RNA of unknown function

Secondary structure of RUF21, an RNA of unknown function from S. cerevisiae[1]

RNA of unknown function (RUF) is a generic name, often appended with a numeric identifier, for a non-coding RNA molecule which has been partially characterised or predicted but the biological function has yet to be determined. The same convention is used for proteins, they can be named domains of unknown function (DUFs).

Examples of RUFs include:

* RUF1–8 found in Saccharomyces cerevisiae,[2] though three of these were later reclassified due to experimental errors[3]
* RUF20–23 also from S. cerevisiae[1]
* RUF1–6 found in Plasmodium falciparum in 2007[4]

## References[edit]

1. ^ a b Kavanaugh LA, Dietrich FS (January 2009). "Non-coding RNA prediction and verification in Saccharomyces cerevisiae". PLOS Genet. 5 (1): e1000321. doi:10.1371/journal.pgen.1000321. PMC 2603021. PMID 19119416.
2. ^ McCutcheon JP, Eddy SR (July 2003). "Computational identification of non-coding RNAs in Saccharomyces cerevisiae by comparative genomics". Nucleic Acids Res. 31 (14): 4119–4128. doi:10.1093/nar/gkg438. PMC 165953. PMID 12853629.
3. ^ McCutcheon, J. P.; Eddy, S. R. (2004). "Computational identification of non-coding RNAs in Saccharomyces cerevisiae by comparative genomics". Nucleic Acids Research. 32 (15): 4119–4128. doi:10.1093/nar/gkh801. PMC 165953. PMID 12853629.
4. ^ Chakrabarti K, Pearson M, Grate L, et al. (November 2007). "Structural RNAs of known and unknown function identified in malaria parasites by comparative genomics and RNA analysis". RNA. 13 (11): 1923–1939. doi:10.1261/rna.751807. PMC 2040097. PMID 17901154. Retrieved 2010-09-16.

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