SARS-CoV-2 Delta variant

Variant of SARS-CoV-2 detected late 2020

For lineage B.1.617.1, see SARS-CoV-2 Kappa variant.

This article is about a variant of the virus that causes COVID-19. Not to be confused with the Deltacoronavirus grouping of coronavirus species that affects birds and non-human mammals.

This article needs to be updated. Please help update this article to reflect recent events or newly available information. (December 2021)

|

SARS-CoV-2 VariantDelta

General details
WHO Designation| Delta
Lineage| B.1.617.2
First detected| India
Date reported| 2020; 2 years ago (2020)
Status| Variant of concern
Symptoms

* None
* headaches[1][2]
* sore throat[1]
* a runny nose[1][2]
* fever[1]

Cases map

Countries with confirmed cases of Delta variant as of 10 August 2021 (GISAID) [needs update]
Legend:

10,000+ confirmed sequences

5,000–9,999 confirmed sequences

1,000–4,999 confirmed sequences

100–999 confirmed sequences

10–99 confirmed sequences

1–9 confirmed sequence

None or no data

Major variants

* Wild type
* Alpha (B.1.1.7)
* Beta (B.1.351)
* Gamma (P.1)
* Delta (B.1.617.2)

Omicron (B.1.1.529)

* BA.1
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* BA.5

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The Delta variant (B.1.617.2) was[3][4] a variant of SARS-CoV-2, the virus that causes COVID-19. It was first detected in India in late 2020. The Delta variant was named on 31 May 2021 and had spread to over 179 countries by 22 November 2021. The World Health Organization (WHO) indicated in June 2021 that the Delta variant was becoming the dominant strain globally.[5]

It has mutations in the gene encoding the SARS-CoV-2 spike protein[6] causing the substitutions T478K, P681R and L452R,[7][8] which are known to affect transmissibility of the virus as well as whether it can be neutralised by antibodies for previously circulating variants of the COVID-19 virus.[9] In August 2021, Public Health England (PHE) reported secondary attack rate in household contacts of non-travel or unknown cases for Delta to be 10.8% vis-à-vis 10.2% for the Alpha variant;[10] the case fatality rate for those 386,835 people with Delta is 0.3%, where 46% of the cases and 6% of the deaths are unvaccinated and below 50 years old.[11] Immunity from previous recovery[12][13] or COVID-19 vaccines are effective in preventing severe disease or hospitalisation from infection with the variant.[14]

On 7 May 2021, PHE changed their classification of lineage B.1.617.2 from a variant under investigation (VUI) to a variant of concern (VOC) based on an assessment of transmissibility being at least equivalent to B.1.1.7 (Alpha variant);[15] the UK's SAGE using May data estimated a "realistic" possibility of being 50% more transmissible.[16] On 11 May 2021, the WHO also classified this lineage VOC, and said that it showed evidence of higher transmissibility and reduced neutralisation. On 15 June 2021, the Centers for Disease Control and Prevention (CDC) declared Delta a variant of concern.[17]

The variant is thought to be partly responsible for India's deadly second wave of the pandemic beginning in February 2021.[18][19][20] It later contributed to a third wave in Fiji, the United Kingdom[21][22][23] and South Africa,[24] and the WHO warned in July 2021 that it could have a similar effect elsewhere in Europe and Africa.[25][24] By late July, it had also driven an increase in daily infections in parts of Asia,[26] the United States,[27] Australia, and New Zealand.[28]

## Contents

* 1 Classification
* 1.1 Names
* 1.2 Other sublineages of B.1.617
* 1.3 Mutations
* 1.4 Lineages
* 1.4.1 "Delta plus" variant
* 2 Symptoms
* 3 Prevention
* 4 Treatment
* 5 Epidemiology
* 5.1 Transmissibility
* 5.2 Infection age groups
* 5.3 Virulence
* 6 Statistics
* 7 History
* 7.1 Government responses
* 8 Extinction
* 9 See also
* 10 Notes
* 11 References
* 12 External links

## Classification[edit]

The Delta variant has mutations in the gene encoding the SARS-CoV-2 spike protein[6] causing the substitutions D614G, T478K, P681R and L452R.[29][8] It is identified as the 21A, 21I, and 21J clades under the Nextstrain phylogenetic classification system.[30]

### Names[edit]

The virus has also been referred to by the term "Indian Variant"[31] as it was originally detected in India. However, the Delta variant is only one of three variants of the lineage B.1.617, all of which were first detected in India.[32] At the end of May 2021, the WHO assigned the label Delta to lineage B.1.617.2 after introducing a new policy of using Greek letters for variants of concern and variants of interest.[33]

### Other sublineages of B.1.617[edit]

There are three sublineages of lineage B.1.617 categorised so far.

B.1.617.1 (Kappa variant) was designated a Variant Under Investigation in April 2021 by Public Health England. Later in April 2021, two other variants B.1.617.2 and B.1.617.3 were designated as Variants Under Investigation. While B.1.617.3 shares the L452R and E484Q mutations found in B.1.617.1, B.1.617.2 lacks the E484Q mutation. B.1.617.2 has the T478K mutation, not found in B.1.617.1 and B.1.617.3.[34][35] Simultaneously, the ECDC released a brief maintaining all three sublineages of B.1.617 as VOI, estimating that a "greater understanding of the risks related to these B.1.617 lineages is needed before any modification of current measures can be considered".[36]

### Mutations[edit]

* Amino acid mutations of SARS-CoV-2 Delta variant plotted on a genome map of SARS-CoV-2 with a focus on Spike.[37]

Defining mutations in the
SARS-CoV-2 Delta variant
Gene | Nucleotide | Amino acid

|
|

ORF1b |  | P314L
| P1000L
Spike |  | G142D
| T19R
| R158G
| L452R
| T478K
| D614G
| P681R
| D950N
| E156del
| F157del
M |  | I82T
N |  | D63G
| R203M
| D377Y
ORF3a |  | S26L
ORF7a |  | V82A
| T120I
Sources: CDC[38] Covariants.org[39]

The Delta/ B.1.617.2 genome has 13 mutations (15 or 17 according to some sources,[which?] depending on whether more common mutations are included) which produce alterations in the amino-acid sequences of the proteins it encodes.[40]

The list of spike protein mutations is: 19R, (G142D), Δ156-157, R158G, L452R, T478K, D614G, P681R, D950N according to GVN,[41] or T19R, G142D, del 156–157, R158G, L452R, T478K, D614G, P681R according to Genscript[42] Four of them, all of which are in the virus's spike protein code, are of particular concern:

* D614G. The substitution at position 614, an aspartic acid-to-glycine substitution, is shared with other highly transmissible variants like Alpha, Beta and Gamma.[9]
* T478K.[9][29] The exchange at position 478 is a threonine-to-lysine substitution.[43]
* L452R. The substitution at position 452, a leucine-to-arginine substitution, confers stronger affinity of the spike protein for the ACE2 receptor[44] and decreased recognition capability of the immune system.[8][45]
* P681R. The substitution at position 681, a proline-to-arginine substitution, which, according to William A. Haseltine, may boost cell-level infectivity of the variant "by facilitating cleavage of the S precursor protein to the active S1/S2 configuration".[46]

The E484Q mutation is not present in the B.1.617.2 genome.[46][47]

### Lineages[edit]

As of August 2021, Delta variants have been subdivided in the Pango lineage designation system into variants from AY.1 to AY.28. However, there is no information on whether such classification correlates with biological characteristic changes of the virus.[48] It is said that, as of August 2021, AY.4 to AY.11 are predominant in the UK, AY.12 in Israel, AY.2, AY.3, AY.13, AY.14, AY.25 in the US, AY.20 in the US and Mexico, AY.15 in Canada, AY.16 in Kenya, AY.17 in Ireland and Northern Ireland, AY.19 in South Africa, AY.21 in Italy and Switzerland, AY.22 in Portugal, AY.24 in Indonesia, and AY.23 in Indonesia, Singapore, Japan, and South Korea.[49]

#### "Delta plus" variant[edit]

See also: Variants of SARS-CoV-2 § Delta (lineage B.1.617.2)

Delta with K417N originally corresponded to lineages AY.1 and AY.2,[50] subsequently also lineage AY.3,[51] and has been nicknamed "Delta plus" or "Nepal variant".[52] It has the K417N mutation,[53] which is also present in the Beta variant.[54] The exchange at position 417 is a lysine-to-asparagine substitution.[55]

As of mid-October 2021, the AY.3 variant accounted for a cumulative prevalence of approximately 5% in the United States, and 2% worldwide.[56] In mid-October the AY.4.2 Delta sublineage was expanding in England, and being monitored and assessed. It contains mutations A222V and Y145H in its spike protein,[57] not considered of particular concern. It has been suggested that AY.4.2 might be 10-15% more transmissible than the original Delta variant. Mid-October 2021, AY.4.2 accounted for an estimated 10% of cases, and has led to an additional growth rate rising to about 1% (10% of 10%) per generational time of five days or so. This additional growth rate would grow with increasing prevalence. Without AY.4.2 and no other changes, the number of cases in the UK would have been about 10% lower.[58] AY.4.2 grows about 15% faster per week.[59] In the UK it was reclassified as a "variant under investigation" (but not "of concern") in late October 2021.[60] In Denmark, after a drop in AY.4.2 cases, a new fast surge was detected and monitored, but was not yet considered a cause of concern.[61][62]

## Symptoms[edit]

Main article: Symptoms of COVID-19

The most common symptoms may have changed from the most common symptoms previously associated with standard COVID-19. Infected people may mistake the symptoms for a bad cold and not realize they need to isolate. Common symptoms reported have been headaches, sore throat, a runny nose or a fever.[1][medical citation needed][2] In the United Kingdom, when the Delta variant accounted for 91 percent of new cases, one study found that the most reported symptoms were headache, sore throat, and runny nose.[63]

## Prevention[edit]

See also: COVID-19 § Prevention, Oxford–AstraZeneca COVID-19 vaccine § Effectiveness, Pfizer–BioNTech COVID-19 vaccine § Effectiveness, Moderna COVID-19 vaccine § Effectiveness, Janssen COVID-19 vaccine § Clinical trials, Sinopharm BIBP COVID-19 vaccine § Variants, Sputnik V COVID-19 vaccine § Effectiveness, CoronaVac § Variants, Covaxin § Efficacy, ZF2001 § Efficacy, and Abdala (vaccine) § Efficacy

Summary of Vaccine Protection against Delta
(WHO's update, 24 August 2021[64]) Disease or infection  | Severe: protection retained
Symptomatic: possibly reduced protection

|

Severe disease | : AstraZeneca-Vaxzevria(1), Moderna(1), Pfizer-BioNTech(2)
Symptomatic disease  |  to : Pfizer-BioNTech(3)
: Covaxin(1)
: AstraZeneca-Vaxzevria(2)
Infection  | : AstraZeneca-Vaxzevria(1), Pfizer-BioNTech(1)

Symbols indicate the magnitude of vaccine effectiveness (VE) reduction. Note that VE reduction doesn't mean loss of protection, because original high protection rate (such as 95%) with some reduction (such as 10%) would still retain protection (such as 85%). Enclosed in parentheses is the number of studies supporting the indication. Studies vary in population, outcome definitions, study design, etc., which may explain differences in VE estimates for a product in different studies. Also, the reductions represent VE estimates and do not represent uncertainties around the estimates which may vary substantially across studies. The VE reductions should be interpreted with these limitations.

: VE reduces <10%, or VE >90% without comparator
: VE reduces between 10 to <20%

: VE reduces between 20 to <30%

Effects on Neutralization (fully vaccinated)[65]

to : Anhui-ZIFIVAX(2), Covaxin(3)
: Janssen(3), Moderna(3), Covishield(2)
to : AstraZeneca-Vaxzevria(4), Pfizer-BioNTech(8)
:Moderna & Pfizer-BioNTech(1)*
to : Coronavac(2)
Symbols indicate the magnitude of neutralization reduction with full vaccination. Enclosed in parentheses is the number of studies supporting the indication.

: Neutralization reduces <2-fold
: Neutralization reduces 2 to <5-fold
: Neutralization reduces 5 to <10-fold
: Neutralization reduces ≥ 10-fold
* Moderna & Pfizer-BioNTech were evaluated together.

WHO has not issued preventative measures against Delta specifically; non-pharmaceutical measures recommended to prevent wild type COVID-19 should still be effective. These would include washing hands, wearing a mask, maintaining distance from others, avoiding touching the mouth, nose or eyes, avoiding crowded indoor spaces with poor ventilation especially where people are talking, going to get tested if one develops symptoms and isolating if one becomes sick.[66] Public Health authorities should continue to find infected individuals using testing, trace their contacts, and isolate those who have tested positive or been exposed.[67] Event organizers should assess the potential risks of any mass gathering and develop a plan to mitigate these risks.[68] See also Non-pharmaceutical intervention (epidemiology).

ICMR found that convalescent sera of the COVID-19 cases and recipients of Bharat Biotech's BBV152 (Covaxin) were able to neutralise VUI B.1.617 although with a lower efficacy.[69]

Anurag Agrawal, the director of the Institute of Genomics and Integrative Biology (IGIB), said the study on the effectiveness of the available vaccines on lineage B.1.617 suggests that post-vaccination, the infections are milder.[70]

Anthony Fauci, the Chief Medical Advisor to the President of the United States, has also expressed his confidence regarding the preliminary results. In an interview on 28 April, he said:

> This is something where we're still gaining data daily. But the most recent data was looking at convalescent sera of COVID-19 cases and people who received the vaccine used in India, the Covaxin. It was found to neutralise the 617 variants.[71]

Another study by the Centre for Cellular and Molecular Biology (CCMB) in Hyderabad found Covishield (Oxford–AstraZeneca) vaccinated sera offers protection against lineage B.1.617.[72]

A study conducted by the Public Health England, has found that compared to those who were unvaccinated those who were vaccinated with either the Pfizer-BioNTech or AstraZeneca-Oxford had 33% less instances of symptomatic disease caused by the variant after the first dose. Among those who were two weeks after the receiving their second dose of the Pfizer-BioNTech vaccine 88% less subjects had symptomatic disease from the Delta variant versus those that were unvaccinated. Among those who were two weeks after the receiving their second dose of the AstraZeneca-Oxford vaccine 60% less subjects had symptomatic disease from the Delta variant versus those that were unvaccinated.[73][74]

A study by a group of researchers from the Francis Crick Institute, published in The Lancet, shows that humans fully vaccinated with the Pfizer-BioNTech vaccine are likely to have more than five times lower levels of neutralizing antibodies against the Delta variant compared to the original COVID-19 strain.[75][76]

In June 2021, Public Health England announced it had conducted a study which found that after two shots, the Pfizer-BioNTech vaccine and the AstraZeneca vaccine are respectively 96% and 92% effective at preventing hospitalisation from the Delta variant.[77][78]

On July 3, researchers from the universities of Toronto and Ottawa in Ontario, Canada, released a preprint study suggesting that the Moderna vaccine may be effective against death or hospitalization from the Delta variant.[79][unreliable medical source?]

In a study of the University of Sri Jayewardenepura in July 2021 found the Sinopharm BIBP vaccine caused seroconversion in 95% of individuals studied that had received both doses of the vaccine. The rate was higher in 20-39 age group (98.9%) but slightly lower in the over 60 age group (93.3%). Neutralising antibodies were present among 81.25% of the vaccinated individuals studied.[80][81]

On 29 June 2021, the director of the Gamaleya Institute, Denis Logunov, said that Sputnik V is about 90% effective against the Delta variant.[82]

On July 21, researchers from Public Health England published a study finding that the Pfizer vaccine was 93.7% effective against symptomatic disease from Delta after 2 doses, while the Astrazeneca vaccine was 67% effective.[83]

On August 2, several experts expressed concern that achieving herd immunity may not currently be possible because the Delta variant is transmitted among those immunized with current vaccines.[84]

On August 10, a study showed that the full vaccination coverage rate is correlated inversely to the SARS-CoV-2 delta variant mutation frequency in 16 countries (R-squared=0.878). Data strongly indicates that full vaccination against COVID-19 may slow down virus evolution.[85]

## Treatment[edit]

See also: Treatment and management of COVID-19

In vitro experiments suggest that bamlanivimab may not be effective against Delta on its own.[86] At high enough concentrations, casirivimab, etesevimab and imdevimab appear to still be effective. A preprint study suggests that sotrovimab may also be effective against Delta.[87] Doctors in Singapore have been using supplemental oxygen, remdesivir and corticosteroids on more Delta patients than they did on previous variants.[88]

## Epidemiology[edit]

Summary of impacts for Delta*
(WHO's update, 24 August 2021[64])  Transmissibility | Increased transmissibility and secondary attack rate, similar transmissibility between vaccinated and unvaccinated individuals.

|

Virulence | Increased risk of hospitalization
Reinfection | Decreased neutralizing activity
Diagnostics  | No impacts yet reported
* Generalized finding compared to other strains, based on evidence including non-peer-reviewed publications.

### Transmissibility[edit]

UK scientists have said that the Delta variant is between 40% and 60% more transmissible than the previously dominant Alpha variant, which was first identified in the UK (as the Kent variant).[89] Given that Alpha is already 150% as transmissible as the original SARS-CoV-2 strain that emerged in late 2019 in Wuhan,[89] and if Delta is 150% as transmissible as Alpha, then Delta may be 225% as transmissible as the original strain.[90] BBC reported that  R 0 {\displaystyle R_{0}} - basic reproduction number, or the expected number of cases directly generated by one case in a population where all individuals are susceptible to infection - for the first detected SARS-CoV-2 virus is 2.4-2.6, whereas Alpha's reproduction number is 4-5 and Delta's is 5–9.[91][92] These basic reproduction numbers can be compared to MERS (0.29-0.80[93]), seasonal influenza (1.2-1.4[94]), Ebola (1.4-1.8[95]), common cold (2-3[96]), SARS (2–4[97]), smallpox (3.5-6[98]), and chickenpox (10-12[99]). Due to Delta's high transmissibility even those that are vaccinated are vulnerable,[100] albeit to a lesser extent.[74]

A study[101] published online (not peer-reviewed) by Guangdong Provincial Center for Disease Control and Prevention may partly explain the increased transmissibility: people with infection caused by Delta had 1,000 times more copies of the virus in the respiratory tracts than those with infection caused by variants first identified in the beginning of the pandemic; and it took on average 4 days for people infected with Delta for the virus to be detectable compared to 6 days with initially identified variants.[102][103]

Surveillance data from the U.S., Germany and the Netherlands indicates the Delta variant is growing by about a factor of 4 every two weeks with respect to the Alpha variant.[104][105][106]

In India, the United Kingdom,[107] Portugal,[108] Russia,[109] Mexico, Australia, Indonesia,[110] South Africa, Germany,[111] Luxembourg,[112] the United States,[113] the Netherlands,[114] Denmark,[115] France[116] and probably many other countries, the Delta variant had become the dominant strain by July 2021. Depending on country, there is typically a lag from a few days to several weeks between cases and variant reporting. As of July 20, this variant had spread to 124 countries,[65] and WHO had indicated that it was becoming the dominant strain, if not one already.[117]

In the Netherlands, the virus was still able to propagate significantly in the population with over 93.4% of blood donors being tested positive for SARS-CoV-2 antibodies after week 28, 2021. Many people there are not fully vaccinated, so those antibodies would have been developed from exposure to the wild virus or from a vaccine.[118][119] Similar high seroimmunity levels occur in the United Kingdom in blood donors and general surveillance.[120][121][122]

A preprint found that the viral load in the first positive test of infections with the variant was on average ∼1000 times higher than with compared infections during 2020.[123][124] Preliminary data from a study with 100,000 volunteers in the UK from May to July 2021, when Delta was spreading rapidly, indicates that vaccinated people who test positive for COVID-19, including asymptomatic cases, have a lower viral load in average. Data from the US, UK, and Singapore indicate that vaccinated people infected by Delta may have viral loads as high as unvaccinated infected people, but might remain infectious for a shorter period.[125]

### Infection age groups[edit]

Surveillance data from the Indian government's Integrated Disease Surveillance Programme (IDSP) shows that around 32% of patients, both hospitalised and outside hospitals, were aged below 30 in the second wave compared to 31% during the first wave, among people aged 30–40 the infection rate stayed at 21%. Hospitalisation in the 20-39 bracket increased to 25.5% from 23.7% while the 0-19 range increased to 5.8% from 4.2%. The data also showed a higher proportion of asymptomatic patients were admitted during the second wave, with more complaints of breathlessness.[126]

### Virulence[edit]

See also: Virulence

A few early studies suggest the Delta variant causes more severe illness than other strains.[127] On 7 June 2021, researchers at the National Centre for Infectious Diseases in Singapore posted a paper suggesting that patients testing positive for Delta are more likely to develop pneumonia and/or require oxygen than patients with wild type or Alpha.[128] On June 11, Public Health England released a report finding that there was "significantly increased risk of hospitalization" from Delta as compared with Alpha;[129] the risk was approximately twice as high for those infected with the Delta variant.[130] On June 14, researchers from Public Health Scotland found that the risk of hospitalization from Delta was roughly double that of from Alpha.[131] On July 7, a preprint study from epidemiologists at the University of Toronto found that Delta had a 120% greater – or more than twice as large – risk of hospitalization, 287% greater risk of ICU admission and 137% greater risk of death compared to non-variant of concern strains of SARS-COV-2.[132] However, on July 9, Public Health England reported that the Delta variant in England had a case fatality rate (CFR) of 0.2%, while the Alpha variant's case fatality rate was 1.9%, although the report warns that "case fatality rates are not comparable across variants as they have peaked at different points in the pandemic, and so vary in background hospital pressure, vaccination availability and rates and case profiles, treatment options, and impact of reporting delay, among other factors."[133] James McCreadie, a spokesperson for Public Health England, clarified "It is too early to assess the case fatality ratio compared to other variants."[134]

A Canadian study released on 5 October 2021 revealed that the Delta variant caused a 108 percent rise in hospitalization, 235 percent increase in ICU admission, and a 133 percent surge in death compared to other variants. is more serious and resulted in an increased risk of death compared to previous variants, odds that are significantly decreased with immunization.[135][136]

## Statistics[edit]

The chance of detecting a Delta case varies significantly, especially depending on a country's sequencing rate (less than 0.05% of all COVID-19 cases have been sequenced in the lowest-sequencing countries to around 50 percent in the highest).[137][138]

By 22 June 2021,[needs update] more than 4,500 sequences of the variant had been detected in about 78 countries.[139][140][141] Reported numbers of sequences in countries with detections are:

Cases by country

* view
* talk
* edit

Country/Area  | Confirmed cases (PANGOLIN)[142]
as of 19 December  | Confirmed cases (GISAID)[139]
as of 23 November  | Cases (other sources)
as of 19 January 2022  | First detection  | Last detection

|
|
|
|
|

United Kingdom  | 985,491 | 826,465 | 1,625,557[143] | 22 February 2021  |
United States  | 1,099,811 | 947,472 | 99.4% of cases[144] | 23 February 2021  |
Canada  | 78,412 | 62,008 | 196,866[145] | 15 March 2021  |
Germany  | 150,416 | 117,513 |  | 1 March 2021  |
Denmark  | 138,336 | 89,706 |  | 8 March 2021  |
Japan  | 86,383 | 70,973 | 86,037[146] [147] | 28 March 2021  |
France  | 75,224 | 70,822 |  | 21 February 2021  |
Turkey  | 54,134 | 50,578 | 5[148] | 28 April 2021  |
Fiji  | - | 507 | 47,639 [149][150][151] | 19 April 2021  |
India  | 45,638 | 45,055 |  | 5 October 2020  |
Switzerland  | 48,304 | 38,003 |  | 29 March 2021  |
Sweden  | 46,018 | 37,773 |  | 26 March 2021  |
Belgium  | 37,334 | 31,611 |  | 25 March 2021  |
Italy  | 33,642 | 29,282 |  | 2 April 2021  |
Spain  | 30,618 | 28,257 |  | 22 April 2021  |
The Netherlands  | 33,128 | 27,870 |  | 6 April 2021  |
Australia  | 23,696 | 22,715 | 25,750[152] | 16 March 2021  |
Ireland  | 22,425 | 21,061 |  | 26 February 2021  |
Brazil  | 27,733 | 17,987 | 1051 [153][154] | 20 May 2021[155][156][157][158][159] |
Mexico  | 20,230 | 17,710 |  | 5 April 2021  |
Slovenia  | 16,334 | 13,439 |  | 20 April 2021  |
Israel  | 15,787 | 12,259 | 41[160][161][162] | 16 April 2021  |
Norway  | 15,716 | 12,130 | 1[163] | 15 April 2021  |
Portugal  | 12,984 | 11,983 |  | 5 April 2021  |
South Africa  | 2,582 | 10,619 | 4[164] | 30 April 2021  |
Poland  | 16,484 | 10,320 | 16[165] | 26 April 2021  |
Lithuania  | 899 | 9,070 | 1[166] | 17 June 2021  |
Finland  | 1,570 | 8,733 | 2,876[167][168][169][170] | 18 March 2021  |
Czech Republic  | 11,225 | 8,487 |  | 24 April 2021  |
Singapore  | 2,727 | 7,510 |  | 26 February 2021  |
Slovakia  | 353 | 7,146 |  | 15 June 2021  |
Philippines  | 870 | 3,220 | 8,612[171][172] | 11 May 2021  |
South Korea  | 706 | 6,497 |  | 26 March 2021  |
Croatia  | 479 | 6,165 |  | 11 June 2021  |
Chile  | 64 | 5,858 |  | 13 June 2021  |
Luxembourg  | 1,153 | 5,515 |  | 15 April 2021  |
Indonesia  | 1,623 | 4,980 |  | 3 April 2021  |
Romania  | 294 | 4,655 |  | 26 April 2021  |
Bulgaria  | 231 | 4,614 |  | 5 April 2021  |
Russia  | 1,468 | 4,295 | 16[173] | 21 April 2021  |
Thailand  | 236 | 4,293 | 2[174] | 24 April 2021  |
Iceland  | - | 3,767 |  | 30 August 2021  |
Malaysia  | 146 | 3,624 |  | 10 April 2021  |
Austria  | 1,578 | 3,622 |  | 17 April 2021  |
New Zealand  | 92 | 2,844 | 107[175][176] | 9 March 2021  |
Estonia  | - | 2,740 |  | 21 July 2021  |
Greece  | 17 | 2,642 |  | 23 March 2021  |
Peru  | 6 | 2,580 |  | 10 June 2021  |
Bahrain  | 117 | 2,013 |  | 5 April 2021  |
Nigeria  | 36 | 1,795 | 1[177] | 7 August 2021  |
Kenya  | 256 | 1,700 | 5[177][178] | 17 July 2021  |
Aruba  | 90 | 1,592 |  | 16 April 2021  |
Vietnam  | 54 | 1,414 | 12[179][180] | 18 April 2021  |
Puerto Rico  | - | 1,360 |  | 9 September 2021  |
Qatar  | 121 | 1,343 |  | 19 April 2021  |
Bangladesh  | 283 | 1,273 | 9[181][182] | 28 April 2021  |
Sint Maarten  | - | 1,231 |  | 19 March 2021  |
Ecuador  | 89 | 1,023 |  | 20 July 2021  |
Sri Lanka  | 117 | 984 | 1[183] | 30 April 2021  |
Colombia  | - | 974 |  | 3 July 2021  |
Botswana  | 196 | 912 | 2[184] | 28 April 2021  |
Gibraltar  | - | 848 |  | 5 September 2021  |
Kosovo  | - | 834 |  | 2 May 2021  |
Reunion  | 54 | 754 |  | 4 May 2021  |
Cambodia  | 171 | 733 |  | 5 April 2021  |
Papua New Guinea  | - | 717 |  | 10 August 2021  |
Costa Rica  | 35 | 689 |  | 7 July 2021  |
Pakistan  | 49 | 676 |  | 16 May 2021  |
China  | 86 | 536 |  | 24 April 2021  |
Maldives  | 6 | 525 |  | 31 July 2021  |
Ghana  | 101 | 522 |  | 20 April 2021  |
Curacao  | - | 467 |  | 23 April 2021  |
Bonaire  | - | 458 |  | 13 July 2021  |
Bosnia and Herzegovina  | 31 | 430 |  | 26 July 2021  |
Ethiopia  | - | 424 |  | 16 August 2021  |
Seychelles  | - | 407 |  | 30 September 2021  |
Argentina  | 4 | 385 | 2[185] | 24 April 2021  |
Martinique  | 8 | 365 |  | 10 August 2021  |
Guadeloupe  | - | 362 |  | 10 March 2021  |
Jordan  | 5 | 360 |  | 21 April 2021  |
Uganda  | 134 | 340 | 1[186] | 26 March 2021  |
Zambia  | 82 | 326 |  | 29 May 2021  |
Gambia  | 42 | 316 |  | 12 July 2021  |
Mozambique  | - | 314 |  | 16 July 2021  |
Guatemala  | 4 | 302 |  | 29 July 2021  |
Rwanda  | 91 | 283 |  | 9 July 2021  |
Cameroon  | - | 282 |  | 28 September 2021  |
Georgia  | 19 | 272 |  | 15 May 2021  |
French Guiana  | 53 | 264 |  | 22 July 2021  |
U.S. Virgin Islands  | - | 247 |  | 18 August 2021  |
Nepal  | 100 | 238 | 9[187] | 28 April 2021  |
DR Congo  | 19 | 228 | 5[177] | 3 May 2021  |
Malawi  | 5 | 213 |  | 30 April 2021  |
Kuwait  | 108 | 191 |  | 5 June 2021  |
Montenegro  | - | 178 |  | 8 August 2021  |
Ukraine  | 13 | 170 |  | 24 June 2021  |
Kazakhstan  | - | 167 |  | 19 August 2021  |
Oman  | 8 | 159 |  | 17 May 2021  |
Angola  | 6 | 159 |  | 14 January 2021  |
Hong Kong  | 153 | 10 |  | 22 April 2021  |
Suriname  | - | 150 |  | 3 August 2021  |
Morocco  | 3 | 138 | 2[188] | 3 May 2021  |
Togo  | - | 130 |  | 31 July 2021  |
Trinidad and Tobago  | - | 114 |  | 3 August 2021  |
Namibia  | - | 110 |  | June 2021  |
Paraguay  | 4 | 100 |  | 8 July 2021  |
Belize  | - | 98 |  | 30 June 2021  |
Egypt  | - | 98 |  | 15 July 2021  |
Zimbabwe  | - | 96 |  | 26 July 2021  |
Liechtenstein  | - | 95 |  | 15 July 2021  |
Senegal  | 13 | 93 |  | 6 May 2021  |
Republic of Congo  | - | 87 |  | 15 July 2021  |
Västra Götaland  | - | 86 |  | 19 July 2021  |
Eswatini  | - | 81 |  | 26 July 2021  |
Lebanon  | - | 80 |  | 3 July 2021  |
Latvia  | 22 | 73 |  | 27 May 2021  |
Monaco  | 34 | 70 |  | 15 May 2021  |
Mauritius  | 15 | 67 |  | 8 May 2021  |
Malta  | 42 | 63 |  | 23 June 2021  |
Guinea-Bissau  | - | 62 |  | 3 November 2021  |
Burundi  | 3 | 57 |  | 31 May 2021  |
Antigua and Barbuda  | - | 57 |  | 6 August 2021  |
Liberia  | - | 56 |  | 10 July 2021  |
Armenia  | - | 50 |  | 5 August 2021  |
Uzbekistan  | 30 | 47 | (number unreported)[189] | 25 June 2021  |
Benin  | - | 47 |  | 23 July 2021  |
North Macedonia  | 6 | 38 |  | 11 July 2021  |
The Bahamas  | - | 38 |  | 8 August 2021  |
Cayman Islands  | - | 37 |  | 30 July 2021  |
Myanmar  | 12 | 33 |  | 1 June 2021  |
Serbia  | 5 | 33 |  | 6 July 2021  |
Timor-Leste  | - | 33 | 12[190] | 8 August 2021  |
South Sudan  | - | 29 |  | 7 June 2021  |
United Arab Emirates  | - | 28 |  | 23 June 2021  |
Brunei  | - | 28 |  | 17 August 2021  |
Gabon  | - | 27 |  | 2 August 2021  |
Mayotte  | - | 27 |  | 21 October 2021  |
Algeria  | 17 | 25 | 6[191] | 28 July 2021  |
Andorra  | - | 25 |  | 17 July 2021  |
Barbados  | 3 | 23 |  | 24 May 2021  |
Sierra Leone  | - | 22 |  | 8 September 2021  |
Iran  | 11 | 21 | 3[192] | 11 May 2021  |
Burkina Faso  | - | 21 |  | 21 April 2021  |
Crimea  | - | 21 |  | 1 July 2021  |
Afghanistan  | - | 20 |  | 24 May 2021  |
Northern Mariana Islands  | 2 | 19 |  | 7 July 2021  |
Central African Republic  | - | 17 |  | 14 August 2021  |
Taiwan  | 3 | 15 |  | 14 June 2021  |
Guam  | - | 14 |  | 26 April 2021  |
Dominican Republic  | - | 14 |  | 3 May 2021  |
Hungary  | - | - | 14[193] | 22 July 2021  |
Equatorial Guinea  | - | 14 |  | 30 August 2021  |
Iraq  | 2 | 13 |  | 27 April 2021  |
Moldova  | 11 | 11 |  | 6 July 2021  |
Albania  | 11 | 11 |  | 13 July 2021  |
Comoros  | - | 11 |  | 26 October 2021  |
Jamaica  | - | 10 |  | 23 July 2021  |
Anguilla  | - | 8 |  | 20 April 2021  |
Saint Lucia  | - | 7 |  | 26 July 2021  |
Montserrat  | - | 7 |  | 1 August 2021  |
Saint Barthelemy  | - | 7 |  | 17 August 2021  |
British Virgin Islands  | - | 5 |  | 27 July 2021  |
Cyprus  | - | 1 | 4[194] | 19 May 2021  |
Turks and Caicos Islands  | - | 4 |  | 12 July 2021  |
Azerbaijan  | - | 2 |  | 14 July 2021  |
Honduras  | - | 2 |  | 31 July 2021  |
El Salvador  | - | 2 |  | 2 August 2021  |
Saint Vincent and the Grenadines  | - | 2 |  | 8 August 2021  |
Mali  | - | 2 |  | 11 August 2021  |
Saudi Arabia  | - | 2 |  | 9 September 2021  |
Haiti  | - | 1 | (number unreported)[189] | 27 July 2021  |
Panama  | - | 1 | 1[195] | 29 April 2021  |
Tunisia  | - | 1 |  | 21 May 2021  |
Södermanland  | - | 1 |  | 7 July 2021  |
Venezuela  | - | 1 |  | 7 July 2021  |
Mongolia  | - | 1 |  | 23 September 2021  |
Kyrgyzstan  | - | - | (number unreported)[189] | 16 May 2021[189] |
World (178 countries)  | Total: 3,119,592
(solely B.1.617.2) | Total: 2,768,050
(B.1.617.2+AY.1+AY.2+AY.3) | Total: 1,862,122 |  |

## History[edit]

The first cases of the variant outside India were detected in late February 2021, including the United Kingdom on 22 February, the United States on 23 February and Singapore on 26 February.[196][40][139]

British scientists at Public Health England redesignated the B.1.617.2 variant on 7 May 2021 as "variant of concern" (VOC-21APR-02),[197] after they flagged evidence in May 2021 that it spreads more quickly than the original version of the virus.[21] Another reason was that they identified 48 clusters of B.1.617.2, some of which revealed a degree of community transmission.[198][199] With cases from the Delta variant having risen quickly, British scientists considered the Delta variant having overtaken the Alpha variant as the dominant variant of SARS-CoV-2 in the UK in early June 2021.[200] Researchers at Public Health England later found that over 90% of new cases in the UK in the early part of June 2021 were the Delta variant; they also cited evidence that the Delta variant was associated with an approximately 60% increased risk of household transmission compared to the Alpha variant.[201]

Canada's first confirmed case of the variant was identified in Quebec on 21 April 2021, and later the same day 39 cases of the variant were identified in British Columbia.[202] Alberta reported a single case of the variant on 22 April 2021.[203] Nova Scotia reported two Delta variant cases in June 2021.[204]

Fiji also confirmed its first case of the variant on 19 April 2021 in Lautoka, and has since then climbed up to 47,000 cases and counting.[205] The variant has been identified as a super-spreader and has led to the lockdowns of five cities (Lautoka, Nadi, Suva, Lami and Nausori), an area which accounts for almost two-thirds of the country's population.

On 29 April 2021, health officials from Finland's Ministry of Social Affairs and Health (STM) and the Finnish Institute for Health and Welfare (THL) reported that the variant had been detected in three samples dating back to March 2021.[167]

The Philippines confirmed its first two cases of the variant on 11 May 2021, despite the imposed travel ban of the country from the nations in the Indian subcontinent (except for Bhutan and Maldives). Both patients have no travel history from India for the past 14 days, but instead from Oman and UAE.[206]

North Macedonia confirmed its first case of the variant on 7 June 2021 after a person who was recovering from the virus in Iraq was transported to North Macedonia. In a laboratory test, the variant was detected in the person. On 22 June 2021, the country reported its second case of the Delta variant in a colleague of the first case who had also been in Iraq and who subsequently developed symptoms.[207]

The detection of B.1.617 was hampered in some countries by a lack of specialised kits for the variant and laboratories that can perform the genetic test.[208][209] For example, as of 18 May, Pakistan had not reported any cases, but authorities noted that 15% of COVID-19 samples in the country were of an "unknown variant"; they could not say if it was B.1.617 because they were unable to test for it. Other countries had reported travellers arriving from Pakistan that were infected with B.1.617.[208]

In June 2021, scientist Vinod Scaria of India's Institute of Genomics and Integrative Biology highlighted the existence of the B.1.617.2.1 variant, also known as AY.1 or Delta plus, which has an additional K417N mutation compared to the Delta variant.[53] B.1.617.2.1 was detected in Europe in March 2021, and has since been detected in Asia and America.[53]

On 23 June 2021, the European Centre for Disease Prevention and Control (ECDC) warned that the variant would represent 90% of all new cases in the European Union by the end of August.[210]

By 3 July 2021, Delta became dominant in the US.[211]

On 9 July 2021, Public Health England issued Technical Briefing 18 on SARS-CoV-2 variants, documenting 112 deaths among 45,136 UK cases of SARS-CoV-2 Delta variant with 28 days follow-up with a fatality rate of 0.2%.[212] Briefing 16 notes that "[M]ortality is a lagged indicator, which means that the number of cases who have completed 28 days of follow up is very low – therefore, it is too early to provide a formal assessment of the case fatality of Delta, stratified by age, compared to other variants."[213] Briefing 18 warns that "Case fatality is not comparable across variants as they have peaked at different points in the pandemic, and so vary in background hospital pressure, vaccination availability and rates and case profiles, treatment options, and impact of reporting delay, among other factors."[212] The most concerning issue is the logistic growth rate of 0.93/week relative to Alpha. This means that per week, the number of Delta samples/cases is growing by a factor of exp (0.93)=2.5 with respect to the Alpha variant. This results, under the same infection prevention measures, in a much greater case load over time until a large fraction of people have been infected by it.[214][215]

### Government responses[edit]

After the rise in cases from the second wave, at least 20 countries imposed travel bans and restrictions on passengers from India in April and May. UK prime minister Boris Johnson cancelled his visit to India twice, while Japanese Prime Minister Yoshihide Suga postponed his April trip.[216][217][218]

In May 2021, residents of two tower blocks in Velbert, Germany, were quarantined after a woman in the building tested positive for the Delta variant.[219]

In May, Delhi Chief Minister Arvind Kejriwal said that a new coronavirus variant from Singapore was extremely dangerous for children and could result in a third wave in India.

From 16 May to 13 June 2021, as well as 22 July 2021 to 10 August 2021; Singapore entered lockdowns, known as "Phase 2 Heightened Alert", similar to 2020.

On 14 June, the British prime minister Boris Johnson announced that the proposed end of all restrictions on 21 June in the United Kingdom was delayed for up to four weeks and vaccination roll-out was accelerated following concerns over the Delta variant, which accounted for the vast majority (90%) of new infections.[220] UK scientists have said that the Delta variant is between 40% and 60% more transmissible than the previously dominant Alpha variant, which was first identified in the UK (as the Kent variant).[221]

On 23 June, the province of Ontario in Canada accelerated 2nd dose vaccine appointments for people living in Delta hot spots such as Toronto, Peel and Hamilton.[222]

On 25 June, Israel restored their mask mandate citing the threat of Delta.[223]

On 28 June, Sydney and Darwin went back into lockdown because of Delta outbreaks.[224] South Africa banned indoor and outdoor gatherings apart from funerals, imposed a curfew, and banned the sale of alcohol.[225]

On 3 July, the islands of Bali and Java in Indonesia went into emergency lockdown.[226]

On 8 July, Japanese Prime Minister Yoshihide Suga announced that Tokyo would once again enter a state of emergency, and that most spectators would be barred from attending the Olympics set to start there on 23 July.[227]

On 9 July, Seoul, South Korea ramped up restrictions urging people to wear masks outdoors, and limiting the size of gatherings.[228]

On 12 July, French President Emmanuel Macron announced that all health care workers will need to be vaccinated by 15 September and that France will start using health passports to enter bars, cafés, restaurants and shopping centres from August.[229]

Los Angeles announced it will require masks indoors starting 17 July 2021.[230]

The United Kingdom lifted most COVID-19 restrictions on 19 July, despite a surge in cases as the Delta variant became dominant. The government cited the protection and wide coverage of the COVID-19 vaccination programme, although health experts expressed concern at the move.[231][232]

On 23 July, Vietnam extended its lockdown of Ho Chi Minh City to 1 August, and announced lockdown restrictions would be put in place in Hanoi, affecting a third of the country's population. The Delta variant had brought upon the country's largest outbreak to date, after mostly successful containment measures throughout 2020.[233][234]

On 17 August, New Zealand went into an alert level 4 lockdown, following a positive case being reported in Auckland. More cases soon followed in the Coromandel Peninsula.[235] This was the first reported community transmission case in the country in 170 days (since February 2021).[236]

## Extinction[edit]

In October 2021, Dr Jenny Harries, chief executive of the UK Health and Security Agency stated that previous circulating variants such as Alpha had 'disappeared' and replaced by the Delta variant.[237] In March 2022, the World Health Organization listed the Alpha, Beta and Gamma variants as previously circulating citing lack of any detected cases in the prior weeks and months, in part due to the dominance of the Delta variant and subsequent Omicron variant.[238] However within a few months the Delta variant was listed as a previously circulated variant with countries such as Australia going 12 weeks without any detections of Delta.[4]

## See also[edit]

* COVID-19 portal
* Medicine portal
* Viruses portal

* Variants of SARS-CoV-2: Alpha, Beta, Gamma, Epsilon, Zeta, Eta, Theta, Iota, Kappa, Lambda, Mu, Omicron, Lineage B.1.617

## Notes[edit]

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196. ^ "PANGO lineages Lineage B.1.617". cov-lineages.org. Retrieved 26 May 2021.
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204. ^ "One Death, Eight New Cases of COVID-19, Delta Variant Cases Identified, State of Emergency Renewed". 11 June 2021. Retrieved 11 June 2021.
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## External links[edit]

* Public Health England: Variants of concern or under investigation, B.1.617

* v
* t
* e

COVID-19 pandemic

* COVID-19 (disease)
* SARS-CoV-2 (virus)

Timeline

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By location|

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Southeast|

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Malaysia|

* impact
* social
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* timeline
* 2020
* 2021
* 2022
* statistics
* Johor
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* Sabah
* Sarawak
* Selangor

Philippines|

* timeline
* 2020
* 2021
* 2022
* government response
* community quarantines
* Luzon
* evacuations
* testing controversy
* vaccination
* Bangsamoro
* Bicol Region
* Cagayan Valley
* Calabarzon
* Caraga
* Central Luzon
* Central Visayas
* Cordillera
* Davao Region
* Eastern Visayas
* Ilocos Region
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* Overseas Filipinos

West|

* Armenia
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* timeline
* United Arab Emirates
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Europe|

| United Kingdom|

* history
* timeline
* January–June 2020
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* January–June 2021
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* January–June 2022
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* responses
* government response
* response
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* contracts
* impact
* social
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* education

By location|

* England
* timeline
* 2020
* January–June
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* 2021
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* London
* local lockdown regulations
* first tier regulations
* Northern Ireland
* timeline
* 2020
* 2021
* 2022
* Scotland
* timeline
* 2020
* 2021
* 2022
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* timeline
* 2020
* 2021
* 2022
* Crown dependencies
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* Overseas territories
* Akrotiri and Dhekelia
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* Gibraltar

Eastern|

* Belarus
* timeline
* 2020
* 2021
* 2022
* Kazakhstan
* Moldova
* Gagauzia
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* Russia
* timeline
* January–June 2020
* July–December 2020
* government responses
* political impact
* Crimea
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* timeline
* Ukraine
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Western Balkans|

* Albania
* Bosnia and Herzegovina
* Kosovo
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* timeline
* statistics

European Union|

* Austria
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* Bulgaria
* Croatia
* timeline
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* Åland
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* North Rhine-Westphalia
* government response
* Greece
* Hungary
* Ireland
* timeline
* 2020
* January–June
* July–December
* 2021
* January–June
* July–December
* 2022
* economic impact
* social impact
* vaccination
* Italy
* lockdowns
* timeline
* Latvia
* Lithuania
* Luxembourg
* Malta
* timeline
* Netherlands
* government response
* Poland
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* timeline
* Slovakia
* Slovenia
* Spain
* timeline
* Asturias
* Canary Islands
* Ceuta
* Community of Madrid
* Melilla
* Sweden
* timeline
* government response
* Operation Gloria

EFTA countries|

* Iceland
* Liechtenstein
* Norway
* Svalbard
* Switzerland

Microstates|

* Andorra
* Monaco
* San Marino
* Vatican City

North
America|

| Atlantic|

* Bermuda
* Greenland
* Saint Pierre and Miquelon

|

Canada|

* timeline
* economic impact
* federal aid
* vaccination
* by province
* military response
* Atlantic Bubble
* Alberta
* timeline
* British Columbia
* Manitoba
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* Newfoundland and Labrador
* Northwest Territories
* Nova Scotia
* Nunavut
* Ontario
* timeline
* 2020
* 2021
* 2022
* Ottawa
* Peel Region
* Toronto
* York Region
* Provincial government response
* Vaccination
* Prince Edward Island
* Quebec
* Montreal
* boroughs
* timeline
* Saskatchewan
* timeline
* Yukon

Caribbean|

| Countries|

* Antigua and Barbuda
* Bahamas
* Barbados
* Cuba
* Guantanamo Bay Naval Base
* Dominica
* Dominican Republic
* Grenada
* Haiti
* Jamaica
* Saint Kitts and Nevis
* Saint Lucia
* Saint Vincent and the Grenadines
* Trinidad and Tobago
* timeline

|

British Overseas Territories|

* Anguilla
* British Virgin Islands
* Cayman Islands
* Montserrat
* Turks and Caicos Islands
* response

Dutch Caribbean|

* Aruba
* Curaçao
* Sint Maarten

Caribbean Netherlands|

* Bonaire
* Saba
* Sint Eustatius

French West Indies|

* Guadeloupe
* Martinique
* Saint Barthélemy
* Saint Martin

US insular areas|

* Puerto Rico
* U.S. Virgin Islands

Central America|

* Belize
* Costa Rica
* El Salvador
* Guatemala
* Honduras
* Mexico
* timeline
* vaccination
* Nicaragua
* Panama

United States|

* Trump administration communication
* timeline
* 2020
* 2021
* social impact
* economic impact
* 2021 hospital crisis

responses|

* federal government
* state and local governments
* California government response
* New York government response
* Texas government response
* Eastern States Multi-state Council
* Midwest Governors Regional Pact
* Western States Pact

By location|

* Alabama
* Alaska
* American Samoa
* Arizona
* Navajo Nation
* Arkansas
* California
* timeline
* S.F. Bay Area
* Colorado
* Connecticut
* Delaware
* Florida
* Georgia
* Guam
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* Indiana
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* Maryland
* timeline
* Massachusetts
* timeline
* Boston
* timeline
* Michigan
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* Mississippi
* Missouri
* Montana
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* Nevada
* timeline
* New Hampshire
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* New York
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* timeline
* North Carolina
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* Northern Mariana Islands
* Ohio
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* Oklahoma
* Oregon
* Portland
* Pennsylvania
* Philadelphia
* Puerto Rico
* Rhode Island
* South Carolina
* South Dakota
* Tennessee
* Texas
* timeline
* Austin
* U.S. Virgin Islands
* Utah
* Vermont
* Virginia
* Washington
* Washington, D.C.
* White House
* West Virginia
* Wisconsin
* Wyoming

Oceania|

* American Samoa
* Cook Islands
* Easter Island
* Federated States of Micronesia
* Fiji
* timeline
* French Polynesia
* Guam
* Hawaii
* Kiribati
* Marshall Islands
* Nauru
* New Caledonia
* Niue
* Northern Mariana Islands
* Palau
* Papua New Guinea
* Bougainville
* Pitcairn Islands
* Samoa
* Solomon Islands
* Tonga
* Tuvalu
* Vanuatu
* Wallis and Futuna

Australia|

* timeline
* 2020
* 2021
* January–June
* July–December
* 2022
* Australian Capital Territory
* Christmas Island
* Cocos (Keeling) Islands
* New South Wales
* Norfolk Island
* Northern Territory
* Queensland
* South Australia
* Tasmania
* Victoria
* Western Australia

New Zealand|

* timeline
* 2020
* 2021
* 2022
* economic impact
* government response
* Alert levels
* Traffic light system
* social impact
* managed isolation

South
America|

* Argentina
* timeline
* statistics
* human rights
* Bolivia
* Brazil
* São Paulo
* Chile
* statistics
* Easter Island
* Colombia
* timeline
* Ecuador
* Falkland Islands
* French Guiana
* Guyana
* Paraguay
* Peru
* statistics
* Cusco
* Suriname
* Uruguay
* timeline
* 2020
* 2021
* Venezuela

Others|

* Antarctica
* Cruise ships
* Diamond Princess
* Grand Princess
* Naval ships
* Charles de Gaulle
* USS Theodore Roosevelt

Impact

| Culture and
entertainment|

* Arts and cultural heritage
* references in popular culture
* Cinema
* films affected
* Corona-chan [ja; tl; zh]
* Disney
* Fashion industry
* Music industry
* Performing arts
* Television
* U.S.
* U.S. sports
* programs affected
* Video games

Education|

* Female education
* Homeschooling

By country|

* Ghana
* Ireland
* United Kingdom
* exam grading controversy
* United States

Sports|

* Bio-secure bubble

By country|

* Ireland
* Philippines

By sport|

* Association football
* Baseball
* Basketball
* NBA
* Combat sports
* Cricket
* Disc golf
* Gaelic games
* Gridirion football (NCAAF, NFL, and CFL)
* Ice hockey
* Motorsport
* Rugby league

Society
and rights|

| Social impact|

* Social media
* Stigma
* COVID-19 parties
* Children
* foster care in the U.S.

|

Labor|

* Healthcare workers
* Indian migrant workers
* Great Resignation
* Strikes

Human rights|

* Argentina
* Hong Kong
* Myanmar
* North Korea
* Turkmenistan

Legal|

* Abortion in the U.S.
* Crime
* Ireland
* Domestic violence
* Prisons
* U.S. immigration detention

Minority|

* Gender
* LGBT community
* African-American communities
* Disability community
* Native American communities
* Xenophobia and racism

Religion|

* Catholic Church
* Hajj

Economic|

* Charitable activity
* COVID-19 scams
* Travel restrictions

By country|

* Canada
* India
* Ireland
* COVID-19 Pandemic Unemployment Payment
* Malaysia
* New Zealand
* Russia
* U.K.
* U.S.

By industry|

* Aviation
* Airlines
* Cannabis industry
* Food industry
* meat industry in Canada
* meat industry in the U.S.
* restaurant industry in the U.S.
* Hospitals
* ICU capacity
* Long-term care facilities
* Mink farming
* Public transport
* Retail
* Tourism

Supply and trade|

* Chip supply
* Energy
* Global supply chain
* Oil price war
* Food security

Financial markets|

* Global stock market crash
* COVID-19 recession
* Inflation

Information|

* Journalism
* Media coverage
* Wikipedia's response

Misinformation|

* Governments
* Canada
* China
* United States
* By country
* Philippines
* Ivermectin
* Plandemic

Politics|

* National responses
* Legislation
* European Union

Political impact|

* Ireland
* Malaysia
* Russia

Protests|

* Canada
* convoy protest
* Italy
* Germany
* Idar-Oberstein shooting
* the Netherlands
* New Zealand
* Serbia
* United Kingdom
* United States
* Open the States

International relations|

* Aid
* Italy
* Moldovan–Romanian collaboration
* Nicaragua–Taiwan relations
* Respirator diplomacy of Taiwan
* Vaccine diplomacy

Language|

* Anthropause
* Doomscrolling
* Flattening the curve
* Green recovery
* Living with COVID-19
* Long COVID
* Quarantini
* Social distancing
* Superspreader
* Zero-COVID
* Zoom
* Zoom towns

Others|

* Animals
* Cluster 5
* Environment
* Military
* Science and technology

Health issues

| Medical topics|

* Transmission
* Symptoms
* Cancer
* Skin manifestations
* Long COVID
* Mental health
* neurological, psychological and other mental health outcomes
* Pregnancy
* Non-COVID-19–related health issues
* Shortages
* Raise the line
* Rehabilitation
* Unproven medical methods

|

Testing and
epidemiology|

* Disease testing
* Breathalyzer
* Operation Moonshot
* Test to Release
* UK Rapid Test Consortium
* AbC-19 rapid antibody test
* Rapid antigen test
* investigations into the origins
* lab leak theory
* Surveillance
* Death rates by country
* Datasets
* Undercounting COVID-19 deaths
* Use and development of software

Apps|

* Aarogya Setu
* BlueTrace
* careFIJI
* Coronavirus Australia
* Corona-Warn-App
* COVID-19 Contact-Confirming Application
* COVID Alert (Canada)
* COVID AlertSA (South Africa)
* COVIDSafe
* COVID Symptom Study
* COVID Tracker Ireland
* Covid Watch
* Decentralized Privacy-Preserving Proximity Tracing
* Exposure Notification
* Health Code
* Healthy Together
* Immuni
* Koronavilkku
* LeaveHomeSafe
* MySejahtera
* NHS COVID-19
* NZ COVID Tracer
* NZ Pass Verifier
* PathCheck
* PeduliLindungi
* SafeEntry
* SafePass
* StaySafe.ph
* SwissCovid
* TCN Protocol
* Test, Trace, Protect
* Thai Chana
* TousAntiCovid
* TraceTogether
* Valtrace

Prevention|

* Public health mitigation
* Social distancing
* Face masks
* Anti-mask sentiment
* United States
* Flattening the curve
* Zero-COVID
* Workplace hazard controls
* Lockdowns
* Evacuations
* International aid
* Safe Hands Challenge
* COVID fatigue
* Great Barrington Declaration
* Chloroquine and hydroxychloroquine

Vaccines|

| Topics|

* Development
* Clinical research
* Authorizations
* Deployment
* Post-vaccination complications
* Operation Warp Speed (U.S.)
* Vaccine passports
* Vaccine card
* EU Certificate
* Misinformation and hesitancy
* Deaths of anti-vaccine advocates
* US

|

Authorized|

| DNA|

* ZyCoV-D

|

Inactivated|

* Chinese Academy of Medical Sciences
* CoronaVac
* Covaxin
* COVIran Barekat
* CoviVac (Russia)
* FAKHRAVAC
* Minhai
* QazCovid-in
* Sinopharm BIBP
* Sinopharm WIBP
* Turkovac
* Valneva

mRNA|

* Moderna
* Pfizer–BioNTech

Subunit|

* Abdala
* Corbevax (Bio E COVID-19)
* COVAX-19
* EpiVacCorona
* MVC
* Noora
* Novavax
* Razi Cov Pars
* Sinopharm CNBG
* Soberana 02
* Soberana Plus
* ZF2001 (Zifivax)

Viral vector|

* Convidecia
* Janssen
* Oxford–AstraZeneca
* Sputnik V
* Sputnik Light

Virus-like particles|

* CoVLP

In trials|

| Attenuated|

* COVI-VAC (United States)

|

DNA|

* AG0302-COVID‑19
* GX-19
* Inovio

Inactivated|

* KD-414
* NDV-HXP-S

RNA|

* ARCT-021
* ARCT-154
* Bangavax
* CureVac (terminated)
* HGC019
* mRNA-1283
* PTX-COVID19-B
* Sanofi–Translate Bio (terminated)
* Stemirna COVID-19 vaccine
* Walvax

Subunit|

* 202-CoV
* AKS-452
* EuCorVac-19
* IVX-411
* Nanocovax
* ReCOV
* Sanofi–GSK
* S-268019
* SCB-2019
* SCTV01C
* SKYCovione
* UB-612
* V-01
* V451 (terminated)
* Vabiotech
* West China Hospital
* Zhongyianke Biotech–Liaoning Maokangyuan Biotech‎

Viral vector|

* AdCLD-CoV19
* BBV154
* BriLife
* COH04S1
* DelNS1-2019-nCoV-RBD-OPT
* GRAd-COV2
* ImmunityBio
* INNA-051
* NDV-HXP-S
* Vaxart COVID-19 vaccine

Virus-like particles|

* ABNCoV2
* LYB001
* MigVax-101
* VBI-2902

Deployment
by location|

| Africa|

* Algeria
* Angola
* Benin
* Botswana
* Burkina Faso
* Burundi
* Cameroon
* Cape Verde
* Cameroon
* Chad
* Comoros
* Democratic Republic of the Congo
* Djibouti
* Egypt
* Equatorial Guinea
* Eswatini
* Ghana
* Morocco
* Nigeria
* Senegal
* South Africa
* Zimbabwe

|

Asia|

* Bangladesh
* Bhutan
* Mainland China
* India
* Indonesia
* Iran
* Israel
* Japan
* Kazakhstan
* Malaysia
* Nepal
* Philippines
* Russia
* Singapore
* South Korea
* Sri Lanka
* Taiwan
* Thailand
* Turkey
* United Arab Emirates
* Vietnam

Europe|

* Albania
* Bosnia and Herzegovina
* Bulgaria
* Croatia
* Denmark
* France
* Germany
* Greece
* Hungary
* Iceland
* Ireland
* Italy
* Moldova
* Norway
* Portugal
* Romania
* Russia
* Spain
* Sweden
* Switzerland
* Ukraine
* United Kingdom

North America|

* Canada
* Ontario
* Quebec
* Cuba
* Haiti
* Mexico
* United States
* mandates

Oceania|

* Australia
* Fiji
* New Zealand

South America|

* Argentina
* Brazil
* Colombia
* Peru

Others|

* Antarctica

Treatment|

* Drug development
* Drug repurposing research
* Dexamethasone
* Baricitinib
* RECOVERY Trial (UK)
* Solidarity trial (WHO)
* PANORAMIC trial (UK)
* Open-source ventilator
* Extracorporeal membrane oxygenation

Monoclonal antibodies|

* Bamlanivimab/etesevimab
* Bamlanivimab
* Etesevimab
* Bebtelovimab
* Casirivimab/imdevimab
* Regdanvimab
* Sarilumab
* Sotrovimab
* Tixagevimab/cilgavimab
* Tocilizumab

Small molecule antivirals|

* Broad-spectrum
* Remdesivir
* Molnupiravir
* Co-packaged
* Nirmatrelvir
* ritonavir

Variants

* Alpha
* Beta
* Gamma
* Delta
* Epsilon
* Zeta
* Eta
* Theta
* Iota
* Kappa
* Lambda
* Mu
* Omicron
* timeline

* Cluster 5
* Lineage B.1.617
* Lineage B.1.640.2
* Variant of concern

Institutions

| Hospitals and
medical clinics|

| Mainland China|

* Central Hospital of Wuhan
* Dabie Mountain Regional Medical Centre
* Fangcang hospitals
* Huoshenshan Hospital
* Leishenshan Hospital
* Xinjia Express Hotel
* Wuhan Jinyintan Hospital

|

Others|

* Hospital ships
* Canberra Coronavirus Field Hospital (Australia)
* Hospital El Salvador
* SevenHills Hospital (India)
* Kemayoran Athletes Village (Indonesia)
* Pyongyang General Hospital (North Korea)
* Malaysia Agro Exposition Park Serdang (Malaysia)
* Mega Ligtas COVID Centers (Philippines)
* Kandakadu Treatment and Rehabilitation Centre (Sri Lanka)
* Sancaktepe Prof. Dr. Feriha Öz Emergency Hospital (Turkey)
* Yeşilköy Prof. Dr. Murat Dilmener Emergency Hospital (Turkey)
* COVID-19 hospitals in the United Kingdom
* Dragon's Heart Hospital (Wales)
* NHS Louisa Jordan (Scotland)
* NHS Nightingale Hospitals (England)
* Birmingham
* London
* North East
* North West
* Yorkshire and the Humber

Organizations|

| Global|

* Coalition for Epidemic Preparedness Innovations
* Coronavirus Tech Handbook
* COVID-19 Solidarity Response Fund
* Covid Watch
* EcoHealth Alliance
* International Committee on Taxonomy of Viruses
* Joint Committee on Vaccination and Immunisation
* MusiCares COVID-19 Relief Fund
* Pasteur Institute
* in Cambodia
* UN COVID-19 Supply Chain Task Force (WHO)
* United Nations
* resolutions
* World Health Organization

|

By location|

* National Cabinet (Australia)
* ScienceUpFirst (Canada)
* Wuhan Institute of Virology (China)
* Independent SAGE (United Kingdom)

Health
institutes|

* Africa Centres for Disease Control and Prevention (African Union)
* Ghana Infectious Disease Centre (Ghana)
* Department of Health (Hong Kong)
* Korea Disease Control and Prevention Agency (South Korea)
* National Institute for Communicable Diseases (South Africa)
* Taiwan Centers for Disease Control (Taiwan)

Pandemic
institutes|

* National COVID-19 Commission Advisory Board (Australia)
* COVID-19 Immunity Task Force (Canada)
* COVID-19 Supply Council (Canada)
* PREPARE (European Union)
* National Expert Group on Vaccine Administration for COVID-19 (India)
* COVID-19 Response Acceleration Task Force (Indonesia)
* National Public Health Emergency Team (Ireland)
* Novel Coronavirus Expert Meeting (Japan)
* Crisis Preparedness and Response Centre (Malaysia)
* Defeat COVID-19 Ad Hoc Committee (Philippines)
* Inter-Agency Task Force for the Management of Emerging Infectious Diseases (Philippines)
* Central Epidemic Command Center (Taiwan)
* Coronavirus Scientific Advisory Board (Turkey)
* COVID-19 Genomics UK Consortium (United Kingdom)
* Imperial College COVID-19 Response Team (United Kingdom)
* Joint Biosecurity Centre (United Kingdom)
* Vaccine Taskforce (United Kingdom)
* COVID-19 Advisory Board (United States)
* Great American Economic Revival Industry Groups (United States)
* White House Coronavirus Task Force (United States)
* White House COVID-19 Response Team (United States)
* GACH (Uruguay)

Relief funds|

* PM CARES Fund (India)
* SAARC COVID-19 Emergency Fund (India)
* Artist Relief (United States)

People

| Medical
professionals|

* Ai Fen
* Corona Rintawan
* Li Wenliang
* Liu Wen
* Xie Linka
* Zhang Wenhong

|

Researchers|

* Awang Bulgiba Awang Mahmud
* Roberto Burioni
* Chen Wei
* Kizzmekia Corbett
* Andrea Crisanti
* Peter Daszak
* Christian Drosten
* Neil Ferguson
* Dale Fisher
* George F. Gao
* Azra Ghani
* Sarah Gilbert
* Guan Yi
* Kentaro Iwata
* Katalin Karikó
* Matt Keeling
* Trudie Lang
* Li Lanjuan
* W. Ian Lipkin
* Ma Xiaowei
* Shabir Madhi
* Allison McGeer
* Camilla Rothe
* Shi Zhengli
* Moncef Slaoui
* Mike Tildesley
* John Todd
* Wang Chen
* Wang Guangfa
* Drew Weissman
* Yuen Kwok-yung
* Zeng Guang
* Zhang Jixian
* Zhang Yongzhen
* Zhong Nanshan

Officials|

| WHO|

* Tedros Adhanom (Director-General of the WHO)
* Bruce Aylward (Team lead of WHO-China COVID-19 mission)
* Maria Van Kerkhove (Technical Lead for COVID-19 response)
* Michael J. Ryan (Executive Director of the WHO Health Emergencies Programme)

|

By location|

* Frank Atherton (Wales)
* Ashley Bloomfield (New Zealand)
* Catherine Calderwood (Scotland)
* Chang Shan-chwen (Taiwan)
* Anutin Charnvirakul (Thailand)
* Chen Shih-chung (Taiwan)
* Kenneth Chuang Yin-ching (Taiwan)
* Victor Costache (Romania)
* Fabrizio Curcio (Italy)
* Carmen Deseda (Puerto Rico)
* Jaap van Dissel (the Netherlands)
* Christian Drosten (Germany)
* Francisco Duque III (Philippines)
* Anthony Fauci (United States)
* Francesco Paolo Figliuolo (Italy)
* Graça Freitas (Portugal)
* Henrique Gouveia e Melo (Portugal)
* Matt Hancock (United Kingdom)
* Hamad Hasan (Lebanon)
* Greg Hunt (Australia)
* Tony Holohan (Ireland)
* Jeong Eun-kyeong (South Korea)
* Fahrettin Koca (Turkey)
* Li Keqiang (China)
* Hugo López-Gatell Ramírez (Mexico)
* Michael McBride (Northern Ireland)
* Oriol Mitjà (Andorra)
* Zweli Mkhize (South Africa)
* Doni Monardo (Indonesia)
* Alma Möller (Iceland)
* Saeed Namaki (Iran)
* Ala Nemerenco (Moldova)
* Nguyễn Thanh Long (Vietnam)
* Noor Hisham Abdullah (Malaysia)
* Ali Pilli (Northern Cyprus)
* Daniel Salinas (Uruguay)
* Jérôme Salomon (France)
* Fernando Simón (Spain)
* Gregor Smith (Scotland)
* Su Ih-jen (Taiwan)
* Łukasz Szumowski (Poland)
* Theresa Tam (Canada)
* Anders Tegnell (Sweden)
* Þórólfur Guðnason (Iceland)
* Sotiris Tsiodras (Greece)
* Harsh Vardhan (India)
* Víðir Reynisson (Iceland)
* Carla Vizzotti (Argentina)
* Vlad Voiculescu (Romania)
* Chris Whitty (United Kingdom)
* Lawrence Wong (Singapore)
* Jeffrey Zients (United States)

Others|

* Chen Qiushi
* Brett Crozier
* Fang Bin
* Fang Fang
* Joseph Ashitey Hammond
* Li Zehua
* Captain Tom Moore
* Qiu Menghuang
* Ren Zhiqiang

Deaths|

List

Data (templates)

| Global|

* Cases, deaths, recoveries by country
* Tests, cases, tests per capita, cases per capita by country
* Tests, cases, tests per capita, cases per capita by country subdivision
* WHO situation reports
* cases
* January 2020
* February 2020
* March 2020
* April 2020
* May 2020
* June 2020
* July 2020
* August 2020
* September 2020
* October 2020
* November 2020
* December 2020
* January 2021
* February 2021
* April 2021
* May 2021
* June 2021
* July 2021
* deaths
* World map by countries: confirmed per capita
* China
* Hospital beds by country
* Lockdowns

|

Africa|

* Algeria
* Angola
* Benin
* Botswana
* Burkina Faso
* Burundi
* Cameroon
* Comoros
* Egypt
* Eswatini
* Ethiopia
* Ghana
* cases chart
* Ivory Coast
* Kenya
* Libya
* Malawi
* Mali
* Mauritania
* Mauritius
* Morocco (including occupied Western Sahara)
* Mozambique
* Namibia
* Nigera
* cases chart
* São Tomé and Príncipe
* Senegal
* Seychelles
* Sierra Leone
* South Africa
* cases chart
* South Sudan
* Sudan
* Tanzania
* Togo
* Tunisia
* Uganda
* Zambia
* Zimbabwe
* cases chart

Americas|

* Argentina
* Bolivia
* Brazil
* Canada
* by province
* vaccinations by province
* Chile
* by commune
* Colombia
* Costa Rica
* cases chart
* Cuba
* Dominican Republic
* Ecuador
* El Salvador
* Guatemala
* Haiti
* Honduras
* Mexico
* cases chart
* Nicaragua
* Panama
* Paraguay
* Peru
* United States
* by state
* Uruguay
* Venezuela

Asia|

* Afghanistan
* Armenia
* Artsakh
* Azerbaijan
* Bahrain
* Bangladesh
* by division
* Bhutan
* cases chart
* Brunei
* Cambodia
* cases chart
* summary
* China
* cases chart
* confirmed per capita
* lockdowns
* by province
* Hong Kong
* Macau
* Cyprus
* East Timor
* Egypt
* Georgia
* India
* Indonesia
* cases chart
* Iran
* cases chart
* Iraq
* Israel
* cases chart
* Japan
* cases chart
* Jordan
* Kazakhstan
* Kuwait
* cases chart
* Kyrgyzstan
* Laos
* Lebanon
* Malaysia
* cases chart
* charts
* Myanmar
* cases chart
* summary
* Nepal
* cases chart
* Oman
* cases chart
* Pakistan
* cases chart
* Philippines
* cases chart
* areas of quarantine
* vaccinations chart
* Qatar
* Russia
* cases chart
* by federal subject
* North Asia
* Saudi Arabia
* Singapore
* South Korea
* cases chart
* vaccinations charts
* Sri Lanka
* Syria
* Taiwan
* vaccination charts
* Tajikistan
* Thailand
* cases chart
* Turkey
* cases chart
* United Arab Emirates
* cases chart
* Uzbekistan
* cases chart
* Vietnam
* statistics charts
* Yemen

Europe|

* Albania
* Austria
* cases chart
* Belarus
* Belgium
* cases chart
* Bosnia and Herzegovina
* Bulgaria
* cases chart
* Croatia
* Cyprus
* Czech Republic
* Denmark
* cases chart
* Faroe Islands
* Estonia
* cases chart
* Finland
* France
* cases chart
* Germany
* cases chart
* Greece
* Hungary
* Iceland
* cases chart
* Ireland
* cases chart
* Italy
* cases chart
* statistics charts
* vaccinations chart
* Kosovo
* Latvia
* cases chart
* Lithuania
* cases chart
* Luxembourg
* Malta
* Moldova
* Monaco
* Montenegro
* Netherlands
* North Macedonia
* Norway
* cases chart
* Poland
* cases chart
* by voivodeship
* Portugal
* cases chart
* Romania
* cases chart
* Russia
* cases chart
* by federal subject
* North Asia
* San Marino
* Serbia
* Slovakia
* cases chart
* by region
* Slovenia
* cases chart
* Spain
* cases chart
* Sweden
* cases chart
* Switzerland
* cases chart
* Turkey
* cases chart
* Ukraine
* Donetsk People's Republic
* Luhansk People's Republic
* United Kingdom
* Scotland
* 2020
* 2021
* Gibraltar
* vaccinations chart
* daily
* by nation
* Vatican City

Oceania|

* Australia
* by state/territory
* Fiji
* French Polynesia
* New Caledonia
* New Zealand
* Papua New Guinea
* Solomon Islands

Others|

* Cruise ships
* Diamond Princess

* COVID-19 portal
* Category

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