Sarcomatoid carcinoma

Medical condition

Sarcomatoid carcinoma

Metaplastic (sarcomatoid) carcinoma of the breast.
Specialty| Oncology

Sarcomatoid carcinoma, sometimes referred to as pleomorphic carcinoma,[1] is a relatively uncommon form of cancer whose malignant cells have histological, cytological, or molecular properties of both epithelial tumors ("carcinoma") and mesenchymal tumors ("sarcoma"). It is believed that sarcomatoid carcinomas develop from more common forms of epithelial tumors.[2]

## Types[edit]

Sarcomatoid carcinoma is a type of rare lung tumour under the category of poorly differentiated Non-small-cell lung carcinoma (NSCLC). Based on its histological characteristics, it can be classified into giant cell carcinoma (almost completely consists of giant cells), spindle cell carcinoma (almost completely consists of spindle cells), pleomorphic carcinoma (at least 10% spindle/giant cells or consists of giant and spindle cells only), carcinosarcoma (mix of NSCLC and true sarcoma), and biphasic pulmonary blastoma (consists of embryonal type epithelial element and primitive mesenchymal stroma).[3]

## Locations[edit]

Sarcomatoid carcinomas have been identified in the small intestine in rare cases. They may have epithelioid and mesenchymal properties or be composed only of mesenchymal-type spindle cells, and are negative for CD117 and DOG1.[4]

Some cases of sacromatoid carcinoma of the larynx are resistant to radiotherapy.[2]

## Epidemiology[edit]

This type of tumour have less than 1% incidence of all primary lung cancers. Primary lung tumours originated from the tissues of the lung, not metastasized from other locations in the body.[3]

## References[edit]

1. ^ Moran C, Saul S (2010). "Non Small Cell Carcinomas of the Lung". Tumors and Tumor-like Conditions of the Lung and Pleura. Philadelphia: Saunders/Elsevier. pp. 51–110. ISBN 978-1-4557-0550-4.
2. ^ a b Dewhirst M, Stauffer PR, Das S, Craciunescu OI, Vujaskovic Z, Gunderson L, Tepper J (2016). Clinical Radiation Oncology. Elsevier. pp. 649–472.
3. ^ a b Weissferdt A (September 2018). "Pulmonary Sarcomatoid Carcinomas: A Review". Advances in Anatomic Pathology. 25 (5): 304–313. doi:10.1097/PAP.0000000000000202. PMID 29912718.
4. ^ Odze RD, Goldblum JR (2015). Odze and Goldblum Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas. Saunders. pp. 722–736.

## External links[edit]

Classification|

* ICD-O: M8033/3

|

* v
* t
* e

Cancer involving the respiratory tract

Upper RT|

Nasal cavity

Esthesioneuroblastoma

Nasopharynx

Nasopharyngeal carcinoma
Nasopharyngeal angiofibroma

Larynx

Laryngeal cancer
Laryngeal papillomatosis

Lower RT|

| Trachea|

* Tracheal tumor

|

Lung|

| Non-small-cell lung carcinoma|

* Squamous-cell carcinoma
* Adenocarcinoma (Mucinous cystadenocarcinoma)
* Large-cell lung carcinoma
* Rhabdoid carcinoma
* Sarcomatoid carcinoma
* Carcinoid
* Salivary gland–like carcinoma
* Adenosquamous carcinoma
* Papillary adenocarcinoma
* Giant-cell carcinoma

|

Small-cell carcinoma|

* Combined small-cell carcinoma

Non-carcinoma|

* Sarcoma
* Lymphoma
* Immature teratoma
* Melanoma

By location|

* Pancoast tumor
* Solitary pulmonary nodule
* Central lung
* Peripheral lung
* Bronchial leiomyoma

Pleura|

* Mesothelioma
* Malignant solitary fibrous tumor

* v
* t
* e

Glandular and epithelial cancer

Epithelium|

| Papilloma/carcinoma|

* Small-cell carcinoma
* Combined small-cell carcinoma
* Verrucous carcinoma
* Squamous cell carcinoma
* Basal-cell carcinoma
* Transitional cell carcinoma
* Inverted papilloma

|

Complex epithelial|

* Warthin's tumor
* Thymoma
* Bartholin gland carcinoma

Glands|

| Adenomas/
adenocarcinomas|

| Gastrointestinal|

* tract: Linitis plastica
* Familial adenomatous polyposis

* pancreas
* Insulinoma
* Glucagonoma
* Gastrinoma
* VIPoma
* Somatostatinoma

* Cholangiocarcinoma
* Klatskin tumor
* Hepatocellular adenoma/Hepatocellular carcinoma

|

Urogenital|

* Renal cell carcinoma
* Endometrioid tumor
* Renal oncocytoma

Endocrine|

* Prolactinoma
* Multiple endocrine neoplasia
* Adrenocortical adenoma/Adrenocortical carcinoma
* Hürthle cell

Other/multiple|

* Neuroendocrine tumor
* Carcinoid
* Adenoid cystic carcinoma
* Oncocytoma
* Clear-cell adenocarcinoma
* Apudoma
* Cylindroma
* Papillary hidradenoma

Adnexal and
skin appendage|

* sweat gland
* Hidrocystoma
* Syringoma
* Syringocystadenoma papilliferum

Cystic, mucinous,
and serous|

| Cystic general|

* Cystadenoma/Cystadenocarcinoma

|

Mucinous|

* Signet ring cell carcinoma
* Krukenberg tumor
* Mucinous cystadenoma / Mucinous cystadenocarcinoma
* Pseudomyxoma peritonei
* Mucoepidermoid carcinoma

Serous|

* Ovarian serous cystadenoma / Pancreatic serous cystadenoma / Serous cystadenocarcinoma / Papillary serous cystadenocarcinoma

Ductal, lobular,
and medullary|

| Ductal carcinoma|

* Mammary ductal carcinoma
* Pancreatic ductal carcinoma
* Comedocarcinoma
* Paget's disease of the breast / Extramammary Paget's disease

|

Lobular carcinoma|

* Lobular carcinoma in situ
* Invasive lobular carcinoma

Medullary carcinoma|

* Medullary carcinoma of the breast
* Medullary thyroid cancer

Acinar cell|

* Acinic cell carcinoma

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