quinoline-4-carboxylate 2-oxidoreductase

Identifiers
EC no.| 1.3.99.19
CAS no.| 175780-18-4
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In enzymology, a quinoline-4-carboxylate 2-oxidoreductase (EC 1.3.99.19) is an enzyme that catalyzes the chemical reaction

quinoline-4-carboxylate + acceptor + H2O  ⇌ {\displaystyle \rightleftharpoons } 2-oxo-1,2-dihydroquinoline-4-carboxylate + reduced acceptor

The 3 substrates of this enzyme are quinoline-4-carboxylate, acceptor, and H2O, whereas its two products are 2-oxo-1,2-dihydroquinoline-4-carboxylate and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is quinoline-4-carboxylate:acceptor 2-oxidoreductase (hydroxylating). Other names in common use include quinaldic acid 4-oxidoreductase, and quinoline-4-carboxylate:acceptor 2-oxidoreductase (hydroxylating).

## References

[edit]

* Bauer G, Lingens F (1992). "Microbial metabolism of quinoline and related compounds. XV Quinoline-4-carboxylic acid oxidoreductase from Agrobacterium spec.1B: a molybdenum-containing enzyme". Biol. Chem. Hoppe-Seyler. 373 (8): 699–705\. doi:10.1515/bchm3.1992.373.2.699. PMID 1418685.699-705&rft.date=1992&rft_id=info:doi/10.1515/bchm3.1992.373.2.699&rft_id=info:pmid/1418685&rft.aulast=Bauer&rft.aufirst=G&rft.au=Lingens,+F&rfr_id=info:sid/en.wikipedia.org:Quinoline-4-carboxylate+2-oxidoreductase" class="Z3988">

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Oxidoreductases: CH–CH oxidoreductases (EC 1.3)

1.3.1: NAD/NADP acceptor|

* Enoyl-acyl carrier protein reductase/Enoyl ACP reductase
* 7-Dehydrocholesterol reductase
* Biliverdin reductase
* 2,4 Dienoyl-CoA reductase
* Dihydroxymethyloxo-tetrahydroquinoline dehydrogenase

1.3.3: Oxygen acceptor|

* Dihydroorotate dehydrogenase
* Coproporphyrinogen III oxidase
* Protoporphyrinogen oxidase
* Bilirubin oxidase
* Acyl-CoA oxidase
* Dihydrouracil oxidase
* Tetrahydroberberine oxidase
* Secologanin synthase
* Tryptophan alpha,beta-oxidase
* Pyrroloquinoline-quinone synthase
* L-galactonolactone oxidase

1.3.5: Quinone|

* Succinate dehydrogenase
* SDHA
* SDHB
* SDHC
* SDHD

1.3.99: Other acceptors|

* Fumarate reductase
* Butyryl-CoA dehydrogenase
* Acyl CoA dehydrogenase
* ACADSB
* ACADS
* 5α-reductase
* SRD5A1
* SRD5A2
* SRD5A3
* Glutaryl-CoA dehydrogenase
* Isovaleryl coenzyme A dehydrogenase
* 3-oxo-5beta-steroid 4-dehydrogenase

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Enzymes

Activity|

* Active site
* Binding site
* Catalytic triad
* Oxyanion hole
* Enzyme promiscuity
* Diffusion-limited enzyme
* Cofactor
* Enzyme catalysis

Regulation|

* Allosteric regulation
* Cooperativity
* Enzyme inhibitor
* Enzyme activator

Classification|

* EC number
* Enzyme superfamily
* Enzyme family
* List of enzymes

Kinetics|

* Enzyme kinetics
* Eadie–Hofstee diagram
* Hanes–Woolf plot
* Lineweaver–Burk plot
* Michaelis–Menten kinetics

Types|

* EC1 Oxidoreductases (list)
* EC2 Transferases (list)
* EC3 Hydrolases (list)
* EC4 Lyases (list)
* EC5 Isomerases (list)
* EC6 Ligases (list)
* EC7 Translocases (list)

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