RAB6A

Protein-coding gene in the species Homo sapiens

RAB6A

| Available structures

PDB| Ortholog search: PDBe RCSB
| List of PDB id codes

1YZQ, 2GIL, 3BBP, 3CWZ, 4DKX

Identifiers
Aliases| RAB6A, RAB6, member RAS oncogene family
External IDs| OMIM: 179513; MGI: 894313; HomoloGene: 55697; GeneCards: RAB6A; OMA:RAB6A - orthologs
| Gene location (Human)

Chr.| Chromosome 11 (human)[1]

Band| 11q13.4| Start| 73,675,638 bp[1]
End| 73,761,137 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 7 (mouse)[2]

Band| 7|7 E2| Start| 100,256,617 bp[2]
End| 100,290,475 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* Achilles tendon

* anterior cingulate cortex

* ganglionic eminence

* ventricular zone

* Brodmann area 10

* epithelium of colon

* frontal pole

* C1 segment

* right frontal lobe

* stromal cell of endometrium

| Top expressed in

* primary motor cortex

* prefrontal cortex

* cingulate gyrus

* anterior amygdaloid area

* lateral geniculate nucleus

* lateral septal nucleus

* medial dorsal nucleus

* ventral tegmental area

* hippocampus proper

* dentate gyrus of hippocampal formation granule cell

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* nucleotide binding
* protein domain specific binding
* GTP binding
* myosin V binding
* protein binding
* GTPase activity

Cellular component|

* Golgi apparatus
* membrane
* endosome to plasma membrane transport vesicle
* trans-Golgi network
* extracellular exosome
* cytoplasmic vesicle
* trans-Golgi network membrane
* cytosol
* endoplasmic reticulum membrane
* Golgi membrane
* plasma membrane
* secretory granule membrane

Biological process|

* antigen processing and presentation
* early endosome to Golgi transport
* peptidyl-cysteine methylation
* protein localization to Golgi apparatus
* protein transport
* minus-end-directed organelle transport along microtubule
* viral process
* vesicle-mediated transport
* retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
* neutrophil degranulation
* transport
* intracellular protein transport
* intra-Golgi vesicle-mediated transport
* Rab protein signal transduction
* retrograde transport, endosome to Golgi

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

5870

19346

Ensembl| |

ENSG00000175582

ENSMUSG00000030704

UniProt| |

P20340

P35279

RefSeq (mRNA)| |

NM_198896
NM_001243718
NM_001243719
NM_002869

NM_001163663
NM_024287

RefSeq (protein)| |

NP_001230647
NP_001230648
NP_002860
NP_942599

NP_001157135
NP_077249

Location (UCSC)| Chr 11: 73.68 – 73.76 Mb| Chr 7: 100.26 – 100.29 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Ras-related protein Rab-6A is a protein that in humans is encoded by the RAB6A gene located in the eleventh chromosome.[5] Its main function is the regulation of protein transport from the Golgi complex to the endoplasmic reticulum and the exocytosis along with the microtubules.

## Interactions

[edit]

RAB6A has been shown to interact with:

* BICD1,[6][7]
* DCTN1[6]
* ERC1,[8] and
* KIF20A.[9][10]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175582 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030704 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: RAB6A RAB6A, member RAS oncogene family".
6. ^ a b Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA (October 2002). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Curr. Biol. 12 (20): 1792–5\. Bibcode:2002CBio...12.1792S. doi:10.1016/s0960-9822(02)01221-6. PMID 12401177.
7. ^ Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC (December 2002). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex". Nat. Cell Biol. 4 (12): 986–92\. doi:10.1038/ncb891. PMID 12447383. S2CID 7953140.
8. ^ Monier S, Jollivet F, Janoueix-Lerosey I, Johannes L, Goud B (April 2002). "Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport". Traffic. 3 (4): 289–97\. doi:10.1034/j.1600-0854.2002.030406.x. PMID 11929610. S2CID 22993226.
9. ^ Echard A, Jollivet F, Martinez O, Lacapère JJ, Rousselet A, Janoueix-Lerosey I, Goud B (January 1998). "Interaction of a Golgi-associated kinesin-like protein with Rab6". Science. 279 (5350): 580–5\. Bibcode:1998Sci...279..580E. doi:10.1126/science.279.5350.580. PMID 9438855.
10. ^ Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA (November 2000). "Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms". Mol. Biol. Cell. 11 (11): 3819–33\. doi:10.1091/mbc.11.11.3819. PMC 15039. PMID 11071909.

## Further reading

[edit]

* Rousseau-Merck MF, Zahraoui A, Touchot N, Tavitian A, Berger R (1991). "Chromosome assignment of four RAS-related RAB genes". Hum. Genet. 86 (4): 350–4\. doi:10.1007/BF00201831. PMID 1999336. S2CID 30730416.
* Goud B, Zahraoui A, Tavitian A, Saraste J (1990). "Small GTP-binding protein associated with Golgi cisternae". Nature. 345 (6275): 553–6\. Bibcode:1990Natur.345..553G. doi:10.1038/345553a0. PMID 2112230. S2CID 4341620.
* Zahraoui A, Touchot N, Chardin P, Tavitian A (1989). "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion". J. Biol. Chem. 264 (21): 12394–401\. doi:10.1016/S0021-9258(18)63872-4. PMID 2501306.
* Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4\. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.1–2&rft.pages=171-4&rft.date=1994&rft_id=info:doi/10.1016/0378-1119(94)90802-8&rft_id=info:pmid/8125298&rft.aulast=Maruyama&rft.aufirst=K&rft.au=Sugano,+S&rfr_id=info:sid/en.wikipedia.org:RAB6A" class="Z3988">
* Beranger F, Cadwallader K, Porfiri E, Powers S, Evans T, de Gunzburg J, Hancock JF (1994). "Determination of structural requirements for the interaction of Rab6 with RabGDI and Rab geranylgeranyltransferase". J. Biol. Chem. 269 (18): 13637–43\. doi:10.1016/S0021-9258(17)36877-1. PMID 8175798.
* Cremers FP, Armstrong SA, Seabra MC, Brown MS, Goldstein JL (1994). "REP-2, a Rab escort protein encoded by the choroideremia-like gene". J. Biol. Chem. 269 (3): 2111–7\. doi:10.1016/S0021-9258(17)42142-9. PMID 8294464.
* Karniguian A, Zahraoui A, Tavitian A (1993). "Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins". Proc. Natl. Acad. Sci. U.S.A. 90 (16): 7647–51\. Bibcode:1993PNAS...90.7647K. doi:10.1073/pnas.90.16.7647. PMC 47199. PMID 8356066.
* Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13\. doi:10.1006/abio.1996.0138. PMID 8619474.
* Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806\. doi:10.1101/gr.6.9.791. PMID 8889548.
* Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8\. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
* Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56\. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.1–2&rft.pages=149-56&rft.date=1997&rft_id=info:doi/10.1016/S0378-1119(97)00411-3&rft_id=info:pmid/9373149&rft.aulast=Suzuki&rft.aufirst=Y&rft.au=Yoshitomo-Nakagawa,+K&rft.au=Maruyama,+K&rft.au=Suyama,+A&rft.au=Sugano,+S&rfr_id=info:sid/en.wikipedia.org:RAB6A" class="Z3988">
* Echard A, Jollivet F, Martinez O, Lacapère JJ, Rousselet A, Janoueix-Lerosey I, Goud B (1998). "Interaction of a Golgi-associated kinesin-like protein with Rab6". Science. 279 (5350): 580–5\. Bibcode:1998Sci...279..580E. doi:10.1126/science.279.5350.580. PMID 9438855.
* Cuif MH, Possmayer F, Zander H, Bordes N, Jollivet F, Couedel-Courteille A, Janoueix-Lerosey I, Langsley G, Bornens M, Goud B (1999). "Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome". EMBO J. 18 (7): 1772–82\. doi:10.1093/emboj/18.7.1772. PMC 1171263. PMID 10202141.
* Barr FA (1999). "A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins". Curr. Biol. 9 (7): 381–4\. Bibcode:1999CBio....9..381B. doi:10.1016/S0960-9822(99)80167-5. PMID 10209123.
* Bucci C, Chiariello M, Lattero D, Maiorano M, Bruni CB (1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1)". Biochem. Biophys. Res. Commun. 258 (3): 657–62\. doi:10.1006/bbrc.1999.0651. PMID 10329441.
* Caillol N, Pasqualini E, Lloubes R, Lombardo D (2000). "Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells". J. Cell. Biochem. 79 (4): 628–47\. doi:10.1002/1097-4644(20001215)79:4<628::AID-JCB120>3.0.CO;2-T. PMID 10996854. S2CID 11614620.
* Shan J, Mason JM, Yuan L, Barcia M, Porti D, Calabro A, Budman D, Vinciguerra V, Xu H (2001). "Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells". Gene. 257 (1): 67–75\. doi:10.1016/S0378-1119(00)00395-4. PMID 11054569.
* Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA (2001). "Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms". Mol. Biol. Cell. 11 (11): 3819–33\. doi:10.1091/mbc.11.11.3819. PMC 15039. PMID 11071909.
* Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95\. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
* Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35\. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

* v
* t
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PDB gallery

* 1yzq: GppNHp-Bound Rab6 GTPase

* 2fe4: The crystal structure of human neuronal Rab6B in its inactive GDP-bound form

* 2ffq: The crystal structure of human neuronal Rab6B in its active GTPgS-bound form

* 2gil: Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8 resolution

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