Psychoactive cactus

Cactus containing psychoactive chemicals

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Many cacti are known to be psychoactive, containing phenethylamine alkaloids such as mescaline.[1] However, the two main ritualistic (folkloric) genera are Echinopsis, of which the most psychoactive species occur in the San Pedro cactus group (including Echinopsis pachanoi, syn. Trichocereus pachanoi, Echinopsis Peruviana, syn. Trichocereus peruvianus and Echinopsis lageniformis, syn. Trichocereus bridgesii[2][3][4]), and Lophophora, with peyote (Lophophora williamsii) being the most psychoactive species. Several other species pertaining to other genera are also psychoactive, though not always used with a ritualistic intent.[5][6][7]

## Species

[edit]

### Globular cacti

[edit]

* Lophophora williamsii (peyote)

Peyote with flower

Other "peyotes"

* Ariocarpus fissuratus
* Coryphantha compacta (syn. C. palmeri)
* Pelecyphora aselliformis
* Pelecyphora strobiliformis
* Lophophora diffusa
* Ariocarpus retusus
* Ariocarpus agavoides; kotschoubeyanus; and other species
* Astrophytum asterias; capricorne; myriostigma; and other species
* Aztekium ritteri; and other species
* Coryphantha elephantidens; macromeris (var. runyonii); palmeri; and other species
* Echinocactus grandis; grusonii; platyacanthus; visnaga; and other species
* Epithelantha micromeris; and other species
* Leuchtenbergia principis'; and other species
* Lophophora species
* Mammillaria craigii; grahamii (var. oliviae); heyderi; (Dolichothele) longimamma; (Solisia) pectinifera; (Mamillopsis) senilis; sonorensis; and other species
* Obregonia denegrii
* Strombocactus disciformis
* Turbinicarpus laui; lophophoroides; jauernigii; (Pelecyphora) pseudopectinatus; schmiedickeanus; and other species

#### Other

[edit]

Other North American psychoactive and/or medicinal cacti.

* Carnegiea gigantea
* Echinocereus salm-dyckianus (var. scheeri); triglochidiatus; and other species
* Pachycereus pecten-aboriginum; pringlei

### Arborescent and columnar cacti

[edit]

#### Echinopsis

[edit]

* Echinopsis lageniformis (syn. Trichocereus bridgesii) (Bolivian torch cactus)[4]
* Echinopsis macrogona (syn. Trichocereus macrogonus), > 0.01-0.05% Mescaline[8]
* Echinopsis pasacana ssp. atacamensis
* Echinopsis pachanoi (syn. Trichocereus pachanoi) (San Pedro cactus)
* Echinopsis peruviana (syn. Trichocereus peruvianus) (Peruvian torch cactus)
* Echinopsis scopulicola (syn. Trichocereus scopulicolus), 0.82% mescaline by dry weight in the outer green layer.[9]
* Echinopsis spachiana (syn. Trichocereus spachianus), Mescaline;[10] Mescaline[10]
* Echinopsis tacaquirensis subsp. taquimbalensis (syn. Trichocereus taquimbalensis),[11][12] > 0.005-0.025% mescaline[8]
* Echinopsis terscheckii (syn. Trichocereus terscheckii, Trichocereus werdemannianus)[13] > 0.005-0.025% Mescaline;[8] mescaline 0.01%-2.375%[14]
* Echinopsis valida (syn. E. validus), 0.025% mescaline[15]
* Echinopsis werdermannianus

Echinopsis pachanoi

#### Other

[edit]

Other South American psychoactive and/or medicinal cacti

* Austrocylindropuntia cylindrica (syn. Opuntia cylindrica),[16] Mescaline[10]
* Armatocereus laetus
* Browningia spp.
* Cylindropuntia echinocarpa (syn. Opuntia echinocarpa), Mescaline 0.01%, DMPEA 0.01%, 4-hydroxy-3-5-dimethoxyphenethylamine 0.01%[10]
* Cylindropuntia spinosior (syn. Opuntia spinosior),[17] Mescaline 0.00004%, 3-methoxytyramine 0.001%, tyramine 0.002%, 3-4-dimethoxyphenethylamine.[10]
* Epostoa lanata
* Matucana madisoniorum
* Neoraimondia macrostibas
* Opuntia acanthocarpa Mescaline[18]
* Opuntia basilaris Mescaline 0.01%, plus 4-hydroxy-3-5-dimethoxyphenethylamine[10]
* Selenicereus grandiflorus
* Stetsonia coryne

## See also

[edit]

* Cactus alkaloids
* Entheogenic drugs and the archaeological record
* List of Acacia species known to contain psychoactive alkaloids
* List of plants used for smoking
* List of psychoactive plants
* List of psychoactive plants, fungi, and animals
* N,N-Dimethyltryptamine
* Psilocybin mushrooms

## Traditional and Indigenous uses

[edit]

Several world regions have historically used psychoactive cacti for their properties, particularly Indigenous peoples from North America and South America, such as in Mexico and the Andes region. Archaeological studies have found evidence of use going back two thousand years.[19][20] In 2022, the Peruvian Ministry of Culture declared the traditional use of San Pedro cactus in northern Peru as cultural heritage.[21] Lophophora williamsii (peyote) is used by the Native American Church (aka Peyotism).

### Legality

[edit]

Further information: Legality of mescaline cactus by country

## References

[edit]

1. ^ Bruhn, Jan G.; Hesham R. EI-Seedi; Nikolai Stephanson (2008). "Ecstasy Analogues Found in Cacti". Journal of Psychoactive Drugs. 40 (2): 219–222\. CiteSeerX 10.1.1.689.4014. doi:10.1080/02791072.2008.10400635. PMID 18720674. S2CID 11251286.
2. ^ Engel, Liam (2022). The San Pedro Appreciation Guide. The Mescaline Garden.
3. ^ Engel, L. Barratt, M. Ferris, J. Puljevic, C. Winstock, A. (2023). "Mescaline, Peyote and San Pedro: Is sustainability important for cacti consumers?". Journal of Psychedelic Studies. 7 (2): 135–142\. doi:10.1556/2054.2023.00252.`{{cite journal}}`: CS1 maint: multiple names: authors list (link)
4. ^ a b Gaur, Pragna; Engel, Liam; Hall, Damian Robert; Khoo, Cheang; Sarris, Jerome; Perkins, Daniel; Li, Chun Guang; Low, Mitchell (2025-07-01). "A UHPLC-(ESI)MS/MS method for the determination of the psychedelic secondary metabolite mescaline in San Pedro (Trichocereus spp.) and its applicability for screening mescaline in other cacti varieties". Forensic Chemistry. 44: 100659. doi:10.1016/j.forc.2025.100659. ISSN 2468-1709.
5. ^ Bruhn, Jan G. (1973). "Ethnobotanical Search for Hallucinogenic Cacti1". Planta Med. 24 (8): 315–319\. doi:10.1055/s-0028-1099504. PMID 4789553. S2CID 44528398.
6. ^ Bruhn, Jan G.; Catarina Bruhn (1973). "Alkaloids and ethnobotany of Mexican peyote cacti and related species". Economic Botany. 27 (2): 241–251\. Bibcode:1973EcBot..27..241B. doi:10.1007/BF02872994. S2CID 36480873.
7. ^ Pummangura, S.; J. L. McLaughlin; R. C. Schifferdecker (September 1981). "Cactus Alkaloids. XLVII. β-Phenethylamines From the "Missouri Pincushion", Coryphantha (Neobessya) missouriensis". J. Nat. Prod. 44 (5): 614–616\. doi:10.1021/np50017a022.
8. ^ a b c "Partial List of Alkaloids in Trichocereus Cacti". Thennok.org. Archived from the original on 11 February 2009. Retrieved 22 December 2017.
9. ^ Ogunbodede, Olabode; McCombs, Douglas; Trout, Keeper; Daley, Paul; Terry, Martin (September 2010). "New mescaline concentrations from 14 taxa/cultivars of Echinopsis spp. (Cactaceae) ("San Pedro") and their relevance to shamanic practice". Journal of Ethnopharmacology. 131 (2): 356–362\. doi:10.1016/j.jep.2010.07.021. PMID 20637277.
10. ^ a b c d e f "Descriptions of psychoactive Cacti". Users.lycaeum.org. Archived from the original on 15 July 2009. Retrieved 14 January 2015.
11. ^ "Echinopsis tacaquirensis ssp. taquimbalensis". Desert-tropicals.com. Archived from the original on 23 September 2015. Retrieved 14 January 2015.
12. ^ "Mescaline in Trichocereus". The Mescaline Garden. Archived from the original on 2024-08-08. Retrieved 2024-08-30.
13. ^ "Cardon Grande (Echinopsis terscheckii)". Desert-tropicals.com. Archived from the original on 5 April 2015. Retrieved 14 January 2015.
14. ^ Forbidden Fruit Archives Archived 2005-11-28 at the Wayback Machine
15. ^ "Erowid Cacti Vaults : Visionary Cactus Guide - Mescaline from Sawdust". Erowid.org. Retrieved 14 January 2015.
16. ^ "Austrocylindropuntia cylindrica". Desert-tropicals.com. Archived from the original on 11 October 2008. Retrieved 22 December 2017.
17. ^ "Cane Cholla (Cylindropuntia spinosior )". Desert-tropicals.com. Archived from the original on 29 December 2014. Retrieved 14 January 2015.
18. ^ "Opuntia: Visionary Cactus Guide". users.lycaeum.org. Archived from the original on 8 March 2001. Retrieved 17 January 2022.
19. ^ Socha, Dagmara M.; Sykutera, Marzena; Orefici, Giuseppe (2022-12-01). "Use of psychoactive and stimulant plants on the south coast of Peru from the Early Intermediate to Late Intermediate Period". Journal of Archaeological Science. 148: 105688. Bibcode:2022JArSc.148j5688S. doi:10.1016/j.jas.2022.105688. ISSN 0305-4403.
20. ^ El-Seedi, Hesham R.; De Smet, Peter A. G. M.; Beck, Olof; Possnert, Göran; Bruhn, Jan G. (2005-10-03). "Prehistoric peyote use: Alkaloid analysis and radiocarbon dating of archaeological specimens of Lophophora from Texas". Journal of Ethnopharmacology. 101 (1): 238–242\. doi:10.1016/j.jep.2005.04.022. ISSN 0378-8741. PMID 15990261.
21. ^ El Peruano (2022-11-17). "Declaran Patrimonio Cultural de la Nación a los conocimientos, saberes y usos del cactus San Pedro".

## External links

[edit]

* Media related to Psychoactive cacti at Wikimedia Commons
* www.cactus-mall.com

* v
* t
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Psychedelics

Tryptamines|

| No ring subs.|

* CYB004 (deuDMT)
* DALT
* DBT
* DCPT
* DET (T-9)
* DiPT
* DMT
* DPT
* EiPT
* EPT
* iPALT (ALiPT)
* MALT
* MET
* MiPT
* MPT
* NBoc-DMT
* NMT
* PALT
* PiPT
* Tryptamine (T)

|

4-Hydroxytryptamines|

* 4-HO-DALT (daltocin)
* 4-HO-DBT
* 4-HO-DET (ethocin; CZ-74)
* 4-HO-DiPT (iprocin)
* 4-HO-DPT (deprocin)
* 4-HO-EPT
* 4-HO-MALT
* 4-HO-McPT
* 4-HO-MET (metocin)
* 4-HO-MiPT (miprocin)
* 4-HO-MPT (meprocin)
* 4-HO-NALT
* 4-HO-T
* 4-HO-TMT
* 4-HO-5-MeO-DMT
* 4-MeO-DMT
* CYB003 (deupsilocin)
* Psilocin (4-HO-DMT; CX-59)

* 4-Phosphoryloxytryptamines: Aeruginascin (4-PO-TMT)
* Baeocystin (4-PO-NMT)
* Ethocybin (4-PO-DET; CEY-19)
* Norbaeocystin (4-PO-T)
* Psilocybin (4-PO-DMT; CY-39)

* 4-Acetoxytryptamines: 4-AcO-DALT (daltacetin)
* 4-AcO-DET (ethacetin)
* 4-AcO-DiPT (ipracetin)
* 4-AcO-DMT (psilacetin)
* 4-AcO-DPT (depracetin)
* 4-AcO-MALT
* 4-AcO-MET (metocetin)
* 4-AcO-MiPT (mipracetin)
* 4-GO-DMT (RE-109)
* 4-PrO-DMT
* Luvesilocin (4-GO-DiPT; RE-104, FT-104)

5-Hydroxytryptamines|

* Bufotenin (5-HO-DMT)
* Serotonin (5-HT; 5-HO-T)

* 5-Acetoxytryptamines: O-Acetylbufotenine (5-AcO-DMT)
* O-Pivalylbufotenine (5-(t-BuCO)-DMT)

5-Methoxytryptamines|

* 4-HO-5-MeO-DMT
* 5-MeO-2,N,N-TMT
* 5-MeO-4,N,N-TMT
* 5-MeO-DALT
* 5-MeO-DET
* 5-MeO-DiPT
* 5-MeO-DMT (mebufotenin)
* 5-MeO-DPT
* 5-MeO-EiPT
* 5-MeO-MALT
* 5-MeO-MET
* 5-MeO-MiPT
* 5-MeO-NiPT
* 5-MeO-NMT
* ASR-3001 (5-MeO-iPALT)

Other ring subs.|

* 2,N,N-TMT
* 4,N,N-TMT
* 5-Bromo-DMT
* 5-Chloro-DMT
* 5-Fluoro-DMT
* 5-N,N-TMT
* 7,N,N-TMT
* 5-MeO-2,N,N-TMT
* 5-MeO-4,N,N-TMT
* 6-Fluoro-DMT
* Bretisilocin (GM-2505; 5-fluoro-MET)

α-Alkyltryptamines|

* 4-HO-AMT
* 4-Methyl-AMT
* 5-Fluoro-AMT
* 6-Fluoro-AMT
* AMT (Indopan)
* α-Methylserotonin (5-HO-αMT)

* 5-Methoxy-α-alkyltryptamines: 5-MeO-AET
* α,N,N-TMT (α-Me-DMT; Alpha-N)
* 5-MeO-AMT (α,O-DMS; Alpha-O)
* α,N,O-TMS (5-MeO-α,N-DMT)
* α,N,N,O-TeMS (5-MeO-α,N,N-TMT)

Others|

* N-DEAOP-Ts (e.g., N-DEAOP-NET, N-DEAOP-NMT, 5-MeO-N-DEAOP-NMT, 5-MeO-N-DEAOP-NET)

* Structure undisclosed: CT-4201
* EB-002 (EB-373)
* MSP-1014
* MYCO-004

Cyclized|

* Ergolines/lysergamides (e.g., LSD)
* β-Carbolines and Harmala alkaloids (e.g., harmine, harmaline, 6-methoxyharmalan)
* Iboga alkaloids (e.g., 18-MAC, 18-MC, coronaridine, ibogaine, ibogamine, ME-18-MC, noribogaine, tabernanthine, voacangine)
* Ibogalogs (e.g., ibogainalog)
* O-Methylnordehydrobufotenine
* Partial ergolines (e.g., NDTDI, RU-28306, CT-5252)
* Piperidinylethylindoles (e.g., pip-T)
* Pyrrolidinylethylindoles (e.g., pyr-T, 5-MeO-pyr-T)
* Pyrrolidinylmethylindoles (e.g., MPMI, 4-HO-MPMI (lucigenol), 5-MeO-MPMI)

Bioisosteres|

* Benzofurans (e.g., 5-MeO-DiBF, dimemebfe (5-MeO-BFE), mebfap)
* Benzothiophenes (e.g., 3-APBT)
* Indazolethylamines (e.g., AL-38022A, O-methyl-AL-34662)
* Indenylethylamines (e.g., C-DMT)
* Isotryptamines (e.g., 6-MeO-isoDMT, Ro60-0175)
* MYCO-005
* Quinolinylethylamines (e.g., mefloquine)

Phenethylamines|

| Scalines|

* 2-Bromomescaline
* 3-TE
* 3-TM
* 4-Desoxymescaline (DESOXY)
* 4-TE
* 4-TM
* Allylescaline
* Beta-D
* Cyclopropylmescaline
* Difluoroescaline
* Difluoromescaline
* Escaline
* Fluoroproscaline
* Isobuscaline
* Isoproscaline
* Jimscaline
* Mescaline (3,4,5-TMPEA)
* Metaescaline
* Methallylescaline
* N-Methylmescaline (M-M)
* NBOMe-escaline
* NBOMe-mescaline
* Proscaline
* Thioproscaline
* Tomscaline
* Trichocereine (N,N-dimethylmescaline; MM-M)
* Trifluoroescaline
* Trifluoromescaline

|

2C-x|

* 2C-B
* 2C-B-AN
* 2C-Bn
* 2C-Bu
* 2C-C
* 2C-CN
* 2C-CP
* 2C-D
* 2C-E
* 2C-EF
* 2C-F
* 2C-H
* 2C-I
* 2C-iBu
* 2C-iP
* 2C-N
* 2C-NH2
* 2C-P
* 2C-SE
* 2C-tBu
* 2C-TFE
* 2C-TFM
* 2C-YN
* 2C-V

* 2C-T-x: 2C-T
* 2C-T-2
* 2C-T-3
* 2C-T-4
* 2C-T-5
* 2C-T-6
* 2C-T-7
* 2C-T-8
* 2C-T-9
* 2C-T-10
* 2C-T-11
* 2C-T-12
* 2C-T-13
* 2C-T-14
* 2C-T-15
* 2C-T-16
* 2C-T-17
* 2C-T-18
* 2C-T-19
* 2C-T-20
* 2C-T-21
* 2C-T-22
* 2C-T-22.5
* 2C-T-23
* 2C-T-24
* 2C-T-25
* 2C-T-27
* 2C-T-28
* 2C-T-30
* 2C-T-31
* 2C-T-32
* CYB210010 (2C-T-TFM, 2C-T-36)

* 2C-O-x: 2C-O
* 2C-O-2
* 2C-O-4

* Others: 2C-G-x (e.g., 2C-G-3, 2C-G-5)
* β-Keto-2C-B (βk-2C-B)
* β-Keto-2C-I (βk-2C-I)
* β-Methyl-2C-B (BMB)
* BOx (e.g., BOB, BOD, BOH-2C-B)
* HOT-x (e.g., HOT-2, HOT-7, HOT-17)
* N-Ethyl-2C-B
* TWEETIOs (e.g., 2CD-2-ETO, 2CD-5-ETO, 2CE-5-ETO, 2CE-5iPrO, 2CT2-5-ETO, ASR-2001 (2CB-5PrO))

3C-x|

* 3C-AL
* 3C-BZ
* 3C-DFE
* 3C-E
* 3C-MAL
* 3C-P
* TMA (3C-M)

DOx|

* DOAM
* DOB
* DOBU
* DOC
* DOEF
* DOET
* DOH (2,5-DMA)
* DOI
* DOIB
* DOIP
* DOM
* DON
* DOPR
* DOTFM
* DOYN

* Aleph-x (DOT-x): Aleph (DOT)
* Aleph-2
* Aleph-4
* Aleph-6
* Aleph-7

* TMA-2 and derivatives (Mxx): MALM
* MEM
* MDFEM
* MFEM
* MIPM
* MMALM
* MPM
* MTFEM
* TMA-2

* Others: DOM-NBOMe
* Ganeshas (G-x) (e.g., Ganesha (G, G-1)

4C-x|

* 4C-B
* 4C-C
* 4C-D (Ariadne)
* 4C-E
* 4C-I
* 4C-N
* 4C-P
* 4C-T-2

Ψ-PEA|

* Ψ-2C-DFMO (ψ-2C-O-35)
* Ψ-2C-T-4
* Ψ-DODFMO
* Ψ-DOM
* TMA-6 (Ψ-TMA-2)

MDxx|

* 5-Methyl-MDA
* 6-Methyl-MDA
* DMMDA
* DMMDA-2
* EIDA
* EMDA-2
* IDA
* Lophophine (MMDPEA)
* Lys-MDA
* Lys-MDMA
* MDA (tenamfetamine)
* MDHMA
* MDMA (midomafetamine; ecstasy)
* MDOH
* MMDA
* MMDA-2
* MMDA-3a
* MMDMA
* N-t-BOC-MDMA
* (R)-MDMA

FLY|

* 2C-B-FLY
* 2C-B-BUTTERFLY
* 2C-B-DragonFLY
* 2C-B-DragonFLY-NBOH
* 2C-B-FLY-NB2EtO5Cl
* 2CB-5-hemifly
* 2CBFly-NBOMe
* Bromo-DragonFLY
* DOB-FLY
* DOH-FLY
* TFMFly

25x-NB (NBOMes)|

* 25x-NBOMe: 25B-NBOMe
* 25C-NBOMe
* 25CN-NBOMe
* 25D-NBOMe
* 25E-NBOMe
* 25F-NBOMe
* 25G-NBOMe
* 25H-NBOMe
* 25I-NBOMe
* 25iP-NBOMe
* 25N-NBOMe
* 25O-NBOMe
* 25P-NBOMe
* 25T-NBOMe
* 25T2-NBOMe
* 25T4-NBOMe
* 25T7-NBOMe
* 25TFM-NBOMe

* 25x-NBOH: 25B-NBOH
* 25C-NBOH
* 25CN-NBOH
* 25D-NBOH
* 25E-NBOH
* 25I-NBOH
* 25P-NBOH

* Others: 25B-NB (N-benzyl-2C-B)
* 2C2-NBOMe
* 2CBCB-NBOMe
* 2CBFly-NBOMe
* DOM-NBOMe
* NBOMe-escaline
* NBOMe-mescaline

Others|

* 2-TOET
* 2-TOM
* 25B-NAcPip
* 4-HA
* 5-TOET
* 5-TOM
* Benzofurans (e.g., 5-APB, 5-APDB, 6-APB, 6-APDB, F, F-2, F-22)
* Benzothiophenes (e.g., 5-APBT, 6-APBT)
* CT-5172
* DMAs (e.g., 2,4-DMA, 3,4-DMA)
* Fenfluramine
* MMA (3-MeO-4-MA)
* Norfenfluramine
* PEA-NDEPAs (e.g., 25D-NM-NDEAOP, DOB-NDEPA, DOI-NDEPA, DOM-NDEPA, DOTFM-NDEPA, M-NDEPA, TMA-2-NDEPA)
* PMA (4-MA)
* TMAs (e.g., TMA-3, TMA-4, TMA-5)
* TOMSO
* ZDCM-04

* Structure undisclosed: CYB005

Cyclized|

* 1-Aminomethylindanes (e.g., 2CB-Ind, jimscaline)
* 2-Aminoindanes (e.g., DOM-AI)
* 3-Phenylpiperidines (e.g., LPH-5, LPH-48)
* Benzazepines (e.g., lorcaserin)
* Benzocyclobutenes (e.g., 2CBCB-NBOMe, TCB-2, tomscaline)
* Benzoxepins (e.g., BBOX, IBOX, TFMBOX)
* DMBMPP (juncosamine)
* Ergolines/lysergamides (e.g., LSD)
* Glaucine
* Partial ergolines (e.g., NDTDI, DEIMDHPCA, DEMPDHPCA, DEMTMPDHPCA, DEMNDHPCA)
* Phenylcyclopropylamines (e.g., DMCPA, TMT)
* Phenyloxazolamines (aminorexes) (e.g., 2C-B-aminorex)
* Pyridopyrroloquinoxalines (e.g., IHCH-7113)
* Z3517967757
* ZC-B

Lysergamides|

* 2,3-Dihydro-LSD
* DAL
* DAM (DAM-57)
* DIPLA
* DPL
* ECPLA
* EIPLA
* EPLA (LEP; LEP-57)
* Ergine (LSA, LA-111)
* Ergometrine (ergonovine, ergobasine)
* ETFELA
* IPLA
* Isoergine (iso-LSA, iso-LA)
* LA-3Cl-SB (Cl-LSB)
* LAE (LAE-32)
* LAM
* LAMPA
* LAP
* LME (LME-54)
* LMP (LMP-55)
* LPD (LPD-824)
* LSB
* LSD (LSD-25, METH-LAD; lysergide)
* LSD-Pip
* LSDP (DPL)
* LSH
* LSM (LSM-775)
* LSP
* LSZ (LA-SS-Az)
* Lysergic acid pyrrolinide (LPN)
* Methylergometrine (methylergonovine, methylergobasine)
* MIPLA

* 6-Alkyllysergamides: BU-LAD
* CE-LAD (CHLORETH-LAD)
* CPM-LAD
* CYP-LAD (TRALA-22)
* ETH-LAD
* FLUORETH-LAD (FE-LAD)
* IP-LAD
* NBOMe-LAD
* PARGY-LAD
* PRO-LAD

* 1-Alkyllysergamides (prodrugs): Methysergide (1-methylmethylergonovine; UML-491)
* MLA-74 (1-methyl-LAE)
* MLD-41 (1-methyl-LSD)
* MPD-75 (1-methyl-LPD)
* OML-632 (1-hydroxymethyl-LSD)

* 1-Acyllysergamides (prodrugs): 1B-LSD
* 1cP-AL-LAD
* 1cP-LSD
* 1cP-MIPLA
* 1D-LSD
* 1DD-LSD
* 1F-LSD
* 1H-LSD
* 1P-AL-LAD
* 1P-ETH-LAD
* 1P-LSD
* 1P-MIPLA
* 1S-LSD
* 1T-AL-LAD
* 1T-LSD
* 1V-LSD
* ALA-10 (1-acetyl-LAE)
* ALD-52 (1-acetyl-LSD)

* Other ring system-substituted lysergamides: 12-Hydroxy-LSD
* 12-Methoxy-LSD

* Bioisosteres: JRT

Others|

* Arylpiperazines (e.g., 2C-B-PP, 2-NP, mCPP, MK-212, ORG-12962, pCPP, pFPP, quipazine, TFMPP)
* Dihydrobenzoxazines (e.g., efavirenz)
* Phenoxyethylamines (e.g., CT-4719, ORG-37684)
* Pyridopyrroloquinoxalines (e.g., IHCH-7113)
* Quinazolinylethylamines (e.g., RH-34)

* Structure undisclosed: BMB-202
* EGX-A
* EGX-B
* HBL20016
* Lucid-PSYCH (Lucid-201)
* MSP-4018
* MSP-4019
* MSP-4020
* Triptax

Natural sources|

* Tryptamines: Acacia spp. (e.g., Acacia acuminata, Acacia confusa)
* Ayahuasca and vinho de Jurema (e.g., Psychotria viridis (chacruna), Dipolopterys cabrerana (chaliponga, chacruna), Mimosa tenuiflora (Mimosa hostilis; jurema))
* Brosimum (e.g., Brosimum acutifolium (takini))
* Hallucinogenic snuffs (e.g., Anadenanthera peregrina (yopo, jopo, cohoba, parica, ebene), Anadenanthera colubrina (vilca, cebil))
* Incilius alvarius (Bufo alvarius; Colorado River toad, Sonoran Desert toad; bufo)
* Psilocybin-containing mushrooms (magic mushrooms, shrooms) (e.g., Psilocybe cubensis, Psilocybe mexicana (teonanacatl))

* Cyclized tryptamines: Banisteriopsis caapi (yagé)
* Peganum harmala (Syrian rue)
* Silene undulata
* Tabernanthe iboga (iboga)

* Phenethylamines: Pachycereus pringlei (saguesa, elephant cactus, cardon)
* Peyote (Lophophora williamsii; peyotl)
* Trichocereus cacti (e.g., San Pedro, Peruvian torch)

* Lysergamides: Achnatherum robustum (sleepy grass)
* Epichloë spp.
* Ergot (Claviceps) (e.g., Claviceps purpurea, Claviceps paspali)
* Morning glory (Convolvulaceae) seeds (e.g., Ipomoea tricolor (tlitliltzin, badoh negro; Ipomoea violacea), Ipomoea corymbosa (coaxihuitl, ololiúqui; Rivea Corymbosa, Turbina Corymbosa), Argyreia nervosa (Hawaiian baby woodrose; HBWR))
* Periglandula spp. (e.g., Periglandula ipomoeae, Periglandula clandestina)

* See also: Hallucinogens
* Entactogens
* Tryptamines
* Phenethylamines
* Ergolines and lysergamides
* Serotonin receptor modulators

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*[NBOMe]: NB: N-benzyl; OMe: methoxy
*[NBOH]: NB: N-benzyl; OH: hydroxy