ROBO2

Protein-coding gene in the species Homo sapiens

ROBO2

| Available structures

PDB| Ortholog search: PDBe RCSB
| List of PDB id codes

1UEM, 1UJT, 2EDJ

Identifiers
Aliases| ROBO2, SAX3, roundabout guidance receptor 2
External IDs| OMIM: 602431; MGI: 1890110; HomoloGene: 43188; GeneCards: ROBO2; OMA:ROBO2 - orthologs
| Gene location (Human)

Chr.| Chromosome 3 (human)[1]

Band| 3p12.3| Start| 75,906,695 bp[1]
End| 77,649,964 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 16 (mouse)[2]

Band| 16|16 C3.1| Start| 73,688,727 bp[2]
End| 74,208,713 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* ganglionic eminence

* ventricular zone

* buccal mucosa cell

* prefrontal cortex

* islet of Langerhans

* cartilage tissue

* Brodmann area 46

* pons

* endothelial cell

* gonad

| Top expressed in

* Rostral migratory stream

* hand

* genital tubercle

* dentate gyrus of hippocampal formation granule cell

* superior frontal gyrus

* neural layer of retina

* ganglionic eminence

* primary visual cortex

* olfactory bulb

* superior colliculus

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* protein binding
* identical protein binding
* axon guidance receptor activity

Cellular component|

* integral component of membrane
* membrane
* cell surface
* axolemma
* extracellular exosome
* plasma membrane

Biological process|

* cell differentiation
* ureteric bud development
* kidney development
* negative regulation of synapse assembly
* Roundabout signaling pathway
* positive regulation of axonogenesis
* nervous system development
* multicellular organism development
* chemotaxis
* central nervous system development
* cellular response to hormone stimulus
* olfactory bulb interneuron development
* apoptotic process involved in luteolysis
* negative regulation of negative chemotaxis
* axon midline choice point recognition
* metanephros development
* homophilic cell adhesion via plasma membrane adhesion molecules
* retinal ganglion cell axon guidance
* brain development
* spinal cord development
* axon guidance
* outflow tract septum morphogenesis
* aortic valve morphogenesis
* pulmonary valve morphogenesis
* endocardial cushion formation
* positive regulation of Notch signaling pathway involved in heart induction
* aorta development
* ventricular septum morphogenesis

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

6092

268902

Ensembl| |

ENSG00000185008

ENSMUSG00000052516

UniProt| |

Q9HCK4

Q7TPD3

RefSeq (mRNA)| | NM_001128929
NM_001290039
NM_001290040
NM_001290065
NM_002942

NM_001378190
NM_001378191
NM_001378192
NM_001378193
NM_001378194
NM_001378195
NM_001378196
NM_001378197
NM_001378198
NM_001378199
NM_001378200
NM_001378201
NM_001378202
NM_001378203
NM_001394212
NM_001394213
NM_001394214
NM_001395656
NM_001395657

| NM_175549
NM_001358490
NM_001358491
NM_001358492
NM_001358493

NM_001358494

RefSeq (protein)| | NP_001122401
NP_001276968
NP_001276969
NP_001276994
NP_002933

NP_001365119
NP_001365120
NP_001365121
NP_001365122
NP_001365123
NP_001365124
NP_001365125
NP_001365126
NP_001365127
NP_001365128
NP_001365129
NP_001365130
NP_001365131
NP_001365132

n/a

Location (UCSC)| Chr 3: 75.91 – 77.65 Mb| Chr 16: 73.69 – 74.21 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Roundabout homolog 2 is a protein that in humans is encoded by the ROBO2 gene.[5][6]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185008 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052516 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Kidd T, Brose K, Mitchell KJ, Fetter RD, Tessier-Lavigne M, Goodman CS, Tear G (January 1998). "Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors". Cell. 92 (2): 205–215\. doi:10.1016/S0092-8674(00)80915-0. PMID 9458045. S2CID 2036419.
6. ^ "Entrez Gene: ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila)".

## Further reading

[edit]

* Hauptman G, Reichert MC, Abdal Rhida MA, Evans TA (December 2022). "Characterization of enhancer fragments in Drosophila robo2". Fly. 16 (1): 312–346\. doi:10.1080/19336934.2022.2126259. PMC 9559326. PMID 36217698.
* Brose K, Bland KS, Wang KH, Arnott D, Henzel W, Goodman CS, et al. (March 1999). "Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance". Cell. 96 (6): 795–806\. doi:10.1016/S0092-8674(00)80590-5. PMID 10102268. S2CID 16301178.
* Nguyen Ba-Charvet KT, Brose K, Marillat V, Kidd T, Goodman CS, Tessier-Lavigne M, et al. (March 1999). "Slit2-Mediated chemorepulsion and collapse of developing forebrain axons". Neuron. 22 (3): 463–473\. doi:10.1016/S0896-6273(00)80702-3. PMID 10197527. S2CID 18663762.
* Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (August 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (4): 273–281\. doi:10.1093/dnares/7.4.271. PMID 10997877.
* Nguyen Ba-Charvet KT, Brose K, Ma L, Wang KH, Marillat V, Sotelo C, et al. (June 2001). "Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance". The Journal of Neuroscience. 21 (12): 4281–4289\. doi:10.1523/JNEUROSCI.21-12-04281.2001. PMC 6762758. PMID 11404413.
* Marillat V, Cases O, Nguyen-Ba-Charvet KT, Tessier-Lavigne M, Sotelo C, Chédotal A (January 2002). "Spatiotemporal expression patterns of slit and robo genes in the rat brain". The Journal of Comparative Neurology. 442 (2): 130–155\. doi:10.1002/cne.10068. PMID 11754167. S2CID 24164570.
* Hivert B, Liu Z, Chuang CY, Doherty P, Sundaresan V (December 2002). "Robo1 and Robo2 are homophilic binding molecules that promote axonal growth". Molecular and Cellular Neurosciences. 21 (4): 534–545\. doi:10.1006/mcne.2002.1193. PMID 12504588. S2CID 19664833.
* Grieshammer U, Plump AS, Wang F, Tessier-Lavigne M, Martin GR (May 2004). "SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site". Developmental Cell. 6 (5): 709–717\. doi:10.1016/S1534-5807(04)00108-X. PMID 15130495.
* Yue Y, Grossmann B, Galetzka D, Zechner U, Haaf T (December 2006). "Isolation and differential expression of two isoforms of the ROBO2/Robo2 axon guidance receptor gene in humans and mice". Genomics. 88 (6): 772–778\. doi:10.1016/j.ygeno.2006.05.011. PMID 16829019.
* Lu W, van Eerde AM, Fan X, Quintero-Rivera F, Kulkarni S, Ferguson H, et al. (April 2007). "Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux". American Journal of Human Genetics. 80 (4): 616–632\. doi:10.1086/512735. PMC 1852714. PMID 17357069.

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PDB gallery

* 1uem: Solution Structure of the First Fibronectin Type III domain of human KIAA1568 Protein

* 1ujt: Solution structure of the second fibronectin Type III domain of human KIAA1568 protein

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