SPRED3

Protein-coding gene in the species Homo sapiens

SPRED3

Identifiers
Aliases| SPRED3, Eve-3, spred-3, sprouty related EVH1 domain containing 3
External IDs| OMIM: 609293; MGI: 2142186; HomoloGene: 28061; GeneCards: SPRED3; OMA:SPRED3 - orthologs
| Gene location (Human)

Chr.| Chromosome 19 (human)[1]

Band| 19q13.2| Start| 38,388,421 bp[1]
End| 38,399,587 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 7 (mouse)[2]

Band| 7|7 B1| Start| 28,858,254 bp[2]
End| 28,869,836 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* parotid gland

* lateral nuclear group of thalamus

* vena cava

* external globus pallidus

* right ventricle

* pars reticulata

* Skeletal muscle tissue of rectus abdominis

* body of tongue

* pons

* subthalamic nucleus

| Top expressed in

* visual cortex

* primary visual cortex

* superior frontal gyrus

* tail of embryo

* spermatid

* neural layer of retina

* dentate gyrus of hippocampal formation granule cell

* lumbar subsegment of spinal cord

* ventricular zone

* genital tubercle

More reference expression data
BioGPS| | n/a

| Gene ontology

Molecular function|

* protein kinase binding

Cellular component|

* membrane

Biological process|

* multicellular organism development
* regulation of signal transduction
* negative regulation of peptidyl-threonine phosphorylation
* positive regulation of DNA damage response, signal transduction by p53 class mediator
* regulation of protein deacetylation

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

399473

101809

Ensembl| |

ENSG00000188766

ENSMUSG00000037239

UniProt| |

Q2MJR0

Q6P6N5

RefSeq (mRNA)| |

NM_001039616
NM_001042522
NM_001394336
NM_001394337
NM_001394338

NM_182927

RefSeq (protein)| |

NP_001035987

NP_891557

Location (UCSC)| Chr 19: 38.39 – 38.4 Mb| Chr 7: 28.86 – 28.87 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Sprouty-related, EVH1 domain-containing protein 3 also known as Spread-3 is a protein that in humans is encoded by the SPRED3 gene.[5]

Spread-3 is a member of the Sprouty (see SPRY1/SPRED) family of proteins that regulate growth factor-induced activation of the MAP kinase cascade.[5][6]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000188766 - Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037239 - Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ a b "Entrez Gene: sprouty-related".
6. ^ Nonami A, Kato R, Taniguchi K, Yoshiga D, Taketomi T, Fukuyama S, Harada M, Sasaki A, Yoshimura A (December 2004). "Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells". The Journal of Biological Chemistry. 279 (50): 52543–51. doi:10.1074/jbc.M405189200. PMID 15465815.

## Further reading

[edit]

* Kato R, Nonami A, Taketomi T, Wakioka T, Kuroiwa A, Matsuda Y, Yoshimura A (March 2003). "Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation". Biochemical and Biophysical Research Communications. 302 (4): 767–72. doi:10.1016/S0006-291X(03)00259-6. PMID 12646235.
* Mizoguchi M, Nutt CL, Louis DN (February 2004). "Mutation analysis of CBL-C and SPRED3 on 19q in human glioblastoma". Neurogenetics. 5 (1): 81–2. doi:10.1007/s10048-003-0164-x. PMID 14618415. S2CID 35025882.
* King JA, Corcoran NM, D'Abaco GM, Straffon AF, Smith CT, Poon CL, Buchert M, I S, Hall NE, Lock P, Hovens CM (April 2006). "Eve-3: a liver enriched suppressor of Ras/MAPK signaling". Journal of Hepatology. 44 (4): 758–67. doi:10.1016/j.jhep.2005.10.031. PMID 16478641.
* Lock P, I ST, Straffon AF, Schieb H, Hovens CM, Stylli SS (December 2006). "Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination". Biochemical and Biophysical Research Communications. 351 (4): 1018–23. doi:10.1016/j.bbrc.2006.10.150. PMID 17094949.

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