Sergey Piletsky

Professor of bio analytical chemistry

Sergey Piletsky

Nationality| British
Education| PhD, DSc
Alma mater|  Kyiv University, Cranfield University
Occupation| Professor
Employer| Leicester University
Known for|

* Biosensors
* Molecularly imprinted polymers
* Computational design of molecular imprinting

Awards| Royal Society Wolfson Research Merit Award

Leverhulme Trust Fellowship

DFG Fellowship Institute of Analytical Chemistry

Award of President of Ukraine

Japan Society for Promotion of Science and Technology Fellowship
Website| https://le.ac.uk/people/sergey-piletsky

Sergey Piletsky is a professor of Bioanalytical Chemistry and the Research Director for School of Chemistry, University of Leicester, United Kingdom.[1]

## Education

[edit]

Sergey graduated from Kyiv University, Ukraine, obtaining an MSc in chemistry in 1985 and researched on synthesis of the polymers selective for nucleic acids, for which he was awarded with a PhD in 1991. Cranfield University awarded Sergey with a DSc for his work on molecularly imprinted polymers for diagnostics applications.[1]

## Awards

[edit]

Sergey is a recipient of Royal Society Wolfson Research Merit Award,[1] Leverhulme Trust Fellowship, DFG Fellowship from the Institute of Analytical Chemistry, Award of President of Ukraine, and Japan Society for Promotion of Science and Technology Fellowship.[1]

## Research

[edit]

Sergey's work in molecular imprinting focuses on: (i) the fundamental study of the recognition properties of molecularly imprinted polymers;[2][3] (ii) the development of sensors and assays for environmental and clinical analysis;[4] and (iii) the development of molecularly imprinted polymer nanoparticles for theranostic applications.[5]

Sergey introduced computational design into the field of molecular imprinting, by scientifically demonstrating that non-covalent interaction between the template molecule and polymer is through the technique known as 'bite and switch' wherein functional groups first non-covalently bond with the binding site, but during the rebinding step, the polymer matrix forms irreversible covalent bonds with the target molecule.[6] A number of research groups around the world follow his ideas in developing functional imprinted polymers for a variety of applications.[7][8]

## Notable publications

[edit]

* Turner, Nicholas W.; Subrahmanyam, Sreenath; Piletsky, Sergey A. (2009-01-26). "Analytical methods for determination of mycotoxins: A review". Analytica Chimica Acta. 632 (2): 168–180\. Bibcode:2009AcAC..632..168T. doi:10.1016/j.aca.2008.11.010. ISSN 0003-2670. PMID 19110091.
* Whitcombe, Michael J.; Chianella, Iva; Larcombe, Lee; Piletsky, Sergey A.; Noble, James; Porter, Robert; Horgan, Adrian (2011-02-22). "The rational development of molecularly imprinted polymer-based sensors for protein detection". Chemical Society Reviews. 40 (3): 1547–1571\. doi:10.1039/C0CS00049C. hdl:1826/6232. ISSN 1460-4744. PMID 21132204.
* Bossi, A.; Bonini, F.; Turner, A. P. F.; Piletsky, S. A. (2007-01-15). "Molecularly imprinted polymers for the recognition of proteins: The state of the art". Biosensors and Bioelectronics. 22 (6): 1131–1137\. doi:10.1016/j.bios.2006.06.023. ISSN 0956-5663. PMID 16891110.
* Surface-grafted molecularly imprinted polymers for protein recognition, A Bossi, SA Piletsky, EV Piletska, PG Righetti, APF Turner, Analytical chemistry 73 (21), 5281-5286[9]
* Electrochemical sensor for catechol and dopamine based on a catalytic molecularly imprinted polymer-conducting polymer hybrid recognition element, Dhana Lakshmi, Alessandra Bossi, Michael J Whitcombe, Iva Chianella, Steven A Fowler, Sreenath Subrahmanyam, Elena V Piletska, Sergey A Piletsky, Analytical Chemistry 81 (9), 3576-3584[10]
* Subrahmanyam, Sreenath; Karim, Kal; Piletsky, Sergey A. (2012), Piletsky, Sergey A.; Whitcombe, Michael J. (eds.), "Computational Approaches in the Design of Synthetic Receptors", Designing Receptors for the Next Generation of Biosensors, vol. 12, Berlin, Heidelberg: Springer Berlin Heidelberg, pp. 131–165, doi:10.1007/5346_2012_22, ISBN 978-3-642-32328-7, retrieved 2022-08-17
* Subrahmanyam, Sreenath; Piletsky, Sergey A. (2009), "Computational Design of Molecularly Imprinted Polymers", Combinatorial Methods for Chemical and Biological Sensors, New York, NY: Springer New York, pp. 135–172, Bibcode:2009cmcb.book..135S, doi:10.1007/978-0-387-73713-3_6, ISBN 978-0-387-73712-6, retrieved 2022-08-16
* Poma, Alessandro; Whitcombe, Michael; Piletsky, Sergey (2012), "Plastic Antibodies", Springer Series on Chemical Sensors and Biosensors, Berlin, Heidelberg: Springer Berlin Heidelberg, pp. 105–129, doi:10.1007/5346_2012_24, ISBN 978-3-642-32328-7, retrieved 2022-08-16
* Rouillon, Régis; Piletsky, Sergey A.; Breton, Florent; Piletska, Elena V.; Carpentier, Robert (2006), Giardi, Maria Teresa; Piletska, Elena V. (eds.), "Photosystem II Biosensors for Heavy Metals Monitoring", Biotechnological Applications of Photosynthetic Proteins: Biochips, Biosensors and Biodevices, Biotechnology Intelligence Unit, Boston, MA: Springer US, pp. 166–174, doi:10.1007/978-0-387-36672-2_15, ISBN 978-0-387-36672-2, retrieved 2022-08-17
* Piletsky S.A., Turner A.P.F. (2006). New generation of chemical sensors based on molecularly imprinted polymers, in: Molecular imprinting of polymers, S. Piletsky and A.P.F. Turner (eds.), Landes Bioscience, Georgetown, TX, USA[11]

## Notable patents

[edit]

* Rationally Designed Selective Binding Polymers (2010), Publication number: 20100009859, Inventors: Sergey A. Piletsky, Olena Piletska, Khalku Karim, Coulton H. Legge, Sreenath Subrahmanyam[12]
* Electrochemical Sensor (2019) Publication number: 20210239643, Inventors: Sergey Piletsky, Omar Sheej Ahamad, Alvaro Garcia Cruz[13]
* Polymerisation method, polymers and uses thereof (2006) Publication number: 20060122288, Inventors: Sergey Piletsky, Olena Piletska, Anthony Turner, Khalku Karim, Beining Chen[14]
* Methods and Kits for determining binding sites (2020) Publication number: 20200033356, Inventors: Sergey Piletsky, Elena Piletska, Francesco Canfarotta, Don Jones[15]
* Photoreactor and Process for Preparing MIP Nanoparticles (2014) Publication number: 20140228472, Inventors: Sergey Piletsky, Olena Piletska, Antonio Guerreiro, Michael Whitcombe, Alessandro Poma[16]

## References

[edit]

1. ^ a b c d "Sergey Piletsky | People | University of Leicester". le.ac.uk. Retrieved 2022-08-16.
2. ^ Piletsky, Sergey A.; Andersson, Håkan S.; Nicholls, Ian A. (1998). "The rational use of hydrophobic effect-based recognition in molecularly imprinted polymers". Journal of Molecular Recognition. 11 (1–6): 94–97\. doi:10.1002/(sici)1099-1352(199812)11:1/6<94::aid-jmr398>3.0.co;2-c. PMID 10076815. S2CID 32111375.1–6&rft.pages=94-97&rft.date=1998&rft_id=https://api.semanticscholar.org/CorpusID:32111375#id-name=S2CID&rft_id=info:pmid/10076815&rft_id=info:doi/10.1002/(sici)1099-1352(199812)11:1/6<94::aid-jmr398>3.0.co;2-c&rft.aulast=Piletsky&rft.aufirst=Sergey+A.&rft.au=Andersson,+Håkan+S.&rft.au=Nicholls,+Ian+A.&rfr_id=info:sid/en.wikipedia.org:Sergey+Piletsky" class="Z3988">
3. ^ Andersson, Håkan S; Karlsson, Jesper G; Piletsky, Sergey A; Koch-Schmidt, Ann-Christin; Mosbach, Klaus; Nicholls, Ian A (1999). "Study of the nature of recognition in molecularly imprinted polymers, II". Journal of Chromatography A. 848 (1–2): 39–49\. doi:10.1016/s0021-9673(99)00483-5. ISSN 0021-9673.1–2&rft.pages=39-49&rft.date=1999&rft_id=info:doi/10.1016/s0021-9673(99)00483-5&rft.issn=0021-9673&rft.aulast=Andersson&rft.aufirst=Håkan+S&rft.au=Karlsson,+Jesper+G&rft.au=Piletsky,+Sergey+A&rft.au=Koch-Schmidt,+Ann-Christin&rft.au=Mosbach,+Klaus&rft.au=Nicholls,+Ian+A&rft_id=http://dx.doi.org/10.1016/s0021-9673(99)00483-5&rfr_id=info:sid/en.wikipedia.org:Sergey+Piletsky" class="Z3988">
4. ^ Piletsky, Sergey A.; Subrahmanyam, S.; Turner, Anthony P.F. (2001-12-01). "Application of molecularly imprinted polymers in sensors for the environment and biotechnology". Sensor Review. 21 (4): 292–296\. doi:10.1108/eum0000000005998. ISSN 0260-2288.
5. ^ Corrigan, Damion K; Salton, Neale A; Preston, Chris; Piletsky, Sergey (2010-08-02). "Towards the development of a rapid, portable, surface enhanced Raman spectroscopy based cleaning verification system for the drug nelarabine". Journal of Pharmacy and Pharmacology. 62 (9): 1195–1200\. doi:10.1111/j.2042-7158.2010.01152.x. ISSN 0022-3573. PMID 20796200. S2CID 37284684.
6. ^ Subrahmanyam, Sreenath; Piletsky, Sergey A; Piletska, Elena V; Chen, Beining; Karim, Kal; Turner, Anthony P.F (2001). "'Bite-and-Switch' approach using computationally designed molecularly imprinted polymers for sensing of creatinine11Editors Selection". Biosensors and Bioelectronics. 16 (9–12): 631–637\. doi:10.1016/s0956-5663(01)00191-9. ISSN 0956-5663. PMID 11679238.9–12&rft.pages=631-637&rft.date=2001&rft.issn=0956-5663&rft_id=info:pmid/11679238&rft_id=info:doi/10.1016/s0956-5663(01)00191-9&rft.aulast=Subrahmanyam&rft.aufirst=Sreenath&rft.au=Piletsky,+Sergey+A&rft.au=Piletska,+Elena+V&rft.au=Chen,+Beining&rft.au=Karim,+Kal&rft.au=Turner,+Anthony+P.F&rft_id=http://dx.doi.org/10.1016/s0956-5663(01)00191-9&rfr_id=info:sid/en.wikipedia.org:Sergey+Piletsky" class="Z3988">
7. ^ Marć, Mariusz; Kupka, Teobald; Wieczorek, Piotr Paweł; Namieśnik, Jacek (2018). "Computational modeling of molecularly imprinted polymers as a green approach to the development of novel analytical sorbents". TrAC Trends in Analytical Chemistry. 98: 64–78\. doi:10.1016/j.trac.2017.10.020. ISSN 0165-9936.
8. ^ Reyes, N B D; Pajarito, B B (2019-10-01). "Computational design of dummy molecularly imprinted polymers via hydrogen bonding investigation for oxytetracycline determination". IOP Conference Series: Materials Science and Engineering. 634 (1): 012035. Bibcode:2019MS&E..634a2035R. doi:10.1088/1757-899x/634/1/012035. ISSN 1757-8981. S2CID 210806505.
9. ^ Bossi, Alessandra; Piletsky, Sergey A.; Piletska, Elena V.; Righetti, Pier Giorgio; Turner, Anthony P. F. (2001-11-01). "Surface-Grafted Molecularly Imprinted Polymers for Protein Recognition". Analytical Chemistry. 73 (21): 5281–5286\. doi:10.1021/ac0006526. ISSN 0003-2700. PMID 11721930.
10. ^ Lakshmi, Dhana; Bossi, Alessandra; Whitcombe, Michael J.; Chianella, Iva; Fowler, Steven A.; Subrahmanyam, Sreenath; Piletska, Elena V.; Piletsky, Sergey A. (2009-05-01). "Electrochemical Sensor for Catechol and Dopamine Based on a Catalytic Molecularly Imprinted Polymer-Conducting Polymer Hybrid Recognition Element". Analytical Chemistry. 81 (9): 3576–3584\. doi:10.1021/ac802536p. ISSN 0003-2700. PMID 19354259.
11. ^ F., Piletsky, Sergey. Turner, Anthony P. (2006). Molecular imprinting of polymers. Landes Bioscience. ISBN 1-58706-219-4. OCLC 65195271.`{{cite book}}`: CS1 maint: multiple names: authors list (link)
12. ^ "US Patent Application for RATIONALLY DESIGNED SELECTIVE BINDING POLYMERS Patent Application (Application #20100009859 issued January 14, 2010) - Justia Patents Search". patents.justia.com. Retrieved 2022-08-16.
13. ^ "US Patent Application for ELECTROCHEMICAL SENSOR Patent Application (Application #20210239643 issued August 5, 2021) - Justia Patents Search". patents.justia.com. Retrieved 2022-08-16.
14. ^ "US Patent Application for Polymerisation method, polymers and uses thereof Patent Application (Application #20060122288 issued June 8, 2006) - Justia Patents Search". patents.justia.com. Retrieved 2022-08-16.
15. ^ "US Patent Application for METHODS AND KITS FOR DETERMINING BINDING SITES Patent Application (Application #20200033356 issued January 30, 2020) - Justia Patents Search". patents.justia.com. Retrieved 2022-08-16.
16. ^ "US Patent Application for Photoreactor and Process for Preparing MIP Nanoparticles Patent Application (Application #20140228472 issued August 14, 2014) - Justia Patents Search". patents.justia.com. Retrieved 2022-08-16.

## External links

[edit]

* Sergey Piletsky publications indexed by Google Scholar

Authority control databases: Academics |

* ORCID
* Scopus

|