Ras association domain family member 10

Protein-coding gene in the species Homo sapiens

RASSF10

Identifiers
Aliases| RASSF10, Ras association domain family member 10
External IDs| OMIM: 614713; MGI: 1925998; HomoloGene: 121963; GeneCards: RASSF10; OMA:RASSF10 - orthologs
| Gene location (Human)

Chr.| Chromosome 11 (human)[1]

Band| 11p15.3| Start| 13,009,316 bp[1]
End| 13,012,119 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 7 (mouse)[2]

Band| 7|7 F1| Start| 112,553,169 bp[2]
End| 112,556,664 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* bronchial epithelial cell

* testicle

* oral cavity

* gums

* lactiferous duct

* olfactory zone of nasal mucosa

* buccal mucosa cell

* nipple

* pancreatic ductal cell

* gingival epithelium

| Top expressed in

* otolith organ

* utricle

* lumbar spinal ganglion

* hair follicle

* trigeminal ganglion

* vestibular membrane of cochlear duct

* Paneth cell

* aortic valve

* renal corpuscle

* ciliary body

More reference expression data
BioGPS| | n/a

| Orthologs

Species| Human| Mouse
Entrez| |

644943

78748

Ensembl| |

ENSG00000189431

ENSMUSG00000098132

UniProt| |

A6NK89

Q8BL43

RefSeq (mRNA)| |

NM_001080521

NM_175279

RefSeq (protein)| |

NP_001073990

NP_780488

Location (UCSC)| Chr 11: 13.01 – 13.01 Mb| Chr 7: 112.55 – 112.56 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Ras association domain family member 10 is a protein that in humans is encoded by the RASSF10 gene. [5]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000189431 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000098132 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: Ras association domain family member 10". Retrieved 2018-04-12.

## Further reading

[edit]

* Dansranjavin T, Wagenlehner F, Gattenloehner S, Steger K, Weidner W, Dammann R, Schagdarsurengin U (October 2012). "Epigenetic down regulation of RASSF10 and its possible clinical implication in prostate carcinoma". The Prostate. 72 (14): 1550–8. doi:10.1002/pros.22510. PMID 22415519. S2CID 36361388.
* Hill VK, Underhill-Day N, Krex D, Robel K, Sangan CB, Summersgill HR, Morris M, Gentle D, Chalmers AD, Maher ER, Latif F (February 2011). "Epigenetic inactivation of the RASSF10 candidate tumor suppressor gene is a frequent and an early event in gliomagenesis". Oncogene. 30 (8): 978–89. doi:10.1038/onc.2010.471. PMID 20956940.
* Helmbold P, Richter AM, Walesch S, Skorokhod A, Marsch WC, Enk A, Dammann RH (March 2012). "RASSF10 promoter hypermethylation is frequent in malignant melanoma of the skin but uncommon in nevus cell nevi". The Journal of Investigative Dermatology. 132 (3 Pt 1): 687–94. doi:10.1038/jid.2011.380. PMID 22113481.
* Hesson LB, Dunwell TL, Cooper WN, Catchpoole D, Brini AT, Chiaramonte R, Griffiths M, Chalmers AD, Maher ER, Latif F (July 2009). "The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias". Molecular Cancer. 8: 42. doi:10.1186/1476-4598-8-42. PMC 2711046. PMID 19570220.
* Li X, Liang Q, Liu W, Zhang N, Xu L, Zhang X, Zhang J, Sung JJ, Yu J (May 2016). "Ras association domain family member 10 suppresses gastric cancer growth by cooperating with GSTP1 to regulate JNK/c-Jun/AP-1 pathway". Oncogene. 35 (19): 2453–64. doi:10.1038/onc.2015.300. PMID 26279301. S2CID 25076216.
* Li Z, Chang X, Dai D, Deng P, Sun Q (April 2014). "RASSF10 is an epigenetically silenced tumor suppressor in gastric cancer". Oncology Reports. 31 (4): 1661–8. doi:10.3892/or.2014.3039. PMID 24573726.
* Lu D, Ma J, Zhan Q, Li Y, Qin J, Guo M (April 2014). "Epigenetic silencing of RASSF10 promotes tumor growth in esophageal squamous cell carcinoma". Discovery Medicine. 17 (94): 169–78. PMID 24759621.
* Schagdarsurengin U, Richter AM, Wöhler C, Dammann RH (November 2009). "Frequent epigenetic inactivation of RASSF10 in thyroid cancer". Epigenetics. 4 (8): 571–6. doi:10.4161/epi.4.8.10056. PMID 19934646.
* Wei Z, Chen X, Chen J, Wang W, Xu X, Cai Q (March 2013). "RASSF10 is epigenetically silenced and functions as a tumor suppressor in gastric cancer". Biochemical and Biophysical Research Communications. 432 (4): 632–7. doi:10.1016/j.bbrc.2013.02.033. PMID 23428420.

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