STARD13

Protein-coding gene in the species Homo sapiens

STARD13

| Available structures

PDB| Ortholog search: PDBe RCSB
| List of PDB id codes

2H80, 2JW2, 2PSO

Identifiers
Aliases| STARD13, ARHGAP37, DLC2, GT650, LINC00464, StAR related lipid transfer domain containing 13
External IDs| OMIM: 609866; MGI: 2385331; HomoloGene: 64844; GeneCards: STARD13; OMA:STARD13 - orthologs
| Gene location (Human)

Chr.| Chromosome 13 (human)[1]

Band| 13q13.1-q13.2| Start| 33,103,137 bp[1]
End| 33,350,630 bp[1]
| Gene location (Mouse)

Chr.| Chromosome 5 (mouse)[2]

Band| 5|5 G3| Start| 150,960,975 bp[2]
End| 151,157,301 bp[2]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* sural nerve

* muscle layer of sigmoid colon

* epithelium of colon

* spinal ganglia

* trigeminal ganglion

* right lung

* thyroid gland

* left lobe of thyroid gland

* right lobe of thyroid gland

* Achilles tendon

| Top expressed in

* zygote

* secondary oocyte

* lumbar spinal ganglion

* vestibular membrane of cochlear duct

* primary oocyte

* retinal pigment epithelium

* sciatic nerve

* left lung lobe

* right lung lobe

* saccule

More reference expression data
BioGPS| |

More reference expression data
| Gene ontology

Molecular function|

* protein binding
* lipid binding
* GTPase activator activity

Cellular component|

* cytoplasm
* cytosol
* lipid droplet
* mitochondrial membranes
* mitochondrion
* membrane

Biological process|

* negative regulation of cell migration involved in sprouting angiogenesis
* positive regulation of GTPase activity
* endothelial tube lumen extension
* regulation of small GTPase mediated signal transduction
* endothelial cell migration
* signal transduction

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

90627

243362

Ensembl| |

ENSG00000133121

ENSMUSG00000016128

UniProt| |

Q9Y3M8

Q923Q2

RefSeq (mRNA)| | NM_001243466
NM_001243474
NM_001243476
NM_052851
NM_178006

NM_178007
NM_178008

NM_001163493
NM_146258
NM_001359985

RefSeq (protein)| | NP_001230395
NP_001230403
NP_001230405
NP_443083
NP_821074

NP_821075

NP_001156965
NP_666370
NP_001346914

Location (UCSC)| Chr 13: 33.1 – 33.35 Mb| Chr 5: 150.96 – 151.16 Mb
PubMed search| [3]| [4]
Wikidata
| View/Edit Human| View/Edit Mouse

|

StAR-related lipid transfer domain protein 13 (STARD13) also known as deleted in liver cancer 2 protein (DLC-2) is a protein that in humans is encoded by the STARD13 gene and a member of the DLC family of proteins.[5][6]

## Function and structure

[edit]

STARD13 serves as a Rho GTPase-activating protein (GAP), a type of protein that regulates members of the Rho family of GTPases.[7] It selectively activates RhoA and CDC42 and suppresses cell growth by inhibiting actin stress fiber assembly.[7]

The protein consists of an N-terminal sterile alpha motif (SAM) domain,[8] a serine-rich domain, a RhoGAP domain and at the C-terminus, a StAR-related lipid-transfer domain (START).

## Tissue distribution and pathology

[edit]

The protein was identified in part through its differential expression in cancers. A low level of STARD13 was observed in less differentiated hepatocellular carcinoma tissue with higher RhoA expression. A small patient study finds that the absence of STARD13 in hepatocellular carcinomas correlates with higher levels of RhoA and a poorer prognosis than patients with carcinomas that were STARD13-positive.[9]

## References

[edit]

1. ^ a b c GRCh38: Ensembl release 89: ENSG00000133121 – Ensembl, May 2017
2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000016128 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Couch FJ, Rommens JM, Neuhausen SL, Bélanger C, Dumont M, Abel K, Bell R, Berry S, Bogden R, Cannon-Albright L, Farid L, Frye C, Hattier T, Janecki T, Jiang P, Kehrer R, Leblanc JF, McArthur-Morrison J, Meney D, Miki Y, Peng Y, Samson C, Schroeder M, Snyder SC, Simard J (August 1996). "Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13". Genomics. 36 (1): 86–99\. doi:10.1006/geno.1996.0428. PMID 8812419.
6. ^ "Entrez Gene: STARD13 START domain containing 13".
7. ^ a b Ching YP, Wong CM, Chan SF, Leung TH, Ng DC, Jin DY, Ng IO (March 2003). "Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma". The Journal of Biological Chemistry. 278 (12): 10824–30\. doi:10.1074/jbc.M208310200. PMID 12531887.
8. ^ Li, Hongyan; Fung, King-Leung; Jin, Dong-Yan; Chung, Stephen S. M.; Ching, Yick-Pang; Ng, Irene Oi-lin; Sze, Kong-Hung; Ko, Ben C. B.; Sun, Hongzhe (2007-06-01). "Solution structures, dynamics, and lipid-binding of the sterile alpha-motif domain of the deleted in liver cancer 2". Proteins. 67 (4): 1154–1166\. doi:10.1002/prot.21361. ISSN 1097-0134. PMID 17380510. S2CID 20407564.
9. ^ Xiaorong L, Wei W, Liyuan Q, Kaiyan Y (2008). "Underexpression of deleted in liver cancer 2 (DLC2) is associated with overexpression of RhoA and poor prognosis in hepatocellular carcinoma". BMC Cancer. 8: 205. doi:10.1186/1471-2407-8-205. PMC 2496915. PMID 18651974.

## Further reading

[edit]

* Ching YP, Wong CM, Chan SF, Leung TH, Ng DC, Jin DY, Ng IO (March 2003). "Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma". The Journal of Biological Chemistry. 278 (12): 10824–30\. doi:10.1074/jbc.M208310200. PMID 12531887.
* Day CL, Puthalakath H, Skea G, Strasser A, Barsukov I, Lian LY, Huang DC, Hinds MG (February 2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". The Biochemical Journal. 377 (Pt 3): 597–605\. doi:10.1042/BJ20031251. PMC 1223895. PMID 14561217.
* Nagaraja GM, Kandpal RP (January 2004). "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins". Biochemical and Biophysical Research Communications. 313 (3): 654–65\. doi:10.1016/j.bbrc.2003.12.001. PMID 14697242.
* Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32\. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
* Leung TH, Ching YP, Yam JW, Wong CM, Yau TO, Jin DY, Ng IO (October 2005). "Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity". Proceedings of the National Academy of Sciences of the United States of America. 102 (42): 15207–12\. Bibcode:2005PNAS..10215207L. doi:10.1073/pnas.0504501102. PMC 1250229. PMID 16217026.

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PDB gallery

* 2h80: NMR structures of SAM domain of Deleted in Liver Cancer 2 (DLC2)

* 2pso: Human StarD13 (DLC2) lipid transfer and protein localization domain

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