Regina G. Ziegler

American nutritional epidemiologist

Not to be confused with Regina Ziegler.

Regina G. Ziegler

Ziegler in 2009

Alma mater| Swarthmore College
University of California, Berkeley
Harvard T.H. Chan School of Public Health
Scientific career
Fields| Biochemistry, cancer and nutritional epidemiology
Institutions| National Cancer Institute

Regina Gale Ziegler is an American biochemist and nutritional epidemiologist who researched dietary, nutritional, anthropometric, and hormonal determinants of cancer risk. She was a senior investigator in the National Cancer Institute's epidemiology and biostatistics program.

## Life

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Ziegler received a B.A. from Swarthmore College.[1] She completed a Ph.D. in biochemistry from the University of California, Berkeley.[1] Her 1971 dissertation was titled, Affinity labelling lysozyme with a carbene.[2] She earned a M.P.H. from Harvard T.H. Chan School of Public Health.[1] After graduate school, she taught international nutrition and global food resources courses at Yale University, Harvard University, and Tufts University.[1]

Ziegler joined the National Cancer Institute (NCI) in 1979, was tenured in 1987, and has served most recently as a senior investigator in the epidemiology and biostatistics program.[1] Ziegler’s research has focused broadly on dietary, nutritional, anthropometric, and hormonal determinants of cancer risk.[1] Her early work helped characterize the role of vegetables and fruits, individual carotenoids, folate and one-carbon metabolism in cancer etiology.[1] In addition, she has conducted a number of breast cancer studies with emphasis on anthropometry, diet and endogenous hormones and growth factors.[1] She helped design and direct a large, population-based case-control study of breast cancer in Asian-American women to elucidate the modifiable exposures, related to lifestyle and/or environment, that explained the 6-fold difference in breast cancer incidence between Asia and the West.[1] Ziegler collaboratively developed an international pooled analysis of circulating vitamin D concentrations in relation to risk of colorectal and breast cancer.[1]

Ziegler applied her training in chemistry and biochemistry to the development of new and improved methods for measuring various hormones and nutrients in epidemiologic studies.[1] She played a critical role in the successful development of a sensitive assay for assessment of estrogen metabolites and a validated assay for concurrent measurement of the major steroid hormones.[1] Ziegler is a fellow of the American Society for Nutrition and helped establish its nutritional epidemiology research interest section.[1]

Ziegler retired in October 2018.[1]

## References

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1. ^ a b c d e f g h i j k l m n "Ziegler Retires from NCI". NIH Record. 2018-11-30. Retrieved 2022-10-25. This article incorporates text from this source, which is in the public domain.
2. ^ Ziegler, Regina Gale (1971). Affinity labelling lysozyme with a carbene (Ph.D. thesis). University of California, Berkeley. OCLC 17901294.

This article incorporates public domain material from websites or documents of the National Institutes of Health.

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