-CoA

Thus, the two substrates of this enzyme are acetyl-CoA and propanoate, whereas its two products are acetate and propanoyl-CoA.

This enzyme belongs to the family of transferases, specifically the CoA-transferases. The systematic name of this enzyme class is acetyl-CoA:propanoate CoA-transferase. Other names in common use include propionate coenzyme A-transferase, propionate-CoA:lactoyl-CoA transferase, propionyl CoA:acetate CoA transferase, and propionyl-CoA transferase. This enzyme participates in 3 metabolic pathways: pyruvate metabolism, propanoate metabolism, and styrene degradation.

## References

[edit]

* Stadtman ER (1952). "Acyl-coenzyme A synthesis by phosphotransacetylase and coenzyme A transphorase". Fed. Proc. 11: 291.

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Transferases: sulfur-containing group (EC 2.8)

2.8.1: Sulfurtransferases|

* Thiosulfate sulfurtransferase
* Rhodanese
* 3-mercaptopyruvate sulfurtransferase
* thiosulfate—thiol sulfurtransferase
* tRNA sulfurtransferase
* thiosulfate—dithiol sulfurtransferase
* biotin synthase
* cysteine desulfurase
* lipoyl synthase
* molybdenum cofactor sulfurtransferase
* thiazole synthase
* molybdopterin synthase sulfurtransferase
* molybdopterin synthase
* tRNA-uridine 2-sulfurtransferase (*)
* tRNA-5-taurinomethyluridine 2-sulfurtransferase (*)
* tRNA-5-methyluridine54 2-sulfurtransferase (*)
* L-aspartate semialdehyde sulfurtransferase (*)

2.8.2: Sulfotransferases|

* aryl sulfotransferase
* amine sulfotransferase
* estrone sulfotransferase
* chondroitin 4-sulfotransferase
* choline sulfotransferase
* UDP-N-acetylgalactosamine-4-sulfate sulfotransferase
* heparan sulfate-glucosamine N-sulfotransferase
* tyrosine-ester sulfotransferase
* Renilla-luciferin sulfotransferase
* galactosylceramide sulfotransferase
* psychosine sulfotransferase
* bile salt sulfotransferase
* steroid sulfotransferase
* thiol sulfotransferase
* chondroitin 6-sulfotransferase
* cortisol sulfotransferase
* triglucosylalkylacylglycerol sulfotransferase
* protein-tyrosine sulfotransferase
* keratan sulfotransferase
* aryl-sulfate sulfotransferase
* (heparan sulfate)-glucosamine 3-sulfotransferase 1
* desulfoglucosinolate sulfotransferase
* flavonol 3-sulfotransferase
* quercetin-3-sulfate 3′-sulfotransferase
* quercetin-3-sulfate 4′-sulfotransferase
* quercetin-3,3′-bissulfate 7-sulfotransferase
* (heparan sulfate)-glucosamine 3-sulfotransferase 2
* (heparan sulfate)-glucosamine 3-sulfotransferase 3
* petromyzonol sulfotransferase
* scymnol sulfotransferase
* N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
* glycochenodeoxycholate sulfotransferase
* dermatan 4-sulfotransferase
* desulfo-A47934 sulfotransferase (*)
* trehalose 2-sulfotransferase (*)
* aliphatic desulfoglucosinolate sulfotransferase (*)
* hydroxyjasmonate sulfotransferase (*)
* ω-hydroxy-β-dihydromenaquinone-9 sulfotransferase (*)
* Alcohol sulfotransferase
* Tyrosylprotein sulfotransferase

2.8.3: CoA-transferases|

* Propionate CoA-transferase
* oxalate CoA-transferase
* malonate CoA-transferase
* 3-oxoacid CoA-transferase
* 3-oxoadipate CoA-transferase
* succinyl-CoA—Dcitramalate CoA-transferase
* acetate CoA-transferase
* butyrate—acetoacetate CoA-transferase
* citrate CoA-transferase
* citramalate CoA-transferase
* glutaconate CoA-transferase
* succinate—hydroxymethylglutarate CoA-transferase
* 5-hydroxypentanoate CoA-transferase
* succinyl-CoA:(R)-benzylsuccinate CoA-transferase
* formyl-CoA transferase
* cinnamoyl-CoA:phenyllactate CoA-transferase
* succinyl-CoA:acetate CoA-transferase (*)
* CoA:oxalate CoA-transferase (*)
* succinyl-CoA—D-citramalate CoA-transferase (*)
* L-carnitine CoA-transferase (*)
* succinyl-CoA—L-malate CoA-transferase (*)
* caffeate CoA-transferase (*)
* (R)-2-hydroxy-4-methylpentanoate CoA-transferase (*)
* bile acid CoA-transferase (*)
* succinyl-CoA:mesaconate CoA transferase (*)

2.8.4: Alkylthio|

2.8.4:

* Coenzyme-B sulfoethylthiotransferase
* arsenate-mycothiol transferase
* tRNA-2-methylthio-N6-dimethylallyladenosine synthase (*)
* [ribosomal protein S12] (aspartate89-C3)-methylthiotransferase (*)
* tRNA (N6-L-threonylcarbamoyladenosine37-C2)-methylthiotransferase (*)

2.8.5:|

2.8.5:
* S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent) (*)
* L-cysteine S-thiosulfotransferase (*)

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Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Diffusion-limited enzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)
* EC7 Translocases (list)

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