Salivary gland tumour

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Medical condition

Salivary gland tumour

Parotid gland tumour
Specialty| Oncology, oral and maxillofacial surgery, oral and maxillofacial pathology

Salivary gland tumours, or neoplasms, are tumours that form in the tissues of salivary glands. The salivary glands are classified as major or minor. The major salivary glands consist of the parotid, submandibular, and sublingual glands. The minor salivary glands consist of 800 to 1000 small mucus-secreting glands located throughout the lining of the oral cavity.[1] People with these types of tumours may be asymptomatic.

## Presentation

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Salivary gland tumours usually present as a lump or swelling in the affected gland which may or may not have been present for a long time. The lump may be accompanied by symptoms of duct blockage (e.g. xerostomia). Usually, in their early stages, it is not possible to distinguish a benign tumour from a malignant one. One of the key differentiating symptoms of malignant growth is nerve involvement; for example, signs of facial nerve damage (e.g. facial palsy) are associated with malignant parotid tumours. Facial pain and paraesthesia are also very often associated with malignant tumours.[2] Other red flag symptoms which may suggest malignancy and warrant further investigation are fixation of the lump to the overlying skin, ulceration and induration (hardening) of the mucosa.[3]

A 71-year-old woman diagnosed with a massive salivary gland mixed tumour, also known as pleomorphic adenoma.

## Diagnosis

[edit]

Many diagnostic methods can be used to determine the type of salivary gland tumour and if it is benign or malignant. Examples of diagnostic methods include:

Physical exam and history: An exam of the body to check general signs of health. The head, neck, mouth, and throat will be checked for signs of disease, such as lumps or anything else that seems unusual. A medical history will also be taken.

Endoscopy: A procedure to look at organs and tissues inside the body to check for abnormal areas. For salivary gland cancer, an endoscope is inserted into the mouth to look at the mouth, throat, and larynx. An endoscope is a thin, tube-like instrument with a light and a lens for viewing.

MRI or CT Scan: These tests can confirm the presence of a tumour. An MRI or CT Scan can also show whether metastasis has occurred.[4]

Biopsy: The removal of cells or tissues so they can be viewed under a microscope by a pathologist to check for signs of cancer.[5]

Fine needle aspiration (FNA) biopsy: The removal of tissue or fluid using a thin needle. An FNA is the most common type of biopsy used for salivary gland cancer and has been shown to produce accurate results when differentiating between benign and malignant tumours.[6]

Radiographs: An OPG (orthopantomogram) can be taken to rule out mandibular involvement. A chest radiograph may also be taken to rule out any secondary tumours.[7]

Ultrasound: Ultrasound can be used to initially assess a tumour that is located superficially in either the submandibular or parotid gland. It can distinguish an intrinsic from an extrinsic neoplasm. Ultrasonic images of malignant tumours include ill-defined margins.[8] Furthermore, high resolution ultrasound can identify the exact tumour location within the parotid gland, its relationship to the retromandibular vein and assist surgical excision.[9]

### Classification

[edit]

Relative incidence of parotid tumours.[10] Relative incidence of submandibular tumours.[10]

Due to the diverse nature of salivary gland tumours, many different terms and classification systems have been used. Perhaps the most widely used currently is that system proposed by the World Health Organization in 2005. This system defines five broad categories of salivary gland neoplasms: benign epithelial, malignant epithelial, soft tissue, hematolymphoid, and secondary.[11][12]

Benign epithelial tumours

* Pleomorphic adenomaCoronal MRI showing right parotid adenoid cystic carcinoma.
* Benign tumour of the submandibular gland, also known as pleomorphic adenoma, presented as a painless neck mass in a 40-year-old man. At the left of the image is the white tumour with its characteristic cartilaginous cut surface. To the right is the normally lobated submandibular salivary gland.Warthin's tumor
* Myoepithelioma
* Basal cell adenoma
* Oncocytoma
* Canalicular adenoma
* Lymphadenoma
* Sebaceous lymphadenoma
* Nonsebaceous lymphadenoma
* Ductal papilloma
* Inverted ductal papilloma
* Intraductal papilloma
* Sialadenoma papilliferum
* Cystadenoma
* Malignant epithelial tumours
* Acinic cell carcinoma
* Mucoepidermoid carcinoma
* Adenoid cystic carcinoma
* Polymorphous low-grade adenocarcinoma
* Epithelial-myoepithelial carcinoma
* Clear cell carcinoma, not otherwise specified
* Basal cell adenocarcinoma
* Sebaceous carcinoma
* Sebaceous lymphadenocarcinoma
* Cystadenocarcinoma
* Low-grade cribriform cystadenocarcinoma
* Mucinous adenocarcinoma
* Oncocytic carcinoma
* Salivary duct carcinoma
* Salivary duct carcinoma, not otherwise specified
* Adenocarcinoma, not otherwise specified
* Myoepithelial carcinoma
* Carcinoma ex pleomorphic adenoma
* Mammary analogue secretory carcinoma
* Carcinosarcoma
* Metastasizing pleomorphic adenoma
* Squamous cell carcinoma
* Large cell carcinoma
* Lymphoepithelial carcinoma
* Sialoblastoma
* Soft tissue tumours
* Hemangioma
* Hematolymphoid tumours
* Hodgkin lymphoma
* Diffuse large B-cell lymphoma
* Extranodal marginal zone B cell lymphoma
* Secondary tumours (i.e. a tumour which has metastasized to the salivary gland from a distant location)

Others, not included in the WHO classification above, include:[11]

* Intraosseous (central) salivary gland tumours
* Hybrid tumours (i.e. a tumour displaying combined forms of histologic tumour types)
* Hybrid carcinoma
* Others
* Others
* Keratocystoma
* Sialolipoma

## Treatment

[edit]

Early-stage lesions may be able to be treated surgically. More advanced or unresectable cancers tend to be treated with radiotherapy (RT) alone or chemoradiotherapy (CRT), which hampered the comparison of the efficacy of RT alone with that of surgery combined with adjuvant RT. But some effort had been made to reflect the role of surgery in salivary gland tumours.

Specimen from a parotid gland tumour. It was removed by John Hunter from a 37-year-old man named John Burley on 24 October 1785. The tumour weighed over 4 kilograms and took twenty-five minutes to remove. The specimen currently resides in the Hunterian Museum at the Royal College of Surgeons of England.

Treatment may include the following:

* Surgery Complete surgical resection, with adequate free margins, is currently the mainstay treatment for salivary gland tumours. However elective treatment of the N0 neck region remains a controversial topic
* Radiotherapy[4] If a salivary gland tumour is cancerous, Radiation Therapy may be necessary

Fast neutron therapy has been used successfully to treat salivary gland tumours,[13] and has shown to be significantly more effective than photons in studies treating unresectable salivary gland tumours.[14][15]

* Chemotherapy Currently little is known about the efficacy of chemotherapy in treating salivary gland tumours. Chemotherapy, which plays an important role in systemic therapy, is generally reserved for the palliative treatment of symptomatic locally recurrent and/or metastatic disease that is not amenable to further surgery or radiation. Conventional chemotherapy regimens, such as cisplatin and 5-FU or CAP (cisplatin, doxorubicin, and cyclophosphamide) are still utilized as first-line therapy for those with advanced lesions.[16]

Targeted therapy \- Due to the poor results with chemotherapy, it's urgent to explore novel therapeutic interventions for this disease. And great expectations have been put into individualized therapies: in particular, the EGF receptors family (EGFR and HER2), KIT and androgen receptors are the most commonly investigated molecular targets in SGCs. Their expression seems not to be linked to its pathogenetic role in the development of SGCs, but more to the histogenetic origin of the tumour cells. Various targeted agents, such as imatinib, cetuximab, gefitinib, trastuzumab, had been used for exploring new treatment for salivary gland tumours, but on account of the rare incidence of salivary gland tumours, the number of cases available on targeted therapy for analysis is relatively small.[17]

## Epidemiology

[edit]

Little is known about the total incidence of salivary gland tumours as most benign tumours go unrecorded in national cancer registries.[2] The majority of salivary tumours are benign (65-70%).[3] Within the parotid gland 75 - 80% of tumours are benign. Around 50% of the tumours found in the submandibular glands are benign. Sublingual gland tumours are very rare but if present, they are most likely to be malignant.[3][18] Saku et al. in 1997 [19] and Venturi [20][21] in 2021, reported the causal role for ionizing radiation in salivary gland tumorigenesis, particularly for mucoepidermoid carcinoma.

In the United States, salivary gland cancers are uncommon with an incidence rate of 1.7 in 100000 between 2009 and 2013.[22]

## See also

[edit]

* Head and neck cancer
* Salivary gland pathology

## References

[edit]

1. ^ Shah JP; Patel SG (2001). Cancer of the Head and Neck. PMPH-USA. p. 240\. ISBN 978-1-55009-084-0.
2. ^ a b Odell, Edward W. (2017). Cawson's essentials of oral pathology and oral medicine (Ninth ed.). [Edinburgh]: Elsevier Health Sciences. ISBN 978-0702049828. OCLC 960030340.
3. ^ a b c Mehanna, Hisham; McQueen, Andrew; Robinson, Max; Paleri, Vinidh (23 October 2012). "Salivary gland swellings". BMJ. 345: e6794. doi:10.1136/bmj.e6794. ISSN 1756-1833. PMID 23092898. S2CID 373247.
4. ^ a b "Salivary gland tumors: MedlinePlus Medical Encyclopedia". medlineplus.gov. Retrieved 28 October 2019.
5. ^ "Salivary Gland Cancer". MedicineNet.
6. ^ Vaishali H Anand et al. FNAC and Histopathology of Salivary Gland Tumors. SEAJCRR. 2014 Feb 3(1):609-618
7. ^ Mounika, C (7 March 2016). "Salivary Gland Tumors". SlideShare.
8. ^ Lee YY, Wong KT, King AD, Ahuja AT (June 2008). "Imaging of salivary gland tumours". Eur J Radiol. 66 (3): 419–36\. doi:10.1016/j.ejrad.2008.01.027. PMID 18337041.419-36&rft.date=2008-06&rft_id=info:doi/10.1016/j.ejrad.2008.01.027&rft_id=info:pmid/18337041&rft.aulast=Lee&rft.aufirst=YY&rft.au=Wong,+KT&rft.au=King,+AD&rft.au=Ahuja,+AT&rfr_id=info:sid/en.wikipedia.org:Salivary+gland+tumour" class="Z3988">
9. ^ Psychogios, Georgios; Rueger, Holger; Jering, Monika; Tsoures, Eleni; Künzel, Julian; Zenk, Johannes (September 2019). "Ultrasound can help to indirectly predict contact of parotid tumors to the facial nerve, correct intraglandular localization, and appropriate surgical technique". Head & Neck. 41 (9): 3211–3218\. doi:10.1002/hed.25811. ISSN 1043-3074. PMID 31179604. S2CID 182948983.3211-3218&rft.date=2019-09&rft.issn=1043-3074&rft_id=https://api.semanticscholar.org/CorpusID:182948983#id-name=S2CID&rft_id=info:pmid/31179604&rft_id=info:doi/10.1002/hed.25811&rft.aulast=Psychogios&rft.aufirst=Georgios&rft.au=Rueger,+Holger&rft.au=Jering,+Monika&rft.au=Tsoures,+Eleni&rft.au=Künzel,+Julian&rft.au=Zenk,+Johannes&rft_id=https://onlinelibrary.wiley.com/doi/abs/10.1002/hed.25811&rfr_id=info:sid/en.wikipedia.org:Salivary+gland+tumour" class="Z3988">
10. ^ a b Steve C Lee (22 December 2022). "Salivary Gland Neoplasms". Medscape. Updated: 13 Jan 2021
Diagrams by Mikael Häggström
11. ^ a b Barnes L (23 December 2008). Surgical Pathology of the Head and Neck. Vol. 1 (3rd ed.). Taylor & Francis. p. 511\. ISBN 978-0-8493-9023-4.
12. ^ Barnes L (2005). "Chapter 5: Tumors of the salivary glands (chapter authors: Eveson JW, Auclair P, Gnepp DR, El-Naggar AK)" (PDF). Pathology and Genetics of Head and Neck Tumours. International Agency for Research on Cancer, World Health Organization. p. 210\. ISBN 978-92-832-2417-4.
13. ^ Douglas JG, Koh WJ, Austin-Seymour M, Laramore GE (September 2003). "Treatment of salivary gland neoplasms with fast neutron radiotherapy". Arch. Otolaryngol. Head Neck Surg. 129 (9): 944–8\. doi:10.1001/archotol.129.9.944. PMID 12975266.944-8&rft.date=2003-09&rft_id=info:doi/10.1001/archotol.129.9.944&rft_id=info:pmid/12975266&rft.aulast=Douglas&rft.aufirst=JG&rft.au=Koh,+WJ&rft.au=Austin-Seymour,+M&rft.au=Laramore,+GE&rft_id=https://doi.org/10.1001%2Farchotol.129.9.944&rfr_id=info:sid/en.wikipedia.org:Salivary+gland+tumour" class="Z3988">
14. ^ Laramore GE, Krall JM, Griffin TW, Duncan W, Richter MP, Saroja KR, Maor MH, Davis LW (September 1993). "Neutron versus photon irradiation for unresectable salivary gland tumors: final report of an RTOG-MRC randomized clinical trial. Radiation Therapy Oncology Group. Medical Research Council". Int. J. Radiat. Oncol. Biol. Phys. 27 (2): 235–40\. doi:10.1016/0360-3016(93)90233-L. PMID 8407397.235-40&rft.date=1993-09&rft_id=info:doi/10.1016/0360-3016(93)90233-L&rft_id=info:pmid/8407397&rft.aulast=Laramore&rft.aufirst=GE&rft.au=Krall,+JM&rft.au=Griffin,+TW&rft.au=Duncan,+W&rft.au=Richter,+MP&rft.au=Saroja,+KR&rft.au=Maor,+MH&rft.au=Davis,+LW&rfr_id=info:sid/en.wikipedia.org:Salivary+gland+tumour" class="Z3988">
15. ^ Krüll A, Schwarz R, Engenhart R, Huber P, Lessel A, Koppe H, Favre A, Breteau N, Auberger T (1996). "European results in neutron therapy of malignant salivary gland tumors". Bull Cancer Radiother. 83 Suppl: 125–9s. doi:10.1016/0924-4212(96)84897-3. PMID 8949764.
16. ^ Creagan, ET; Woods, JE; Schutt, AJ; O'Fallon, JR (1 December 1983). "Cyclophosphamide, adriamycin, and cis-diamminedichloroplatinum (II) in the treatment of advanced nonsquamous cell head and neck cancer". Cancer. 52 (11): 2007–10\. doi:10.1002/1097-0142(19831201)52:11<2007::AID-CNCR2820521106>3.0.CO;2-T. PMID 6684986. S2CID 2813393.2007-10&rft.date=1983-12-01&rft_id=https://api.semanticscholar.org/CorpusID:2813393#id-name=S2CID&rft_id=info:pmid/6684986&rft_id=info:doi/10.1002/1097-0142(19831201)52:11<2007::AID-CNCR2820521106>3.0.CO;2-T&rft.aulast=Creagan&rft.aufirst=ET&rft.au=Woods,+JE&rft.au=Schutt,+AJ&rft.au=O'Fallon,+JR&rft_id=https://doi.org/10.1002%2F1097-0142%2819831201%2952%3A11%3C2007%3A%3AAID-CNCR2820521106%3E3.0.CO%3B2-T&rfr_id=info:sid/en.wikipedia.org:Salivary+gland+tumour" class="Z3988">
17. ^ Mino M, Pilch BZ, Faquin WC (December 2003). "Expression of KIT (CD117) in neoplasms of the head and neck: an ancillary marker for adenoid cystic carcinoma". Mod. Pathol. 16 (12): 1224–31\. doi:10.1097/01.MP.0000096046.42833.C7. PMID 14681323.1224-31&rft.date=2003-12&rft_id=info:doi/10.1097/01.MP.0000096046.42833.C7&rft_id=info:pmid/14681323&rft.aulast=Mino&rft.aufirst=M&rft.au=Pilch,+BZ&rft.au=Faquin,+WC&rft_id=https://doi.org/10.1097%2F01.MP.0000096046.42833.C7&rfr_id=info:sid/en.wikipedia.org:Salivary+gland+tumour" class="Z3988">
18. ^ "About salivary gland cancer | Salivary gland cancer | Cancer Research UK". www.cancerresearchuk.org. Retrieved 17 November 2017.
19. ^ Saku T, Hayashi Y, Takahara O, Matsuura H, Tokunaga M, Tokunaga M, Tokuoka S, Soda M, Mabuchi K, Land CE (1997). "Salivary gland tumors among atomic bomb survivors, 1950-1987". Cancer. 15 (79 (8)): 1465–75\. doi:10.1002/(SICI)1097-0142(19970415)79:8<1465::AID-CNCR4>3.0.CO;2-A. PMID 9118025. S2CID 11199713.1465-75&rft.date=1997&rft_id=https://api.semanticscholar.org/CorpusID:11199713#id-name=S2CID&rft_id=info:pmid/9118025&rft_id=info:doi/10.1002/(SICI)1097-0142(19970415)79:8<1465::AID-CNCR4>3.0.CO;2-A&rft.aulast=Saku&rft.aufirst=T&rft.au=Hayashi,+Y&rft.au=Takahara,+O&rft.au=Matsuura,+H&rft.au=Tokunaga,+M&rft.au=Tokunaga,+M&rft.au=Tokuoka,+S&rft.au=Soda,+M&rft.au=Mabuchi,+K&rft.au=Land,+CE&rfr_id=info:sid/en.wikipedia.org:Salivary+gland+tumour" class="Z3988">,
20. ^ Venturi, Sebastiano (January 2021). "Cesium in Biology, Pancreatic Cancer, and Controversy in High and Low Radiation Exposure Damage—Scientific, Environmental, Geopolitical, and Economic Aspects". International Journal of Environmental Research and Public Health. 18 (17): 8934. doi:10.3390/ijerph18178934. PMC 8431133. PMID 34501532. Text was copied from this source, which is available under a Creative Commons Attribution 4.0 International License.
21. ^ Venturi, S. | Correlation of Diabetes, Salivary gland cancer and Pancreatic Cancer with Iodine and Cesium Radionuclides| Researchgate | December| 2022 | https://www.researchgate.net/profile/Sebastiano-Venturi-4/publication/366530240
22. ^ American Cancer Society (2017). Cancer Facts and Figures 2017, Special Section: Rare Cancer in Adults. Atlanta: American Cancer Society.

* v
* t
* e

Oral and maxillofacial pathology

Lips

* Cheilitis
* Actinic
* Angular
* Plasma cell
* Cleft lip
* Congenital lip pit
* Eclabium
* Herpes labialis
* Macrocheilia
* Microcheilia
* Nasolabial cyst
* Sun poisoning
* Trumpeter's wart

Tongue

* Ankyloglossia
* Black hairy tongue
* Caviar tongue
* Crenated tongue
* Cunnilingus tongue
* Fissured tongue
* Foliate papillitis
* Glossitis
* Geographic tongue
* Median rhomboid glossitis
* Transient lingual papillitis
* Glossoptosis
* Hypoglossia
* Lingual thyroid
* Macroglossia
* Microglossia
* Rhabdomyoma

Palate

* Bednar's aphthae
* Cleft palate
* High-arched palate
* Palatal cysts of the newborn
* Inflammatory papillary hyperplasia
* Stomatitis nicotina
* Torus palatinus

Oral mucosa – Lining of mouth

* Amalgam tattoo
* Angina bullosa haemorrhagica
* Behçet's disease
* Bohn's nodules
* Burning mouth syndrome
* Candidiasis
* Condyloma acuminatum
* Darier's disease
* Epulis fissuratum
* Erythema multiforme
* Erythroplakia
* Fibroma
* Giant-cell
* Focal epithelial hyperplasia
* Fordyce spots
* Hairy leukoplakia
* Hand, foot and mouth disease
* Hereditary benign intraepithelial dyskeratosis
* Herpangina
* Herpes zoster
* Intraoral dental sinus
* Irritation fibroma
* Leukoedema
* Leukoplakia
* Lichen planus
* Linea alba
* Lupus erythematosus
* Melanocytic nevus
* Melanocytic oral lesion
* Molluscum contagiosum
* Morsicatio buccarum
* Oral cancer
* Benign: Squamous cell papilloma
* Keratoacanthoma
* Malignant: Adenosquamous carcinoma
* Basaloid squamous carcinoma
* Mucosal melanoma
* Spindle cell carcinoma
* Squamous cell carcinoma
* Verrucous carcinoma
* Oral florid papillomatosis
* Oral melanosis
* Smoker's melanosis
* Pemphigoid
* Benign mucous membrane
* Pemphigus
* Plasmoacanthoma
* Stomatitis
* Aphthous
* Denture-related
* Herpetic
* Smokeless tobacco keratosis
* Submucous fibrosis
* Ulceration
* Riga–Fede disease
* Verruca vulgaris
* Verruciform xanthoma
* White sponge nevus

Teeth (pulp, dentin, enamel)

* Amelogenesis imperfecta
* Ankylosis
* Anodontia
* Caries
* Early childhood caries
* Concrescence
* Failure of eruption of teeth
* Dens evaginatus
* Talon cusp
* Dentin dysplasia
* Dentin hypersensitivity
* Dentinogenesis imperfecta
* Dilaceration
* Discoloration
* Ectopic enamel
* Enamel hypocalcification
* Enamel hypoplasia
* Turner's hypoplasia
* Enamel pearl
* Fluorosis
* Fusion
* Gemination
* Hyperdontia
* Hypodontia
* Maxillary lateral incisor agenesis
* Impaction
* Wisdom tooth impaction
* Macrodontia
* Meth mouth
* Microdontia
* Odontogenic tumors
* Keratocystic odontogenic tumour
* Odontoma
* Dens in dente
* Open contact
* Premature eruption
* Neonatal teeth
* Pulp calcification
* Pulp stone
* Pulp canal obliteration
* Pulp necrosis
* Pulp polyp
* Pulpitis
* Regional odontodysplasia
* Resorption
* Shovel-shaped incisors
* Supernumerary root
* Taurodontism
* Trauma
* Avulsion
* Cracked tooth syndrome
* Vertical root fracture
* Occlusal
* Tooth loss
* Edentulism
* Tooth wear
* Abrasion
* Abfraction
* Acid erosion
* Attrition

Periodontium (gingiva, periodontal ligament, cementum, alveolus) – Gums and tooth-supporting structures

* Cementicle
* Cementoblastoma
* Gigantiform
* Cementoma
* Eruption cyst
* Epulis
* Pyogenic granuloma
* Congenital epulis
* Gingival enlargement
* Gingival cyst of the adult
* Gingival cyst of the newborn
* Gingivitis
* Desquamative
* Granulomatous
* Plasma cell
* Hereditary gingival fibromatosis
* Hypercementosis
* Hypocementosis
* Linear gingival erythema
* Necrotizing periodontal diseases
* Acute necrotizing ulcerative gingivitis
* Pericoronitis
* Peri-implantitis
* Periodontal abscess
* Periodontal trauma
* Periodontitis
* Aggressive
* As a manifestation of systemic disease
* Chronic
* Perio-endo lesion
* Teething

Periapical, mandibular and maxillary hard tissues – Bones of jaws

* Agnathia
* Alveolar osteitis
* Buccal exostosis
* Cherubism
* Idiopathic osteosclerosis
* Mandibular fracture
* Microgenia
* Micrognathia
* Intraosseous cysts
* Odontogenic: periapical
* Dentigerous
* Buccal bifurcation
* Lateral periodontal
* Globulomaxillary
* Calcifying odontogenic
* Glandular odontogenic
* Non-odontogenic: Nasopalatine duct
* Median mandibular
* Median palatal
* Traumatic bone
* Osteoma
* Osteomyelitis
* Osteonecrosis
* Bisphosphonate-associated
* Neuralgia-inducing cavitational osteonecrosis
* Osteoradionecrosis
* Osteoporotic bone marrow defect
* Paget's disease of bone
* Periapical abscess
* Phoenix abscess
* Periapical periodontitis
* Stafne defect
* Torus mandibularis

Temporomandibular joints, muscles of mastication and malocclusions – Jaw joints, chewing muscles and bite abnormalities

* Bruxism
* Condylar resorption
* Mandibular dislocation
* Malocclusion
* Crossbite
* Open bite
* Overbite
* Overeruption
* Overjet
* Prognathia
* Retrognathia
* Scissor bite
* Maxillary hypoplasia
* Temporomandibular joint dysfunction
* Condylar hypoplasia
* Condylar hyperplasia

Salivary glands

* Benign lymphoepithelial lesion
* Ectopic salivary gland tissue
* Frey's syndrome
* HIV salivary gland disease
* Necrotizing sialometaplasia
* Mucocele
* Ranula
* Pneumoparotitis
* Salivary duct stricture
* Salivary gland aplasia
* Salivary gland atresia
* Salivary gland diverticulum
* Salivary gland fistula
* Salivary gland hyperplasia
* Salivary gland hypoplasia
* Salivary gland neoplasms
* Benign: Basal cell adenoma
* Canalicular adenoma
* Ductal papilloma
* Monomorphic adenoma
* Myoepithelioma
* Oncocytoma
* Papillary cystadenoma lymphomatosum
* Pleomorphic adenoma
* Sebaceous adenoma
* Malignant: Acinic cell carcinoma
* Adenocarcinoma
* Adenoid cystic carcinoma
* Carcinoma ex pleomorphic adenoma
* Lymphoma
* Mucoepidermoid carcinoma
* Sclerosing polycystic adenosis
* Sialadenitis
* Parotitis
* Chronic sclerosing sialadenitis
* Sialectasis
* Sialocele
* Sialodochitis
* Sialosis
* Sialolithiasis
* Sjögren's syndrome

Stomatognathic system – Teeth, jaws, tongue and associated soft tissues

* Bruxism
* Mouth breathing
* Sleep apnea
* Catathrenia
* Central hypoventilation syndrome
* Obesity hypoventilation syndrome
* Obstructive sleep apnea
* Periodic breathing
* Snoring

Orofacial soft tissues – Soft tissues around the mouth

* Actinomycosis
* Angioedema
* Basal cell carcinoma
* Cutaneous sinus of dental origin
* Cystic hygroma
* Gnathophyma
* Ludwig's angina
* Macrostomia
* Melkersson–Rosenthal syndrome
* Microstomia
* Noma
* Oral Crohn's disease
* Orofacial granulomatosis
* Perioral dermatitis
* Pyostomatitis vegetans

Other

* Eagle syndrome
* Hemifacial hypertrophy
* Facial hemiatrophy
* Oral manifestations of systemic disease

* v
* t
* e

Tumors of lip, oral cavity and pharynx / head and neck cancer

Oral cancer|

| Salivary gland|

| malignant epithelial tumors|

* Acinic cell carcinoma
* Mucoepidermoid carcinoma
* Adenoid cystic carcinoma
* Salivary duct carcinoma
* Epithelial-myoepithelial carcinoma
* Polymorphous low-grade adenocarcinoma
* Hyalinizing clear cell carcinoma

|

benign epithelial tumors|

* Pleomorphic adenoma
* Warthin's tumor

ungrouped|

* Oncocytoma

Tongue|

* Leukoplakia
* Rhabdomyoma

* Oropharynx

## External links

[edit]

* Salivary gland cancer entry in the public domain NCI Dictionary of Cancer Terms

Classification|

* ICD-10: C07-C08, D11
* ICD-9-CM: 142, 210.2
* MeSH: D012468

|

External resources|

* MedlinePlus: 001040

This article incorporates public domain material from Dictionary of Cancer Terms. U.S. National Cancer Institute.
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