SARNP

Protein-coding gene in the species Homo sapiens

SARNP

| Available structures

PDB| Ortholog search: PDBe RCSB
| List of PDB id codes

2DO1

Identifiers
Aliases| SARNP, CIP29, HCC1, HSPC316, THO1, SAP domain containing ribonucleoprotein
External IDs| OMIM: 610049; MGI: 1913368; HomoloGene: 41628; GeneCards: SARNP; OMA:SARNP - orthologs
| Gene location (Mouse)

Chr.| Chromosome 10 (mouse)[1]

Band| 10|10 D3| Start| 128,817,333 bp[1]
End| 128,877,629 bp[1]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* ganglionic eminence

* smooth muscle tissue

* Achilles tendon

* monocyte

* tibial nerve

* right adrenal gland

* ascending aorta

* islet of Langerhans

* gastrocnemius muscle

* left coronary artery

| Top expressed in

* ventricular zone

* ganglionic eminence

* epiblast

* lens

* neural tube

* yolk sac

* ovary

* thymus

* embryo

* embryo

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* DNA binding
* protein binding
* RNA binding
* RNA polymerase II cis-regulatory region sequence-specific DNA binding
* DNA-binding transcription repressor activity, RNA polymerase II-specific
* protein C-terminus binding
* RS domain binding

Cellular component|

* nuclear speck
* transcription export complex
* nucleus
* nucleoplasm
* cytoplasmic ribonucleoprotein granule

Biological process|

* mRNA transport
* regulation of transcription, DNA-templated
* regulation of translation
* transcription, DNA-templated
* RNA export from nucleus
* mRNA export from nucleus
* termination of RNA polymerase II transcription
* mRNA 3'-end processing
* transport
* negative regulation of transcription by RNA polymerase II

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

84324

66118

Ensembl| |

n/a

ENSMUSG00000078427

UniProt| |

P82979

Q9D1J3

RefSeq (mRNA)| |

NM_033082

NM_025364

RefSeq (protein)| |

NP_149073

| NP_079640
NP_001346332
NP_001346333
NP_001346334
NP_001346335

NP_001346336

Location (UCSC)| n/a| Chr 10: 128.82 – 128.88 Mb
PubMed search| [2]| [3]
Wikidata
| View/Edit Human| View/Edit Mouse

|

SAP domain-containing ribonucleoprotein is a protein that in humans is encoded by the SARNP gene.[4][5][6]

## References

[edit]

1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000078427 - Ensembl, May 2017
2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ Choong ML, Tan LK, Lo SL, Ren EC, Ou K, Ong SE, Liang RC, Seow TK, Chung MC (May 2001). "An integrated approach in the discovery and characterization of a novel nuclear protein over-expressed in liver and pancreatic tumors". FEBS Lett. 496 (2–3): 109–16. doi:10.1016/S0014-5793(01)02409-7. PMID 11356193. S2CID 24122700.
5. ^ Fukuda S, Wu DW, Stark K, Pelus LM (Mar 2002). "Cloning and characterization of a proliferation-associated cytokine-inducible protein, CIP29". Biochem Biophys Res Commun. 292 (3): 593–600. doi:10.1006/bbrc.2002.6680. PMID 11922608.
6. ^ "Entrez Gene: CIP29 cytokine induced protein 29 kDa".

## External links

[edit]

* Human SARNP genome location and SARNP gene details page in the UCSC Genome Browser.

## Further reading

[edit]

* Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
* Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
* Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
* Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
* Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
* Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
* Navakauskiene R, Treigyte G, Gineitis A, Magnusson KE (2004). "Identification of apoptotic tyrosine-phosphorylated proteins after etoposide or retinoic acid treatment". Proteomics. 4 (4): 1029–41. doi:10.1002/pmic.200300671. PMID 15048984. S2CID 26389150.
* Hashii Y, Kim JY, Sawada A, et al. (2004). "A novel partner gene CIP29 containing a SAP domain with MLL identified in infantile myelomonocytic leukemia". Leukemia. 18 (9): 1546–8. doi:10.1038/sj.leu.2403450. PMID 15284855. S2CID 23982148.
* Leaw CL, Ren EC, Choong ML (2004). "Hcc-1 is a novel component of the nuclear matrix with growth inhibitory function". Cell. Mol. Life Sci. 61 (17): 2264–73. doi:10.1007/s00018-004-4205-x. PMC 11138947. PMID 15338056. S2CID 19729441.
* Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
* Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
* Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
* Sugiura T, Sakurai K, Nagano Y (2007). "Intracellular characterization of DDX39, a novel growth-associated RNA helicase". Exp. Cell Res. 313 (4): 782–90. doi:10.1016/j.yexcr.2006.11.014. PMID 17196963.

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PDB gallery

* 2do1: Solution structure of the SAP domain of human nuclear protein Hcc-1

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