SURF4

Protein-coding gene humans

SURF4

Identifiers
Aliases| SURF4, ERV29, surfeit 4
External IDs| OMIM: 185660; MGI: 98445; HomoloGene: 6052; GeneCards: SURF4; OMA:SURF4 - orthologs
| Gene location (Human)

Chr.| Chromosome 9 (human)[1]

Band| 9q34.2| Start| 133,361,450 bp[1]
End| 133,376,166 bp[1]
| RNA expression pattern

Bgee| | Human| Mouse (ortholog)

|

| Top expressed in

* islet of Langerhans

* stromal cell of endometrium

* duodenum

* body of pancreas

* placenta

* right lobe of liver

* gallbladder

* smooth muscle tissue

* left adrenal gland

* left adrenal cortex

n/a

More reference expression data
BioGPS| | n/a

| Gene ontology

Molecular function|

* protein binding

Cellular component|

* integral component of membrane
* Golgi apparatus
* endoplasmic reticulum-Golgi intermediate compartment membrane
* endoplasmic reticulum
* membrane
* endoplasmic reticulum-Golgi intermediate compartment
* transport vesicle
* endoplasmic reticulum membrane
* Golgi membrane
* plasma membrane
* azurophil granule membrane
* cytosol

Biological process|

* early endosome to Golgi transport
* positive regulation of organelle organization
* protein exit from endoplasmic reticulum
* Golgi organization
* retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
* neutrophil degranulation

Sources:Amigo / QuickGO
| Orthologs

Species| Human| Mouse
Entrez| |

6836

20932

Ensembl| |

ENSG00000148248
ENSG00000280951

n/a

UniProt| |

O15260

Q64310

RefSeq (mRNA)| | NM_001280788
NM_001280789
NM_001280790
NM_001280791
NM_001280792

NM_001280793
NM_033161

NM_011512

RefSeq (protein)| | NP_001267717
NP_001267718
NP_001267719
NP_001267720
NP_001267721

NP_001267722
NP_149351

NP_035642

Location (UCSC)| Chr 9: 133.36 – 133.38 Mb| n/a
PubMed search| [2]| [3]
Wikidata
| View/Edit Human| View/Edit Mouse

|

Surfeit locus protein 4 or Surf4 is a protein involved in regulating export of some proteins from the endoplasmic reticulum to the golgi bodies.[4][5] Surf4 is involved in trafficking soluble (i.e. non-membrane-bound) proteins, namely lipoproteins and PCSK9.[4] It recognizes cargo proteins via a three-amino-acid sequence near the N-termini.[4] The related protein in yeast is called Erv29p.[5]

This gene is named based on its location in the surfeit gene cluster, composed of six housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein containing multiple putative transmembrane regions. Surf4's yeast homolog is directly required for packaging glycosylated pro-alpha-factor into COPII vesicles.[6]

Eliminating Surf4 in the liver reduces the amount of lipid in the plasma and prevents atherosclerosis in mice.[4]

## References

[edit]

1. ^ a b c ENSG00000280951 GRCh38: Ensembl release 89: ENSG00000148248, ENSG00000280951 - Ensembl, May 2017
2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ a b c d Sun S, Tang X, Guo Y, Hu J (August 2021). "Endoplasmic reticulum composition and form: Proteins in and out". Current Opinion in Cell Biology. 71: 1–6. doi:10.1016/j.ceb.2021.01.008. PMID 33611096. S2CID 231987943.
5. ^ a b "SURF4 Gene - Surfeit 4". Retrieved 8 June 2022.
6. ^ "Entrez Gene: SURF4 surfeit 4".

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